THREE-DIMENSIONAL PLOTTING IS A VERSATILE RAPID PROTOTYPING METHOD FOR THE CUSTOMIZED MANUFACTURING OF COMPLEX SCAFFOLDS AND TISSUE ENGINEERING CONSTRUCTS_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

 Yongxiang LUO ^# , Rahul Akkineni Ashwini , Lode Anja , Gelinsky Michael

Center for Translational Bone, Joint and Soft Tissue Research, Technical University of Dresden, Fetscherstr, 74, 01307 Dresden, Germany;

Corresponding author：

Yongxiang LUO, Email: luoyongxiang@mail.sic.ac.cn

Keywords：

Three-dimensional plotting; Rapid prototyping; Additive manufacturing; Specific implant

DOI：

10.7507/1002-1892.20140064

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To review recent literature on three-dimensional (3-D) plotting as a rapid prototyping method for the manufacturing of patient specific biomaterial scaffolds and tissue engineering constructs. Methods Literature review and description of own recent work. Results In contrast to many other rapid prototyping technologies which can be used only for the processing of distinct materials, 3-D plotting can be utilized for all pasty biomaterials and therefore opens up many new options for the manufacturing of bi- or multiphasic scaffolds or even tissue engineering constructs, containing e. g. living cells. Conclusion 3-D plotting is a rapid prototyping technology of growing importance which provides flexibility concerning choice of material and allows integration of sensitive biological components.

Citation： Yongxiang LUO, Rahul Akkineni Ashwini, Lode Anja, Gelinsky Michael. THREE-DIMENSIONAL PLOTTING IS A VERSATILE RAPID PROTOTYPING METHOD FOR THE CUSTOMIZED MANUFACTURING OF COMPLEX SCAFFOLDS AND TISSUE ENGINEERING CONSTRUCTS. Chinese Journal of Reparative and Reconstructive Surgery, 2014, 28(3): 279-285. doi: 10.7507/1002-1892.20140064 Copy

1.	Horn TJ, Harrysson OL. Overview of current additive manufacturing technologies and selected applications. Sci Prog, 2012, 95(Pt 3):255-282.
2.	Bose S, Vahabzadeh S, Bandyopadhyay A. Bone tissue engineering using 3D printing. Mater Today, 2013, 16(12):496-504.
3.	Derby B. Printing and prototyping of tissues and scaffolds. Science, 2012, 338(6109):921-926.
4.	Lantada AD, Morgado PL. Rapid prototyping for biomedical engineering:current capabilities and challenges. Annu Rev Biomed Eng, 2012, 14:73-96.
5.	Hutmacher DW, Sittinger M, Risbud MV. Scaffold-based tissue engineering:rationale for computer-aided design and solid free-form fabrication systems. Trends Biotechnol, 2004, 22(7):354-362.
6.	Hutmacher DW, Schantz T, Zein I, et al. Mechanical properties and cell cultural response of polycaprolactone scaffolds designed and fabricated via fused deposition modeling. J Biomed Mater Res, 2001, 55(2):203-216.
7.	Sachs E, Cima M, Cornie J, et al. Three-dimensional printing:the physics and implications of additive manufacturing. CIRP Ann Manufact Technol, 1993, 42(1):257-260.
8.	Seitz H, Rieder W, Irsen S, et al. Three-dimensinal printing of porous ceramic scaffolds for bone tissue engineering. J Biomed Mater Res B Appl Biomater, 2005, 74(2):782-788.
9.	Khalyfa A, Vogt S, Weisser J, et al. Development of a new calcium phosphate powder-binder system for the 3D printing of patient specific implants. J Mater Sci Mater Med, 2007, 18(5):909-916.
10.	Butscher A, Bohner M, Doebelin N, et al. New depowdering-friendly designs for three-dimensional printing of calcium phosphate bone substitutes. Acta Biomater, 2013, 9(11):9149-9158.
11.	Miranda P, Pajares A, Saiz E, et al. Fracture modes under uniaxial compression in hydroxyapatite scaffolds fabricated by robocasting. J Biomed Mater Res A, 2007, 83(3):646-655.
12.	Miranda P, Pajares A, Saiz E, et al. Mechanical properties of calcium phosphate scaffolds fabricated by robocasting. J Biomed Mater Res A, 2008, 85(1):218-227.
13.	Franco J, Hunger P, Launey ME, et al. Direct write assembly of calcium phosphate scaffolds using a water-based hydrogel. Acta Biomater, 2010, 6(1):218-228.
14.	Lode A, Meissner K, Luo Y, et al. Fabrication of porous scaffolds by three-dimensional plotting of a pasty calcium phosphate bone cement under mild conditions. J Tissue Eng Regen Med, 2012.[Epub ahead of print].
15.	Heinemann S, Rössler S, Lemm M, et al. Properties of injectable ready-to-use calcium phosphate cement based on water-immiscible liquid. Acta Biomater, 2013, 9(4):6199-6207.
16.	Bio-scaffold printer for tissue engineering[EB/OL].(2013-11)[2014-02-18]http://www.gesim.de/en/bioscaffolder.
17.	Xia W, Chang J. Well-ordered mesoporous bioactive glasses(MBG):a promising bioactive drug delivery system. J Contr Release, 2006, 110(3):522-530.
18.	Wu C, Ramaswamy Y, Zhu Y, et al. The effect of mesoporous bioactive glass on the physiochemical, biological and drug-release properties of poly (DL-lactide-co-glycolide) films. Biomaterials, 2009, 30(12):2199-2208.
19.	Yun HS, Kim SE, Hyeon YT. Design and preparation of bioactive glasses with hierarchical pore networks. Chem Commun (Camb), 2007, (21):2139-2141.
20.	García A, Izquierdo-Barba I, Colilla M, et al. Preparation of 3-D scaffolds in the SiO2-P2O5 system with tailored hierarchical meso-macroporosity. Acta Biomater, 2011, 7(3):1265-1273.
21.	Wu C, Luo Y, Cuniberti G, et al. Three-dimensional printing of hierarchical and tough mesoporous bioactive glass scaffolds with a controllable pore architecture, excellent mechanical strength and mineralization ability. Acta Biomater, 2011, 7(6):2644-2650.
22.	Nakamura M, Iwanaga S, Henmi C, et al. Biomatrices and biomaterials for future developments of bioprinting and biofabrication. Biofabrication, 2010, 2(1):014110.
23.	Khalil S, Nam J, Sun W. Multi-nozzle deposition for construction of 3D biopolymer tissue scaffolds. Rapid Prototyping J, 2005, 11(1):9-17.
24.	Luo Y, Wu C, Lode A, et al. Hierarchical mesoporous bioactive glass/alginate composite scaffolds fabricated by three-dimensional plotting for bone tissue engineering. Biofabrication, 2013, 5(1):015005.
25.	Poh PS, Hutmacher DW, Stevens MM, et al. Fabrication and in vitro characterization of bioactive glass composite scaffolds for bone regeneration. Biofabrication, 2013, 5(4):045005.
26.	Chang CH, Liu HC, Lin CC, et al. Gelatin-chondroitin-hyaluronan tri-copolymer scaffold for cartilage tissue engineering. Biomaterials, 2003, 24(26):4853-4858.
27.	Xia W, Liu W, Cui L, et al. Tissue engineering of cartilage with the use of chitosan-gelatin complex scaffolds. J Biomed Mater Res B Appl Biomater, 2004, 71(2):373-380.
28.	Lien SM, Ko LY, Huang TJ. Effect of pore size on ECM secretion and cell growth in gelatin scaffold for articular cartilage tissue engineering. Acta Biomater, 2009, 5(2):670-679.
29.	Luo Y, Lode A, Sonntag F, et al. Well-ordered biphasic calcium phosphate/alginate scaffolds fabricated by multi-channel 3D plotting under mild conditions. J Mater Chem B, 2013, 1:4088-4098.
30.	Lee KH, Shin SJ, Park Y, et al. Synthesis of cell-laden alginate hollow fibers using microfluidic chips and microvascularized tissue-engineering applications. Small, 2009, 5(11):1264-1268.
31.	Onoe H, Okitsu T, Itou A, et al. Metre-long cell-laden microfibres exhibit tissue morphologies and functions. Nat Mater, 2013, 12(6):584-590.
32.	Luo Y, Lode A, Gelinsky M. Direct plotting of three-dimensional hollow fiber scaffolds based on concentrated alginate pastes for tissue engineering. Adv Healthcare Mater, 2013, 2(6):777-783.
33.	Winkelmann C, Luo Y, Lode A, et al. Hollow fibres integrated in a microfluidic cell culture system. Biomed Tech (Berl), 2012.[Epub ahead of print].

1. Horn TJ, Harrysson OL. Overview of current additive manufacturing technologies and selected applications. Sci Prog, 2012, 95(Pt 3):255-282.
2. Bose S, Vahabzadeh S, Bandyopadhyay A. Bone tissue engineering using 3D printing. Mater Today, 2013, 16(12):496-504.
3. Derby B. Printing and prototyping of tissues and scaffolds. Science, 2012, 338(6109):921-926.
4. Lantada AD, Morgado PL. Rapid prototyping for biomedical engineering:current capabilities and challenges. Annu Rev Biomed Eng, 2012, 14:73-96.
5. Hutmacher DW, Sittinger M, Risbud MV. Scaffold-based tissue engineering:rationale for computer-aided design and solid free-form fabrication systems. Trends Biotechnol, 2004, 22(7):354-362.
6. Hutmacher DW, Schantz T, Zein I, et al. Mechanical properties and cell cultural response of polycaprolactone scaffolds designed and fabricated via fused deposition modeling. J Biomed Mater Res, 2001, 55(2):203-216.
7. Sachs E, Cima M, Cornie J, et al. Three-dimensional printing:the physics and implications of additive manufacturing. CIRP Ann Manufact Technol, 1993, 42(1):257-260.
8. Seitz H, Rieder W, Irsen S, et al. Three-dimensinal printing of porous ceramic scaffolds for bone tissue engineering. J Biomed Mater Res B Appl Biomater, 2005, 74(2):782-788.
9. Khalyfa A, Vogt S, Weisser J, et al. Development of a new calcium phosphate powder-binder system for the 3D printing of patient specific implants. J Mater Sci Mater Med, 2007, 18(5):909-916.
10. Butscher A, Bohner M, Doebelin N, et al. New depowdering-friendly designs for three-dimensional printing of calcium phosphate bone substitutes. Acta Biomater, 2013, 9(11):9149-9158.
11. Miranda P, Pajares A, Saiz E, et al. Fracture modes under uniaxial compression in hydroxyapatite scaffolds fabricated by robocasting. J Biomed Mater Res A, 2007, 83(3):646-655.
12. Miranda P, Pajares A, Saiz E, et al. Mechanical properties of calcium phosphate scaffolds fabricated by robocasting. J Biomed Mater Res A, 2008, 85(1):218-227.
13. Franco J, Hunger P, Launey ME, et al. Direct write assembly of calcium phosphate scaffolds using a water-based hydrogel. Acta Biomater, 2010, 6(1):218-228.
14. Lode A, Meissner K, Luo Y, et al. Fabrication of porous scaffolds by three-dimensional plotting of a pasty calcium phosphate bone cement under mild conditions. J Tissue Eng Regen Med, 2012.[Epub ahead of print].
15. Heinemann S, Rössler S, Lemm M, et al. Properties of injectable ready-to-use calcium phosphate cement based on water-immiscible liquid. Acta Biomater, 2013, 9(4):6199-6207.
16. Bio-scaffold printer for tissue engineering[EB/OL].(2013-11)[2014-02-18]http://www.gesim.de/en/bioscaffolder.
17. Xia W, Chang J. Well-ordered mesoporous bioactive glasses(MBG):a promising bioactive drug delivery system. J Contr Release, 2006, 110(3):522-530.
18. Wu C, Ramaswamy Y, Zhu Y, et al. The effect of mesoporous bioactive glass on the physiochemical, biological and drug-release properties of poly (DL-lactide-co-glycolide) films. Biomaterials, 2009, 30(12):2199-2208.
19. Yun HS, Kim SE, Hyeon YT. Design and preparation of bioactive glasses with hierarchical pore networks. Chem Commun (Camb), 2007, (21):2139-2141.
20. García A, Izquierdo-Barba I, Colilla M, et al. Preparation of 3-D scaffolds in the SiO2-P2O5 system with tailored hierarchical meso-macroporosity. Acta Biomater, 2011, 7(3):1265-1273.
21. Wu C, Luo Y, Cuniberti G, et al. Three-dimensional printing of hierarchical and tough mesoporous bioactive glass scaffolds with a controllable pore architecture, excellent mechanical strength and mineralization ability. Acta Biomater, 2011, 7(6):2644-2650.
22. Nakamura M, Iwanaga S, Henmi C, et al. Biomatrices and biomaterials for future developments of bioprinting and biofabrication. Biofabrication, 2010, 2(1):014110.
23. Khalil S, Nam J, Sun W. Multi-nozzle deposition for construction of 3D biopolymer tissue scaffolds. Rapid Prototyping J, 2005, 11(1):9-17.
24. Luo Y, Wu C, Lode A, et al. Hierarchical mesoporous bioactive glass/alginate composite scaffolds fabricated by three-dimensional plotting for bone tissue engineering. Biofabrication, 2013, 5(1):015005.
25. Poh PS, Hutmacher DW, Stevens MM, et al. Fabrication and in vitro characterization of bioactive glass composite scaffolds for bone regeneration. Biofabrication, 2013, 5(4):045005.
26. Chang CH, Liu HC, Lin CC, et al. Gelatin-chondroitin-hyaluronan tri-copolymer scaffold for cartilage tissue engineering. Biomaterials, 2003, 24(26):4853-4858.
27. Xia W, Liu W, Cui L, et al. Tissue engineering of cartilage with the use of chitosan-gelatin complex scaffolds. J Biomed Mater Res B Appl Biomater, 2004, 71(2):373-380.
28. Lien SM, Ko LY, Huang TJ. Effect of pore size on ECM secretion and cell growth in gelatin scaffold for articular cartilage tissue engineering. Acta Biomater, 2009, 5(2):670-679.
29. Luo Y, Lode A, Sonntag F, et al. Well-ordered biphasic calcium phosphate/alginate scaffolds fabricated by multi-channel 3D plotting under mild conditions. J Mater Chem B, 2013, 1:4088-4098.
30. Lee KH, Shin SJ, Park Y, et al. Synthesis of cell-laden alginate hollow fibers using microfluidic chips and microvascularized tissue-engineering applications. Small, 2009, 5(11):1264-1268.
31. Onoe H, Okitsu T, Itou A, et al. Metre-long cell-laden microfibres exhibit tissue morphologies and functions. Nat Mater, 2013, 12(6):584-590.
32. Luo Y, Lode A, Gelinsky M. Direct plotting of three-dimensional hollow fiber scaffolds based on concentrated alginate pastes for tissue engineering. Adv Healthcare Mater, 2013, 2(6):777-783.
33. Winkelmann C, Luo Y, Lode A, et al. Hollow fibres integrated in a microfluidic cell culture system. Biomed Tech (Berl), 2012.[Epub ahead of print].

Previous Article
3-D打印技术在血管外科的应用
Next Article
APPLICATION OF DIGITAL DESIGN AND THREE-DIMENSIONAL PRINTING TECHNIQUE ON INDIVIDUALIZED MEDICAL TREATMENT

Chinese Journal of Reparative and Reconstructive Surgery

THREE-DIMENSIONAL PLOTTING IS A VERSATILE RAPID PROTOTYPING METHOD FOR THE CUSTOMIZED MANUFACTURING OF COMPLEX SCAFFOLDS AND TISSUE ENGINEERING CONSTRUCTS

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content