RESEARCH PROGRESS OF TISSUE ENGINEERED SCAFFOLDS AND STROMALDERIVED FACTOR 1 COMPOSITE GRAFT_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

GAOHuanyu ,  LIYanlin , JIADi , YUYang , WANGKun

Department of Sports Medicine, First Affiliated Hospital of Kunming Medical University, Kunming Yunnan, 650000, P. R. China;

Corresponding author：

LIYanlin, Email: 852387873@qq.com

Keywords：

Stromal-derived factor 1; Tissue engineered scaffold; Tissue injury; Repair in situ

DOI：

10.7507/1002-1892.20150250

Video：

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Objective To review the research progress of tissue engineered scaffolds and stromal-derived factor 1 (SDF-1) composite graft. Methods The recent papers about SDF-1 with different kinds of tissue engineered scaffolds were reviewed and analyzed. The primary mechanism of SDF-1 homing function for stem cells was retrospected. The results of different kinds of tissue engineered scaffolds carrying SDF-1 for repairing the injured tissues and organs were reviewed. Results It is shown that SDF-1 combined with tissue engineered scaffolds will play a role of multipotent stem cells chemotaxis, however, the exact chemotaxis mechanism has not been fully understood. It still needs more researches of SDF-1 effects in vivo. Conclusion Although some research progress has been made in regeneration in situ of tissue engineered scaffolds combined with SDF-1, it will need to further study on the mechanism of chemotactic functions of SDF-1 and its influence on proliferation and differentiation of cells.

Citation： GAOHuanyu, LIYanlin, JIADi, YUYang, WANGKun. RESEARCH PROGRESS OF TISSUE ENGINEERED SCAFFOLDS AND STROMALDERIVED FACTOR 1 COMPOSITE GRAFT. Chinese Journal of Reparative and Reconstructive Surgery, 2015, 29(9): 1155-1159. doi: 10.7507/1002-1892.20150250 Copy

1.	Heng BC, Haider HK, Cao T. Combining transfusion of stem/ progenitor cells into the peripheral circulation with localized transplantation in situ at the site of tissue/organ damage:a possible strategy to optimize the efficacy of stem cell transplantation therapy. Med Hypotheses, 2005, 65(3):494-497.
2.	Lau TT, Wang DA. Stromal cell-derived factor-1 (SDF-1):homing factor for engineered regenerative medicine. Expert Opin Biol Ther, 2011, 11(2):189-197.
3.	Kucia M, Ratajczak J, Reca R, et al. Tissue-specific muscle, neural and liver stem/progenitor cells reside in the bone marrow, respond to an SDF-1 gradient and are mobilized into peripheral blood during stress and tissue injury. Blood Cells Mol Dis, 2004, 32(1):52-57.
4.	Peled A, Kollet O, Ponomaryov T, et al. The chemokine SDF-1 activates the integrins LFA-1, VLA-4, and VLA-5 on immature human CD34(+) cells:role in transendothelial/stromal migration and engraftment of NOD/SCID mice. Blood, 2000, 95(11):3289-3296.
5.	Wynn RF, Hart CA, Corradi-Perini C, et al. A small proportion of mesenchymal stem cells strongly expresses functionally active CXCR4 receptor capable of promoting migration to bone marrow. Blood, 2004, 104(9):2643-2645.
6.	Weeks S, Kulkarni A, Smith H, et al. The effects of chemokine, adhesion and extracellu-lar matrix molecules on binding of mesenchymal stromal cells to poly (L-lactic acid). Cytotherapy, 2012, 14(9):1080-1088.
7.	Narita T, Shintani Y, Ikebe C, et al. The use of scaffold-free cell sheet technique to refine mesenchymal stromal cell-based therapy for heart failure. Mol Ther, 2013, 21(4):860-867.
8.	Veronesi E, Murgia A, Caselli A, et al. Transportation conditions for prompt use of ex vivo expanded and freshly harvested clinicalgrade bone marrow mesenchymal stromal/stem cells for bone regeneration. Tissue Eng Part C Methods, 2014, 20(3):239-251.
9.	Yamaguchi J, Kusano KF, Masuo O, et al. Stromal cell-derived factor-1 effects on ex vivo expanded endothelial progenitor cell recruitment for ischemic neovascularization. Circulation, 2003, 107(9):1322-1328.
10.	Suzuki T, Lee CH, Chen M, et al. Induced migration of dental pulp stem cells for in vivo pulp regeneration. J Dent Res, 2011, 90(8): 1013-1018.
11.	Mendelson A, Frank E, Allred C, et al. Chondrogenesis by chemotactic homing of synovium, bone marrow, and adipose stem cells in vitro. FASEB J, 2011, 25(10):3496-3504.
12.	Lee KW, Johnson NR, Gao J, et al. Human progenitor cell recruitment via SDF-1alpha coacervate-laden PGS vascular grafts. Biomaterials, 2013, 34(38):9877-9885.
13.	Chim H, Miller E, Gliniak C, et al. Stromal-cell-derived factor (SDF) 1-alpha in combination with BMP-2 and TGF-β1 induces site-directed cell homing and osteogenic and chondrogenic differentiation for tissue engineering without the requirement for cell seeding. Cell Tissue Res, 2012, 350(1):89-94.
14.	Blumenthal B, Poppe A, Golsong P, et al. Functional regeneration of ischemic myocardium by transplanted cells overexpressing stromal cell-derived factor-1 (SDF-1):intramyocardial injection versus scaffold-based application. Eur J Cardiothorac Surg, 2011, 40(4): e135-141.
15.	Kim K, Lee CH, Kim BK, et al. Anatomically shaped tooth and periodontal regeneration by cell homing. J Dent Res, 2010, 89(8): 842-847.
16.	Misra P, Lebeche D, Ly H, et al. Quantitation of CXCR4 expression in myocardial infarction using 99mTc-labeled SDF-1alpha. J Nucl Med, 2008, 49(6):963-969.
17.	Baumann L, Prokoph S, Gabriel C, et al. A novel, biased-like SDF-1 derivative acts synergistically with starPEG-based heparin hydrogels and improves eEPC migration in vitro. J Control Release, 2012, 162(1):68-75.
18.	Ko IK, Ju YM, Chen T, et al. Combined systemic and local delivery of stem cell inducing/recruiting factors for in situ tissue regeneration. FASEB J, 2012, 26(1):158-168.
19.	Thevenot PT, Nair AM, Shen J, et al. The effect of incorporation of SDF-1alpha into PLGA scaffolds on stem cell recruitment and the inflammatory response. Biomaterials, 2010, 31(14):3997-4008.
20.	Zhang W, Chen J, Tao J, et al. The use of type I collagen scaffold containing stromal cell-derived factor-1 to create a matrix environment conducive to partial-thickness cartilage defects repair. Biomaterials, 2013, 34(3):713-723.
21.	Chen P, Tao J, Zhu S, et al. Radially oriented collagen scaffold with SDF-1 promotes osteochondral repair by facilitating cell homing. Biomaterials, 2015, 39:114-123.
22.	Dashnyam K, Perez R, Lee EJ, et al. Hybrid scaffolds of gelatinsiloxane releasing stromal derived factor-1 effective for cell recruitment. J Biomed Mater Res A, 2014, 102(6):1859-1867.
23.	Niu LN, Jiao K, Qi YP, et al. Intrafibrillar silicification of collagen scaffolds for sustained release of stem cell homing chemokine in hard tissue regeneration. FASEB J, 2012, 26(11):4517-4529.
24.	Jin Q, Giannobile WV. SDF-1 enhances wound healing of criticalsized calvarial defects beyond self-repair capacity. PLoS One, 2014, 9(5):e97035.
25.	Thieme S, Ryser M, Gentsch M, et al. Stromal cell-derived factor-1alpha-directed chemoattraction of transiently CXCR4-overexpressing bone marrow stromal cells into functionalized threedimensional biomimetic scaffolds. Tissue Eng Part C Methods, 2009, 15(4):687-696.
26.	Sarkar A, Tatlidede S, Scherer SS, et al. Combination of stromal cellderived factor-1 and collagen-glycosaminoglycan scaffold delays contraction and accelerates reepithelialization of dermal wounds in wild-type mice. Wound Repair Regen, 2011, 19(1):71-79.
27.	Shen W, Chen X, Chen J, et al. The effect of incorporation of exogenous stromal cell-derived factor-1 alpha within a knitted silkcollagen sponge scaffold on tendon regeneration. Biomaterials, 2010, 31(28):7239-7249.
28.	Caliari SR, Harley BA. Composite growth factor supplementation strategies to enhance tenocyte bioactivity in aligned collagen-GAG scaffolds. Tissue Eng Part A, 2013, 19(9-10):1100-1112.
29.	Grefte S, Kuijpers-Jagtman AM, Torensma R, et al. Skeletal muscle fibrosis:the effect of stromal-derived factor-1α-loaded collagen scaffolds. Regen Med, 2010, 5(5):737-747.
30.	Liu Z, Wang H, Wang Y, et al. The influence of chitosan hydrogel on stem cell engraftment, survival and homing in the ischemic myocardial microenvironment. Biomaterials, 2012, 33(11):3093-3106.
31.	Naderi-Meshkin H, Matin MM, Heirani-Tabasi A, et al. Injectable hydrogel delivery plus preconditioning of mesenchymal stem cells: exploitation of SDF-1/CXCR4 axis towards enhancing the efficacy of stem cells' homing. Cell Biol Int, 2015.[Epub ahead of print].
32.	Henderson PW, Singh SP, Krijgh DD, et al. Stromal-derived factor-1 delivered via hydrogel drug-delivery vehicle accelerates wound healing in vivo. Wound Repair Regen, 2011, 19(3):420-425.
33.	Rabbany SY, Pastore J, Yamamoto M, et al. Continuous delivery of stromal cell-derived factor-1 from alginate scaffolds accelerates wound healing. Cell Transplant, 2010, 19(4):399-408.
34.	Kurane A, Vyavahare N. In vivo vascular tissue engineering: influence of cytokine and implant location on tissue specific cellular recruitment. J Tissue Eng Regen Med, 2009, 3(4):280-289.
35.	Zhang F, Leong W, Su K, et al. A transduced living hyaline cartilage graft releasing transgenic stromal cell-derived factor-1 inducing endogenous stem cell homing in vivo. Tissue Eng Part A, 2013, 19(9-10):1091-1099.
36.	Gonçalves RM, Antunes JC, Barbosa MA. mesenchymal stem cell recruitment by stromal derived factor-1-delivery systems based on chitosan/poly (gamma-glutamic acid) polyel-ectrolyte complexes. Eur Cell Mater, 2012, 23:249-261.

1. Heng BC, Haider HK, Cao T. Combining transfusion of stem/ progenitor cells into the peripheral circulation with localized transplantation in situ at the site of tissue/organ damage:a possible strategy to optimize the efficacy of stem cell transplantation therapy. Med Hypotheses, 2005, 65(3):494-497.
2. Lau TT, Wang DA. Stromal cell-derived factor-1 (SDF-1):homing factor for engineered regenerative medicine. Expert Opin Biol Ther, 2011, 11(2):189-197.
3. Kucia M, Ratajczak J, Reca R, et al. Tissue-specific muscle, neural and liver stem/progenitor cells reside in the bone marrow, respond to an SDF-1 gradient and are mobilized into peripheral blood during stress and tissue injury. Blood Cells Mol Dis, 2004, 32(1):52-57.
4. Peled A, Kollet O, Ponomaryov T, et al. The chemokine SDF-1 activates the integrins LFA-1, VLA-4, and VLA-5 on immature human CD34(+) cells:role in transendothelial/stromal migration and engraftment of NOD/SCID mice. Blood, 2000, 95(11):3289-3296.
5. Wynn RF, Hart CA, Corradi-Perini C, et al. A small proportion of mesenchymal stem cells strongly expresses functionally active CXCR4 receptor capable of promoting migration to bone marrow. Blood, 2004, 104(9):2643-2645.
6. Weeks S, Kulkarni A, Smith H, et al. The effects of chemokine, adhesion and extracellu-lar matrix molecules on binding of mesenchymal stromal cells to poly (L-lactic acid). Cytotherapy, 2012, 14(9):1080-1088.
7. Narita T, Shintani Y, Ikebe C, et al. The use of scaffold-free cell sheet technique to refine mesenchymal stromal cell-based therapy for heart failure. Mol Ther, 2013, 21(4):860-867.
8. Veronesi E, Murgia A, Caselli A, et al. Transportation conditions for prompt use of ex vivo expanded and freshly harvested clinicalgrade bone marrow mesenchymal stromal/stem cells for bone regeneration. Tissue Eng Part C Methods, 2014, 20(3):239-251.
9. Yamaguchi J, Kusano KF, Masuo O, et al. Stromal cell-derived factor-1 effects on ex vivo expanded endothelial progenitor cell recruitment for ischemic neovascularization. Circulation, 2003, 107(9):1322-1328.
10. Suzuki T, Lee CH, Chen M, et al. Induced migration of dental pulp stem cells for in vivo pulp regeneration. J Dent Res, 2011, 90(8): 1013-1018.
11. Mendelson A, Frank E, Allred C, et al. Chondrogenesis by chemotactic homing of synovium, bone marrow, and adipose stem cells in vitro. FASEB J, 2011, 25(10):3496-3504.
12. Lee KW, Johnson NR, Gao J, et al. Human progenitor cell recruitment via SDF-1alpha coacervate-laden PGS vascular grafts. Biomaterials, 2013, 34(38):9877-9885.
13. Chim H, Miller E, Gliniak C, et al. Stromal-cell-derived factor (SDF) 1-alpha in combination with BMP-2 and TGF-β1 induces site-directed cell homing and osteogenic and chondrogenic differentiation for tissue engineering without the requirement for cell seeding. Cell Tissue Res, 2012, 350(1):89-94.
14. Blumenthal B, Poppe A, Golsong P, et al. Functional regeneration of ischemic myocardium by transplanted cells overexpressing stromal cell-derived factor-1 (SDF-1):intramyocardial injection versus scaffold-based application. Eur J Cardiothorac Surg, 2011, 40(4): e135-141.
15. Kim K, Lee CH, Kim BK, et al. Anatomically shaped tooth and periodontal regeneration by cell homing. J Dent Res, 2010, 89(8): 842-847.
16. Misra P, Lebeche D, Ly H, et al. Quantitation of CXCR4 expression in myocardial infarction using 99mTc-labeled SDF-1alpha. J Nucl Med, 2008, 49(6):963-969.
17. Baumann L, Prokoph S, Gabriel C, et al. A novel, biased-like SDF-1 derivative acts synergistically with starPEG-based heparin hydrogels and improves eEPC migration in vitro. J Control Release, 2012, 162(1):68-75.
18. Ko IK, Ju YM, Chen T, et al. Combined systemic and local delivery of stem cell inducing/recruiting factors for in situ tissue regeneration. FASEB J, 2012, 26(1):158-168.
19. Thevenot PT, Nair AM, Shen J, et al. The effect of incorporation of SDF-1alpha into PLGA scaffolds on stem cell recruitment and the inflammatory response. Biomaterials, 2010, 31(14):3997-4008.
20. Zhang W, Chen J, Tao J, et al. The use of type I collagen scaffold containing stromal cell-derived factor-1 to create a matrix environment conducive to partial-thickness cartilage defects repair. Biomaterials, 2013, 34(3):713-723.
21. Chen P, Tao J, Zhu S, et al. Radially oriented collagen scaffold with SDF-1 promotes osteochondral repair by facilitating cell homing. Biomaterials, 2015, 39:114-123.
22. Dashnyam K, Perez R, Lee EJ, et al. Hybrid scaffolds of gelatinsiloxane releasing stromal derived factor-1 effective for cell recruitment. J Biomed Mater Res A, 2014, 102(6):1859-1867.
23. Niu LN, Jiao K, Qi YP, et al. Intrafibrillar silicification of collagen scaffolds for sustained release of stem cell homing chemokine in hard tissue regeneration. FASEB J, 2012, 26(11):4517-4529.
24. Jin Q, Giannobile WV. SDF-1 enhances wound healing of criticalsized calvarial defects beyond self-repair capacity. PLoS One, 2014, 9(5):e97035.
25. Thieme S, Ryser M, Gentsch M, et al. Stromal cell-derived factor-1alpha-directed chemoattraction of transiently CXCR4-overexpressing bone marrow stromal cells into functionalized threedimensional biomimetic scaffolds. Tissue Eng Part C Methods, 2009, 15(4):687-696.
26. Sarkar A, Tatlidede S, Scherer SS, et al. Combination of stromal cellderived factor-1 and collagen-glycosaminoglycan scaffold delays contraction and accelerates reepithelialization of dermal wounds in wild-type mice. Wound Repair Regen, 2011, 19(1):71-79.
27. Shen W, Chen X, Chen J, et al. The effect of incorporation of exogenous stromal cell-derived factor-1 alpha within a knitted silkcollagen sponge scaffold on tendon regeneration. Biomaterials, 2010, 31(28):7239-7249.
28. Caliari SR, Harley BA. Composite growth factor supplementation strategies to enhance tenocyte bioactivity in aligned collagen-GAG scaffolds. Tissue Eng Part A, 2013, 19(9-10):1100-1112.
29. Grefte S, Kuijpers-Jagtman AM, Torensma R, et al. Skeletal muscle fibrosis:the effect of stromal-derived factor-1α-loaded collagen scaffolds. Regen Med, 2010, 5(5):737-747.
30. Liu Z, Wang H, Wang Y, et al. The influence of chitosan hydrogel on stem cell engraftment, survival and homing in the ischemic myocardial microenvironment. Biomaterials, 2012, 33(11):3093-3106.
31. Naderi-Meshkin H, Matin MM, Heirani-Tabasi A, et al. Injectable hydrogel delivery plus preconditioning of mesenchymal stem cells: exploitation of SDF-1/CXCR4 axis towards enhancing the efficacy of stem cells' homing. Cell Biol Int, 2015.[Epub ahead of print].
32. Henderson PW, Singh SP, Krijgh DD, et al. Stromal-derived factor-1 delivered via hydrogel drug-delivery vehicle accelerates wound healing in vivo. Wound Repair Regen, 2011, 19(3):420-425.
33. Rabbany SY, Pastore J, Yamamoto M, et al. Continuous delivery of stromal cell-derived factor-1 from alginate scaffolds accelerates wound healing. Cell Transplant, 2010, 19(4):399-408.
34. Kurane A, Vyavahare N. In vivo vascular tissue engineering: influence of cytokine and implant location on tissue specific cellular recruitment. J Tissue Eng Regen Med, 2009, 3(4):280-289.
35. Zhang F, Leong W, Su K, et al. A transduced living hyaline cartilage graft releasing transgenic stromal cell-derived factor-1 inducing endogenous stem cell homing in vivo. Tissue Eng Part A, 2013, 19(9-10):1091-1099.
36. Gonçalves RM, Antunes JC, Barbosa MA. mesenchymal stem cell recruitment by stromal derived factor-1-delivery systems based on chitosan/poly (gamma-glutamic acid) polyel-ectrolyte complexes. Eur Cell Mater, 2012, 23:249-261.

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RESEARCH PROGRESS OF TISSUE ENGINEERED SCAFFOLDS AND STROMALDERIVED FACTOR 1 COMPOSITE GRAFT

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