Effects of taurine on ventricular remodeling of rats with acute myocardial infarction_West China Medical Journal

Authors：

 QIU Nan

Department of Emergency Internal Medicine, Guizhou Provincial People’s Hospital, Guiyang, Guizhou 550002, P. R. China;

Corresponding author：

QIU Nan, Email: gyqn111@163.com

Keywords：

Acute myocardial infarction; Taurine; Ventricular remodeling; Rat

DOI：

10.7507/1002-0179.201705118

Video：

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Objective To observe the effects of taurine on ventricular remodeling of rats with acute myocardial infarction (AMI) though the establishment of rat AMI model by ligating the left anterior descending coronary branch. Methods Sixty 8-week-old male Wistar rats were randomly divided into four groups: sham group, AMI group, small-dose and high-dose taurine group, with 15 rats in each. Rats in the AMI group and taurine groups received ligation of the anterior descending coronary branch to establish an animal model of AMI. Meanwhile, rats in the sham group were subjected to sham coronary ligature. From the next day of the operation, rats in the taurine groups were dosed orally per day with taurine 300 mg/kg or 400 mg/kg for 8 weeks, respectively. Echocardiographic images were acquired before and 8 weeks after the operation, to get the indexes such as left ventricular end systolic diameter (LVIDs), left ventricular end diastolic diameter (LVIDd), left ventricular posterior wall end diastolic thickness (LVPWd), left ventricular ejection fraction (LVEF), fractional shortening (FS), mitral inflow velocity E (E), mitral inflow velocity A (A), and E/A ratio, and all the measurements above were expressed as the average of 6 consecutive cardiac cycles. After the animals were executed, cardiac mass and left ventricular mass were measured, and cardiac mass index (CMI) and left ventricular mass index (LVMI) were calculated. Brain natriuretic peptide (BNP) in all groups were measured by enzyme-linked immunosorbent assay before and 8 weeks after the operation. Results In comparison with the AMI group, CMI, LVMI, LVIDd and LVIDs of the small-dose and high-dose taurine groups were lower, and LVPWd, LVEF, FS and E/A were higher (P<0.05). Plasma BNP level in the AMI group and two taurine-treated groups were higher than that in the sham group, and it was the highest in the AMI group (P<0.05). Conclusion Taurine has a protective effect on ventricular remodeling in rats with AMI, and the protective effect is dose-dependent.

Citation： QIU Nan. Effects of taurine on ventricular remodeling of rats with acute myocardial infarction. West China Medical Journal, 2017, 32(6): 833-837. doi: 10.7507/1002-0179.201705118 Copy

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2.	Hsu JT, Chung CM, Chu CM, et al. Predictors of left ventricle remodeling: combined plasma B-type natriuretic peptide decreasing ratio and peak creatine kinase-MB. Int J Med Sci, 2017, 14(1): 75-85.
3.	Lin JF, Hsu SY, Teng MS, et al. Activin a predicts left ventricular remodeling and mortality in patients with ST-Elevation myocardial infarction. Acta Cardiol Sin, 2016, 32(4): 420-427.
4.	Nägele MP. Letter by nägele regarding article, " effect of omega-3 acid ethyl esters on left ventricular remodeling after acute myocardial infarction: the OMEGA-REMODEL randomized clinical trial”. Circulation, 2017, 135(2): e11-e12.
5.	Reichert K, Pereira do Carmo HR, Galluce Torina A, et al. Atorvastatin improves ventricular remodeling after myocardial infarction by interfering with collagen metabolism. PLoS One, 2016, 11(11): e0166845.
6.	Mccarty MF. Complementary vascular-protective actions of magnesium and taurine: a rationale for magnesium taurate. Med Hypotheses, 1996, 46(2): 89-100.
7.	Hunt SA, Abraham WT, Chin MH, et al. 2009 focused update incorporated into the ACC/AHA 2005 guidelines for the diagnosis and management of heart failure in adults a report of the American college of cardiology foundation/American heart association task force on practice guidelines developed in collaboration with the international society for heart and lung transplantation. J Am Coll Cardiol, 2009, 53(15): e1-e90.
8.	Sadek MM, Haddad T, Haddad H. The role of statins in chronic heart failure. Curr Opin Cardiol, 2009, 24(2): 167-171.
9.	Yang YJ, Zhang YE, Liu XY, et al. Exogenous taurine attenuates mitochondrial oxidative stress and endoplasmic reticulum stress in rat cardiomyocytes. Acta Biochim Biophys Sin (Shanghai), 2013, 45(5): 359-367.
10.	Zulli A. Taurine in cardiovascular disease. Curr Opin Clin Nutr Metab Care, 2011, 14(1): 57-60.
11.	Schaffer SW, Jong CJ, Ito T, et al. Effect of taurine on ischemia-reperfusion injury. Amino Acids, 2014, 46(1): 21-30.
12.	Pansani MC, Azevedo PS, Rafacho BP, et al. Atrophic cardiac remodeling induced by taurine deficiency in wistar rats. PLoS One, 2012, 7(7): e41439.
13.	贵州省科学技术委员会. 黔科条通宇(1993)第 25 号关于发布《贵州省实验动物管理实施细则》的通知. (1993-04-20)[2015-06-01]. http://dwzx.gmc.edu.cn/info/1377/2544.htm.
14.	刘蜜, 王琛, 王晓礽, 等. 西洋参茎叶总皂苷通过抑制内质网应激相关细胞凋亡减轻大鼠急性心肌梗死后心室重构. 中国病理生理杂志, 2013, 29(5): 796-803.
15.	Litwin SE, Katz SE, Morgan JP, et al. Serial echocardiographic assessment of left-ventricular geometry and function after large myocardial infarction in the rat. Circulation, 1994, 89(1): 345-354.
16.	Tang XL, Sanganalmath SK, Sato H, et al. Atorvastatin therapy during the peri-infarct period attenuates left ventricular dysfunction and remodeling after myocardial infarction. PLoS One, 2011, 6(9): e25320.
17.	Bendall JK, Damy T, Ratajczak P, et al. Role of myocardial neuronal nitric oxide synthase-derived nitric oxide in beta-adrenergic hyporesponsiveness after myocardial infarction-induced heart failure in rat. Circulation, 2004, 110(16): 2368-2375.
18.	Miyamoto TA, Ueno T, Iguro Y, et al. Taurine-mediated cardioprotection is greater when administered upon reperfusion than prior toischemia. Adv Exp Med Biol, 2009, 643: 27-36.
19.	Sahin MA, Yucel O, Guler A, et al. Is there any cardioprotective role of taurine during cold ischemic period following global myocardial ischemia?. J Cardiothorac Surg, 2011, 6: 31.
20.	Xu YJ, Saini HK, Zhang M, et al. MAPK activation and apoptotic alterations in hearts subjected to calcium paradox are attenuated by taurine. Cardiovasc Res, 2006, 72(1): 163-174.
21.	孙凌, 杨吉成, 袁志昌, 等. 牛磺酸抑制新生大鼠心肌重塑的体外研究. 江苏医药, 2004, 30(2): 81-83.

1. Liu XX, Yuan L, Chen F, et al. Circulating miR-208b: a potentially sensitive and reliable biomarker for the diagnosis and prognosis of acute myocardial infarction. Clin Lab, 2017, 63(1): 101-109.
2. Hsu JT, Chung CM, Chu CM, et al. Predictors of left ventricle remodeling: combined plasma B-type natriuretic peptide decreasing ratio and peak creatine kinase-MB. Int J Med Sci, 2017, 14(1): 75-85.
3. Lin JF, Hsu SY, Teng MS, et al. Activin a predicts left ventricular remodeling and mortality in patients with ST-Elevation myocardial infarction. Acta Cardiol Sin, 2016, 32(4): 420-427.
4. Nägele MP. Letter by nägele regarding article, " effect of omega-3 acid ethyl esters on left ventricular remodeling after acute myocardial infarction: the OMEGA-REMODEL randomized clinical trial”. Circulation, 2017, 135(2): e11-e12.
5. Reichert K, Pereira do Carmo HR, Galluce Torina A, et al. Atorvastatin improves ventricular remodeling after myocardial infarction by interfering with collagen metabolism. PLoS One, 2016, 11(11): e0166845.
6. Mccarty MF. Complementary vascular-protective actions of magnesium and taurine: a rationale for magnesium taurate. Med Hypotheses, 1996, 46(2): 89-100.
7. Hunt SA, Abraham WT, Chin MH, et al. 2009 focused update incorporated into the ACC/AHA 2005 guidelines for the diagnosis and management of heart failure in adults a report of the American college of cardiology foundation/American heart association task force on practice guidelines developed in collaboration with the international society for heart and lung transplantation. J Am Coll Cardiol, 2009, 53(15): e1-e90.
8. Sadek MM, Haddad T, Haddad H. The role of statins in chronic heart failure. Curr Opin Cardiol, 2009, 24(2): 167-171.
9. Yang YJ, Zhang YE, Liu XY, et al. Exogenous taurine attenuates mitochondrial oxidative stress and endoplasmic reticulum stress in rat cardiomyocytes. Acta Biochim Biophys Sin (Shanghai), 2013, 45(5): 359-367.
10. Zulli A. Taurine in cardiovascular disease. Curr Opin Clin Nutr Metab Care, 2011, 14(1): 57-60.
11. Schaffer SW, Jong CJ, Ito T, et al. Effect of taurine on ischemia-reperfusion injury. Amino Acids, 2014, 46(1): 21-30.
12. Pansani MC, Azevedo PS, Rafacho BP, et al. Atrophic cardiac remodeling induced by taurine deficiency in wistar rats. PLoS One, 2012, 7(7): e41439.
13. 贵州省科学技术委员会. 黔科条通宇(1993)第 25 号关于发布《贵州省实验动物管理实施细则》的通知. (1993-04-20)[2015-06-01]. http://dwzx.gmc.edu.cn/info/1377/2544.htm.
14. 刘蜜, 王琛, 王晓礽, 等. 西洋参茎叶总皂苷通过抑制内质网应激相关细胞凋亡减轻大鼠急性心肌梗死后心室重构. 中国病理生理杂志, 2013, 29(5): 796-803.
15. Litwin SE, Katz SE, Morgan JP, et al. Serial echocardiographic assessment of left-ventricular geometry and function after large myocardial infarction in the rat. Circulation, 1994, 89(1): 345-354.
16. Tang XL, Sanganalmath SK, Sato H, et al. Atorvastatin therapy during the peri-infarct period attenuates left ventricular dysfunction and remodeling after myocardial infarction. PLoS One, 2011, 6(9): e25320.
17. Bendall JK, Damy T, Ratajczak P, et al. Role of myocardial neuronal nitric oxide synthase-derived nitric oxide in beta-adrenergic hyporesponsiveness after myocardial infarction-induced heart failure in rat. Circulation, 2004, 110(16): 2368-2375.
18. Miyamoto TA, Ueno T, Iguro Y, et al. Taurine-mediated cardioprotection is greater when administered upon reperfusion than prior toischemia. Adv Exp Med Biol, 2009, 643: 27-36.
19. Sahin MA, Yucel O, Guler A, et al. Is there any cardioprotective role of taurine during cold ischemic period following global myocardial ischemia?. J Cardiothorac Surg, 2011, 6: 31.
20. Xu YJ, Saini HK, Zhang M, et al. MAPK activation and apoptotic alterations in hearts subjected to calcium paradox are attenuated by taurine. Cardiovasc Res, 2006, 72(1): 163-174.
21. 孙凌, 杨吉成, 袁志昌, 等. 牛磺酸抑制新生大鼠心肌重塑的体外研究. 江苏医药, 2004, 30(2): 81-83.

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