DEVELOPMENT OF HYPOXIA-INDUCIBLE FACTOR 1α IN TISSUE ENGINEERED ANGIOGENESIS AND OSTEOGENESIS_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

ZHANGDan ,  RENLiling

School of Stomatology, Lanzhou University, Lanzhou Gansu, 730000, P. R. China;

Corresponding author：

RENLiling, Email: renlil@lzu.edu.cn

Keywords：

Tissue engineering; Hypoxia-inducible factor 1α; Osteogenesis; Angiogenesis

DOI：

10.7507/1002-1892.20160100

Video：

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Objective To review the development and applications of hypoxia-inducible factor 1α (HIF-1α) in the strategy of tissue engineered angiogenesis and osteogenesis. Method The literature about HIF-1α in tissue engineering technology was reviewed, analyzed, and summarized. Results HIF-1α plays a key role in angiogenic-osteogenic coupling, and as an upstream regulator, HIF-1α can regulate the expressions of its target genes related with angiogenesis and osteogenesis. In addition, HIF-1α not only can control and improve the angiogenesis, but also has important significance in proliferation and differentiation of seed cells, especially stem cells, which is the foundation for bone healing. Conclusions With the development of tissue engineering technology, the problems in the applications of HIF-1α, such as the effective dose of targeting controlled-release, pro-inflammatory effect, and carcinogenicity, will be explored and solved in the future, so it can be used better in clinical.

Citation： ZHANGDan, RENLiling. DEVELOPMENT OF HYPOXIA-INDUCIBLE FACTOR 1α IN TISSUE ENGINEERED ANGIOGENESIS AND OSTEOGENESIS. Chinese Journal of Reparative and Reconstructive Surgery, 2016, 30(4): 504-508. doi: 10.7507/1002-1892.20160100 Copy

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2.	Semenza GL. Hypoxia-Inducible factors in physiology and medicine. Cell, 2012, 148(3) :399-408.
3.	王彦梅, 邹多宏, 何家才. HIF-1在骨缺损修复中的作用. 口腔医学研究, 2014, 30(2) :183-185.
4.	Haase VH. Regulation of erythropoiesis by hypoxia-inducible factors. Blood Rev, 2013, 27(1) :41-53.
5.	Hong WX, Hu MS, Esquivel M, et al. The role of hypoxia-inducible factor in wound healing. Adv Wound Care (New Rochelle), 2014, 3(5) :390-399.
6.	Niyaz M, Gürpınar ÖA, Oktar GL, et al. Effect of VEGF and MSCs on vascular regeneration in a trauma model in rats. Wound Repair Regen, 2015, 23(2) :262-267.
7.	邹多宏, 黄远亮. 低氧诱导因子-1α的研究进展. 国际口腔医学杂志, 2010, 37(3) :320-323.
8.	Han Y, Kuang SZ, Gomer A, et al. Hypoxia influences the vascular expansion and differentiation of embryonic stem cell cultures through the temporal expression of vascular endothelial growth factor receptors in an ARNT-dependent manner. Stem Cells, 2010, 28(4) :799-809.
9.	Bluteau G, Julien M, Magne D, et al. VEGF and VEGF receptors are differentially expressed in chondrocytes. Bone, 2007, 40(3) :568-576.
10.	Carmeliet P. Angiogenesis in health and disease. Nat Med, 2003, 9(6) :653-660.
11.	Rankin EB, Giaccia AJ, Schipani E. A central role for hypoxic signaling in cartilage, bone, and hematopoiesis. Curr Osteoporos Rep, 2011, 9(2) :46-52.
12.	朱勋兵, 周建生, 肖玉周, 等. 低氧诱导因子-1α在长骨发育中的表达研究. 中国骨伤, 2009, 22(8) :599-601.
13.	张鹏, 王越, 王文良, 等. 骨形成耦连血管生成中HIF-1α作用. 武警后勤学院学报(医学版), 2012, 21(8) :654-657.
14.	徐林, 柏小金, 骆旭东, 等. 大鼠股骨骨折合并脑外伤时HIF-1α及Cbfα1的血清表达及意义. 临床和实验医学杂志, 2014, 13(9) :689-692.
15.	金小岚, 郎红梅, 万勇, 等. 不同氧浓度对骨髓基质细胞向成骨细胞分化的影响. 中国病理生理杂志, 2010, 26(5) :982-986.
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31.	Cummins EP, Seeballuck F, Keely SJ, et al. Th hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis. Gastroenterology, 2008, 134(1) :156-165.
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33.	张磊, 赵学凌, 李彪, 等. 二甲基乙二酰基甘氨酸促进骨髓间充质干细胞成骨分化. 中国骨质疏松杂志, 2012, 18(11) :1048-1053.
34.	Peng J, Lai ZG, Fang ZL, et al. Dimethyloxalylglycine prevents bone loss in ovariectomized C57BL/6J mice through enhanced angiogenesis and osteogenesis. PLoS One, 2014, 9(11) :e112744.
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40.	Azevedo MM, Jell G, O'Donnell MD, et al. Synthesis and characterization of hypoxia-mimicking bioactive glasses for skeletal regeneration. J Mater Chem, 2010, 20(40) :8854-8864.
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1. 黄姣. 低氧微环境对骨髓间充质干细胞成骨分化影响的研究. 重庆:重庆医科大学, 2012.
2. Semenza GL. Hypoxia-Inducible factors in physiology and medicine. Cell, 2012, 148(3) :399-408.
3. 王彦梅, 邹多宏, 何家才. HIF-1在骨缺损修复中的作用. 口腔医学研究, 2014, 30(2) :183-185.
4. Haase VH. Regulation of erythropoiesis by hypoxia-inducible factors. Blood Rev, 2013, 27(1) :41-53.
5. Hong WX, Hu MS, Esquivel M, et al. The role of hypoxia-inducible factor in wound healing. Adv Wound Care (New Rochelle), 2014, 3(5) :390-399.
6. Niyaz M, Gürpınar ÖA, Oktar GL, et al. Effect of VEGF and MSCs on vascular regeneration in a trauma model in rats. Wound Repair Regen, 2015, 23(2) :262-267.
7. 邹多宏, 黄远亮. 低氧诱导因子-1α的研究进展. 国际口腔医学杂志, 2010, 37(3) :320-323.
8. Han Y, Kuang SZ, Gomer A, et al. Hypoxia influences the vascular expansion and differentiation of embryonic stem cell cultures through the temporal expression of vascular endothelial growth factor receptors in an ARNT-dependent manner. Stem Cells, 2010, 28(4) :799-809.
9. Bluteau G, Julien M, Magne D, et al. VEGF and VEGF receptors are differentially expressed in chondrocytes. Bone, 2007, 40(3) :568-576.
10. Carmeliet P. Angiogenesis in health and disease. Nat Med, 2003, 9(6) :653-660.
11. Rankin EB, Giaccia AJ, Schipani E. A central role for hypoxic signaling in cartilage, bone, and hematopoiesis. Curr Osteoporos Rep, 2011, 9(2) :46-52.
12. 朱勋兵, 周建生, 肖玉周, 等. 低氧诱导因子-1α在长骨发育中的表达研究. 中国骨伤, 2009, 22(8) :599-601.
13. 张鹏, 王越, 王文良, 等. 骨形成耦连血管生成中HIF-1α作用. 武警后勤学院学报(医学版), 2012, 21(8) :654-657.
14. 徐林, 柏小金, 骆旭东, 等. 大鼠股骨骨折合并脑外伤时HIF-1α及Cbfα1的血清表达及意义. 临床和实验医学杂志, 2014, 13(9) :689-692.
15. 金小岚, 郎红梅, 万勇, 等. 不同氧浓度对骨髓基质细胞向成骨细胞分化的影响. 中国病理生理杂志, 2010, 26(5) :982-986.
16. 刘晓东, 邓廉夫, 王君, 等. 低氧诱导因子-1α对成骨细胞功能的调控作用. 上海交通大学学报(医学版), 2007, 27(3) :298-302.
17. Riddle RC, Khatri R, Schipani E, et al. Role of hypoxia-inducible factor-1alpha in angiogenic-osteogenic coupling. J Mol Med (Berl), 2009, 87(6) :583-590.
18. Rankin EB, Wu C, Khatri R, et al. The HIF signaling pathway in osteoblasts directly modulates erythropoiesis through the production of EPO. Cell, 2012, 149(1) :63-74.
19. 周年. HIF-1α对BMP2诱导干细胞成软骨、成骨分化的影响的研究. 重庆:重庆医科大学, 2014.
20. 孔令擘. IGF-1表达载体转染兔骨髓间充质干细胞体外成骨的实验研究. 西安:第四军医大学, 2009.
21. 薛鹏. IGF1对BMSCs向成骨细胞分化的影响和机制研究. 石家庄:河北医科大学, 2014.
22. 孙鑫, 侯玉东. 转化生长因子β超家族在修复骨缺损方面的应用研究. 口腔医学研究, 2014, 30(1) :85-88.
23. 亓云龙, 张睿, 李红喜, 等. TGF-β2在低氧条件下诱导骨髓基质干细胞向软骨细胞分化的研究. 现代生物医学进展, 2014, 14(14) :2632-2635.
24. 胡宁. 缺氧诱导因子-1α增强骨形态发生蛋白-9介导的间充质干细胞成骨分化及其机制研究. 重庆:重庆医科大学, 2012.
25. Lord-Dufour S, Copland IB, Levros LC Jr, et al. Evidence for transcriptional regulation of the glucose-6-phosphate transporter by HIF-1alpha:Targeting G6PT with mumbaistatin analogs in hypoxic mesenchymal stromal cells. Stem Cells, 2009, 27(3) :489-497.
26. 孔宏亮, 孙洪波, 宋丽杰, 等. 缺氧诱导因子-1α过表达对骨髓间充质干细胞缺氧时生存能力的影响. 中国普外基础与临床杂志, 2011, 18(3) :261-266.
27. Liu J, Hao H, Huang H, et al. Hypoxia regulates the therapeutic potential of mesenchymal stem cells through enhanced autophagy. Int J Low Extrem Wounds, 2015, 14(1) :63-72.
28. Yew TL, Huang TF, Ma HL, et al. Scale-up of MSC under hypoxic conditions for allogeneic transplantation and enhancing bony regeneration in a rabbit calvarial defect model. J Orthop Res, 2012, 30(8) :1213-1220.
29. Hill P, Shukla D, Tran MG, et al. Inhibition of hypoxia inducible factor hydroxylases protects against renal ischemiareperfusion injury. J Am Soc Nephrol, 2008, 19(1) :39-46.
30. Eckle T, Köhler D, Lehmann R, et al. Hypoxia-inducible factor-1 is central to cardioprotection:a new paradigm for ischemic preconditioning. Circulation, 2008, 118(2) :166-175.
31. Cummins EP, Seeballuck F, Keely SJ, et al. Th hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis. Gastroenterology, 2008, 134(1) :156-165.
32. Safran M, Kim WY, O'Connell F, et al. Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity:assessment of an oral agent that stimulates erythropoietin production. Proc Natl Acad Sci U S A, 2006, 103(1) :105-110.
33. 张磊, 赵学凌, 李彪, 等. 二甲基乙二酰基甘氨酸促进骨髓间充质干细胞成骨分化. 中国骨质疏松杂志, 2012, 18(11) :1048-1053.
34. Peng J, Lai ZG, Fang ZL, et al. Dimethyloxalylglycine prevents bone loss in ovariectomized C57BL/6J mice through enhanced angiogenesis and osteogenesis. PLoS One, 2014, 9(11) :e112744.
35. 刘丽珍. 缺氧与缺氧模拟剂对间充质干细胞的动员作用及机理研究. 杭州:浙江大学, 2012.
36. 侯跃龙, 李彤, 张臣, 等. CoCl2缺氧处理对脐带间充质干细胞促血管生长因子表达的影响. 心脏杂志, 2011, 23(1) :59-64.
37. 李文迪. 氯化钴在BMSCs修复HIBD认知功能中的作用. 重庆:重庆医科大学, 2013.
38. Hou Z, Nie C, Si Z, et al. Deferoxamine enhances neovascularization and accelerates wound healing in diabetic rats via the accumulation of hypoxia. Diabetes Res Clin Prac, 2013, 101(1) :62-71.
39. Schofild CJ, Ratcliff PJ. Oxygen sensing by HIF hydroxylases. Nat Rev Mol Cell Biol, 2004, 5(5) :343-354.
40. Azevedo MM, Jell G, O'Donnell MD, et al. Synthesis and characterization of hypoxia-mimicking bioactive glasses for skeletal regeneration. J Mater Chem, 2010, 20(40) :8854-8864.
41. Azevedo MM, Tsigkou O, Nair R, et al. Hypoxia inducible factor-stabilizing bioactive glasses for directing mesenchymal stem cell behavior. Tissue Eng Part A, 2015, 21(1-2) :382-389.
42. Wu C, Zhou Y, Fan W, et al. Hypoxia-mimicking mesoporous bioactive glass scaffolds with controllable cobalt ion release for bone tissue engineering. Biomaterials, 2012, 33(7) :2076-2085.
43. Quinlan E, Partap S, Azevedo MM, et al. Hypoxia-mimicking bioactive glass/collagen glycosaminoglycan composite scaffolds to enhance angiogenesis and bone repair. Biomaterials, 2015, 52:358-366.
44. Wu C, Zhou Y, Chang J, et al. Delivery of dimethyloxallyl glycine in mesoporous bioactive glass scaffolds to improve angiogenesis and osteogenesis of human bone marrow stromal cells. Acta Biomater, 2013, 9(11) :9159-9168.
45. 邹多宏, 吴轶群, 张秀丽, 等. HIF-1α促进BMSCs成骨及成血管作用的体内外研究. 中国口腔颌面外科杂志, 2012, 10(6) :441-453.
46. Ding H, Gao YS, Hu C, et al. HIF-1α transgenic bone marrow cells can promote tissue repair in cases of corticosteroid-induced osteonecrosis of the femoral head in rabbits. PLoS One, 2013, 8(5) :e63628.
47. 张劲娥, 王淑红, 张忻, 等. 低氧诱导因子1α慢病毒载体转染骨髓间充质干细胞的成骨基因表达. 中国组织工程研究, 2014, 18(1) :57-62.
48. Zou D, Zhang Z, He J, et al. Repairing critical-sized calvarial defects with BMSCs modified by a constitutively active form of hypoxia-inducible factor-1α and a phosphate cement scaffold. Biomaterials, 2011, 32(36) :9707-9718.
49. Li C, Liu D, Zhang Z, et al. Triple point-mutants of hypoxia-inducible factor-1α accelerate in vivo angiogenesis in bone defect regions. Cell Biochem Biophys, 2013, 67(2) :557-566.
50. Rios CN, Skoracki RJ, Mathur AB. GNAS1 and PHD2 short-interfering RNA support bone regeneration in vitro and in an in vivo sheep model. Clin Orthop Relat Res, 2012, 470(9) :2541-2553.
51. 徐大朋, 王绪凯. 骨组织工程支架研究进展. 中国实用口腔科杂志, 2014, 7(3) :177-181.
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Chinese Journal of Reparative and Reconstructive Surgery

DEVELOPMENT OF HYPOXIA-INDUCIBLE FACTOR 1α IN TISSUE ENGINEERED ANGIOGENESIS AND OSTEOGENESIS

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