EFFECTIVENESS OF APONEUROSIS BRISEMEN FOR TREATMENT OF SPASTIC PALSY AFTER SPINAL CORD INJURY_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

 LIUWenhua

Department of Spinal Surgery, the Affiliated Hospital of Weifang Medical College, Weifang Shandong, 261041, P. R. China;

Corresponding author：

LIUWenhua, Email: lwhgk@163.com

Keywords：

Aponeurosis brisemen; Spinal cord injury; Spastic palsy

DOI：

10.7507/1002-1892.20140189

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Objective To investigate the expression changes of the receptor activator of nuclear factor-κB ligand (RANKL) in the peripheral blood of patients with aseptic loosening of the implant after total hip arthroplasty (THA) by comparing with that of patients with femoral neck fracture and to analyze the correlation between RANKL expression and aseptic loosening. Methods Between January 2008 and January 2013,the peripheral blood were harvested from 58 patients with aseptic loosening of the implant after THA (trial group) and 63 patients with femoral neck fracture (control group).The 2 groups were well matched,with no significant differences in age and gender (P>0.05).The expressions of the RANKL mRNA and RANKL protein were evaluated by quantitative real-time PCR and Western blot respectively.At the same time,the concentration of RANKL was also measured by ELISA. Results The expression of the RANKL mRNA in the trial group was 18.30±1.09,which was significantly higher than that of control group (1.00±0.05)(t=125.390,P=0.000).The relative RANKL protein expression values in trial group and control group were 0.856±0.254 and 0.404±0.102 respectively,showing significant difference (t=13.032,P=0.000).The results of ELISA showed that the concentration of RANKL in trial group [(3.553 5±0.129 7) ng/mL] was significantly higher than that of control group [(1.912 3±0.126 2) ng/mL] (t=18.124,P=0.000). Conclusion The high RANKL expression in peripheral blood is probably correlated with aseptic loosening of the implant in patients undergoing THA,which possibly is the prognostic factor of aseptic loosening of the implant.

Citation： LIUWenhua. EFFECTIVENESS OF APONEUROSIS BRISEMEN FOR TREATMENT OF SPASTIC PALSY AFTER SPINAL CORD INJURY. Chinese Journal of Reparative and Reconstructive Surgery, 2014, 28(7): 857-861. doi: 10.7507/1002-1892.20140189 Copy

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13.	程吉强,刘亚,邱玉金,等.腱膜松解术治疗四肢痉挛性瘫痪15例疗效观察.山东医药,2010,50(19):90-91.
14.	Rabchevsky AG,Patel SP,Duale H,et al.Gabapentin for spasticity & autonomic dysreflexia after severe spinal cord injury.Spinal Cord,2011,49(1):99-105.
15.	Naftchi NE,Richardson JS.Autonomic dysreflexia:pharmacological management of hypertensive crises in spinal cord injured patients.J Spinal Cord Med,1997,20(3):355-360.
16.	Coffey RJ,Edgar TS,Francisco GE,et al.Abrupt withdrawal from intrathecal baclofen:recognition and management of a potentially life-threatening syndrome.Arch Phys Med Rehabil,2002,83(6):735-741.
17.	Trivedi R,Agarwal S,Rathore RK,et al.Understanding development and lateralization of major cerebral fiber bundles in pediatric population through quantitative diffusion tensor tractography.Pediatr Res,2009,66(6):636-641.
18.	Trivedi R,Gupta RK,Shah V,et al.Treatment-induced plasticity in cerebral palsy:a diffusion tensor imaging study.Pediatr Neurol,2008,39(5):341-349.
19.	Mirbagheri MM,Chen D,Rymer WZ.Quantification of the effects of an alpha-2 adrenergic agonist on reflex properties in spinal cord injury using a system identification technique.J Neuroeng Rehabil,2010,7:29.
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21.	Rowbotham M,Harden N,Stacey B,et al.Gabapentin for the treatment of postherpetic neuralgia:arandomized controlled trial.JAMA,1998,280(21):1837-1842.

1. Yates CC,Garrison K,Charlesworth A,et al.Therapeutic approaches for spinal cord injury induced spasticity.Translational Neuroscience,2010,1(2):160-169.
2. 谭吉林,李国辉,白伟杰,等.痉挛性瘫痪的中西医结合治疗的现状.中国康复医学杂志,2005,20(5):399-400.
3. Rabchevsky AG,Patel SP,Lyttle TS,et al.Effects of chronic versus acute gabapentin administration on spasticity & autonomic dysreflexia after severe spinal cord injury.J Neurotrauma,2010,26:A-73.
4. Soni BM,Mani RM,Oo T,et al.Treatment of spasticity in a spinal cord-injured patient with intrathecal morphine due to intrathecal baclofen tolerance-case report and review of literature.Spinal Cord,2003,41(10):586-589.
5. McMahon D,Tutt M,Cook AM.Pharmacological management of hemodynamic complications following spinal cord injury.Orthopedics,2009,32(5):331.
6. 杨楠,谭吉林,王本国.中西医结合治疗卒中后痉挛性瘫痪的临床疗效观察.中华中医药学刊,2007,27(7):1532-1533.
7. Hoon AH Jr,Stashinko EE,Nagae LM,et al.Sensory and motor deficits in children with cerebral palsy born preterm correlate with diffusion tensor imaging abnormalities in thalamocortical pathways.Dev Med Child Neurol,2009,51(9):697-704.
8. Kitzman P.VGLUT1 and GLYT2 labeling of sacrocaudal motoneurons in the spinal cord injured spastic rat.Exp Neurol,2007,204(1):195-204.
9. 肖代坤,郑宁,陈义藩,等.软组织松解术治疗脑瘫痉挛性四肢畸形.现代医院,2007,7(5):22-23.
10. Rabchevsky AG,Kitzman PH.Latest approaches for the treatment of spasticity and autonomic dysreflexia in chronic spinal cord injury.Neurotherapeutics,2011,8(2):274-282.
11. Trivedi R,Agarwal S,Shal V,et al.Correlation of quantitative sensorimotor tractography with clinical grade of cerebral palsy.Neuroradiology,2010,5(8):759-765.
12. Popa C,Popa F,Grigorean VT,et al.Vascular dysfunctions following spinal cord injury.J Med Life,2010,3(3):275-285.
13. 程吉强,刘亚,邱玉金,等.腱膜松解术治疗四肢痉挛性瘫痪15例疗效观察.山东医药,2010,50(19):90-91.
14. Rabchevsky AG,Patel SP,Duale H,et al.Gabapentin for spasticity & autonomic dysreflexia after severe spinal cord injury.Spinal Cord,2011,49(1):99-105.
15. Naftchi NE,Richardson JS.Autonomic dysreflexia:pharmacological management of hypertensive crises in spinal cord injured patients.J Spinal Cord Med,1997,20(3):355-360.
16. Coffey RJ,Edgar TS,Francisco GE,et al.Abrupt withdrawal from intrathecal baclofen:recognition and management of a potentially life-threatening syndrome.Arch Phys Med Rehabil,2002,83(6):735-741.
17. Trivedi R,Agarwal S,Rathore RK,et al.Understanding development and lateralization of major cerebral fiber bundles in pediatric population through quantitative diffusion tensor tractography.Pediatr Res,2009,66(6):636-641.
18. Trivedi R,Gupta RK,Shah V,et al.Treatment-induced plasticity in cerebral palsy:a diffusion tensor imaging study.Pediatr Neurol,2008,39(5):341-349.
19. Mirbagheri MM,Chen D,Rymer WZ.Quantification of the effects of an alpha-2 adrenergic agonist on reflex properties in spinal cord injury using a system identification technique.J Neuroeng Rehabil,2010,7:29.
20. Levendoglu F,Ogun CO,Ozerbil O,et al.Gabapentin is a first line drug for the treatment of neuropathic pain in spinal cord injury.Spine (Phila Pa 1976),2004,29(7):743-751.
21. Rowbotham M,Harden N,Stacey B,et al.Gabapentin for the treatment of postherpetic neuralgia:arandomized controlled trial.JAMA,1998,280(21):1837-1842.

Chinese Journal of Reparative and Reconstructive Surgery

EFFECTIVENESS OF APONEUROSIS BRISEMEN FOR TREATMENT OF SPASTIC PALSY AFTER SPINAL CORD INJURY

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