APPLICATION OF SILK FIBROIN SCAFFOLD IN BONE TISSUE ENGINEERING_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

LUShijun ^1,2 , ZUOBaoqi ³ ,  LIUHongchen ¹

1. Medical School of Chinese PLA, Beijing, 100853, P. R. China;
2. Suzhou Huaxia Stomatological Hospital Affiliated to Suzhou Health College;
3. National Engineering Laboratory for Modern Silk of Soochow University;

Corresponding author：

LIUHongchen, Email: liu-hc@301dent.com

Keywords：

Bone tissue engineering; Silk fibroin; Three-dimensional scaffold; Hydrogel; Film; Electrospinning

DOI：

10.7507/1002-1892.20140282

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To review the application of silk fibroin scaffold in bone tissue engineering. Methods The related literature about the application of silk fibroin scaffold in bone tissue engineering was reviewed, analyzed, and summarized. Results Silk fibroin can be manufactured into many types, such as hydrogel, film, nano-fiber, and three-dimensional scaffold, which have superior biocompatibility, slow biodegradability, nontoxic degradation products, and excellent mechanical strength. Meanwhile these silk fibroin biomaterials can be chemically modified and can be used to carry stem cells, growth factors, and compound inorganic matter. Conclusion Silk fibroin scaffolds can be widely used in bone tissue engineering. But it still needs further study to prepare the scaffold in accordance with the requirement of tissue engineering.

Citation： LUShijun, ZUOBaoqi, LIUHongchen. APPLICATION OF SILK FIBROIN SCAFFOLD IN BONE TISSUE ENGINEERING. Chinese Journal of Reparative and Reconstructive Surgery, 2014, 28(10): 1307-1310. doi: 10.7507/1002-1892.20140282 Copy

1.	Bucholz RW.Nonallograft osteoconductive bone graft substitutes.Clin Orthop Relat Res, 2002, (395):44-52.
2.	Marques PA, Gonçalves G, Singh MK, et al.Graphene oxide and hydroxyapatite as fillers of polylactic acid nanocomposites:preparation and characterization.J Nanosci Nanotechnol, 2012, 12(8):6686-6692.
3.	Meinel L, Karageorgiou V, Fajardo R, et al.Bone tissue engineering using human mesenchymal stem cells:effects of scaffold material and medium flow.Ann Biomed Eng, 2004, 32(1):112-122.
4.	Wang Y, Kim HJ, Vunjak-Novakovic G, et al.Stem cell-based tissue engineering with silk biomaterials.Biomaterials, 2006, 27(36):6064-6082.
5.	Kundu B, Rajkhowa R, Kundu SC, et al.Silk fibroin biomaterials for tissue regenerations.Adv Drug Deliv Rev, 2013, 65(4):457-470.
6.	Meinel L, Hofmann S, Karageorgiou V, et al.The inflammatory responses to silk films in vitro and in vivo.Biomaterials, 2005, 26(2):147-155.
7.	Perez-Rigueiro J, Biancotto L, Corsini P, et al.Supramolecular organization of regenerated silkworm silk fibers.Int J Biol Macromol, 2009, 44(2):195-202.
8.	Altman GH, Diaz F, Jakuba C, et al.Silk-based biomaterials.Biomaterials, 2003, 24(3):401-416.
9.	Zhang W, Ahluwalia IP, Literman R, et al.Human dental pulp progenitor cell behavior on aqueous and hexafluoroisopropanol based silk scaffolds.J Biomed Mater Res A, 2011, 97(4):414-422.
10.	Wang Y, Rudym DD, Walsh A, et al.In vivo degradation of three-dimensional silk fibroin scaffolds.Biomaterials, 2008, 29(24-25):3415-3428.
11.	Motta A, Migliaresi C, Faccioni F, et al.Fibroin hydrogels for biomedical applications:preparation, characterization and in vitro cell culture studies.J Biomater Sci Polym Ed, 2004, 15(7):851-864.
12.	Guziewicz N, Best A, Perez-Ramirez B, et al.Lyophilized silk fibroin hydrogels for the sustained local delivery of therapeutic monoclonal antibodies.Biomaterials, 2011, 32(10):2642-2650.
13.	Wu X, Hou J, Li M, et al.Sodium dodecyl sulfate-induced rapid gelation of silk fibroin.Acta Biomaterialia, 2012, 8(6):2185-2192.
14.	Zhang W, Wang X, Wang S, et al.The use of injectable sonication-induced silk hydrogel for VEGF (165) and BMP-2 delivery for elevation of the maxillary sinus floor.Biomaterials, 2011, 32(35):9415-9424.
15.	Hu J, Chen B, Guo F, et al.Injectable silk fibroin/polyurethane composite hydrogel for nucleus pulposus replacement.J Mater Sci Mater Med, 2012, 23(3):711-722.
16.	Gu Y, Chen L, Yang HL, et al.Evaluation of an injectable silk fibroin enhanced calcium phosphate cement loaded with human recombinant bone morphogenetic protein-2 in ovine lumbar interbody fusion.J Biomed Mater Res A, 2011, 97(2):177-185.
17.	Mirahmadi F, Tafazzoli-Shadpour M, Shokrgozar MA, et al.Enhanced mechanical properties of thermosensitive chitosan hydrogel by silk fibers for cartilage tissue engineering.Mater Sci Eng C Mater Biol Appl, 2013, 33(8):4786-4794.
18.	Murphy AR, St John P, Kaplan DL.Modification of silk fibroin using diazonium coupling chemistry and the effects on hMSC proliferation and differentiation.Biomaterials, 2008, 29(19):2829-2838.
19.	Hofmann S, Foo CT, Rossetti F, et al.Silk fibroin as an organic polymer for controlled drug delivery.J Control Release, 2006, 111(1-2):219-227.
20.	Song JY, Kim SG, Lee JW, et al.Accelerated healing with the use of a silk fibroin membrane for the guided bone regeneration technique.Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2011, 112(6):e26-33.
21.	Zhu H, Wu B, Feng X, et al.Preparation and characterization of bioactive mesoporous calcium silicate-silk fibroin composite films.J Biomed Mater Res B Appl Biomater, 2011, 98(2):330-341.
22.	Sukigara S, Gandhi M, Ayutsede J, et al.Regeneration of Bombyx mori silk by electrospinning-part 1:processing parameters and geometric properties.Polymer, 2003, 44(19):5721-5727.
23.	Sukigara S, Gandhi M, Ayutsede J, et al.Regeneration of Bombyx mori silk by electrospinning.Part 2.Process optimization and empirical modeling using response surface methodology.Polymer, 2004, 45(11):3701-3708.
24.	Ayutsede J, Gandhi M, Sukigara S, et al.Regeneration of Bombyx mori silk by electrospinning.Part 3:characterization of electrospun nonwoven mat.Polymer, 2005, 46(5):1625-1634.
25.	Zhang K, Mo X, Huang C, et al.Electrospun scaffolds from silk fibroin and their cellular compatibility.J Biomed Mater Res A, 2010, 93(3):976-983.
26.	Meechaisue C, Wutticharoenmongkol P, Waraput R, et al.Preparation of electrospun silk fibroin fiber mats as bone scaffolds:a preliminary study.Biomed Mater, 2007, 2(3):181-188.
27.	Li C, Vepari C, Jin HJ, et al.Electrospun silk-BMP-2 scaffolds for bone tissue engineering.Biomaterials, 2006, 27(16):3115-3124.
28.	Bai S, Liu S, Zhang C, et al.Controllable transition of silk fibroin nanostructures:an insight into in vitro silk self-assembly process.Acta Biomater, 2013, 9(8):7806-7813.
29.	Harris LD, Kim BS, Mooney DJ.Open pore biodegradable matrices formed with gas foaming.J Biomed Mater Res, 1998, 42(3):396-402.
30.	Li M, Wu Z, Zhang C, et al.Study on porous silk fibroin materials.â…¡.Preparation and characteristics of spongy porous silk fibroin materials.J Applied Polymer Science, 2001, 79(12):2192-2199.
31.	Kim UJ, Park J, Kim HJ, et al.Three-dimensional aqueous-derived biomaterial scaffolds from silk fibroin.Biomaterials, 2005, 26(15):2775-2785.
32.	Park SY, Ki CS, Park YH, et al.Electrospun silk fibroin scaffolds with macropores for bone regeneration:an in vitro and in vivo study.Tissue Eng Part A, 2010, 16(4):1271-1279.
33.	Ju HW, Sheikh FA, Moon BM, et al.Fabrication of poly (lactic-co-glycolic acid) scaffolds containing silk fibroin scaffolds for tissue engineering applications.J Biomed Mater Res A, 2014, 102(8):2713-2724.
34.	Zhao J, Zhang Z, Wang S, et al.Apatite-coated silk fibroin scaffolds to healing mandibular border defects in canines.Bone, 2009, 45(3):517-527.
35.	Riccio M, Maraldi T, Pisciotta A, et al.Fibroin scaffold repairs critical-size bone defects in vivo supported by human amniotic fluid and dental pulp stem cells.Tissue Eng Part A, 2012, 18(9-10):1006-1013.

1. Bucholz RW.Nonallograft osteoconductive bone graft substitutes.Clin Orthop Relat Res, 2002, (395):44-52.
2. Marques PA, Gonçalves G, Singh MK, et al.Graphene oxide and hydroxyapatite as fillers of polylactic acid nanocomposites:preparation and characterization.J Nanosci Nanotechnol, 2012, 12(8):6686-6692.
3. Meinel L, Karageorgiou V, Fajardo R, et al.Bone tissue engineering using human mesenchymal stem cells:effects of scaffold material and medium flow.Ann Biomed Eng, 2004, 32(1):112-122.
4. Wang Y, Kim HJ, Vunjak-Novakovic G, et al.Stem cell-based tissue engineering with silk biomaterials.Biomaterials, 2006, 27(36):6064-6082.
5. Kundu B, Rajkhowa R, Kundu SC, et al.Silk fibroin biomaterials for tissue regenerations.Adv Drug Deliv Rev, 2013, 65(4):457-470.
6. Meinel L, Hofmann S, Karageorgiou V, et al.The inflammatory responses to silk films in vitro and in vivo.Biomaterials, 2005, 26(2):147-155.
7. Perez-Rigueiro J, Biancotto L, Corsini P, et al.Supramolecular organization of regenerated silkworm silk fibers.Int J Biol Macromol, 2009, 44(2):195-202.
8. Altman GH, Diaz F, Jakuba C, et al.Silk-based biomaterials.Biomaterials, 2003, 24(3):401-416.
9. Zhang W, Ahluwalia IP, Literman R, et al.Human dental pulp progenitor cell behavior on aqueous and hexafluoroisopropanol based silk scaffolds.J Biomed Mater Res A, 2011, 97(4):414-422.
10. Wang Y, Rudym DD, Walsh A, et al.In vivo degradation of three-dimensional silk fibroin scaffolds.Biomaterials, 2008, 29(24-25):3415-3428.
11. Motta A, Migliaresi C, Faccioni F, et al.Fibroin hydrogels for biomedical applications:preparation, characterization and in vitro cell culture studies.J Biomater Sci Polym Ed, 2004, 15(7):851-864.
12. Guziewicz N, Best A, Perez-Ramirez B, et al.Lyophilized silk fibroin hydrogels for the sustained local delivery of therapeutic monoclonal antibodies.Biomaterials, 2011, 32(10):2642-2650.
13. Wu X, Hou J, Li M, et al.Sodium dodecyl sulfate-induced rapid gelation of silk fibroin.Acta Biomaterialia, 2012, 8(6):2185-2192.
14. Zhang W, Wang X, Wang S, et al.The use of injectable sonication-induced silk hydrogel for VEGF (165) and BMP-2 delivery for elevation of the maxillary sinus floor.Biomaterials, 2011, 32(35):9415-9424.
15. Hu J, Chen B, Guo F, et al.Injectable silk fibroin/polyurethane composite hydrogel for nucleus pulposus replacement.J Mater Sci Mater Med, 2012, 23(3):711-722.
16. Gu Y, Chen L, Yang HL, et al.Evaluation of an injectable silk fibroin enhanced calcium phosphate cement loaded with human recombinant bone morphogenetic protein-2 in ovine lumbar interbody fusion.J Biomed Mater Res A, 2011, 97(2):177-185.
17. Mirahmadi F, Tafazzoli-Shadpour M, Shokrgozar MA, et al.Enhanced mechanical properties of thermosensitive chitosan hydrogel by silk fibers for cartilage tissue engineering.Mater Sci Eng C Mater Biol Appl, 2013, 33(8):4786-4794.
18. Murphy AR, St John P, Kaplan DL.Modification of silk fibroin using diazonium coupling chemistry and the effects on hMSC proliferation and differentiation.Biomaterials, 2008, 29(19):2829-2838.
19. Hofmann S, Foo CT, Rossetti F, et al.Silk fibroin as an organic polymer for controlled drug delivery.J Control Release, 2006, 111(1-2):219-227.
20. Song JY, Kim SG, Lee JW, et al.Accelerated healing with the use of a silk fibroin membrane for the guided bone regeneration technique.Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2011, 112(6):e26-33.
21. Zhu H, Wu B, Feng X, et al.Preparation and characterization of bioactive mesoporous calcium silicate-silk fibroin composite films.J Biomed Mater Res B Appl Biomater, 2011, 98(2):330-341.
22. Sukigara S, Gandhi M, Ayutsede J, et al.Regeneration of Bombyx mori silk by electrospinning-part 1:processing parameters and geometric properties.Polymer, 2003, 44(19):5721-5727.
23. Sukigara S, Gandhi M, Ayutsede J, et al.Regeneration of Bombyx mori silk by electrospinning.Part 2.Process optimization and empirical modeling using response surface methodology.Polymer, 2004, 45(11):3701-3708.
24. Ayutsede J, Gandhi M, Sukigara S, et al.Regeneration of Bombyx mori silk by electrospinning.Part 3:characterization of electrospun nonwoven mat.Polymer, 2005, 46(5):1625-1634.
25. Zhang K, Mo X, Huang C, et al.Electrospun scaffolds from silk fibroin and their cellular compatibility.J Biomed Mater Res A, 2010, 93(3):976-983.
26. Meechaisue C, Wutticharoenmongkol P, Waraput R, et al.Preparation of electrospun silk fibroin fiber mats as bone scaffolds:a preliminary study.Biomed Mater, 2007, 2(3):181-188.
27. Li C, Vepari C, Jin HJ, et al.Electrospun silk-BMP-2 scaffolds for bone tissue engineering.Biomaterials, 2006, 27(16):3115-3124.
28. Bai S, Liu S, Zhang C, et al.Controllable transition of silk fibroin nanostructures:an insight into in vitro silk self-assembly process.Acta Biomater, 2013, 9(8):7806-7813.
29. Harris LD, Kim BS, Mooney DJ.Open pore biodegradable matrices formed with gas foaming.J Biomed Mater Res, 1998, 42(3):396-402.
30. Li M, Wu Z, Zhang C, et al.Study on porous silk fibroin materials.â…¡.Preparation and characteristics of spongy porous silk fibroin materials.J Applied Polymer Science, 2001, 79(12):2192-2199.
31. Kim UJ, Park J, Kim HJ, et al.Three-dimensional aqueous-derived biomaterial scaffolds from silk fibroin.Biomaterials, 2005, 26(15):2775-2785.
32. Park SY, Ki CS, Park YH, et al.Electrospun silk fibroin scaffolds with macropores for bone regeneration:an in vitro and in vivo study.Tissue Eng Part A, 2010, 16(4):1271-1279.
33. Ju HW, Sheikh FA, Moon BM, et al.Fabrication of poly (lactic-co-glycolic acid) scaffolds containing silk fibroin scaffolds for tissue engineering applications.J Biomed Mater Res A, 2014, 102(8):2713-2724.
34. Zhao J, Zhang Z, Wang S, et al.Apatite-coated silk fibroin scaffolds to healing mandibular border defects in canines.Bone, 2009, 45(3):517-527.
35. Riccio M, Maraldi T, Pisciotta A, et al.Fibroin scaffold repairs critical-size bone defects in vivo supported by human amniotic fluid and dental pulp stem cells.Tissue Eng Part A, 2012, 18(9-10):1006-1013.

Previous Article
RESEARCH PROGRESS OF SELF-ASSEMBLING PEPTIDE NANOFIBER SCAFFOLD FOR BONE REPAIR
Next Article
APPLICATION OF PLATELET-RICH PLASMA IN CLINICAL ORTHOPEDICS

Chinese Journal of Reparative and Reconstructive Surgery

APPLICATION OF SILK FIBROIN SCAFFOLD IN BONE TISSUE ENGINEERING

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content