Research progress on risk factors and pathogenesis of chronic obstructive pulmonary disease complicated with anxiety or depression_West China Medical Journal

Authors：

MU Xingyu , XU Jiao , ZHANG Lin , YANG Yuhao , ZENG Qingyue , LIU Simin , QIN Yu , LI Shuangqing ,  SU Qiaoli

General Practice Medical Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

SU Qiaoli, Email: 2961774468@qq.com

Keywords：

Chronic obstructive pulmonary disease; anxiety; depression; risk factors; pathogenesis

DOI：

10.7507/1002-0179.202211131

Video：

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Abstract Full text Figures/Tables Video References Cited by

Chronic obstructive pulmonary disease is often accompanied by anxiety or depression. The exacerbation of anxiety and depression can lead to the deterioration of chronic obstructive pulmonary disease, reduce patients’ quality of life, worsen poor prognosis, and increase the risk of death. Anxiety and depression are one of the important causes of death in patients with chronic obstructive pulmonary disease, but the complexity of their risk factors and pathogenesis often lead to clinicians being unable to make accurate diagnosis and treatment in a timely manner. Based on existing research, this article elaborates on the risk factors and pathogenesis of chronic obstructive pulmonary disease complicated with anxiety or depression, aiming to improve the diagnosis and treatment ability of clinical physicians for chronic obstructive pulmonary disease complicated with anxiety or depression, achieve timely diagnosis and treatment, improve patients’ prognosis, and improve quality of life.

Citation： MU Xingyu, XU Jiao, ZHANG Lin, YANG Yuhao, ZENG Qingyue, LIU Simin, QIN Yu, LI Shuangqing, SU Qiaoli. Research progress on risk factors and pathogenesis of chronic obstructive pulmonary disease complicated with anxiety or depression. West China Medical Journal, 2023, 38(4): 591-596. doi: 10.7507/1002-0179.202211131 Copy

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9.	Omachi TA, Katz PP, Yelin EH, et al. Depression and health-related quality of life in chronic obstructive pulmonary disease. Am J Med, 2009, 122(8): 778.e9-e15.
10.	Schneider C, Jick SS, Bothner U, et al. COPD and the risk of depression. Chest, 2010, 137(2): 341-347.
11.	Laforest L, Roche N, Devouassoux G, et al. Frequency of comorbidities in chronic obstructive pulmonary disease, and impact on all-cause mortality: a population-based cohort study. Respir Med, 2016, 117: 33-39.
12.	Regvat J, Žmitek A, Vegnuti M, et al. Anxiety and depression during hospital treatment of exacerbation of chronic obstructive pulmonary disease. J Int Med Res, 2011, 39(3): 1028-1038.
13.	Brook A, Zhang C. The role of personal attributes in the genesis and progression of lung disease and cigarette smoking. Am J Public Health, 2013, 103(5): 931-937.
14.	Trosclair A, Dube SR. Smoking among adults reporting lifetime depression, anxiety, anxiety with depression, and major depressive episode, United States, 2005-2006. Addict Behav, 2010, 35(5): 438-443.
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24.	老启芳, 曾小良, 钟小宁, 等. 肺功能正常吸烟者和慢性阻塞性肺疾病患者肺动脉炎症和小气道炎症的相关性研究. 中华结核和呼吸杂志, 2014, 37(12): 903-908.
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1. Buist AS, McBurnie MA, Vollmer WM, et al. International variation in the prevalence of COPD (the BOLD Study): a population-based prevalence study. Lancet, 2007, 370(9589): 741-750.
2. Australian Institute of Health Welfare. Chronic obstructive pulmonary disease. Canberra: Australian Institute of Health Welfare, 2020.
3. Hynninen KM, Breitve MH, Wiborg AB, et al. Psychological characteristics of patients with chronic obstructive pulmonary disease: a review. J Psychosom Res, 2005, 59(6): 429-443.
4. Atlantis E, Fahey P, Cochrane B, et al. Bidirectional associations between clinically relevant depression or anxiety and COPD: a systematic review and meta-analysis. Chest, 2013, 144(3): 766-777.
5. Solano JP, Gomes B, Higginson IJ. A comparison of symptom prevalence in far advanced cancer, AIDS, heart disease, chronic obstructive pulmonary disease and renal disease. J Pain Symptom Manage, 2006, 31(1): 58-69.
6. Kunik ME, Roundy K, Veazey C, et al. Surprisingly high prevalence of anxiety and depression in chronic breathing disorders. Chest, 2005, 127(4): 1205-1211.
7. Yohannes AM, Kaplan A, Hanania NA. Anxiety and depression in chronic obstructive pulmonary disease: recognition and management. Cleve Clin J Med, 2018, 85(Suppl 1): S11-S18.
8. Lacasse Y, Rousseau L, Maltais F. Prevalence of depressive symptoms and depression in patients with severe oxygen-dependent chronic obstructive pulmonary disease. J Cardiopulm Rehabil, 2001, 21(2): 80-86.
9. Omachi TA, Katz PP, Yelin EH, et al. Depression and health-related quality of life in chronic obstructive pulmonary disease. Am J Med, 2009, 122(8): 778.e9-e15.
10. Schneider C, Jick SS, Bothner U, et al. COPD and the risk of depression. Chest, 2010, 137(2): 341-347.
11. Laforest L, Roche N, Devouassoux G, et al. Frequency of comorbidities in chronic obstructive pulmonary disease, and impact on all-cause mortality: a population-based cohort study. Respir Med, 2016, 117: 33-39.
12. Regvat J, Žmitek A, Vegnuti M, et al. Anxiety and depression during hospital treatment of exacerbation of chronic obstructive pulmonary disease. J Int Med Res, 2011, 39(3): 1028-1038.
13. Brook A, Zhang C. The role of personal attributes in the genesis and progression of lung disease and cigarette smoking. Am J Public Health, 2013, 103(5): 931-937.
14. Trosclair A, Dube SR. Smoking among adults reporting lifetime depression, anxiety, anxiety with depression, and major depressive episode, United States, 2005-2006. Addict Behav, 2010, 35(5): 438-443.
15. Patton GC, Carlin JB, Coffey C, et al. Depression, anxiety, and smoking initiation: a prospective study over 3 years. Am J Public Health, 1998, 88(10): 1518-1522.
16. van Gool CH, Kempen GI, Penninx BW, et al. Relationship between changes in depressive symptoms and unhealthy lifestyles in late middle aged and older persons: results from the Longitudinal Aging Study Amsterdam. Age Ageing, 2003, 32(1): 81-87.
17. Patten SB, Williams JV, Lavorato DH, et al. A longitudinal community study of major depression and physical activity. Gen Hosp Psychiatry, 2009, 31(6): 571-575.
18. McClave AK, Dube SR, Strine TW, et al. Associations between smoking cessation and anxiety and depression among U. S. adults. Addict Behav, 2009, 34(6/7): 491-497.
19. Fluharty M, Taylor AE, Grabski M, et al. The association of cigarette smoking with depression and anxiety: a systematic review. Nicotine Tob Res, 2017, 19(1): 3-13.
20. Silverman EK, Speizer FE. Risk factors for the development of chronic obstructive pulmonary disease. Med Clin North Am, 1996, 80(3): 501-522.
21. Mineur YS, Picciotto MR. Nicotine receptors and depression: revisiting and revising the cholinergic hypothesis. Trends Pharmacol Sci, 2010, 31(12): 580-586.
22. Sinden NJ, Stockley RA. Systemic inflammation and comorbidity in COPD: a result of ‘overspill’ of inflammatory mediators from the lungs? Review of the evidence. Thorax, 2010, 65(10): 930-936.
23. Cekerevac I, Lazic Z, Novkovic L, et al. Characteristics of chronic obstructive pulmonary disease patients with depressive disorder. Srp Arh Celok Lek, 2017, 145: 39.
24. 老启芳, 曾小良, 钟小宁, 等. 肺功能正常吸烟者和慢性阻塞性肺疾病患者肺动脉炎症和小气道炎症的相关性研究. 中华结核和呼吸杂志, 2014, 37(12): 903-908.
25. 王亚丽, 吴峰, 胡锋, 等. 慢性阻塞性肺疾病急性加重期合并抑郁症状的发生率及危险因素分析. 中华老年多器官疾病杂志, 2017, 16(1): 51-55.
26. Sundar IK, Yao H, Huang Y, et al. Serotonin and corticosterone rhythms in mice exposed to cigarette smoke and in patients with COPD: implication for COPD-associated neuropathogenesis. PLoS One, 2014, 9(2): e87999.
27. Anda RF, Brown DW, Dube SR, et al. Adverse childhood experiences and chronic obstructive pulmonary disease in adults. Am J Prev Med, 2008, 34(5): 396-403.
28. Sonu S, Post S, Feinglass J. Adverse childhood experiences and the onset of chronic disease in young adulthood. Prev Med, 2019, 123: 163-170.
29. Cunningham TJ, Ford ES, Croft JB, et al. Sex-specific relationships between adverse childhood experiences and chronic obstructive pulmonary disease in five states. Int J Chron Obstruct Pulmon Dis, 2014, 9: 1033-1042.
30. Cougle JR, Timpano KR, Sachs-Ericsson N, et al. Examining the unique relationships between anxiety disorders and childhood physical and sexual abuse in the National Comorbidity Survey-Replication. Psychiatry Res, 2010, 177(1/2): 150-155.
31. Danese A, Moffitt TE, Harrington H, et al. Adverse childhood experiences and adult risk factors for age-related disease: depression, inflammation, and clustering of metabolic risk markers. Arch Pediatr Adolesc Med, 2009, 163(12): 1135-1143.
32. Su S, Jimenez MP, Roberts CT, et al. The role of adverse childhood experiences in cardiovascular disease risk: a review with emphasis on plausible mechanisms. Curr Cardiol Rep, 2015, 17(10): 88.
33. Dong M, Giles WH, Felitti VJ, et al. Insights into causal pathways for ischemic heart disease: adverse childhood experiences study. Circulation, 2004, 110(13): 1761-1766.
34. Brown DW, Anda RF, Felitti VJ, et al. Adverse childhood experiences are associated with the risk of lung cancer: a prospective cohort study. BMC Public Health, 2010, 10: 20.
35. Brown MJ, Thacker LR, Cohen SA. Association between adverse childhood experiences and diagnosis of cancer. PLoS One, 2013, 8(6): e65524.
36. Alcalá HE, Mitchell E, Keim-Malpass J. Adverse childhood experiences and cervical cancer screening. J Womens Health (Larchmt), 2017, 26(1): 58-63.
37. Shonkoff JP, Boyce WT, McEwen BS. Neuroscience, molecular biology, and the childhood roots of health disparities: building a new framework for health promotion and disease prevention. JAMA, 2009, 301(21): 2252-2259.
38. Johnson MH. Sensitive periods in functional brain development: problems and prospects. Dev Psychobiol, 2005, 46(3): 287-292.
39. Barker DJ, Osmond C, Forsén TJ, et al. Trajectories of growth among children who have coronary events as adults. N Engl J Med, 2005, 353(17): 1802-1809.
40. Barker DJ. The fetal and infant origins of adult disease. BMJ, 1990, 301(6761): 1111.
41. Barker DJ, Osmond C, Simmonds SJ, et al. The relation of small head circumference and thinness at birth to death from cardiovascular disease in adult life. BMJ, 1993, 306(6875): 422-426.
42. Roseboom TJ, van der Meulen JH, Osmond C, et al. Coronary heart disease after prenatal exposure to the Dutch famine, 1944-45. Heart, 2000, 84(6): 595-598.
43. Weight in infancy and death from ischaemic heart disease. Lancet, 1989, 2(8675): 1335.
44. Nomura Y, Wickramaratne PJ, Pilowsky DJ, et al. Low birth weight and risk of affective disorders and selected medical illness in offspring at high and low risk for depression. Compr Psychiatry, 2007, 48(5): 470-478.
45. McEwen BS. The neurobiology of stress: from serendipity to clinical relevance. Brain Res, 2000, 886(1/2): 172-189.
46. Boyce WT, Ellis BJ. Biological sensitivity to context: I. An evolutionary-developmental theory of the origins and functions of stress reactivity. Dev Psychopathol, 2005, 17(2): 271-301.
47. Gunnar MR, Fisher PA, Early Experience, Stress, and Prevention Network. Bringing basic research on early experience and stress neurobiology to bear on preventive interventions for neglected and maltreated children. Dev Psychopathol, 2006, 18(3): 651-677.
48. Keeshin BR, Cronholm PF, Strawn JR. Physiologic changes associated with violence and abuse exposure: an examination of related medical conditions. Trauma Violence Abuse, 2012, 13(1): 41-56.
49. Anda RF, Croft JB, Felitti VJ, et al. Adverse childhood experiences and smoking during adolescence and adulthood. JAMA, 1999, 282(17): 1652-1658.
50. Ford ES, Anda RF, Edwards VJ, et al. Adverse childhood experiences and smoking status in five states. Prev Med, 2011, 53(3): 188-193.
51. Fuller-Thomson E, Filippelli J, Lue-Crisostomo CA. Gender-specific association between childhood adversities and smoking in adulthood: findings from a population-based study. Public Health, 2013, 127(5): 449-460.
52. Celli BR, Rassulo J, Make BJ. Dyssynchronous breathing during arm but not leg exercise in patients with chronic airflow obstruction. N Engl J Med, 1986, 314(23): 1485-1490.
53. Vermeulen J, Neyens JC, van Rossum E, et al. Predicting ADL disability in community-dwelling elderly people using physical frailty indicators: a systematic review. BMC Geriatr, 2011, 11: 33.
54. Liu Y, Croft JB, Anderson LA, et al. The association of chronic obstructive pulmonary disease, disability, engagement in social activities, and mortality among US adults aged 70 years or older, 1994-2006. Int J Chron Obstruct Pulmon Dis, 2014, 9: 75-83.
55. Kanervisto M, Saarelainen S, Vasankari T, et al. COPD, chronic bronchitis and capacity for day-to-day activities: negative impact of illness on the health-related quality of life. Chron Respir Dis, 2010, 7(4): 207-215.
56. Stegenga BT, Nazareth I, Torres-González F, et al. Depression, anxiety and physical function: exploring the strength of causality. J Epidemiol Community Health, 2012, 66(7): e25.
57. McWilliams LA, Cox BJ, Enns MW. Mood and anxiety disorders associated with chronic pain: an examination in a nationally representative sample. Pain, 2003, 106(1/2): 127-133.
58. Lee AL, Harrison SL, Goldstein RS, et al. Pain and its clinical associations in individuals with COPD: a systematic review. Chest, 2015, 147(5): 1246-1258.
59. van Dam van Isselt EF, Groenewegen-Sipkema KH, Spruit-van Eijk M, et al. Pain in patients with COPD: a systematic review and meta-analysis. BMJ Open, 2014, 4(9): e005898.
60. Fuller-Thomson E, Lacombe-Duncan A. Understanding the association between chronic obstructive pulmonary disease and current anxiety: a population-based study. COPD, 2016, 13(5): 622-631.
61. Grassi M, Caldirola D, Vanni G, et al. Baseline respiratory parameters in panic disorder: a meta-analysis. J Affect Disord, 2013, 146(2): 158-173.
62. Freire RC, Perna G, Nardi AE. Panic disorder respiratory subtype: psychopathology, laboratory challenge tests, and response to treatment. Harv Rev Psychiatry, 2010, 18(4): 220-229.
63. Mikkelsen RL, Middelboe T, Pisinger C, et al. Anxiety and depression in patients with chronic obstructive pulmonary disease (COPD). A review. Nord J Psychiatry, 2004, 58(1): 65-70.
64. Rybka J, Korte SM, Czajkowska-Malinowska M, et al. The links between chronic obstructive pulmonary disease and comorbid depressive symptoms: role of IL-2 and IFN-γ. Clin Exp Med, 2016, 16(4): 493-502.
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