Research progress of correlation between traumatic brain injury and fracture healing_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

ZHANG Chong , DENG Kai , GUO Yongchun , WANG Zhe ,  YU Guorong

Department of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan Hubei, 430071, P.R.China;

Corresponding author：

YU Guorong, Email: yuguorong195505@126.com

Keywords：

Traumatic brain injury; fracture healing; mechanism

DOI：

10.7507/1002-1892.201612048

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To review the current status and advances of the correlation between traumatic brain injury (TBI) and fracture healing. Methods The related domestic and abroad literature about the correlation between TBI and fracture healing was extensively reviewed and analyzed. Results There are a variety of studies on the correlation between TBI and fracture healing, which can be divided into two major aspects: revascularization and osteogenesis; the local and systemic changes of the neuropeptide and hormone after TBI. Conclusion TBI facilitates callus formation, the further research is needed to clarify the exact mechanism.

Citation： ZHANG Chong, DENG Kai, GUO Yongchun, WANG Zhe, YU Guorong. Research progress of correlation between traumatic brain injury and fracture healing. Chinese Journal of Reparative and Reconstructive Surgery, 2017, 31(7): 885-889. doi: 10.7507/1002-1892.201612048 Copy

1.	Hu X, Zhang P, Xu Z, et al. GPNMB enhances bone regeneration by promoting angiogenesis and osteogenesis: potential role for tissue engineering bone. J Cell Biochem, 2013, 114(12): 2729-2737.
2.	Hinson HE, Rowell S, Schreiber M. Clinical evidence of inflammation driving secondary brain injury: a systematic review. J Trauma Acute Care Surg, 2015, 78(1): 184-191.
3.	Hofman M, Koopmans G, Kobbe P, et al. Improved fracture healing in patients with concomitant traumatic brain injury: proven or not? Mediators Inflamm, 2015, 2015: 204842.
4.	Helmy A, De Simoni MG, Guilfoyle MR, et al. Cytokines and innate inflammation in the pathogenesis of human traumatic brain injury. Prog Neurobiol, 2011, 95(3): 352-372.
5.	Liu X, Zhou C, Li Y, et al. SDF-1 promotes endochondral bone repair during fracture healing at the traumatic brain injury condition. PLoS One, 2013, 8(1): e54077.
6.	Boes M, Kain M, Kakar S, et al. Osteogenic effects of traumatic brain injury on experimental fracture-healing. J Bone Joint Surg (Am), 2006, 88(4): 738-743.
7.	Yang S, Ma Y, Liu Y, et al. Arachidonic acid: a bridge between traumatic brain injury and fracture healing. J Neurotrauma, 2012, 29(17): 2696-2705.
8.	Cadosch D, Gautschi OP, Thyer M, et al. Humoral factors enhance fracture-healing and callus formation in patients with traumatic brain injury. J Bone Joint Surg (Am), 2009, 91(2): 282-288.
9.	Gautschi OP, Cadosch D, Frey SP, et al. Serum-mediated osteogenic effect in traumatic brain-injured patients. ANZ J Surg, 2009, 79(6): 449-455.
10.	Giannoudis PV, Mushtaq S, Harwood P, et al. Accelerated bone healing and excessive callus formation in patients with femoral fracture and head injury. Injury, 2006, 37 Suppl 3: S18-24.
11.	Wei Y, Wang L, Clark JC, et al. Elevated leptin expression in a rat model of fracture and traumatic brain injury. J Pharm Pharmacol, 2008, 60(12): 1667-1672.
12.	García-Castellano JM, Díaz-Herrera P, Morcuende JA. Is bone a target-tissue for the nervous system? New advances on the understanding of their interactions. Iowa Orthop J, 2000, 20: 49-58.
13.	Hukkanen M, Konttinen YT, Santavirta S, et al. Effect of sciatic nerve section on neural ingrowth into the rat tibial fracture callus. Clin Orthop Relat Res, 1995, 311(311): 247-257.
14.	Song Y, Bi L, Zhang Z, et al. Increased levels of calcitonin gene-related peptide in serum accelerate fracture healing following traumatic brain injury. Mol Med Rep, 2012, 5(2): 432-438.
15.	Zhang D, Zhang P, Wang Y, et al. The influence of brain injury or peripheral nerve injury on calcitonin gene-related peptide concentration variation and fractures healing process. Artif Cells Blood Substit Immobil Biotechnol, 2009, 37(2): 85-91.
16.	Wang L, Yao X, Xiao L, et al. The effects of spinal cord injury on bone healing in patients with femoral fractures. J Spinal Cord Med, 2014, 37(4): 414-419.
17.	Yan H, Zhang HW, Fu P, et al. Leptin’s effect on accelerated fracture healing after traumatic brain injury. Neurol Res, 2013, 35(5): 537-544.
18.	李争争, 赵军伟, 罗伟, 等. 神经毡蛋白-1 在创伤性颅脑损伤伴胫骨骨折愈合过程中的表达变化.中南大学学报: 医学版, 2017, 42(2): 154-160.
19.	Fukuda T, Takeda S, Xu R, et al. Sema3A regulates bone-mass accrual through sensory innervations. Nature, 2013, 497(7450): 490-493.
20.	Hayashi M, Nakashima T, Taniguchi M, et al. Osteoprotection by semaphorin 3A. Nature, 2012, 485(7396): 69-74.
21.	李争争, 赵军伟, 移志刚, 等. 脑信号蛋白 3A 在创伤性颅脑损伤伴胫骨骨折愈合过程中的表达变化. 中国修复重建外科杂志, 2016, 30(10): 1225-1232.
22.	Suzuki A, Uemura T, Nakamura H. Control of bone remodeling by nervous system. Neural involvement in fracture healing and bone regeneration. Clin Calcium, 2010, 20(12): 1820-1827.
23.	Gu XC, Zhang XB, Hu B, et al. Neuropeptide Y accelerates post-fracture bone healing by promoting osteogenesis of mesenchymal stem cells. Neuropeptides, 2016, 60: 6061-6666.
24.	刘继超, 孙骥, 李钰龙. 肢体骨折合并脑外伤患者血清中 VEGF、PDGF 的变化. 生物骨科材料与临床研究, 2016, 13(4): 52-54.
25.	陈雯辉, 王大业, 麻松, 等. 脑外伤后血小板衍生生长因子及血管内皮生长因子对骨折愈合影响的实验研究. 首都医科大学学报, 2008, 29(6): 745-753.
26.	田宝鹏, 陈雯辉, 潘海涛, 等. 脑外伤后胰岛素样生长因子-Ⅰ及血小板衍生生长因子对骨折愈合的影响. 首都医科大学学报, 2008, 29(1): 69-73.
27.	Sang XG, Wang ZY, Qin T, et al. Elevated concentrations of hypoxia-inducible factor-1α in patients with fracture and concomitant traumatic brain injury. Ann Clin Biochem, 2016. [Epub ahead of print].
28.	徐林, 柏小金, 骆旭东, 等. 大鼠股骨骨折合并脑外伤时 HIF-1α 及 Cbfα1 的血清表达及意义. 临床和实验医学杂志, 2014, 13(9): 689-692.
29.	Lolmède K, Durand de Saint Front V, Galitzky J, et al. Effects of hypoxia on the expression of proangiogenic factors in differentiated 3T3-F442A adipocytes. Int J Obes Relat Metab Disord, 2003, 27(10): 1187-1195.
30.	王守君, 张柳, 孙良智, 等. 大鼠股骨骨折合并脑外伤时骨愈合过程中 TGF-β₁ 的作用. 第四军医大学学报, 2006, 27(15): 1407-1410.
31.	梁春雨, 田发明, 张柳, 等. 颅脑损伤对骨折愈合中 BMP-2 和 VEGF 表达的影响. 中国煤炭工业医学杂志, 2012, 15(11): 1761-1763.
32.	Li M, Ke HZ, Qi H, et al. A novel, non-prostanoid EP2 receptor-selective prostaglandin E2 agonist stimulates local bone formation and enhances fracture healing. J Bone Miner Res, 2003, 18(11): 2033-2042.
33.	Niki Y, Takaishi H, Takito J, et al. Administration of cyclooxygenase-2 inhibitor reduces joint inflammation but exacerbates osteopenia in IL-1 alpha transgenic mice due to GM-CSF overproduction. J Immunol, 2007, 179(1): 639-646.
34.	郑少涛, 林喜容, 周少鹏. 脑外伤合并骨折患者血清胰岛素生长因子Ⅱ水平的变化. 中国现代医生, 2014, 52(2): 19-20, 23.
35.	Zhuang YF, Li J. Serum EGF and NGF levels of patients with brain injury and limb fracture. Asian Pac J Trop Med, 2013, 6(5): 383-386.
36.	陈雅波, 吴珊鹏, 徐亚运, 等. 肢体骨折合并脑外伤神经元特异性烯醇化酶与骨痂生长的关系. 中华实验外科杂志, 2016, 33(12): 2739-2740.
37.	汤俊君, 吴克俭, 张建, 等. 上皮钙离子通道 TRPV6 在脑外伤合并骨折大鼠模型骨折部位表达的实验研究. 临床和实验医学杂志, 2015, 14(12): 961-964.

1. Hu X, Zhang P, Xu Z, et al. GPNMB enhances bone regeneration by promoting angiogenesis and osteogenesis: potential role for tissue engineering bone. J Cell Biochem, 2013, 114(12): 2729-2737.
2. Hinson HE, Rowell S, Schreiber M. Clinical evidence of inflammation driving secondary brain injury: a systematic review. J Trauma Acute Care Surg, 2015, 78(1): 184-191.
3. Hofman M, Koopmans G, Kobbe P, et al. Improved fracture healing in patients with concomitant traumatic brain injury: proven or not? Mediators Inflamm, 2015, 2015: 204842.
4. Helmy A, De Simoni MG, Guilfoyle MR, et al. Cytokines and innate inflammation in the pathogenesis of human traumatic brain injury. Prog Neurobiol, 2011, 95(3): 352-372.
5. Liu X, Zhou C, Li Y, et al. SDF-1 promotes endochondral bone repair during fracture healing at the traumatic brain injury condition. PLoS One, 2013, 8(1): e54077.
6. Boes M, Kain M, Kakar S, et al. Osteogenic effects of traumatic brain injury on experimental fracture-healing. J Bone Joint Surg (Am), 2006, 88(4): 738-743.
7. Yang S, Ma Y, Liu Y, et al. Arachidonic acid: a bridge between traumatic brain injury and fracture healing. J Neurotrauma, 2012, 29(17): 2696-2705.
8. Cadosch D, Gautschi OP, Thyer M, et al. Humoral factors enhance fracture-healing and callus formation in patients with traumatic brain injury. J Bone Joint Surg (Am), 2009, 91(2): 282-288.
9. Gautschi OP, Cadosch D, Frey SP, et al. Serum-mediated osteogenic effect in traumatic brain-injured patients. ANZ J Surg, 2009, 79(6): 449-455.
10. Giannoudis PV, Mushtaq S, Harwood P, et al. Accelerated bone healing and excessive callus formation in patients with femoral fracture and head injury. Injury, 2006, 37 Suppl 3: S18-24.
11. Wei Y, Wang L, Clark JC, et al. Elevated leptin expression in a rat model of fracture and traumatic brain injury. J Pharm Pharmacol, 2008, 60(12): 1667-1672.
12. García-Castellano JM, Díaz-Herrera P, Morcuende JA. Is bone a target-tissue for the nervous system? New advances on the understanding of their interactions. Iowa Orthop J, 2000, 20: 49-58.
13. Hukkanen M, Konttinen YT, Santavirta S, et al. Effect of sciatic nerve section on neural ingrowth into the rat tibial fracture callus. Clin Orthop Relat Res, 1995, 311(311): 247-257.
14. Song Y, Bi L, Zhang Z, et al. Increased levels of calcitonin gene-related peptide in serum accelerate fracture healing following traumatic brain injury. Mol Med Rep, 2012, 5(2): 432-438.
15. Zhang D, Zhang P, Wang Y, et al. The influence of brain injury or peripheral nerve injury on calcitonin gene-related peptide concentration variation and fractures healing process. Artif Cells Blood Substit Immobil Biotechnol, 2009, 37(2): 85-91.
16. Wang L, Yao X, Xiao L, et al. The effects of spinal cord injury on bone healing in patients with femoral fractures. J Spinal Cord Med, 2014, 37(4): 414-419.
17. Yan H, Zhang HW, Fu P, et al. Leptin’s effect on accelerated fracture healing after traumatic brain injury. Neurol Res, 2013, 35(5): 537-544.
18. 李争争, 赵军伟, 罗伟, 等. 神经毡蛋白-1 在创伤性颅脑损伤伴胫骨骨折愈合过程中的表达变化.中南大学学报: 医学版, 2017, 42(2): 154-160.
19. Fukuda T, Takeda S, Xu R, et al. Sema3A regulates bone-mass accrual through sensory innervations. Nature, 2013, 497(7450): 490-493.
20. Hayashi M, Nakashima T, Taniguchi M, et al. Osteoprotection by semaphorin 3A. Nature, 2012, 485(7396): 69-74.
21. 李争争, 赵军伟, 移志刚, 等. 脑信号蛋白 3A 在创伤性颅脑损伤伴胫骨骨折愈合过程中的表达变化. 中国修复重建外科杂志, 2016, 30(10): 1225-1232.
22. Suzuki A, Uemura T, Nakamura H. Control of bone remodeling by nervous system. Neural involvement in fracture healing and bone regeneration. Clin Calcium, 2010, 20(12): 1820-1827.
23. Gu XC, Zhang XB, Hu B, et al. Neuropeptide Y accelerates post-fracture bone healing by promoting osteogenesis of mesenchymal stem cells. Neuropeptides, 2016, 60: 6061-6666.
24. 刘继超, 孙骥, 李钰龙. 肢体骨折合并脑外伤患者血清中 VEGF、PDGF 的变化. 生物骨科材料与临床研究, 2016, 13(4): 52-54.
25. 陈雯辉, 王大业, 麻松, 等. 脑外伤后血小板衍生生长因子及血管内皮生长因子对骨折愈合影响的实验研究. 首都医科大学学报, 2008, 29(6): 745-753.
26. 田宝鹏, 陈雯辉, 潘海涛, 等. 脑外伤后胰岛素样生长因子-Ⅰ及血小板衍生生长因子对骨折愈合的影响. 首都医科大学学报, 2008, 29(1): 69-73.
27. Sang XG, Wang ZY, Qin T, et al. Elevated concentrations of hypoxia-inducible factor-1α in patients with fracture and concomitant traumatic brain injury. Ann Clin Biochem, 2016. [Epub ahead of print].
28. 徐林, 柏小金, 骆旭东, 等. 大鼠股骨骨折合并脑外伤时 HIF-1α 及 Cbfα1 的血清表达及意义. 临床和实验医学杂志, 2014, 13(9): 689-692.
29. Lolmède K, Durand de Saint Front V, Galitzky J, et al. Effects of hypoxia on the expression of proangiogenic factors in differentiated 3T3-F442A adipocytes. Int J Obes Relat Metab Disord, 2003, 27(10): 1187-1195.
30. 王守君, 张柳, 孙良智, 等. 大鼠股骨骨折合并脑外伤时骨愈合过程中 TGF-β₁ 的作用. 第四军医大学学报, 2006, 27(15): 1407-1410.
31. 梁春雨, 田发明, 张柳, 等. 颅脑损伤对骨折愈合中 BMP-2 和 VEGF 表达的影响. 中国煤炭工业医学杂志, 2012, 15(11): 1761-1763.
32. Li M, Ke HZ, Qi H, et al. A novel, non-prostanoid EP2 receptor-selective prostaglandin E2 agonist stimulates local bone formation and enhances fracture healing. J Bone Miner Res, 2003, 18(11): 2033-2042.
33. Niki Y, Takaishi H, Takito J, et al. Administration of cyclooxygenase-2 inhibitor reduces joint inflammation but exacerbates osteopenia in IL-1 alpha transgenic mice due to GM-CSF overproduction. J Immunol, 2007, 179(1): 639-646.
34. 郑少涛, 林喜容, 周少鹏. 脑外伤合并骨折患者血清胰岛素生长因子Ⅱ水平的变化. 中国现代医生, 2014, 52(2): 19-20, 23.
35. Zhuang YF, Li J. Serum EGF and NGF levels of patients with brain injury and limb fracture. Asian Pac J Trop Med, 2013, 6(5): 383-386.
36. 陈雅波, 吴珊鹏, 徐亚运, 等. 肢体骨折合并脑外伤神经元特异性烯醇化酶与骨痂生长的关系. 中华实验外科杂志, 2016, 33(12): 2739-2740.
37. 汤俊君, 吴克俭, 张建, 等. 上皮钙离子通道 TRPV6 在脑外伤合并骨折大鼠模型骨折部位表达的实验研究. 临床和实验医学杂志, 2015, 14(12): 961-964.

Previous Article
Research progress of three-dimensional printing technique in foot and ankle surgery
Next Article
一个切口两个入路治疗肘关节三联征疗效观察

Chinese Journal of Reparative and Reconstructive Surgery

Research progress of correlation between traumatic brain injury and fracture healing

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content