STUDY ON RELATIONSHIP BETWEEN DIFFUSION TENSOR IMAGING AND VISUAL EVOKED POTENTIAL IN VISUAL PATHWAY OF NEUROMYELITIS OPTICA_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

ZHANGYan ¹ , CHENXiuying ¹ , HEDian ¹ , WUQizhu ² , GONGQiyong ² ,  ZHOUHongyu ¹

1. Department of Neurology West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P. R. China;
2. Department of the Image Center, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P. R. China;

Corresponding author：

ZHOUHongyu, Email: hyzhou98@yahoo.com

Keywords：

Neuromyelitis optica; Diffusion tenor imaging; Visual evoked potential; Visual pathway

DOI：

10.7507/1002-1892.20150185

Video：

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Objective To study the relationship between brain white matter fiber occult lesions and P100 wave latency of visual evoked potential (VEP) in neuromyelitis optica (NMO) patients by diffusion tensor imaging (DTI). Methods Twenty patients with NMO who were treated between July 2008 and April 2009 were selected as the trial group. According to the VEP test, the latency of P100 wave was prolonged, the NMO patients were divided into VEP abnormal group (trial group 1) and VEP normal group (trial group 2). Twenty healthy adult volunteers served as the control group. The DTI examination in brain was done to measure the fractional anisotropy (FA) value of optic nerve (FAn), optic tract (FAt), and optic radiation (FAr);and the mean diffusivity (MD) value of optic nerve (MDn), optic tract (MDt), and optic radiation (MDr). The FA, MD, and P100 wave latency were compared between groups, and the correlation between MD, FA, and P100 wave latency of NMO were analyzed. Results In the 20 NMO patients, 13 patients with VEP had prolonged bilateral P100 wave latency prolongation or no wave (trial group 1), and 7 patients had normal bilateral P100 wave latency (trial group 2). Compared with the trial group 2 and the control group, the FA values were significantly decreased, and the MD values were significantly increased in the trial group 1 (P<0.05). There was no significant difference in the FA and MD values between the trial group 2 and the control group (P>0.05). All FA (FAn, FAt, and FAr) values of each part of NMO patients were negatively correlated with the latency of P100 wave (P<0.05), all MD (MDn, MDt, and MDr) values were positively correlated with the latency of P100 wave (P<0.05). Conclusion DTI could show small pathylogical changes in the white matter fibers of visual pathway, and there is a correlation between DTI and VEP in NMO, suggesting that a more comprehensive assessment to the condition and prognosis can be made through the VEP in the clinical indicators.

Citation： ZHANGYan, CHENXiuying, HEDian, WUQizhu, GONGQiyong, ZHOUHongyu. STUDY ON RELATIONSHIP BETWEEN DIFFUSION TENSOR IMAGING AND VISUAL EVOKED POTENTIAL IN VISUAL PATHWAY OF NEUROMYELITIS OPTICA. Chinese Journal of Reparative and Reconstructive Surgery, 2015, 29(7): 853-856. doi: 10.7507/1002-1892.20150185 Copy

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2.	Etemadifar M,Nasr Z,Khalili B,et al.Epidemiology of neuromyelitis optica in the world:a systematic review and meta-analysis.Mult Scler Int,2015,2015:174720.
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10.	Jeantroux J,Kremer S,Lin XZ,et al.Diffusion tensor imaging of normal-appearing white matter in neuromyelitis optica.J Neuroradiol,2012,39(5):295-300.
11.	Odom JV,Bach M,Barber C,et al.Visual evoked potentials standard (2004).Doc Ophthalmol,2004,108(2):115-123.
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13.	陈彧,赵建民,王夏红,等.视觉诱发电位在视神经脊髓炎中的诊断价值.中国实用神经疾病杂志,2008,11(9):48-50.
14.	Wingerchuk DM,Lennon VA,Pittock SJ,et al.Revised diagnostic criteria for neuromyelitis optica.Neurology,2006,66(10):1485-1489.
15.	蒋文华.神经解剖学.上海:复旦大学出版社,2002:389-395.
16.	Nakajima H,Hosokawa T,Sugino M,et al.Visual field defects of optic neuritis in neuromyelitis optica compared with multiple sclerosis.BMC Neurol,2010,10:45.
17.	Nakamura M,Nakazawa T,Doi H,et al.Early high-dose intravenous methylprednisolone is effective in preserving retinal nerve fiber layer thickness in patients with neuromyelitis optica.Graefes Arch Clin Exp Ophthalmol,2010,248(12):1777-1785.
18.	Jeantroux J,Kremer S,Lin XZ,et al.Diffusion tensor imaging of normal-appearing white matter in neuromyelitis optica.J Neuroradiol,2012,39(5):295-300.
19.	Lopes FC,Alves-Leon SV,Godoy JM,et al.Optic neuritis and the visual pathway:evaluation of neuromyelitis pptica spectrum by resting-state fMRI and diffusion tensor MRI.J Neuroimaging,2015.[Epub ahead of print].
20.	Mamata H,MamataY,Weatin CF,et al.High-resolution line scan diffusion tensor MR imaging of white matter fiber tract anatomy.AJNR Am J Neuroradiol,2002,23(1):67-75.

1. Yu CS,Lin FC,Li KC,et al.Diffusion tensor imaging in the assessment of normal-appearing brain tissue damage in relapsing neuromyelitis optica.AJNR Am J Neuroradiol,2009,27(5):1009-1015.
2. Etemadifar M,Nasr Z,Khalili B,et al.Epidemiology of neuromyelitis optica in the world:a systematic review and meta-analysis.Mult Scler Int,2015,2015:174720.
3. Lin A,Zhu J,Yao X,et al.Clinical manifestations and spinal cord magnetic resonance imaging findings in Chinese neuromyelitis optica patients.Eur Neurol,2014,71(1-2):35-41.
4. Uzawa A,Mori M,Kuwabara S.Neuromyelitis optica:concept,immunology and treatment.J Clin Neurosci,2014,21(1):12-21.
5. Wang Y,Wu A,Chen X,et al.Comparison of clinical characteristics between neuromyelitis optica spectrum disorders with and without spinal cord atrophy.BMC Neurol,2014,14(1):246.
6. Drori T,Chapman J.Diagnosis and classification of neuromyelitis optica (Devic's syndrome).Autoimmun Rev,2014,13(4-5):531-533.
7. de Seze J,Collongues N.Novel advances in the diagnosis and treatment of neuromyelitis optica:is there a need to redefine the gold standard? Expert Rev Clin Immunol,2013,9(10):979-986.
8. Sato DK,Lana-Peixoto MA,Fujihara K,et al.Clinical spectrum and treatment of neuromyelitis optica spectrum disorders:evolution and current status.Brain Pathol,2013,23(6):647-660.
9. Rivero RL,Oliveira EM,Bichuetti DB,et al.Diffusion tensor imaging of the cervical spinal cord of patients with Neuromyelitis Optica.Magn Reson Imaging,2014,32(5):457-463.
10. Jeantroux J,Kremer S,Lin XZ,et al.Diffusion tensor imaging of normal-appearing white matter in neuromyelitis optica.J Neuroradiol,2012,39(5):295-300.
11. Odom JV,Bach M,Barber C,et al.Visual evoked potentials standard (2004).Doc Ophthalmol,2004,108(2):115-123.
12. Neto SP,Alvarenga RM,Vasconcelos CC,et al.Evaluation of pattern-reversal visual evoked potential in patients with neuromyelitis optica.Mult Scler,2013,19(2):173-178.
13. 陈彧,赵建民,王夏红,等.视觉诱发电位在视神经脊髓炎中的诊断价值.中国实用神经疾病杂志,2008,11(9):48-50.
14. Wingerchuk DM,Lennon VA,Pittock SJ,et al.Revised diagnostic criteria for neuromyelitis optica.Neurology,2006,66(10):1485-1489.
15. 蒋文华.神经解剖学.上海:复旦大学出版社,2002:389-395.
16. Nakajima H,Hosokawa T,Sugino M,et al.Visual field defects of optic neuritis in neuromyelitis optica compared with multiple sclerosis.BMC Neurol,2010,10:45.
17. Nakamura M,Nakazawa T,Doi H,et al.Early high-dose intravenous methylprednisolone is effective in preserving retinal nerve fiber layer thickness in patients with neuromyelitis optica.Graefes Arch Clin Exp Ophthalmol,2010,248(12):1777-1785.
18. Jeantroux J,Kremer S,Lin XZ,et al.Diffusion tensor imaging of normal-appearing white matter in neuromyelitis optica.J Neuroradiol,2012,39(5):295-300.
19. Lopes FC,Alves-Leon SV,Godoy JM,et al.Optic neuritis and the visual pathway:evaluation of neuromyelitis pptica spectrum by resting-state fMRI and diffusion tensor MRI.J Neuroimaging,2015.[Epub ahead of print].
20. Mamata H,MamataY,Weatin CF,et al.High-resolution line scan diffusion tensor MR imaging of white matter fiber tract anatomy.AJNR Am J Neuroradiol,2002,23(1):67-75.

Chinese Journal of Reparative and Reconstructive Surgery

STUDY ON RELATIONSHIP BETWEEN DIFFUSION TENSOR IMAGING AND VISUAL EVOKED POTENTIAL IN VISUAL PATHWAY OF NEUROMYELITIS OPTICA

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