APPLICATION OF PLATELET-RICH PLASMA IN CLINICAL ORTHOPEDICS_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

FUWeili , LIQi ,  LIJian

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P. R. China;

Corresponding author：

LIJian, Email: hxlijian.china@163.com

Keywords：

Platelet-rich plasma; Bone healing; Cartilage repair; Tendon regeneration; Ligament reconstruction

DOI：

10.7507/1002-1892.20140283

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To summarize the application status and progress of platelet-rich plasma (PRP) in clinical orthopedics. Methods The recent related literature concerning the application of PRP in clinical orthopedics was extensively reviewed and analyzed. Results Recently, a large number of clinical studies on PRP have been carried out, which are applied in bone defects or nonunion, spinal fusion, osteoarthritis and cartilage injuries, ligament reconstruction, muscle strain, tendon terminal diseases, and a variety of acute and chronic soft tissue injuries. Some results show certain effectiveness, while others demonstrate invalid. Conclusion Easily drawing, achieving autologous transplantation, and the biological repair potential of the musculoskeletal tissues make PRP to be widely used in clinical orthopedics. However, there are still no uniform standards accepted and reliable clinical guidelines about the application of PRP. Furthermore, a variety of PRP products and their respective indications are also different. The clinical evidences with the greater sample size and higher quality are still needed to further support the safety and effectiveness of PRP in clinical orthopedics.

Citation： FUWeili, LIQi, LIJian. APPLICATION OF PLATELET-RICH PLASMA IN CLINICAL ORTHOPEDICS. Chinese Journal of Reparative and Reconstructive Surgery, 2014, 28(10): 1311-1316. doi: 10.7507/1002-1892.20140283 Copy

1.	Halpern BC, Chaudhury S, Rodeo SA.The role of platelet-rich plasma in inducing musculoskeletal tissue healing.HSS J, 2012, 8(2):137-145.
2.	Andia I, Abate M.Platelet-rich plasma:underlying biology and clinical correlates.Regen Med, 2013, 8(5):645-658.
3.	Arnoczky SP, Shebani-Rad S.The basic science of platelet-rich plasma (PRP):what clinicians need to know.Sports Med Arthrosc, 2013, 21(4):180-185.
4.	Iqbal J, Pepkowitz SH, Klapper E.Platelet-rich plasma for the replenishment of bone.Curr Osteoporos Rep, 2011, 9(31):258-263.
5.	Hakimi M, Jungbluth P, Thelen S, et al.Platelet-rich plasma combined with autologous cancellous bone:An alternative therapy for persistent non-union? Unfallchirurg, 2011, 114(11):998-1006.
6.	Chen L, Yang X, Huang G, et al.Platelet-rich plasma promotes healing of osteoporotic fractures.Orthopedics, 2013, 36(6):e687-694.
7.	于绍斌, 王亚斌, 董启榕.富血小板血浆及其在骨科领域的应用进展.中国修复重建外科杂志, 2008, 22(7):880-882.
8.	仇建军, 张长青, 郭彦杰, 等.PRP促进骨折修复的临床实验研究.中国修复重建外科杂志, 2009, 23(7):784-787.
9.	Martin JR, Houdek MT, Sierra RJ.Use of concentrated bone marrow aspirate and platelet rich plasma during minimally invasive decompression of the femoral head in the treatment of osteonecrosis.Croat Med J, 2013, 54(3):219-224.
10.	Guadilla J, Fiz N, Andia I, et al.Arthroscopic management and platelet-rich plasma therapy for avascular necrosis of the hip.Knee Surg Sports Traumatol Arthrosc, 2012, 20(2):393-398.
11.	Latalski M, Elbatrawy YA, Thabet AM, et al.Enhancing bone healing during distraction osteogenesis with platelet-rich plasma.Injury, 2011, 42(8):821-824.
12.	Peerbooms JC, Colaris JW, Hakkert AA, et al.No positive bone healing after using platelet rich plasma in a skeletal defect.An observational prospective cohort study.Int Orthop, 2012, 36(10):2113-2119.
13.	Tsai CH, Hsu HC, Chen YJ, et al.Using the growth factors-enriched platelet glue in spinal fusion and its efficiency.J Spinal Disord Tech, 2009, 22(4):246-250.
14.	Malhotra A, Pelletier MH, Yu Y, et al.Can platelet-rich plasma (PRP) improve bone healing? A comparison between the theory and experimental outcomes.Arch Orthop Trauma Surg, 2013, 133(2):153-165.
15.	Paderni S, Terzi S, Amendola L.Major bone defect treatment with an osteoconductive bone substitute.Chir Organi Mov, 2009, 93(2):89-96.
16.	Yuan T, Guo SC, Han P, et al.Applications of leukocyte-and platelet-rich plasma (L-PRP) in trauma surgery.Curr Pharm Biotechnol, 2012, 13(7):1173-1184.
17.	Lee KS, Shetty AA, Kim SJ, et al.Intra-articular injections of platelet-rich plasma in patients with knee pain of articular cartilage origin (degenerative chondropathy and early OA).Tissue Eng Regen Med, 2013, 10(6):329-335.
18.	Smyth NA, Murawski CD, Fortier LA, et al.Platelet-rich plasma in the pathologic processes of cartilage:review of basic science evidence.Arthroscopy, 2013, 29(8):1399-1409.
19.	Say F, Gürler D, Yener K, et al.Platelet-rich plasma injection is more effective than hyaluronic acid in the treatment of knee osteoarthritis.Acta Chir Orthop Traumatol Cech, 2013, 80(4):278-283.
20.	Khoshbin A, Leroux T, Wasserstein D, et al.The efficacy of platelet-rich plasma in the treatment of symptomatic knee osteoarthritis:a systematic review with quantitative synthesis.Arthroscopy, 2013, 29(12):2037-2048.
21.	Patel S, Dhillon MS, Aggarwal S, et al.Treatment with platelet-rich plasma is more effective than placebo for knee osteoarthritis:a prospective, double-blind, randomized trial.Am J Sport Med, 2013, 41(2):356-364.
22.	Sánchez M, Fiz N, Azofra J, et al.A randomized clinical trial evaluating plasma rich in growth factors (PRGF-Endoret) versus hyaluronic acid in the short-term treatment of symptomatic knee osteoarthritis.Arthroscopy, 2012, 28(8):1070-1078.
23.	李明, 张长青, 艾自胜, 等.关节内注射富血小板血浆对膝关节软骨退行性变的治疗作用.中国修复重建外科杂志, 2011, 25(10):1192-1196.
24.	Filardo G, Kon E, Di Martino A, et al.Platelet-rich plasma vs hyaluronic acid to treat knee degenerative pathology:study design and preliminary results of a randomized controlled trial.BMC Musculoskeletal Disord, 2012, 13:229.
25.	Lee GW, Son JH, Kim JD, et al.Is platelet-rich plasma able to enhance the results of arthroscopic microfracture in early osteoarthritis and cartilage lesion over 40 years of age? Eur J Orthop Surg Traumatol, 2013, 23(5):581-587.
26.	Klaassen MA, Pietrzak WS.Platelet-rich plasma application and heterotopic bone formation following total hip arthroplasty.J Invest Surg, 2011, 24(6):257-261.
27.	Freitag J, Barnard A, Rotstein A.Photoactivated platelet-rich plasma therapy for a traumatic knee chondral lesion.BMJ Case Rep, 2012, pii:bcr2012006858.
28.	Freitag JB, Barnard A.To evaluate the effect of combining photo-activation therapy with platelet-rich plasma injections for the novel treatment of osteoarthritis.BMJ Case Rep, 2013, pii:bcr2012007463.
29.	Mei-Dan O, Carmont MR, Laver L, et al.Platelet-rich plasma or hyaluronate in the management of osteochondral lesions of the talus.Am J Sports Med, 2012, 40(3):534-541.
30.	Soomekh DJ.Current concepts for the use of platelet-rich plasma in the foot and ankle.Clin Podiatr Med Surg, 2011, 28(1):155-170.
31.	Wei LC, Gao SG, Xu M, et al.A novel hypothesis:The application of platelet-rich plasma can promote the clinical healing of white-white meniscal tears.Med Sci Monitor, 2012, 18(8):HY47-HY50.
32.	Barber FA.Platelet-rich plasma for rotator cuff repair.Sports Med Arthrosc, 2013, 21(4):199-205.
33.	McCarrel TM, Minas T, Fortier LA.Optimization of leukocyte concentration in platelet-rich plasma for the treatment of tendinopathy.J Bone Joint Surg (Am), 2012, 94(19):e143(1-8).
34.	Castricini R, Longo UG, De Benedetto M, et al.Platelet-rich plasma augmentation for arthroscopic rotator cuff repair:a randomized controlled trial.Am J Sports Med, 2011, 39(2):258-265.
35.	Boswell SG, Schnabel LV, Mohammed HO, et al.Increasing platelet concentrations in leukocyte-reduced platelet-rich plasma decrease collagen gene synthesis in tendons.Am J Sport Med, 2014, 42(1):42-49.
36.	Chahal J, Van Thiel GS, Mall N, et al.The Role of Platelet-rich plasma in arthroscopic rotator cuff repair:a systematic review with quantitative synthesis.Arthroscopy, 2012, 28(11):1718-1727.
37.	Weber SC, Kauffman JI, Parise C, et al.Platelet-rich fibrin matrix in the management of arthroscopic repair of the rotator cuff:a prospective, randomized, double-blinded study.Am J Sport Med, 2013, 41(2):263-270.
38.	Kesikburun S, Tan AK, Yilmaz B, et al.Platelet-rich plasma injections in the treatment of chronic rotator cuff tendinopathy:a randomized controlled trial with 1-year follow-up.Am J Sport Med, 2013, 41(11):2609-2616.
39.	Jo CH, Shin JS, Lee YG, et al.Platelet-rich plasma for arthroscopic repair of large to massive rotator cuff tears:a randomized, single-blind, parallel-group trial.Am J Sport Med, 2013, 41(10):2240-2248.
40.	Chaudhury S, de La Lama M, Adler RS, et al.Platelet-rich plasma for the treatment of lateral epicondylitis:sonographic assessment of tendon morphology and vascularity (pilot study).Skeletal Radiol, 2013, 42(1):91-97.
41.	Martin JI, Merino J, Atilano L, et al.Platelet-rich plasma (PRP) in chronic epicondylitis:study protocol for a randomized controlled trial.Trials, 2013, 14:410.
42.	Ahmad Z, Brooks R, Kang SN, et al.The effect of platelet-rich plasma on clinical outcomes in lateral epicondylitis.Arthroscopy, 2013, 29(11):1851-1862.
43.	Filardo G, Kon E, Di Matteo B, et al.Platelet-rich plasma for the treatment of patellar tendinopathy:clinical and imaging findings at medium-term follow-up.Int Orthop, 2013, 37(8):1583-1589.
44.	Bowman KF Jr, Muller B, Middleton K, et al.Progression of patellar tendinitis following treatment with platelet-rich plasma:case reports.Knee Surg Sports Traumatol Arthrosc, 2013, 21(9):2035-2039.
45.	Vetrano M, Castorina A, Vulpiani MC, et al.Platelet-rich plasma versus focused shock waves in the treatment of jumper's knee in athletes.Am J Sports Med, 2013, 41(4):795-803.
46.	de Almeida AM, Demange MK, Sobrado MF, et al.Patellar tendon healing with platelet-rich plasma:a prospective randomized controlled trial.Am J Sports Med, 2012, 40(6):1282-1288.
47.	Monto RR.Platelet rich plasma treatment for chronic Achilles tendinosis.Foot Ankle Int, 2012, 33(5):379-385.
48.	Braun HJ, Wasterlain AS, Dragoo JL.The use of PRP in ligament and meniscal healing.Sports Med Arthrosc, 2013, 21(4):206-212.
49.	Gokce A, Beyzadeoglu T, Ozyer F, et al.Does bone impaction technique reduce tunnel enlargement in ACL reconstruction? Int Orthop, 2009, 33(2):407-412.
50.	Rupreht M, Vogrin M, Hussein M.MRI evaluation of tibial tunnel wall cortical bone formation after platelet-rich plasma applied during anterior cruciate ligament reconstruction.Radiol Oncol, 2013, 47(2):119-124.
51.	Mirzatolooei F, Alamdari MT, Khalkhali HR.The impact of platelet-rich plasma on the prevention of tunnel widening in anterior cruciate ligament reconstruction using quadrupled autologous hamstring tendon:a randomised clinical trial.Bone Joint J, 2013, 95-B (1):65-69.
52.	Figueroa PD, Figueroa F, Ahumada PX, et al.Use of platelet rich plasma in knee ligament surgery.Rev Med Chil, 2013, 141(10):1315-1320.
53.	Eirale C, Mauri E, Hamilton B.Use of platelet rich plasma in an isolated complete medial collateral ligament lesion in a professional football (soccer) player:a case report.Asian J Sports Med, 2013, 4(2):158-162.
54.	Podesta L, Crow SA, Volkmer D, et al.Treatment of partial ulnar collateral ligament tears in the elbow with platelet-rich plasma.Am J Sports Med, 2013, 41(7):1689-1694.
55.	Andia I, Maffulli N.Platelet-rich plasma for muscle injury and tendinopathy.Sports Med Arthrosc, 2013, 21(4):191-198.
56.	AHamid MS, Mohamed Ali MR, Yusof A, et al.Platelet-rich plasma (PRP):an adjuvant to hasten hamstring muscle recovery.A randomized controlled trial protocol (ISCRTN66528592).BMC Musculoskelet Disord, 2012, 13:138.
57.	Lanzetti RM, Vadalà A, Morelli F, et al.Bilateral quadriceps rupture:results with and without platelet-rich plasma.Orthopedics, 2013, 36(11):e1474-e1478.
58.	Peck E, Ely E.Successful treatment of de Quervain tenosynovitis with ultrasound-guided percutaneous needle tenotomy and platelet-rich plasma injection:a case presentation.PM R, 2013, 5(5):438-441.
59.	Martinelli N, Marinozzi A, Carni S, et al.Platelet-rich plasma injections for chronic plantar fasciitis.Int Orthop, 2013, 37(5):839-842.
60.	董佩龙, 唐晓波, 王健, 等.富血小板血浆对人工全髋关节置换术创面愈合的影响.中国修复重建外科杂志, 2014, 28(4):432-434.

1. Halpern BC, Chaudhury S, Rodeo SA.The role of platelet-rich plasma in inducing musculoskeletal tissue healing.HSS J, 2012, 8(2):137-145.
2. Andia I, Abate M.Platelet-rich plasma:underlying biology and clinical correlates.Regen Med, 2013, 8(5):645-658.
3. Arnoczky SP, Shebani-Rad S.The basic science of platelet-rich plasma (PRP):what clinicians need to know.Sports Med Arthrosc, 2013, 21(4):180-185.
4. Iqbal J, Pepkowitz SH, Klapper E.Platelet-rich plasma for the replenishment of bone.Curr Osteoporos Rep, 2011, 9(31):258-263.
5. Hakimi M, Jungbluth P, Thelen S, et al.Platelet-rich plasma combined with autologous cancellous bone:An alternative therapy for persistent non-union? Unfallchirurg, 2011, 114(11):998-1006.
6. Chen L, Yang X, Huang G, et al.Platelet-rich plasma promotes healing of osteoporotic fractures.Orthopedics, 2013, 36(6):e687-694.
7. 于绍斌, 王亚斌, 董启榕.富血小板血浆及其在骨科领域的应用进展.中国修复重建外科杂志, 2008, 22(7):880-882.
8. 仇建军, 张长青, 郭彦杰, 等.PRP促进骨折修复的临床实验研究.中国修复重建外科杂志, 2009, 23(7):784-787.
9. Martin JR, Houdek MT, Sierra RJ.Use of concentrated bone marrow aspirate and platelet rich plasma during minimally invasive decompression of the femoral head in the treatment of osteonecrosis.Croat Med J, 2013, 54(3):219-224.
10. Guadilla J, Fiz N, Andia I, et al.Arthroscopic management and platelet-rich plasma therapy for avascular necrosis of the hip.Knee Surg Sports Traumatol Arthrosc, 2012, 20(2):393-398.
11. Latalski M, Elbatrawy YA, Thabet AM, et al.Enhancing bone healing during distraction osteogenesis with platelet-rich plasma.Injury, 2011, 42(8):821-824.
12. Peerbooms JC, Colaris JW, Hakkert AA, et al.No positive bone healing after using platelet rich plasma in a skeletal defect.An observational prospective cohort study.Int Orthop, 2012, 36(10):2113-2119.
13. Tsai CH, Hsu HC, Chen YJ, et al.Using the growth factors-enriched platelet glue in spinal fusion and its efficiency.J Spinal Disord Tech, 2009, 22(4):246-250.
14. Malhotra A, Pelletier MH, Yu Y, et al.Can platelet-rich plasma (PRP) improve bone healing? A comparison between the theory and experimental outcomes.Arch Orthop Trauma Surg, 2013, 133(2):153-165.
15. Paderni S, Terzi S, Amendola L.Major bone defect treatment with an osteoconductive bone substitute.Chir Organi Mov, 2009, 93(2):89-96.
16. Yuan T, Guo SC, Han P, et al.Applications of leukocyte-and platelet-rich plasma (L-PRP) in trauma surgery.Curr Pharm Biotechnol, 2012, 13(7):1173-1184.
17. Lee KS, Shetty AA, Kim SJ, et al.Intra-articular injections of platelet-rich plasma in patients with knee pain of articular cartilage origin (degenerative chondropathy and early OA).Tissue Eng Regen Med, 2013, 10(6):329-335.
18. Smyth NA, Murawski CD, Fortier LA, et al.Platelet-rich plasma in the pathologic processes of cartilage:review of basic science evidence.Arthroscopy, 2013, 29(8):1399-1409.
19. Say F, Gürler D, Yener K, et al.Platelet-rich plasma injection is more effective than hyaluronic acid in the treatment of knee osteoarthritis.Acta Chir Orthop Traumatol Cech, 2013, 80(4):278-283.
20. Khoshbin A, Leroux T, Wasserstein D, et al.The efficacy of platelet-rich plasma in the treatment of symptomatic knee osteoarthritis:a systematic review with quantitative synthesis.Arthroscopy, 2013, 29(12):2037-2048.
21. Patel S, Dhillon MS, Aggarwal S, et al.Treatment with platelet-rich plasma is more effective than placebo for knee osteoarthritis:a prospective, double-blind, randomized trial.Am J Sport Med, 2013, 41(2):356-364.
22. Sánchez M, Fiz N, Azofra J, et al.A randomized clinical trial evaluating plasma rich in growth factors (PRGF-Endoret) versus hyaluronic acid in the short-term treatment of symptomatic knee osteoarthritis.Arthroscopy, 2012, 28(8):1070-1078.
23. 李明, 张长青, 艾自胜, 等.关节内注射富血小板血浆对膝关节软骨退行性变的治疗作用.中国修复重建外科杂志, 2011, 25(10):1192-1196.
24. Filardo G, Kon E, Di Martino A, et al.Platelet-rich plasma vs hyaluronic acid to treat knee degenerative pathology:study design and preliminary results of a randomized controlled trial.BMC Musculoskeletal Disord, 2012, 13:229.
25. Lee GW, Son JH, Kim JD, et al.Is platelet-rich plasma able to enhance the results of arthroscopic microfracture in early osteoarthritis and cartilage lesion over 40 years of age? Eur J Orthop Surg Traumatol, 2013, 23(5):581-587.
26. Klaassen MA, Pietrzak WS.Platelet-rich plasma application and heterotopic bone formation following total hip arthroplasty.J Invest Surg, 2011, 24(6):257-261.
27. Freitag J, Barnard A, Rotstein A.Photoactivated platelet-rich plasma therapy for a traumatic knee chondral lesion.BMJ Case Rep, 2012, pii:bcr2012006858.
28. Freitag JB, Barnard A.To evaluate the effect of combining photo-activation therapy with platelet-rich plasma injections for the novel treatment of osteoarthritis.BMJ Case Rep, 2013, pii:bcr2012007463.
29. Mei-Dan O, Carmont MR, Laver L, et al.Platelet-rich plasma or hyaluronate in the management of osteochondral lesions of the talus.Am J Sports Med, 2012, 40(3):534-541.
30. Soomekh DJ.Current concepts for the use of platelet-rich plasma in the foot and ankle.Clin Podiatr Med Surg, 2011, 28(1):155-170.
31. Wei LC, Gao SG, Xu M, et al.A novel hypothesis:The application of platelet-rich plasma can promote the clinical healing of white-white meniscal tears.Med Sci Monitor, 2012, 18(8):HY47-HY50.
32. Barber FA.Platelet-rich plasma for rotator cuff repair.Sports Med Arthrosc, 2013, 21(4):199-205.
33. McCarrel TM, Minas T, Fortier LA.Optimization of leukocyte concentration in platelet-rich plasma for the treatment of tendinopathy.J Bone Joint Surg (Am), 2012, 94(19):e143(1-8).
34. Castricini R, Longo UG, De Benedetto M, et al.Platelet-rich plasma augmentation for arthroscopic rotator cuff repair:a randomized controlled trial.Am J Sports Med, 2011, 39(2):258-265.
35. Boswell SG, Schnabel LV, Mohammed HO, et al.Increasing platelet concentrations in leukocyte-reduced platelet-rich plasma decrease collagen gene synthesis in tendons.Am J Sport Med, 2014, 42(1):42-49.
36. Chahal J, Van Thiel GS, Mall N, et al.The Role of Platelet-rich plasma in arthroscopic rotator cuff repair:a systematic review with quantitative synthesis.Arthroscopy, 2012, 28(11):1718-1727.
37. Weber SC, Kauffman JI, Parise C, et al.Platelet-rich fibrin matrix in the management of arthroscopic repair of the rotator cuff:a prospective, randomized, double-blinded study.Am J Sport Med, 2013, 41(2):263-270.
38. Kesikburun S, Tan AK, Yilmaz B, et al.Platelet-rich plasma injections in the treatment of chronic rotator cuff tendinopathy:a randomized controlled trial with 1-year follow-up.Am J Sport Med, 2013, 41(11):2609-2616.
39. Jo CH, Shin JS, Lee YG, et al.Platelet-rich plasma for arthroscopic repair of large to massive rotator cuff tears:a randomized, single-blind, parallel-group trial.Am J Sport Med, 2013, 41(10):2240-2248.
40. Chaudhury S, de La Lama M, Adler RS, et al.Platelet-rich plasma for the treatment of lateral epicondylitis:sonographic assessment of tendon morphology and vascularity (pilot study).Skeletal Radiol, 2013, 42(1):91-97.
41. Martin JI, Merino J, Atilano L, et al.Platelet-rich plasma (PRP) in chronic epicondylitis:study protocol for a randomized controlled trial.Trials, 2013, 14:410.
42. Ahmad Z, Brooks R, Kang SN, et al.The effect of platelet-rich plasma on clinical outcomes in lateral epicondylitis.Arthroscopy, 2013, 29(11):1851-1862.
43. Filardo G, Kon E, Di Matteo B, et al.Platelet-rich plasma for the treatment of patellar tendinopathy:clinical and imaging findings at medium-term follow-up.Int Orthop, 2013, 37(8):1583-1589.
44. Bowman KF Jr, Muller B, Middleton K, et al.Progression of patellar tendinitis following treatment with platelet-rich plasma:case reports.Knee Surg Sports Traumatol Arthrosc, 2013, 21(9):2035-2039.
45. Vetrano M, Castorina A, Vulpiani MC, et al.Platelet-rich plasma versus focused shock waves in the treatment of jumper's knee in athletes.Am J Sports Med, 2013, 41(4):795-803.
46. de Almeida AM, Demange MK, Sobrado MF, et al.Patellar tendon healing with platelet-rich plasma:a prospective randomized controlled trial.Am J Sports Med, 2012, 40(6):1282-1288.
47. Monto RR.Platelet rich plasma treatment for chronic Achilles tendinosis.Foot Ankle Int, 2012, 33(5):379-385.
48. Braun HJ, Wasterlain AS, Dragoo JL.The use of PRP in ligament and meniscal healing.Sports Med Arthrosc, 2013, 21(4):206-212.
49. Gokce A, Beyzadeoglu T, Ozyer F, et al.Does bone impaction technique reduce tunnel enlargement in ACL reconstruction? Int Orthop, 2009, 33(2):407-412.
50. Rupreht M, Vogrin M, Hussein M.MRI evaluation of tibial tunnel wall cortical bone formation after platelet-rich plasma applied during anterior cruciate ligament reconstruction.Radiol Oncol, 2013, 47(2):119-124.
51. Mirzatolooei F, Alamdari MT, Khalkhali HR.The impact of platelet-rich plasma on the prevention of tunnel widening in anterior cruciate ligament reconstruction using quadrupled autologous hamstring tendon:a randomised clinical trial.Bone Joint J, 2013, 95-B (1):65-69.
52. Figueroa PD, Figueroa F, Ahumada PX, et al.Use of platelet rich plasma in knee ligament surgery.Rev Med Chil, 2013, 141(10):1315-1320.
53. Eirale C, Mauri E, Hamilton B.Use of platelet rich plasma in an isolated complete medial collateral ligament lesion in a professional football (soccer) player:a case report.Asian J Sports Med, 2013, 4(2):158-162.
54. Podesta L, Crow SA, Volkmer D, et al.Treatment of partial ulnar collateral ligament tears in the elbow with platelet-rich plasma.Am J Sports Med, 2013, 41(7):1689-1694.
55. Andia I, Maffulli N.Platelet-rich plasma for muscle injury and tendinopathy.Sports Med Arthrosc, 2013, 21(4):191-198.
56. AHamid MS, Mohamed Ali MR, Yusof A, et al.Platelet-rich plasma (PRP):an adjuvant to hasten hamstring muscle recovery.A randomized controlled trial protocol (ISCRTN66528592).BMC Musculoskelet Disord, 2012, 13:138.
57. Lanzetti RM, Vadalà A, Morelli F, et al.Bilateral quadriceps rupture:results with and without platelet-rich plasma.Orthopedics, 2013, 36(11):e1474-e1478.
58. Peck E, Ely E.Successful treatment of de Quervain tenosynovitis with ultrasound-guided percutaneous needle tenotomy and platelet-rich plasma injection:a case presentation.PM R, 2013, 5(5):438-441.
59. Martinelli N, Marinozzi A, Carni S, et al.Platelet-rich plasma injections for chronic plantar fasciitis.Int Orthop, 2013, 37(5):839-842.
60. 董佩龙, 唐晓波, 王健, 等.富血小板血浆对人工全髋关节置换术创面愈合的影响.中国修复重建外科杂志, 2014, 28(4):432-434.

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