Clinical trial, an important research method, plays a crucial role in the development of medicine. It provides important decision support for medical workers. Medical research proposal should be posted at clinical trial registries. Researchers should update original data and research results, which contributes to data sharing. Clinical trial registration can avoid repetitive research and make clinical trials more transparent and standardized. This paper briefly introduces the clinical trial registration, including the definition, the significance, the history, the scope of registration, the organization of registration, and some common problems in the process of registration. Taking the application of clinical trial registration in the field of neurological research as an example, the article describes the current application status of clinical trial registration and explores it’s value and deficiency in specific clinical research, to provoke the awareness on trial registration, which can help to improve the quality of clinical trials.
Citation：
LI Wanling, CHEN Lei. A review of clinical trial registration and its application in neurology. West China Medical Journal, 2018, 33(6): 758-761. doi: 10.7507/1002-0179.201805103
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Copyright © the editorial department of West China Medical Journal of West China Medical Publisher. All rights reserved
| 1. |
Proehl JA, Alexander S, Manton AP. Integrity and transparency in reporting clinical trials. Adv Emerg Nurs J, 2017, 39(1): 1-2.
|
| 2. |
于河, 刘建平. 国际临床试验注册概述. 中西医结合学报, 2007, 5(3): 234-242.
|
| 3. |
Tonks A. Registering clinical trials. BMJ, 1999, 319(7224): 1565-1568.
|
| 4. |
World Health Organization International Clinical Trial Registration Platform. WHO ICTRP. http://www.who.int/ictrp/zh/.
|
| 5. |
Taichman DB, Sahni P, Pinborg A, et al. Data sharing statements for clinical trials: a requirement of the international committee of medical journal editors. JAMA, 2017, 317(24): 2491-2492.
|
| 6. |
Steinbrook R. Public registration of clinical trials. N Engl J Med, 2004, 351(4): 315-317.
|
| 7. |
吴泰相, 李幼平, 李静, 等. 临床试验的里程碑事件: 全球临床试验注册制度建成运行. 中国循证医学杂志, 2007, 7(7): 479-480.
|
| 8. |
邬兰, 田国祥, 王行环, 等. 临床试验的注册及注册平台比较分析. 中国循证心血管医学杂志, 2017, 9(2): 129-134.
|
| 9. |
吴泰相, 李幼平, 刘关键, 等. 临床试验注册制度与循证医学. 中国循证医学杂志, 2007, 7(4): 239-243.
|
| 10. |
中国临床试验注册中心. Chinese Clinical Trial Registry, ChiCTR. http://www.chictr.org.cn.
|
| 11. |
Jones CW, Handler L, Crowell KE, et al. Non-publication of large randomized clinical trials: cross sectional analysis. BMJ, 2013, 347: f6104.
|
| 12. |
Lampert A, Hoffmann GF, Ries M. Ten years after the international committee of medical journal editors’ clinical trial registration initiative, one quarter of phase 3 pediatric epilepsy clinical trials still remain unpublished: a cross sectional analysis. PLoS One, 2016, 11(1): e0144973.
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- 1. Proehl JA, Alexander S, Manton AP. Integrity and transparency in reporting clinical trials. Adv Emerg Nurs J, 2017, 39(1): 1-2.
- 2. 于河, 刘建平. 国际临床试验注册概述. 中西医结合学报, 2007, 5(3): 234-242.
- 3. Tonks A. Registering clinical trials. BMJ, 1999, 319(7224): 1565-1568.
- 4. World Health Organization International Clinical Trial Registration Platform. WHO ICTRP. http://www.who.int/ictrp/zh/.
- 5. Taichman DB, Sahni P, Pinborg A, et al. Data sharing statements for clinical trials: a requirement of the international committee of medical journal editors. JAMA, 2017, 317(24): 2491-2492.
- 6. Steinbrook R. Public registration of clinical trials. N Engl J Med, 2004, 351(4): 315-317.
- 7. 吴泰相, 李幼平, 李静, 等. 临床试验的里程碑事件: 全球临床试验注册制度建成运行. 中国循证医学杂志, 2007, 7(7): 479-480.
- 8. 邬兰, 田国祥, 王行环, 等. 临床试验的注册及注册平台比较分析. 中国循证心血管医学杂志, 2017, 9(2): 129-134.
- 9. 吴泰相, 李幼平, 刘关键, 等. 临床试验注册制度与循证医学. 中国循证医学杂志, 2007, 7(4): 239-243.
- 10. 中国临床试验注册中心. Chinese Clinical Trial Registry, ChiCTR. http://www.chictr.org.cn.
- 11. Jones CW, Handler L, Crowell KE, et al. Non-publication of large randomized clinical trials: cross sectional analysis. BMJ, 2013, 347: f6104.
- 12. Lampert A, Hoffmann GF, Ries M. Ten years after the international committee of medical journal editors’ clinical trial registration initiative, one quarter of phase 3 pediatric epilepsy clinical trials still remain unpublished: a cross sectional analysis. PLoS One, 2016, 11(1): e0144973.
