• 1. Department of Urology, West China Hospital / Institute of Urology, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
  • 2. Department of Urology, Hospital of Chengdu University, Chengdu, Sichuan 610081, P. R. China;
WEI Qiang, Email: weiqiang933@126.com; LIU Liangren, Email: liuliangren5-17@163.com
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Varicocele (VC) is one of the common diseases of the male genitourinary system, and its incidence is higher in young adults. Among them, 80%-98% of VC are more likely to occur in the left spermatic vein. Previous research has found that VC could affect the temperature of the local microenvironment of the testis, oxidative stress process in the spermatogenic environment, mitochondrial function of sperm, endocrine system, and apoptosis of testes and epididymal cells. Therefore, VC will have an important impact on spermatogenic process of the testicles to cause male infertility. However, the specific molecular mechanism of VC affecting male spermatogenesis has not been fully studied. Therefore, this article will review the effect and mechanism of VC on testicular spermatogenesis.

Citation: WANG Puze, CAO Dehong, CHEN Zeyu, LI Jin, HUANG Yin, WANG Ruyi, CHEN Bo, ZHU Yuchun, WEI Qiang, DONG Qiang, LIU Liangren. Advance of varicocele on testicular spermatogenesis. West China Medical Journal, 2023, 38(2): 311-315. doi: 10.7507/1002-0179.202111010 Copy

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