MECHANICAL PROPERTIES OF POLYLACTIC ACID/β-TRICALCIUM PHOSPHATE COMPOSITE SCAFFOLD WITH DOUBLE CHANNELS BASED ON THREE-DIMENSIONAL PRINTING TECHNIQUE_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

 LIANQin ¹ , ZHUANGPei ¹ , LIChanghai ¹ , JINZhongmin ^1,2 , LIDichen ¹

1. State Key Laboratory for Manufacturing Systems Engineering, Xi'an Jiaotong University, Xi'an Shaanxi, 710049, P. R. China;
2. Institute of Medical and Biological Engineering, Leeds University, UK.;

Corresponding author：

LIANQin, Email: lqiamt@mail.xjtu.edu.cn

Keywords：

Three-dimensional printing technique; Double-channel composite scaffold; Polylactic acid; β-tricalcium phosphate; Mechanical property

DOI：

10.7507/1002-1892.20140070

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To improve the poor mechanical strength of porous ceramic scaffold, an integrated method based on three-dimensional (3-D) printing technique is developed to incorporate the controlled double-channel porous structure into the polylactic acid/β-tricalcium phosphate (PLA/β-TCP) reinforced composite scaffolds (double-channel composite scaffold) to improve their tissue regeneration capability and the mechanical properties. Methods The designed double-channel structure inside the ceramic scaffold consisted of both primary and secondary micropipes, which parallel but un-connected. The set of primary channels was used for cell ingrowth, while the set of secondary channels was used for the PLA perfusion. Integration technology of 3-D printing technique and gel-casting was firstly used to fabricate the double-channel ceramic scaffolds. PLA/β-TCP composite scaffolds were obtained by the polymer gravity perfusion process to pour PLA solution into the double-channel ceramic scaffolds through the secondary channel set. Microscope, porosity, and mechanical experiments for the standard samples were used to evaluate the composite properties. The ceramic scaffold with only the primary channel (single-channel scaffold) was also prepared as a control. Results Morphology observation results showed that there was no PLA inside the primary channels of the double-channel composite scaffolds but a dense interface layer between PLA and β-TCP obviously formed on the inner wall of the secondary channels by the PLA penetration during the perfusion process. Finite element simulation found that the compressive strength of the double-channel composite scaffold was less than that of the single-channel scaffold; however, mechanical tests found that the maximum compressive strength of the double-channel composite scaffold[(21.25±1.15) MPa] was higher than that of the single-channel scaffold[(9.76±0.64) MPa]. Conclusion The double-channel composite scaffolds fabricated by 3-D printing technique have controlled complex micropipes and can significantly enhance mechanical properties, which is a promising strategy to solve the contradiction of strength and high-porosity of the ceramic scaffolds for the bone tissue engineering application.

Citation： LIANQin, ZHUANGPei, LIChanghai, JINZhongmin, LIDichen. MECHANICAL PROPERTIES OF POLYLACTIC ACID/β-TRICALCIUM PHOSPHATE COMPOSITE SCAFFOLD WITH DOUBLE CHANNELS BASED ON THREE-DIMENSIONAL PRINTING TECHNIQUE. Chinese Journal of Reparative and Reconstructive Surgery, 2014, 28(3): 309-313. doi: 10.7507/1002-1892.20140070 Copy

1.	Miranda P, Pajares A, Guiberteau F. Finite element modeling as a tool for predicting the fracture behavior of robocast scaffolds. Acta Biomater, 2008, 4(6):1715-1724.
2.	Wu Q, Zhang XL, Wu B, et al. Fabrication and characterization of porous HA/β-TCP scaffolds strengthened with micro-ribs structure. Materials Letters, 2013, 92:274-277.
3.	Best SM, Porter AE, Thian ES, et al. Bioceramics:Past, present and for the future. J Eur Ceram Soc, 2008, 28(7):1319-1327.
4.	Santos CF, Silva AP, Lopes L, et al. Design and production of sintered β-tricalcium phosphate 3D scaffolds for bone tissue regeneration. Materials Science and Engineering C, 2012, 32(5):1293-1298.
5.	Martínez-Vázquez FJ, Perera FH, Miranda P, et al. Improving the compressive strength of bioceramic robocast scaffolds by polymer inffltration. Acta Biomater, 2010, 6(11):4361-4368.
6.	连芩, 刘亚雄, 贺健康, 等. 生物制造技术及发展. 中国工程科学, 2013, 15(1):45-50.
7.	Xiang Li, Dichen Li, Bingheng Lu, et al. Fabrication of bioceramic scaffolds with pre-designed internal architecture by gel casting and indirect stereolithography techniques. J Porous Mater, 2008, 15:667-671.
8.	Li X, Bian W, Li D, et al. Fabrication of porous beta-tricalcium phosphate with microchannel and customized geometry based on gel-casting and rapid prototyping. Proc Inst Mech Eng H, 2011, 225(3):315-323.
9.	Miranda P, Pajares A, Saiz E, et al. Fracture modes under uniaxial compression in hydroxyapatite scaffolds fabricated by robocasting. J Biomed Mater Res A, 2007, 83(3):646-655.
10.	Miranda P, Pajares A, Guiberteau F. Finite element modeling as a tool for predicting the fracture behavior of robocast scaffolds. Acta Biomater, 2008, 4(6):1715-1724.
11.	Karageorgiou V, Kaplan D. Porosity of 3D biomaterial scaffolds and osteogenesis. Biomaterials, 2005, 26(27):5474-5491.

1. Miranda P, Pajares A, Guiberteau F. Finite element modeling as a tool for predicting the fracture behavior of robocast scaffolds. Acta Biomater, 2008, 4(6):1715-1724.
2. Wu Q, Zhang XL, Wu B, et al. Fabrication and characterization of porous HA/β-TCP scaffolds strengthened with micro-ribs structure. Materials Letters, 2013, 92:274-277.
3. Best SM, Porter AE, Thian ES, et al. Bioceramics:Past, present and for the future. J Eur Ceram Soc, 2008, 28(7):1319-1327.
4. Santos CF, Silva AP, Lopes L, et al. Design and production of sintered β-tricalcium phosphate 3D scaffolds for bone tissue regeneration. Materials Science and Engineering C, 2012, 32(5):1293-1298.
5. Martínez-Vázquez FJ, Perera FH, Miranda P, et al. Improving the compressive strength of bioceramic robocast scaffolds by polymer inffltration. Acta Biomater, 2010, 6(11):4361-4368.
6. 连芩, 刘亚雄, 贺健康, 等. 生物制造技术及发展. 中国工程科学, 2013, 15(1):45-50.
7. Xiang Li, Dichen Li, Bingheng Lu, et al. Fabrication of bioceramic scaffolds with pre-designed internal architecture by gel casting and indirect stereolithography techniques. J Porous Mater, 2008, 15:667-671.
8. Li X, Bian W, Li D, et al. Fabrication of porous beta-tricalcium phosphate with microchannel and customized geometry based on gel-casting and rapid prototyping. Proc Inst Mech Eng H, 2011, 225(3):315-323.
9. Miranda P, Pajares A, Saiz E, et al. Fracture modes under uniaxial compression in hydroxyapatite scaffolds fabricated by robocasting. J Biomed Mater Res A, 2007, 83(3):646-655.
10. Miranda P, Pajares A, Guiberteau F. Finite element modeling as a tool for predicting the fracture behavior of robocast scaffolds. Acta Biomater, 2008, 4(6):1715-1724.
11. Karageorgiou V, Kaplan D. Porosity of 3D biomaterial scaffolds and osteogenesis. Biomaterials, 2005, 26(27):5474-5491.

Chinese Journal of Reparative and Reconstructive Surgery

MECHANICAL PROPERTIES OF POLYLACTIC ACID/β-TRICALCIUM PHOSPHATE COMPOSITE SCAFFOLD WITH DOUBLE CHANNELS BASED ON THREE-DIMENSIONAL PRINTING TECHNIQUE

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