Analysis of Fibrinogen Level in Patients Injured in Lushan and Wenchuan Earthquake_West China Medical Journal

Authors：

 HuangXunbei , NiuQian , LiaoJuan , WangXia ,  JiangHong

Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

JiangHong, Email: jianghong6656@126.com

Keywords：

Earthquake; Fibrinogen; Treatment time

DOI：

10.7507/1002-0179.20160073

Video：

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Objective To explore fibrinogen (Fbg) variety in the patients wounded in Lushan and Wenchuan earthquake. Methods As the research subjects, 276 Lushan earthquake victims (from April 20th to 24th, 2013) and 503 Wenchuan earthquake victims (from May 13th to 17th, 2008) were divided into five groups according to the admission date, and then the Fbg variety in those earthquake victims were analyzed. We carried out pairwise comparison among these groups in the Lushan earthquake and Wenchuan earthquake respectively on the Fbg variety. Ninety-one fracture patients in the Lushsan earthquake and 130 fracture patients in the Wenchuan earthquake were divided into two groups according to clinical diagnosis:multiple fracture and single fracture, and then we evaluated the Fbg values in patients with different degrees of disability. Results The whole Fbg level[(2.70±1.15) g/L] in Lushan earthquake was below the level[(4.47±1.94) g/L] in Wenchuan earthquake, and the difference was statistically significant (P<0.01). The Fbg level in the patients whose admission date was within 48 hours was significantly different with that in patients whose admission date was more than 48 hours (P<0.01). The Fbg level in Lushan earthquake was below the level in Wenchuan earthquake, not only in the multiple fracture group but also in the single fracture group[in Lushan earthquake, the former was (2.21±0.76) g/L, and the latter was (1.98±0.85) g/L; in Wenchuan earthquake, the former was (3.35±1.48) g/L, and the latter was (3.11±1.05) g/L], and the difference was statistically significant (P<0.01). Conclusion Blood coagulation, especially Fbg level, has different degrees of changes in acute stress caused by emergency and in different treatment times, and it is better to take preventive measures.

Citation： HuangXunbei, NiuQian, LiaoJuan, WangXia, JiangHong. Analysis of Fibrinogen Level in Patients Injured in Lushan and Wenchuan Earthquake. West China Medical Journal, 2016, 31(2): 270-273. doi: 10.7507/1002-0179.20160073 Copy

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10.	赖绍林, 王庆, 胥伶杰, 等. 汶川地震伤员的早期伤情评估指标与其在一线医院住院时间的相关性分析[J]. 华西医学, 2015, 30(6):1023-1026.
11.	曾朝蓉, 李建南, 程光丽, 等. 芦山地震震中医院早期医疗救护组织管理分析[J]. 临床急诊杂志, 2014, 15(2):103-105.
12.	王谦, 刘遄, 王朴, 等. 芦山地震骨折伤员伤情特点及功能分析[J]. 四川大学学报:医学版, 2015, 46(4):606-610.
13.	孟昭军. 骨折患者监测纤维蛋白原、D-二聚体和血小板指标的意义[J]. 中国实验诊断学, 2014, 18(9):1477-1478.
14.	Aissaoui N, Martins E, Mouly S, et al. A meta-analysis of bed rest versus early ambulation in the management of pulmonary embolism, deep vein thrombosis, or both[J]. Int J Cardiol, 2009, 137(1):37-41.
15.	王兵, 唐锡章, 胡敏, 等. 创伤能量与大鼠肢体深静脉血栓形成的相关性[J]. 中国临床康复, 2005, 9(14):136-137.
16.	王刚, 李强, 徐云钦, 等. 纤维蛋白原及D-二聚体双动态曲线变化在下肢骨折深静脉血栓预防中的价值[J]. 中国骨与关节损伤杂志, 2014, 29(10):1015-1017.

1. van Hylckama Vlieg A, Rosendaal FR. High levels of fibrinogen are associated with the risk of deep venous thrombosis mainly in the elderly[J]. J Thromb Haemost, 2003, 1(12):2677-2678.
2. 刘晓毅, 杨林, 祁光裕, 等. 白介素、C-反应蛋白和纤维蛋白原在下肢深静脉血栓炎症反应中的作用[J]. 中国普外基础与临床杂志, 2010, 17(7):660-663.
3. Ueda S, Hanzawa K, Shibata M, et al. High prevalence of deep vein thrombosis in tsunami-flooded shelters established after the great East-Japan earthquake[J]. Tohoku J Exp Med, 2012, 227(3):199-202.
4. 陈旭, 杨俊华, 黄雨兰, 等. 芦山地震住院伤员应激障碍及其影响因素分析[J]. 实用医院临床杂志, 2015, 12(6):55-58.
5. 王艳琼, 宁宁, 刘欢, 等. 76名芦山地震伤员创伤后应激障碍情况调查分析[J]. 护理学报, 2014, 21(6):9-11.
6. 刘瑞安, 黄垒, 李小麟, 等. 168名芦山地震伤员急性应激障碍发生情况及影响因素分析[J]. 护理学报, 2015, 22(19):22-26.
7. Vitorino de Almeida V, Silva-Herdade A, Calado A, et al. Fibrinogen modulates leukocyte recruitment in vivo during the acute inflammatory response[J]. Clin Hemorheol Microcirc, 2012, 59(2):97-106.
8. 张毅, 司徒明镜, 方慧, 等. 汶川大地震灾区儿童青少年的地震经历与抑郁情绪[J]. 华西医学, 2009, 24(1):21-24.
9. 郎学勤. 云南鲁甸8. 03地震成批伤员的急诊分诊及救护[J]. 中外医学研究, 2015, 13(4):154-155.
10. 赖绍林, 王庆, 胥伶杰, 等. 汶川地震伤员的早期伤情评估指标与其在一线医院住院时间的相关性分析[J]. 华西医学, 2015, 30(6):1023-1026.
11. 曾朝蓉, 李建南, 程光丽, 等. 芦山地震震中医院早期医疗救护组织管理分析[J]. 临床急诊杂志, 2014, 15(2):103-105.
12. 王谦, 刘遄, 王朴, 等. 芦山地震骨折伤员伤情特点及功能分析[J]. 四川大学学报:医学版, 2015, 46(4):606-610.
13. 孟昭军. 骨折患者监测纤维蛋白原、D-二聚体和血小板指标的意义[J]. 中国实验诊断学, 2014, 18(9):1477-1478.
14. Aissaoui N, Martins E, Mouly S, et al. A meta-analysis of bed rest versus early ambulation in the management of pulmonary embolism, deep vein thrombosis, or both[J]. Int J Cardiol, 2009, 137(1):37-41.
15. 王兵, 唐锡章, 胡敏, 等. 创伤能量与大鼠肢体深静脉血栓形成的相关性[J]. 中国临床康复, 2005, 9(14):136-137.
16. 王刚, 李强, 徐云钦, 等. 纤维蛋白原及D-二聚体双动态曲线变化在下肢骨折深静脉血栓预防中的价值[J]. 中国骨与关节损伤杂志, 2014, 29(10):1015-1017.

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Analysis of Fibrinogen Level in Patients Injured in Lushan and Wenchuan Earthquake

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