Prognostic significance of microRNA-21 expression in esophageal cancer: a systematic review and meta-analysis_West China Medical Journal

Authors：

WANG Chaokun ^1,2 ,  WANG Xinshuai ² , CHEN Jing ² , LIU Zhiwei ² , GAO Shegan ²

1. Department of Oncology, Shangqiu Municipal Hospital, Shangqiu, Henan 476000, P. R. China;
2. Department of Oncology, the First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan 471003, P. R. China;

Corresponding author：

WANG Xinshuai, Email: xshuaiw@haust.edu.cn

Keywords：

MicroRNA-21; esophageal cancer; prognosis; meta-analysis

DOI：

10.7507/1002-0179.202004240

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To systematically evaluate the correlation between the expression of microRNA (miRNA)-21 and the prognosis of esophageal cancer. Methods PubMed, Cochrane Library, Embase, Wanfang Data, China National Knowledge Infrastructure and VIP Databases were searched by for the literature on the correlation between miRNA-21 and the prognosis of esophageal cancer till July 10, 2022. Two researchers independently performed literature screening, quality evaluation, and data extraction. Statistical analysis was conducted with Stata 14.0. Results A total of 13 articles were included, including 1 204 patients. The results of meta-analysis showed that: the overall survival (OS) of patients with high expression of miRNA-21 was lower than that of patients with low expression of miRNA-21 [hazard ratio (HR)=2.11, 95% confidence interval (CI) (1.56, 2.84), P<0.001]. miRNA-21 expression was not associated with disease free survival [HR=2.53, 95%CI (0.67, 8.22), P=0.182]. The OS of Asian patients with high expression of miRNA-21 was significantly lower [HR=2.44, 95%CI (1.71, 3.49), P=0.005], while the OS of non-Asian patients was not related to miRNA-21 expression [HR=1.34, 95%CI (0.94, 1.91), P=0.363]. The high expression of miRNA-21 was correlated with the decreased OS in patients with esophageal squamous cell carcinoma [HR=2.22, 95%CI (1.52, 3.26), P=0.001], while the OS in patients with esophageal adenocarcinoma was not correlated with the expression of miRNA-21 [HR=1.39, 95%CI (0.63, 3.06), P=0.409]. Conclusion The overexpression of miRNA-21 is associated with poor prognosis and might be regarded as a potential prognostic biomarker for patients with esophageal cancer.

Citation： WANG Chaokun, WANG Xinshuai, CHEN Jing, LIU Zhiwei, GAO Shegan. Prognostic significance of microRNA-21 expression in esophageal cancer: a systematic review and meta-analysis. West China Medical Journal, 2022, 37(8): 1213-1220. doi: 10.7507/1002-0179.202004240 Copy

1.	Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2018, 68(6): 394-424.
2.	Zeng H, Chen W, Zheng R, et al. Changing cancer survival in China during 2003-15: a pooled analysis of 17 population-based cancer registries. Lancet Glob Health, 2018, 6(5): e555-e567.
3.	Winter J, Jung S, Keller S, et al. Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat Cell Biol, 2009, 11(3): 228-234.
4.	Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell, 2004, 116(2): 281-297.
5.	Zhang Q, Gan H, Song W, et al. MicroRNA-145 promotes esophageal cancer cells proliferation and metastasis by targeting SMAD5. Scand J Gastroenterol, 2018, 53(7): 769-776.
6.	Uhlmann S, Mannsperger H, Zhang JD, et al. Global microRNA level regulation of EGFR-driven cell-cycle protein network in breast cancer. Mol Syst Biol, 2012, 8: 570.
7.	Hayes J, Peruzzi PP, Lawler S. MicroRNAs in cancer: biomarkers, functions and therapy. Trends Mol Med, 2014, 20(8): 460-469.
8.	Cao D, Di M, Liang J, et al. MicroRNA-183 in cancer progression. J Cancer, 2020, 11(6): 1315-1324.
9.	Jansson MD, Lund AH. MicroRNA and cancer. Mol Oncol, 2012, 6(6): 590-610.
10.	Mavridis K, Stravodimos K, Scorilas A. Downregulation and prognostic performance of microRNA 224 expression in prostate cancer. Clin Chem, 2013, 59(1): 261-269.
11.	Cui Y, Xu HF, Liu MY, et al. Mechanism of exosomal microRNA-224 in development of hepatocellular carcinoma and its diagnostic and prognostic value. World J Gastroenterol, 2019, 25(15): 1890-1898.
12.	Peng Z, Zhu W, Dai J, et al. MicroRNA-200 as potential diagnostic markers for colorectal cancer: meta-analysis and experimental validation. Cell Mol Biol (Noisy-le-grand), 2018, 64(6): 77-85.
13.	黄声凯, 王佳, 李燕, 等. 血清 miR-378 和 miR-21 联合检测对胃癌的诊断价值. 中华肿瘤杂志, 2018, 40(6): 441-445.
14.	Liao J, Liu R, Shi YJ, et al. Exosome-shuttling microRNA-21 promotes cell migration and invasion-targeting PDCD4 in esophageal cancer. Int J Oncol, 2016, 48(6): 2567-2579.
15.	刘思玉, 李宏卫. 微 RNA 在口腔鳞状细胞癌中表达的研究进展. 中华口腔医学杂志, 2013, 48(6): 376-380.
16.	Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol, 2010, 25(9): 603-605.
17.	周支瑞, 张天嵩, 李博, 等. 生存曲线中 Meta 分析适宜数据的提取与转换. 中国循证心血管医学杂志, 2014, 6(3): 243-247.
18.	Egger M, Davey Smith G, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. BMJ, 1997, 315(7109): 629-634.
19.	Hamano R, Miyata H, Yamasaki M, et al. Overexpression of miR-200c induces chemoresistance in esophageal cancers mediated through activation of the Akt signaling pathway. Clin Cancer Res, 2011, 17(9): 3029-3038.
20.	He Y, Jin J, Wang L, et al. Evaluation of miR-21 and miR-375 as prognostic biomarkers in oesophageal cancer in high-risk areas in China. Clin Exp Metastasis, 2017, 34(1): 73-84.
21.	Hu Y, Correa AM, Hoque A, et al. Prognostic significance of differentially expressed miRNAs in esophageal cancer. Int J Cancer, 2011, 128(1): 132-143.
22.	Komatsu S, Ichikawa D, Takeshita H, et al. Prognostic impact of circulating miR-21 and miR-375 in plasma of patients with esophageal squamous cell carcinoma. Expert Opin Biol Ther, 2012, 12(Suppl 1): S53-S59.
23.	Li P, Mao WM, Zheng ZG, et al. Down-regulation of PTEN expression modulated by dysregulated miR-21 contributes to the progression of esophageal cancer. Dig Dis Sci, 2013, 58(12): 3483-3493.
24.	Li BX, Yu Q, Shi ZL, et al. Circulating microRNAs in esophageal squamous cell carcinoma: association with locoregional staging and survival. Int J Clin Exp Med, 2015, 8(5): 7241-7250.
25.	Lv H, He Z, Wang H, et al. Differential expression of miR-21 and miR-75 in esophageal carcinoma patients and its clinical implication. Am J Transl Res, 2016, 8(7): 3288-3298.
26.	Mathé EA, Nguyen GH, Bowman ED, et al. MicroRNA expression in squamous cell carcinoma and adenocarcinoma of the esophagus: associations with survival. Clin Cancer Res, 2009, 15(19): 6192-6200.
27.	Winther M, Alsner J, Tramm T, et al. Evaluation of miR-21 and miR-375 as prognostic biomarkers in esophageal cancer. Acta Oncol, 2015, 54(9): 1582-1591.
28.	Zhao Y, Schetter AJ, Yang GB, et al. microRNA and inflammatory gene expression as prognostic marker for overall survival in esophageal squamous cell carcinoma. Int J Cancer, 2013, 132(12): 2901-2909.
29.	Tanaka K, Miyata H, Yamasaki M, et al. Circulating miR-200c levels significantly predict response to chemotherapy and prognosis of patients undergoing neoadjuvant chemotherapy for esophageal cancer. Ann Surg Oncol, 2013, 20 (Suppl 3): S607-S615.
30.	向正凯, 严宝国. 食管癌组织中 microRNA-21 的表达及其意义. 肿瘤防治研究, 2014, 41(8): 902-905.
31.	Luo D, Huang Z, Lv H, et al. Up-regulation of microRNA-21 indicates poor prognosis and promotes cell proliferation in esophageal squamous cell carcinoma via upregulation of lncRNA SNHG1. Cancer Manag Res, 2020, 12: 1-14.
32.	王斌, 姜雷, 王冰冰, 等. miRNA-21 表达水平与结直肠癌患者预后关系的 Meta 分析. 肿瘤, 2015, 35(1): 84-91.
33.	Yuan Y, Xu XY, Zheng HG, et al. Elevated miR-21 is associated with poor prognosis in non-small cell lung cancer: a systematic review and meta-analysis. Eur Rev Med Pharmacol Sci, 2018, 22(13): 4166-4180.
34.	Wang H, Tan Z, Hu H, et al. microRNA-21 promotes breast cancer proliferation and metastasis by targeting LZTFL1. BMC Cancer, 2019, 19(1): 738.
35.	Wen SW, Zhang YF, Li Y, et al. Association of miR-21 with esophageal cancer prognosis: a meta-analysis. Genet Mol Res, 2015, 14(2): 6578-6582.
36.	Arnold M, Soerjomataram I, Ferlay J, et al. Global incidence of oesophageal cancer by histological subtype in 2012. Gut, 2015, 64(3): 381-387.
37.	Yang Z, Zeng H, Xia R, et al. Annual cost of illness of stomach and esophageal cancer patients in urban and rural areas in China: a multi-center study. Chin J Cancer Res, 2018, 30(4): 439-448.

1. Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2018, 68(6): 394-424.
2. Zeng H, Chen W, Zheng R, et al. Changing cancer survival in China during 2003-15: a pooled analysis of 17 population-based cancer registries. Lancet Glob Health, 2018, 6(5): e555-e567.
3. Winter J, Jung S, Keller S, et al. Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat Cell Biol, 2009, 11(3): 228-234.
4. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell, 2004, 116(2): 281-297.
5. Zhang Q, Gan H, Song W, et al. MicroRNA-145 promotes esophageal cancer cells proliferation and metastasis by targeting SMAD5. Scand J Gastroenterol, 2018, 53(7): 769-776.
6. Uhlmann S, Mannsperger H, Zhang JD, et al. Global microRNA level regulation of EGFR-driven cell-cycle protein network in breast cancer. Mol Syst Biol, 2012, 8: 570.
7. Hayes J, Peruzzi PP, Lawler S. MicroRNAs in cancer: biomarkers, functions and therapy. Trends Mol Med, 2014, 20(8): 460-469.
8. Cao D, Di M, Liang J, et al. MicroRNA-183 in cancer progression. J Cancer, 2020, 11(6): 1315-1324.
9. Jansson MD, Lund AH. MicroRNA and cancer. Mol Oncol, 2012, 6(6): 590-610.
10. Mavridis K, Stravodimos K, Scorilas A. Downregulation and prognostic performance of microRNA 224 expression in prostate cancer. Clin Chem, 2013, 59(1): 261-269.
11. Cui Y, Xu HF, Liu MY, et al. Mechanism of exosomal microRNA-224 in development of hepatocellular carcinoma and its diagnostic and prognostic value. World J Gastroenterol, 2019, 25(15): 1890-1898.
12. Peng Z, Zhu W, Dai J, et al. MicroRNA-200 as potential diagnostic markers for colorectal cancer: meta-analysis and experimental validation. Cell Mol Biol (Noisy-le-grand), 2018, 64(6): 77-85.
13. 黄声凯, 王佳, 李燕, 等. 血清 miR-378 和 miR-21 联合检测对胃癌的诊断价值. 中华肿瘤杂志, 2018, 40(6): 441-445.
14. Liao J, Liu R, Shi YJ, et al. Exosome-shuttling microRNA-21 promotes cell migration and invasion-targeting PDCD4 in esophageal cancer. Int J Oncol, 2016, 48(6): 2567-2579.
15. 刘思玉, 李宏卫. 微 RNA 在口腔鳞状细胞癌中表达的研究进展. 中华口腔医学杂志, 2013, 48(6): 376-380.
16. Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol, 2010, 25(9): 603-605.
17. 周支瑞, 张天嵩, 李博, 等. 生存曲线中 Meta 分析适宜数据的提取与转换. 中国循证心血管医学杂志, 2014, 6(3): 243-247.
18. Egger M, Davey Smith G, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. BMJ, 1997, 315(7109): 629-634.
19. Hamano R, Miyata H, Yamasaki M, et al. Overexpression of miR-200c induces chemoresistance in esophageal cancers mediated through activation of the Akt signaling pathway. Clin Cancer Res, 2011, 17(9): 3029-3038.
20. He Y, Jin J, Wang L, et al. Evaluation of miR-21 and miR-375 as prognostic biomarkers in oesophageal cancer in high-risk areas in China. Clin Exp Metastasis, 2017, 34(1): 73-84.
21. Hu Y, Correa AM, Hoque A, et al. Prognostic significance of differentially expressed miRNAs in esophageal cancer. Int J Cancer, 2011, 128(1): 132-143.
22. Komatsu S, Ichikawa D, Takeshita H, et al. Prognostic impact of circulating miR-21 and miR-375 in plasma of patients with esophageal squamous cell carcinoma. Expert Opin Biol Ther, 2012, 12(Suppl 1): S53-S59.
23. Li P, Mao WM, Zheng ZG, et al. Down-regulation of PTEN expression modulated by dysregulated miR-21 contributes to the progression of esophageal cancer. Dig Dis Sci, 2013, 58(12): 3483-3493.
24. Li BX, Yu Q, Shi ZL, et al. Circulating microRNAs in esophageal squamous cell carcinoma: association with locoregional staging and survival. Int J Clin Exp Med, 2015, 8(5): 7241-7250.
25. Lv H, He Z, Wang H, et al. Differential expression of miR-21 and miR-75 in esophageal carcinoma patients and its clinical implication. Am J Transl Res, 2016, 8(7): 3288-3298.
26. Mathé EA, Nguyen GH, Bowman ED, et al. MicroRNA expression in squamous cell carcinoma and adenocarcinoma of the esophagus: associations with survival. Clin Cancer Res, 2009, 15(19): 6192-6200.
27. Winther M, Alsner J, Tramm T, et al. Evaluation of miR-21 and miR-375 as prognostic biomarkers in esophageal cancer. Acta Oncol, 2015, 54(9): 1582-1591.
28. Zhao Y, Schetter AJ, Yang GB, et al. microRNA and inflammatory gene expression as prognostic marker for overall survival in esophageal squamous cell carcinoma. Int J Cancer, 2013, 132(12): 2901-2909.
29. Tanaka K, Miyata H, Yamasaki M, et al. Circulating miR-200c levels significantly predict response to chemotherapy and prognosis of patients undergoing neoadjuvant chemotherapy for esophageal cancer. Ann Surg Oncol, 2013, 20 (Suppl 3): S607-S615.
30. 向正凯, 严宝国. 食管癌组织中 microRNA-21 的表达及其意义. 肿瘤防治研究, 2014, 41(8): 902-905.
31. Luo D, Huang Z, Lv H, et al. Up-regulation of microRNA-21 indicates poor prognosis and promotes cell proliferation in esophageal squamous cell carcinoma via upregulation of lncRNA SNHG1. Cancer Manag Res, 2020, 12: 1-14.
32. 王斌, 姜雷, 王冰冰, 等. miRNA-21 表达水平与结直肠癌患者预后关系的 Meta 分析. 肿瘤, 2015, 35(1): 84-91.
33. Yuan Y, Xu XY, Zheng HG, et al. Elevated miR-21 is associated with poor prognosis in non-small cell lung cancer: a systematic review and meta-analysis. Eur Rev Med Pharmacol Sci, 2018, 22(13): 4166-4180.
34. Wang H, Tan Z, Hu H, et al. microRNA-21 promotes breast cancer proliferation and metastasis by targeting LZTFL1. BMC Cancer, 2019, 19(1): 738.
35. Wen SW, Zhang YF, Li Y, et al. Association of miR-21 with esophageal cancer prognosis: a meta-analysis. Genet Mol Res, 2015, 14(2): 6578-6582.
36. Arnold M, Soerjomataram I, Ferlay J, et al. Global incidence of oesophageal cancer by histological subtype in 2012. Gut, 2015, 64(3): 381-387.
37. Yang Z, Zeng H, Xia R, et al. Annual cost of illness of stomach and esophageal cancer patients in urban and rural areas in China: a multi-center study. Chin J Cancer Res, 2018, 30(4): 439-448.

Previous Article
Bioinformatics analysis for bicuspid aortic valve with ascending aorta dilation
Next Article
A meta-analysis of the incidence of resorption of lumbar disc herniation

West China Medical Journal

Prognostic significance of microRNA-21 expression in esophageal cancer: a systematic review and meta-analysis

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content