Correlation analysis between grip strength and subjective cognitive decline in maintenance hemodialysis patients of different genders_West China Medical Journal

Authors：

LI Xianghong , LI Jie , LI Yajuan ,  YUAN Huaihong

Department of Nephrology and Institute of Kidney Diseases, West China Hospital, Sichuan University / West China School of Nursing, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

YUAN Huaihong, Email: yuanhuaihong@wchscu.cn

Keywords：

Maintenance hemodialysis; grip strength; subjective cognitive decline; influencing factor

DOI：

10.7507/1002-0179.202406084

Video：

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Objective To investigate the correlation between grip strength and subjective cognitive decline (SCD) in maintenance hemodialysis (MHD) patients of different genders. Methods Patients who underwent outpatient MHD in the Wenjiang Hemodialysis Unit, Department of Nephrology, West China Hospital, Sichuan University between March and June 2024 were selected as the research subjects. Multiple linear regression analysis was used to explore the relationship between grip strength and SCD in MHD patients of different genders. Results A total of 171 patients were investigated, with 76 in the non-SCD group and 95 in the SCD group. The results of multiple linear regression analysis showed that educational level (P=0.039), nutritional status (P=0.026), and grip strength (P=0.042) were the influencing factors of SCD in male MHD patients. Work status (P=0.001) and nutritional status (P=0.011) were the influencing factors of SCD in female MHD patients. Conclusions Educational level, nutritional status, and grip strength are influencing factors of SCD in male MHD patients. Work status and nutritional status are influencing factors of SCD in female MHD patients. Grip strength may serve as an indicator for evaluating SCD in male MHD patients.

Citation： LI Xianghong, LI Jie, LI Yajuan, YUAN Huaihong. Correlation analysis between grip strength and subjective cognitive decline in maintenance hemodialysis patients of different genders. West China Medical Journal, 2024, 39(7): 1096-1101. doi: 10.7507/1002-0179.202406084 Copy

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2.	O’Lone E, Connors M, Masson P, et al. Cognition in people with end-stage kidney disease treated with hemodialysis: a systematic review and meta-analysis. Am J Kidney Dis, 2016, 67(6): 925-935.
3.	Kalirao P, Pederson S, Foley RN, et al. Cognitive impairment in peritoneal dialysis patients. Am J Kidney Dis, 2011, 57(4): 612-620.
4.	San A, Hiremagalur B, Muircroft W, et al. Screening of cognitive impairment in the dialysis population: a scoping review. Dement Geriatr Cogn Disord, 2017, 44(3/4): 182-195.
5.	Kallenberg MH, Kleinveld HA, Dekker FW, et al. Functional and cognitive impairment, frailty, and adverse health outcomes in older patients reaching ESRD-a systematic review. Clin J Am Soc Nephrol, 2016, 11(9): 1624-1639.
6.	van Zwieten A, Wong G, Ruospo M, et al. Associations of cognitive function and education level with all-cause mortality in adults on hemodialysis: findings from the COGNITIVE-HD study. Am J Kidney Dis, 2019, 74(4): 452-462.
7.	张雷, 范占芳, 张作鹏, 等. 阿尔兹海默症发病机制及相关治疗药物的研究进展. 中国药物化学杂志, 2021, 31(6): 438-446, 469.
8.	Burns JM, Johnson DK, Watts A, et al. Reduced lean mass in early Alzheimer disease and its association with brain atrophy. Arch Neurol, 2010, 67(4): 428-433.
9.	Leong DP, Teo KK, Rangarajan S, et al. Prognostic value of grip strength: findings from the Prospective Urban Rural Epidemiology (PURE) study. Lancet, 2015, 386(9990): 266-273.
10.	Cui M, Zhang S, Liu Y, et al. Grip strength and the risk of cognitive decline and dementia: a systematic review and meta-analysis of longitudinal cohort studies. Front Aging Neurosci, 2021, 13: 625551.
11.	董雅勤, 王为强. 社区老年人群主观认知下降与握力的相关性研究. 中华全科医学, 2022, 20(8): 1363-1366, 1426.
12.	Detsky AS, McLaughlin JR, Baker JP, et al. What is subjective global assessment of nutritional status?. JPEN J Parenter Enteral Nutr, 1987, 11(1): 8-13.
13.	Kopple JD. National kidney foundation K/DOQI clinical practice guidelines for nutrition in chronic renal failure. Am J Kidney Dis, 2001, 37(Suppl 2): S66-S70.
14.	郝立晓, 邢悦, 贾建国, 等. 英文版主观认知下降问卷 21 的汉化研究. 中国全科医学, 2021, 24(18): 2349-2354.
15.	Gifford KA, Liu D, Romano R 3rd, et al. Development of a subjective cognitive decline questionnaire using item response theory: a pilot study. Alzheimers Dement (Amst), 2015, 1(4): 429-439.
16.	张波, 胡益, 孙若琳, 等. 握力与主观认知下降在不同性别老年人群中的相关性分析. 中国实用神经疾病杂志, 2023, 26(12): 1532-1536.
17.	宋银华, 刘玉双, 杨青, 等. 老年人主观认知下降与慢性病共病的相关性分析. 中国全科医学, 2023, 26(10): 1241-1249.
18.	Wen C, Hu H, Ou YN, et al. Risk factors for subjective cognitive decline: the CABLE study. Transl Psychiatry, 2021, 11(1): 576.
19.	顾怀聪, 王为强, 董雅勤. 社区老年人群主观认知下降的影响因素分析. 中国医药导报, 2023, 20(26): 55-59, 99.
20.	Reuben R, Karkaby L, McNamee C, et al. Menopause and cognitive complaints: are ovarian hormones linked with subjective cognitive decline?. Climacteric, 2021, 24(4): 321-332.
21.	Liu Y, Lachman ME. Education and cognition in middle age and later life: the mediating role of physical and cognitive activity. J Gerontol B Psychol Sci Soc Sci, 2020, 75(7): e93-e104.
22.	迟晨汝, 陈梦奇, 杨丹, 等. 维持性血液透析病人认知功能障碍影响因素及干预的研究进展. 全科护理, 2023, 21(14): 1920-1924.
23.	常晓东, 薛痕, 肖峰, 等. 维持性血液透析患者认知功能障碍影响因素及与血清 Klotho 蛋白的相关性分析. 国际精神病学杂志, 2021, 48(5): 901-904.
24.	欧琴琴, 查艳. 维持性血液透析患者营养不良与认知损害的研究进展. 中华肾脏病杂志, 2022, 38(11): 1006-1010.
25.	胡美玲, 罗棉, 覃勋, 等. 维持性血液透析患者握力与营养指标的相关性. 广东医学, 2019, 40(11): 1589-1593.
26.	Sharma R, Agrawal S, Saxena A, et al. Association of IL-6, IL-10, and TNF-α gene polymorphism with malnutrition inflammation syndrome and survival among end stage renal disease patients. J Interferon Cytokine Res, 2013, 33(7): 384-391.
27.	Mantzorou M, Vadikolias K, Pavlidou E, et al. Nutritional status is associated with the degree of cognitive impairment and depressive symptoms in a Greek elderly population. Nutr Neurosci, 2020, 23(3): 201-209.
28.	Doorduijn AS, Visser M, van de Rest O, et al. Associations of AD biomarkers and cognitive performance with nutritional status: the NUDAD project. Nutrients, 2019, 11(5): 1161.
29.	Prins ND, Scheltens P. White matter hyperintensities, cognitive impairment and dementia: an update. Nat Rev Neurol, 2015, 11(3): 157-165.
30.	宋雅云. 中老年人认知功能与握力的相关性研究——基于 CHARLS 数据. 中华养生保健, 2022, 40(19): 1-5.
31.	杨佳佳, 程光文, 李正宏, 等. 老年人握力与认知功能的关联性. 中华老年医学杂志, 2022, 41(2): 206-210.
32.	Shaughnessy KA, Hackney KJ, Clark BC, et al. A narrative review of handgrip strength and cognitive functioning: bringing a new characteristic to muscle memory. J Alzheimers Dis, 2020, 73(4): 1265-1278.
33.	Chen ST, Siddarth P, Ercoli LM, et al. Modifiable risk factors for Alzheimer disease and subjective memory impairment across age groups. PLoS One, 2014, 9(6): e98630.

1. GBD Chronic Kidney Disease Collaboration. Global, regional, and national burden of chronic kidney disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet, 2020, 395(10225): 709-733.
2. O’Lone E, Connors M, Masson P, et al. Cognition in people with end-stage kidney disease treated with hemodialysis: a systematic review and meta-analysis. Am J Kidney Dis, 2016, 67(6): 925-935.
3. Kalirao P, Pederson S, Foley RN, et al. Cognitive impairment in peritoneal dialysis patients. Am J Kidney Dis, 2011, 57(4): 612-620.
4. San A, Hiremagalur B, Muircroft W, et al. Screening of cognitive impairment in the dialysis population: a scoping review. Dement Geriatr Cogn Disord, 2017, 44(3/4): 182-195.
5. Kallenberg MH, Kleinveld HA, Dekker FW, et al. Functional and cognitive impairment, frailty, and adverse health outcomes in older patients reaching ESRD-a systematic review. Clin J Am Soc Nephrol, 2016, 11(9): 1624-1639.
6. van Zwieten A, Wong G, Ruospo M, et al. Associations of cognitive function and education level with all-cause mortality in adults on hemodialysis: findings from the COGNITIVE-HD study. Am J Kidney Dis, 2019, 74(4): 452-462.
7. 张雷, 范占芳, 张作鹏, 等. 阿尔兹海默症发病机制及相关治疗药物的研究进展. 中国药物化学杂志, 2021, 31(6): 438-446, 469.
8. Burns JM, Johnson DK, Watts A, et al. Reduced lean mass in early Alzheimer disease and its association with brain atrophy. Arch Neurol, 2010, 67(4): 428-433.
9. Leong DP, Teo KK, Rangarajan S, et al. Prognostic value of grip strength: findings from the Prospective Urban Rural Epidemiology (PURE) study. Lancet, 2015, 386(9990): 266-273.
10. Cui M, Zhang S, Liu Y, et al. Grip strength and the risk of cognitive decline and dementia: a systematic review and meta-analysis of longitudinal cohort studies. Front Aging Neurosci, 2021, 13: 625551.
11. 董雅勤, 王为强. 社区老年人群主观认知下降与握力的相关性研究. 中华全科医学, 2022, 20(8): 1363-1366, 1426.
12. Detsky AS, McLaughlin JR, Baker JP, et al. What is subjective global assessment of nutritional status?. JPEN J Parenter Enteral Nutr, 1987, 11(1): 8-13.
13. Kopple JD. National kidney foundation K/DOQI clinical practice guidelines for nutrition in chronic renal failure. Am J Kidney Dis, 2001, 37(Suppl 2): S66-S70.
14. 郝立晓, 邢悦, 贾建国, 等. 英文版主观认知下降问卷 21 的汉化研究. 中国全科医学, 2021, 24(18): 2349-2354.
15. Gifford KA, Liu D, Romano R 3rd, et al. Development of a subjective cognitive decline questionnaire using item response theory: a pilot study. Alzheimers Dement (Amst), 2015, 1(4): 429-439.
16. 张波, 胡益, 孙若琳, 等. 握力与主观认知下降在不同性别老年人群中的相关性分析. 中国实用神经疾病杂志, 2023, 26(12): 1532-1536.
17. 宋银华, 刘玉双, 杨青, 等. 老年人主观认知下降与慢性病共病的相关性分析. 中国全科医学, 2023, 26(10): 1241-1249.
18. Wen C, Hu H, Ou YN, et al. Risk factors for subjective cognitive decline: the CABLE study. Transl Psychiatry, 2021, 11(1): 576.
19. 顾怀聪, 王为强, 董雅勤. 社区老年人群主观认知下降的影响因素分析. 中国医药导报, 2023, 20(26): 55-59, 99.
20. Reuben R, Karkaby L, McNamee C, et al. Menopause and cognitive complaints: are ovarian hormones linked with subjective cognitive decline?. Climacteric, 2021, 24(4): 321-332.
21. Liu Y, Lachman ME. Education and cognition in middle age and later life: the mediating role of physical and cognitive activity. J Gerontol B Psychol Sci Soc Sci, 2020, 75(7): e93-e104.
22. 迟晨汝, 陈梦奇, 杨丹, 等. 维持性血液透析病人认知功能障碍影响因素及干预的研究进展. 全科护理, 2023, 21(14): 1920-1924.
23. 常晓东, 薛痕, 肖峰, 等. 维持性血液透析患者认知功能障碍影响因素及与血清 Klotho 蛋白的相关性分析. 国际精神病学杂志, 2021, 48(5): 901-904.
24. 欧琴琴, 查艳. 维持性血液透析患者营养不良与认知损害的研究进展. 中华肾脏病杂志, 2022, 38(11): 1006-1010.
25. 胡美玲, 罗棉, 覃勋, 等. 维持性血液透析患者握力与营养指标的相关性. 广东医学, 2019, 40(11): 1589-1593.
26. Sharma R, Agrawal S, Saxena A, et al. Association of IL-6, IL-10, and TNF-α gene polymorphism with malnutrition inflammation syndrome and survival among end stage renal disease patients. J Interferon Cytokine Res, 2013, 33(7): 384-391.
27. Mantzorou M, Vadikolias K, Pavlidou E, et al. Nutritional status is associated with the degree of cognitive impairment and depressive symptoms in a Greek elderly population. Nutr Neurosci, 2020, 23(3): 201-209.
28. Doorduijn AS, Visser M, van de Rest O, et al. Associations of AD biomarkers and cognitive performance with nutritional status: the NUDAD project. Nutrients, 2019, 11(5): 1161.
29. Prins ND, Scheltens P. White matter hyperintensities, cognitive impairment and dementia: an update. Nat Rev Neurol, 2015, 11(3): 157-165.
30. 宋雅云. 中老年人认知功能与握力的相关性研究——基于 CHARLS 数据. 中华养生保健, 2022, 40(19): 1-5.
31. 杨佳佳, 程光文, 李正宏, 等. 老年人握力与认知功能的关联性. 中华老年医学杂志, 2022, 41(2): 206-210.
32. Shaughnessy KA, Hackney KJ, Clark BC, et al. A narrative review of handgrip strength and cognitive functioning: bringing a new characteristic to muscle memory. J Alzheimers Dis, 2020, 73(4): 1265-1278.
33. Chen ST, Siddarth P, Ercoli LM, et al. Modifiable risk factors for Alzheimer disease and subjective memory impairment across age groups. PLoS One, 2014, 9(6): e98630.

West China Medical Journal

Correlation analysis between grip strength and subjective cognitive decline in maintenance hemodialysis patients of different genders

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