• 1. Institute of Microsurgery on Extremities, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, 200233, P. R. China;
  • 2. Graduate School of Nanchang University;
WANGYang, Email: wangy63cn@126.com
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Objective To review the current progresses in purification strategies, biological characters, and functions of endothelial progenitor cells (EPCs) derived extracellular vesicles (EVs) (EPC-EVs). Methods Recent relevant publications on the EPC-EVs were extensively reviewed, analyzed, and summarized. Results EPC-EVs are usually isolated by differential centrifugation and exhibit a homogenous pattern of spheroid particles with a diameter ranging from 60 to 160 nm under transmission electron microscopy. EPC-EVs are positive for cell-surface markers of EPCs (CD31, CD34, and CD133), and negative for markers of platelets (P-selectin and CD42b) and monocytes (CD14). Recent studies have shown the effectiveness of EPC-EVs in ischemic injuries, anti-Thy1 glomerulonephritis, and cardiomyocyte hypertrophy, and also shown their predictive role in cardio-cerebral-vascular diseases. Conclusion An alluring prospect exists on the EPC-EVs-related research. Further studies are required to decipher the composition of EPC-EVs and their precise role in pathophysiological processes, and to investigate the molecular mechanisms for their targeting and function.

Citation: CHENChunyuan, LIQing, WANGYang. RESEARCH PROGRESS OF ENDOTHELIAL PROGENITOR CELLS DERIVED EXTRACELLULAR VESICLES. Chinese Journal of Reparative and Reconstructive Surgery, 2015, 29(9): 1150-1154. doi: 10.7507/1002-1892.20150249 Copy

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