Research progress of structured repair of tendon-bone interface_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

LÜ Jingtong , SHI Youxing , WANG Yunjiao , KANG Xia , BIAN Xuting , YUAN Bao , ZHU Min ,  TANG Kanglai

Department of Orthopedics/Sports Medicine Center, State Key Laboratory of Trauma, Burn, and Combined Injury, the First Affiliated Hospital of Army Medical University (the Third Military Medical University), Chongqing, 400038, P.R.China;

Corresponding author：

TANG Kanglai, Email: Tangkanglai@hotmail.com

Keywords：

Tendon-bone interface; tissue engineering; scaffold material; growth factor

DOI：

10.7507/1002-1892.201811139

Video：

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Abstract Full text Figures/Tables Video References Cited by

In sports system, the tendon-bone interface has the effect of tensile and bearing load, so the effect of healing plays a crucial role in restoring joint function. The process of repair is the formation of scar tissue, so it is difficult to achieve the ideal effect for morphology and biomechanical strength. The tissue engineering method can promote the tendon-bone interface healing from the seed cells, growth factors, and scaffolds, and is a new direction in the field of development of the tendon-bone interface healing.

Citation： LÜ Jingtong, SHI Youxing, WANG Yunjiao, KANG Xia, BIAN Xuting, YUAN Bao, ZHU Min, TANG Kanglai. Research progress of structured repair of tendon-bone interface. Chinese Journal of Reparative and Reconstructive Surgery, 2019, 33(9): 1064-1070. doi: 10.7507/1002-1892.201811139 Copy

1.	戴志刚, 钟伟, 冯磊, 等. 复合腱-骨固定的生物力学及形态学研究. 中国矫形外科杂志, 2017, 25(10): 917-921.
2.	Smith L, Xia Y, Galatz LM, et al. Tissue-engineering strategies for the tendon/ligament-to-bone insertion. Connect Tissue Res, 2012, 53(2): 95-105.
3.	Yan Z, Yin H, Nerlich M, et al. Boosting tendon repair: interplay of cells, growth factors and scaffold-free and gel-based carriers. J Exp Orthop, 2018, 5(1): 1.
4.	Zhang C, Zhang E, Yang L, et al. Histone deacetylase inhibitor treated cell sheet from mouse tendon stem/progenitor cells promotes tendon repair. Biomaterials, 2018, 172: 66-82.
5.	Stergiopoulos A, Politis PK. The role of nuclear receptors in controlling the fine balance between proliferation and differentiation of neural stem cells. Arch Biochem Biophys, 2013, 534(1-2): 27-37.
6.	Nourissat G, Diop A, Maurel N, et al. Mesenchymal stem cell therapy regenerates the native bone-tendon junction after surgical repair in a degenerative rat model. PLoS One, 2010, 5(8): e12248.
7.	Hernigou P, Flouzat Lachaniette CH, Delambre J, et al. Biologic augmentation of rotator cuff repair with mesenchymal stem cells during arthroscopy improves healing and prevents further tears: a case-controlled study. Int Orthop, 2014, 38(9): 1811-1818.
8.	Ko E, Alberti K, Lee JS, et al. Nanostructured tendon-derived scaffolds for enhanced bone regeneration by human adipose-derived stem cells. ACS Appl Mater Interfaces, 2016, 8(35): 22819-22829.
9.	金玲, 陈剑, 吴静, 等. 人羊膜上皮细胞的干细胞特性. 中国组织工程研究与临床康复, 2011, 15(19): 3555-3558.
10.	Breidenbach AP, Gilday SD, Lalley AL, et al. Functional tissue engineering of tendon: Establishing biological success criteria for improving tendon repair. J Biomech, 2014, 47(9): 1941-1948.
11.	Kiliçoğlu Öİ, Dikmen G, Koyuncu Ö, et al. Effects of demineralized bone matrix on tendon-bone healing: an in vivo, experimental study on rabbits. Acta Orthop Traumatol Turc, 2012, 46(6): 443-448.
12.	Chen JL, Yin Z, Shen WL, et al. Efficacy of hESC-MSCs in knitted silk-collagen scaffold for tendon tissue engineering and their roles. Biomaterials, 2010, 31(36): 9438-9451.
13.	Wang S, Wang Y, Song L, et al. Decellularized tendon as a prospective scaffold for tendon repair. Mater Sci Eng C Mater Biol Appl, 2017, 77: 1290-1301.
14.	Lu J, Yu H, Chen CZ. Biological properties of calcium phosphate biomaterials for bone repair: a review. Royal Society of Chemistry, 2018, 8(4): 2015-2033.
15.	Weimin P, Dan L, Yiyong W, et al. Tendon-to-bone healing using an injectable calcium phosphate cement combined with bone xenograft/BMP composite. Biomaterials, 2013, 34(38): 9926-9936.
16.	Zhao S, Peng L, Xie G, et al. Effect of the interposition of calcium phosphate materials on tendon-bone healing during repair of chronic rotator cuff tear. Am J Sports Med, 2014, 42(8): 1920-1929.
17.	Zhu C, Pongkitwitoon S, Qiu J, et al. Design and fabrication of a hierarchically structured scaffold for tendon-to-bone repair. Adv Mater, 2018, 30(16): e1707306.
18.	Guo J, Ning C, Liu X. Bioactive calcium phosphate silicate ceramic surface-modified PLGA for tendon-to-bone healing. Colloids Surf B Biointerfaces, 2018, 164: 388-395.
19.	Parry JA, Wagner ER, Kok PL, et al. A combination of a polycaprolactone fumarate scaffold with polyethylene terephthalate sutures for intra-articular ligament regeneration. Tissue Eng Part A, 2018, 24(3-4): 245-253.
20.	Liu W, Lipner J, Xie J, et al. Nanofiber scaffolds with gradients in mineral content for spatial control of osteogenesis. ACS Appl Mater Interfaces, 2014, 6(4): 2842-2849.
21.	Naghashzargar E, Farè S, Catto V, et al. Nano/micro hybrid scaffold of PCL or P3HB nanofibers combined with silk fibroin for tendon and ligament tissue engineering. J Appl Biomater Funct Mater, 2015, 13(2): e156-e168.
22.	Yokoya S, Mochizuki Y, Nagata Y, et al. Tendon-bone insertion repair and regeneration using polyglycolic acid sheet in the rabbit rotator cuff injury model. Am J Sports Med, 2008, 36(7): 1298-1309.
23.	Patel S, Caldwell JM, Doty SB, et al. Integrating soft and hard tissues via interface tissue engineering. J Orthop Res, 2018, 36(4): 1069-1077.
24.	蔡江瑜, 蒋佳, 莫秀梅, 等. 丝素蛋白/聚乳酸-聚己内酯纳米纤维支架对兔腱-骨愈合影响的实验研究. 中国修复重建外科杂志, 2017, 31(8): 957-962.
25.	Zelzer E, Blitz E, Killian ML, et al. Tendon-to-bone attachment: from development to maturity. Birth Defects Res C Embryo Today, 2014, 102(1): 101-112.
26.	Cooper JO, Bumgardner JD, Cole JA, et al. Co-cultured tissue-specific scaffolds for tendon/bone interface engineering. J Tissue Eng, 2014, 5: 2041731414542294.
27.	Lomas AJ, Ryan CN, Sorushanova A, et al. The past, present and future in scaffold-based tendon treatments. Adv Drug Deliv Rev, 2015, 84: 257-277.
28.	Bhatia SN, Ingber DE. Microfluidic organs-on-chips. Nat Biotechnol, 2014, 32(8): 760-772.
29.	Miura T, Yokokawa R. Tissue culture on a chip: Developmental biology applications of self-organized capillary networks in microfluidic devices. Dev Growth Differ, 2016, 58(6): 505-515.
30.	Park SH, Choi YJ, Moon SW, et al. Three-dimensional bio-printed scaffold sleeves with mesenchymal stem cells for enhancement of tendon-to-bone healing in anterior cruciate ligament reconstruction using soft-tissue tendon graft. Arthroscopy, 2018, 34(1): 166-179.
31.	Park H, Lim DJ, Sung M, et al. Microengineered platforms for co-cultured mesenchymal stem cells towards vascularized bone tissue engineering. Tissue Eng Regen Med, 2016, 13(5): 465-474.
32.	Ren Q, Cai M, Zhang K, et al. Effects of bone morphogenetic protein-2 (BMP-2) and vascular endothelial growth factor (VEGF) release from polylactide-poly (ethylene glycol)-polylactide (PELA) microcapsule-based scaffolds on bone. Braz J Med Biol Res, 2017, 51(2): e6520.
33.	Kabuto Y, Morihara T, Sukenari T, et al. Stimulation of rotator cuff repair by sustained release of bone morphogenetic protein-7 using a gelatin hydrogel sheet. Tissue Eng Part A, 2015, 21(13-14): 2025-2033.
34.	Wang Y, Tang Z, Xue R, et al. TGF-β1 promoted MMP-2 mediated wound healing of anterior cruciate ligament fibroblasts through NF-κB. Connect Tissue Res, 2011, 52(3): 218-225.
35.	Jiang K, Wang Z, Du Q, et al. A new TGF-β3 controlled-released chitosan scaffold for tissue engineering synovial sheath. J Biomed Mater Res A, 2014, 102(3): 801-807.
36.	Sakiyama-Elbert SE, Das R, Gelberman RH, et al. Controlled-release kinetics and biologic activity of platelet-derived growth factor-BB for use in flexor tendon repair. J Hand Surg (Am), 2008, 33(9): 1548-1557.
37.	Jo CH, Kim JE, Yoon KS, et al. Platelet-rich plasma stimulates cell proliferation and enhances matrix gene expression and synthesis in tenocytes from human rotator cuff tendons with degenerative tears. Am J Sports Med, 2012, 40(5): 1035-1045.
38.	Wang X, Wenk E, Zhang X, et al. Growth factor gradients via microsphere delivery in biopolymer scaffolds for osteochondral tissue engineering. J Control Release, 2009, 134(2): 81-90.
39.	车伟. BMP-2 和 VEGF165 共表达基因修饰的 BMSCs 对腱骨界面愈合的研究. 合肥: 安徽医科大学, 2017.
40.	杜庆钧, 苏培强, 何家强, 等. BFGF、PDGF对兔膝前交叉韧带重建术后早期腱骨愈合影响的实验研究. 重庆医学, 2015, 44(6): 746-748.
41.	Muller B, Bowman KF Jr, Bedi A. ACL graft healing and biologics. Clin Sports Med, 2013, 32(1): 93-109.
42.	Ning LJ, Zhang Y, Chen XH, et al. Preparation and characterization of decellularized tendon slices for tendon tissue engineering. J Biomed Mater Res A, 2012, 100(6): 1448-1456.
43.	Li H, Jiang J, Wu Y, et al. Potential mechanisms of a periosteum patch as an effective and favourable approach to enhance tendon-bone healing in the human body. Int Orthop, 2012, 36(3): 665-669.
44.	McCarrel T, Fortier L. Temporal growth factor release from platelet-rich plasma, trehalose lyophilized platelets, and bone marrow aspirate and their effect on tendon and ligament gene expression. J Orthop Res, 2010, 27(8): 1033-1042.
45.	Engebretsen L, Steffen K, Alsousou J, et al. IOC consensus paper on the use of platelet-rich plasma in sports medicine. Br J Sports Med, 2010, 44(15): 1072-1081.
46.	马震胜, 张磊, 鄂钢, 等. 自体肌腱加富血小板血浆重建比格犬前交叉韧带的实验研究. 实用骨科杂志, 2016, 22(5): 420-424.
47.	Malavolta EA, Gracitelli ME, Ferreira Neto AA, et al. Platelet-rich plasma in rotator cuff repair: a prospective randomized study. Am J Sports Med, 2014, 42(10): 2446-2454.
48.	喻鑫罡, 张先龙, 曾炳芳, 等. 低频微动后转化生长因子 β₁ 与胰岛素样生长因子Ⅰ在新骨组织中的表达研究. 中国修复重建外科杂志, 2006, 20(7): 685-689.
49.	Walsh WR, Stephens P, Vizesi F, et al. Effects of low-intensity pulsed ultrasound on tendon-bone healing in an intra-articular sheep knee model. Arthroscopy, 2007, 23(2): 197-204.
50.	Wang L, Qin L, Lu HB, et al. Extracorporeal shock wave therapy in treatment of delayed bone-tendon healing. Am J Sports Med, 2008, 36(2): 340-347.
51.	Cao D, Liu W, Wei X, et al. In vitro tendon engineering with avian tenocytes and polyglycolic acids: a preliminary report. Tissue Eng, 2006, 12(5): 1369-1377.
52.	王蕾, 罗涛, 邓廉夫. 应力刺激在肩袖损伤修复中作用机制的实验研究. 中华创伤骨科杂志, 2009, 11(2): 152-156.
53.	Thomopoulos S, Williams GR, Soslowsky LJ. Tendon to bone healing: differences in biomechanical, structural, and compositional properties due to a range of activity levels. J Biomech Eng, 2003, 125(1): 106-113.
54.	Maeda E, Shelton JC, Bader DL, et al. Differential regulation of gene expression in isolated tendon fascicles exposed to cyclic tensile strain in vitro. J Appl Physiol (1985), 2009, 106(2): 506-512.
55.	Skutek M, van Griensven M, Zeichen J, et al. Cyclic mechanical stretching modulates secretion pattern of growth factors in human tendon fibroblasts. Eur J Appl Physiol, 2001, 86(1): 48-52.
56.	Blitz E, Sharir A, Akiyama H, et al. Tendon-bone attachment unit is formed modularly by a distinct pool of Scx- and Sox9-positive progenitors. Development, 2013, 140(13): 2680-2690.
57.	李跑, 高尚, 周梅, 等. 不同机械牵伸条件对大鼠肌腱干细胞分化的影响. 中国修复重建外科杂志, 2017, 31(4): 481-488.
58.	Loozen LD, Vandersteen A, Kragten AH, et al. Bone formation by heterodimers through non-viral gene delivery of BMP-2/6 and BMP-2/7. Eur Cell Mater, 2018, 35: 195-208.
59.	Qu J, Thoreson AR, Chen Q, et al. Tendon gradient mineralization for tendon to bone interface integration. J Orthop Res, 2013, 31(11): 1713-1719.
60.	Leong NL, Arshi A, Kabir N, et al. In vitro and in vivo evaluation of heparin mediated growth factor release from tissue-engineered constructs for anterior cruciate ligament reconstruction. J Orthop Res, 2015, 33(2): 229-236.
61.	Santo VE, Gomes ME, Mano JF, et al. Controlled release strategies for bone, cartilage, and osteochondral engineering—Part Ⅰ: recapitulation of native tissue healing and variables for the design of delivery systems. Tissue Eng Part B Rev, 2013, 19(4): 308-326.
62.	尹迪. 基于微流控芯片的细胞操控及分离方法研究. 上海: 东华大学, 2017.
63.	Font Tellado S, Chiera S, Bonani W, et al. Heparin functionalization increases retention of TGF-β2 and GDF5 on biphasic silk fibroin scaffolds for tendon/ligament-to-bone tissue engineering. Acta Biomater, 2018, 72: 150-166.

1. 戴志刚, 钟伟, 冯磊, 等. 复合腱-骨固定的生物力学及形态学研究. 中国矫形外科杂志, 2017, 25(10): 917-921.
2. Smith L, Xia Y, Galatz LM, et al. Tissue-engineering strategies for the tendon/ligament-to-bone insertion. Connect Tissue Res, 2012, 53(2): 95-105.
3. Yan Z, Yin H, Nerlich M, et al. Boosting tendon repair: interplay of cells, growth factors and scaffold-free and gel-based carriers. J Exp Orthop, 2018, 5(1): 1.
4. Zhang C, Zhang E, Yang L, et al. Histone deacetylase inhibitor treated cell sheet from mouse tendon stem/progenitor cells promotes tendon repair. Biomaterials, 2018, 172: 66-82.
5. Stergiopoulos A, Politis PK. The role of nuclear receptors in controlling the fine balance between proliferation and differentiation of neural stem cells. Arch Biochem Biophys, 2013, 534(1-2): 27-37.
6. Nourissat G, Diop A, Maurel N, et al. Mesenchymal stem cell therapy regenerates the native bone-tendon junction after surgical repair in a degenerative rat model. PLoS One, 2010, 5(8): e12248.
7. Hernigou P, Flouzat Lachaniette CH, Delambre J, et al. Biologic augmentation of rotator cuff repair with mesenchymal stem cells during arthroscopy improves healing and prevents further tears: a case-controlled study. Int Orthop, 2014, 38(9): 1811-1818.
8. Ko E, Alberti K, Lee JS, et al. Nanostructured tendon-derived scaffolds for enhanced bone regeneration by human adipose-derived stem cells. ACS Appl Mater Interfaces, 2016, 8(35): 22819-22829.
9. 金玲, 陈剑, 吴静, 等. 人羊膜上皮细胞的干细胞特性. 中国组织工程研究与临床康复, 2011, 15(19): 3555-3558.
10. Breidenbach AP, Gilday SD, Lalley AL, et al. Functional tissue engineering of tendon: Establishing biological success criteria for improving tendon repair. J Biomech, 2014, 47(9): 1941-1948.
11. Kiliçoğlu Öİ, Dikmen G, Koyuncu Ö, et al. Effects of demineralized bone matrix on tendon-bone healing: an in vivo, experimental study on rabbits. Acta Orthop Traumatol Turc, 2012, 46(6): 443-448.
12. Chen JL, Yin Z, Shen WL, et al. Efficacy of hESC-MSCs in knitted silk-collagen scaffold for tendon tissue engineering and their roles. Biomaterials, 2010, 31(36): 9438-9451.
13. Wang S, Wang Y, Song L, et al. Decellularized tendon as a prospective scaffold for tendon repair. Mater Sci Eng C Mater Biol Appl, 2017, 77: 1290-1301.
14. Lu J, Yu H, Chen CZ. Biological properties of calcium phosphate biomaterials for bone repair: a review. Royal Society of Chemistry, 2018, 8(4): 2015-2033.
15. Weimin P, Dan L, Yiyong W, et al. Tendon-to-bone healing using an injectable calcium phosphate cement combined with bone xenograft/BMP composite. Biomaterials, 2013, 34(38): 9926-9936.
16. Zhao S, Peng L, Xie G, et al. Effect of the interposition of calcium phosphate materials on tendon-bone healing during repair of chronic rotator cuff tear. Am J Sports Med, 2014, 42(8): 1920-1929.
17. Zhu C, Pongkitwitoon S, Qiu J, et al. Design and fabrication of a hierarchically structured scaffold for tendon-to-bone repair. Adv Mater, 2018, 30(16): e1707306.
18. Guo J, Ning C, Liu X. Bioactive calcium phosphate silicate ceramic surface-modified PLGA for tendon-to-bone healing. Colloids Surf B Biointerfaces, 2018, 164: 388-395.
19. Parry JA, Wagner ER, Kok PL, et al. A combination of a polycaprolactone fumarate scaffold with polyethylene terephthalate sutures for intra-articular ligament regeneration. Tissue Eng Part A, 2018, 24(3-4): 245-253.
20. Liu W, Lipner J, Xie J, et al. Nanofiber scaffolds with gradients in mineral content for spatial control of osteogenesis. ACS Appl Mater Interfaces, 2014, 6(4): 2842-2849.
21. Naghashzargar E, Farè S, Catto V, et al. Nano/micro hybrid scaffold of PCL or P3HB nanofibers combined with silk fibroin for tendon and ligament tissue engineering. J Appl Biomater Funct Mater, 2015, 13(2): e156-e168.
22. Yokoya S, Mochizuki Y, Nagata Y, et al. Tendon-bone insertion repair and regeneration using polyglycolic acid sheet in the rabbit rotator cuff injury model. Am J Sports Med, 2008, 36(7): 1298-1309.
23. Patel S, Caldwell JM, Doty SB, et al. Integrating soft and hard tissues via interface tissue engineering. J Orthop Res, 2018, 36(4): 1069-1077.
24. 蔡江瑜, 蒋佳, 莫秀梅, 等. 丝素蛋白/聚乳酸-聚己内酯纳米纤维支架对兔腱-骨愈合影响的实验研究. 中国修复重建外科杂志, 2017, 31(8): 957-962.
25. Zelzer E, Blitz E, Killian ML, et al. Tendon-to-bone attachment: from development to maturity. Birth Defects Res C Embryo Today, 2014, 102(1): 101-112.
26. Cooper JO, Bumgardner JD, Cole JA, et al. Co-cultured tissue-specific scaffolds for tendon/bone interface engineering. J Tissue Eng, 2014, 5: 2041731414542294.
27. Lomas AJ, Ryan CN, Sorushanova A, et al. The past, present and future in scaffold-based tendon treatments. Adv Drug Deliv Rev, 2015, 84: 257-277.
28. Bhatia SN, Ingber DE. Microfluidic organs-on-chips. Nat Biotechnol, 2014, 32(8): 760-772.
29. Miura T, Yokokawa R. Tissue culture on a chip: Developmental biology applications of self-organized capillary networks in microfluidic devices. Dev Growth Differ, 2016, 58(6): 505-515.
30. Park SH, Choi YJ, Moon SW, et al. Three-dimensional bio-printed scaffold sleeves with mesenchymal stem cells for enhancement of tendon-to-bone healing in anterior cruciate ligament reconstruction using soft-tissue tendon graft. Arthroscopy, 2018, 34(1): 166-179.
31. Park H, Lim DJ, Sung M, et al. Microengineered platforms for co-cultured mesenchymal stem cells towards vascularized bone tissue engineering. Tissue Eng Regen Med, 2016, 13(5): 465-474.
32. Ren Q, Cai M, Zhang K, et al. Effects of bone morphogenetic protein-2 (BMP-2) and vascular endothelial growth factor (VEGF) release from polylactide-poly (ethylene glycol)-polylactide (PELA) microcapsule-based scaffolds on bone. Braz J Med Biol Res, 2017, 51(2): e6520.
33. Kabuto Y, Morihara T, Sukenari T, et al. Stimulation of rotator cuff repair by sustained release of bone morphogenetic protein-7 using a gelatin hydrogel sheet. Tissue Eng Part A, 2015, 21(13-14): 2025-2033.
34. Wang Y, Tang Z, Xue R, et al. TGF-β1 promoted MMP-2 mediated wound healing of anterior cruciate ligament fibroblasts through NF-κB. Connect Tissue Res, 2011, 52(3): 218-225.
35. Jiang K, Wang Z, Du Q, et al. A new TGF-β3 controlled-released chitosan scaffold for tissue engineering synovial sheath. J Biomed Mater Res A, 2014, 102(3): 801-807.
36. Sakiyama-Elbert SE, Das R, Gelberman RH, et al. Controlled-release kinetics and biologic activity of platelet-derived growth factor-BB for use in flexor tendon repair. J Hand Surg (Am), 2008, 33(9): 1548-1557.
37. Jo CH, Kim JE, Yoon KS, et al. Platelet-rich plasma stimulates cell proliferation and enhances matrix gene expression and synthesis in tenocytes from human rotator cuff tendons with degenerative tears. Am J Sports Med, 2012, 40(5): 1035-1045.
38. Wang X, Wenk E, Zhang X, et al. Growth factor gradients via microsphere delivery in biopolymer scaffolds for osteochondral tissue engineering. J Control Release, 2009, 134(2): 81-90.
39. 车伟. BMP-2 和 VEGF165 共表达基因修饰的 BMSCs 对腱骨界面愈合的研究. 合肥: 安徽医科大学, 2017.
40. 杜庆钧, 苏培强, 何家强, 等. BFGF、PDGF对兔膝前交叉韧带重建术后早期腱骨愈合影响的实验研究. 重庆医学, 2015, 44(6): 746-748.
41. Muller B, Bowman KF Jr, Bedi A. ACL graft healing and biologics. Clin Sports Med, 2013, 32(1): 93-109.
42. Ning LJ, Zhang Y, Chen XH, et al. Preparation and characterization of decellularized tendon slices for tendon tissue engineering. J Biomed Mater Res A, 2012, 100(6): 1448-1456.
43. Li H, Jiang J, Wu Y, et al. Potential mechanisms of a periosteum patch as an effective and favourable approach to enhance tendon-bone healing in the human body. Int Orthop, 2012, 36(3): 665-669.
44. McCarrel T, Fortier L. Temporal growth factor release from platelet-rich plasma, trehalose lyophilized platelets, and bone marrow aspirate and their effect on tendon and ligament gene expression. J Orthop Res, 2010, 27(8): 1033-1042.
45. Engebretsen L, Steffen K, Alsousou J, et al. IOC consensus paper on the use of platelet-rich plasma in sports medicine. Br J Sports Med, 2010, 44(15): 1072-1081.
46. 马震胜, 张磊, 鄂钢, 等. 自体肌腱加富血小板血浆重建比格犬前交叉韧带的实验研究. 实用骨科杂志, 2016, 22(5): 420-424.
47. Malavolta EA, Gracitelli ME, Ferreira Neto AA, et al. Platelet-rich plasma in rotator cuff repair: a prospective randomized study. Am J Sports Med, 2014, 42(10): 2446-2454.
48. 喻鑫罡, 张先龙, 曾炳芳, 等. 低频微动后转化生长因子 β₁ 与胰岛素样生长因子Ⅰ在新骨组织中的表达研究. 中国修复重建外科杂志, 2006, 20(7): 685-689.
49. Walsh WR, Stephens P, Vizesi F, et al. Effects of low-intensity pulsed ultrasound on tendon-bone healing in an intra-articular sheep knee model. Arthroscopy, 2007, 23(2): 197-204.
50. Wang L, Qin L, Lu HB, et al. Extracorporeal shock wave therapy in treatment of delayed bone-tendon healing. Am J Sports Med, 2008, 36(2): 340-347.
51. Cao D, Liu W, Wei X, et al. In vitro tendon engineering with avian tenocytes and polyglycolic acids: a preliminary report. Tissue Eng, 2006, 12(5): 1369-1377.
52. 王蕾, 罗涛, 邓廉夫. 应力刺激在肩袖损伤修复中作用机制的实验研究. 中华创伤骨科杂志, 2009, 11(2): 152-156.
53. Thomopoulos S, Williams GR, Soslowsky LJ. Tendon to bone healing: differences in biomechanical, structural, and compositional properties due to a range of activity levels. J Biomech Eng, 2003, 125(1): 106-113.
54. Maeda E, Shelton JC, Bader DL, et al. Differential regulation of gene expression in isolated tendon fascicles exposed to cyclic tensile strain in vitro. J Appl Physiol (1985), 2009, 106(2): 506-512.
55. Skutek M, van Griensven M, Zeichen J, et al. Cyclic mechanical stretching modulates secretion pattern of growth factors in human tendon fibroblasts. Eur J Appl Physiol, 2001, 86(1): 48-52.
56. Blitz E, Sharir A, Akiyama H, et al. Tendon-bone attachment unit is formed modularly by a distinct pool of Scx- and Sox9-positive progenitors. Development, 2013, 140(13): 2680-2690.
57. 李跑, 高尚, 周梅, 等. 不同机械牵伸条件对大鼠肌腱干细胞分化的影响. 中国修复重建外科杂志, 2017, 31(4): 481-488.
58. Loozen LD, Vandersteen A, Kragten AH, et al. Bone formation by heterodimers through non-viral gene delivery of BMP-2/6 and BMP-2/7. Eur Cell Mater, 2018, 35: 195-208.
59. Qu J, Thoreson AR, Chen Q, et al. Tendon gradient mineralization for tendon to bone interface integration. J Orthop Res, 2013, 31(11): 1713-1719.
60. Leong NL, Arshi A, Kabir N, et al. In vitro and in vivo evaluation of heparin mediated growth factor release from tissue-engineered constructs for anterior cruciate ligament reconstruction. J Orthop Res, 2015, 33(2): 229-236.
61. Santo VE, Gomes ME, Mano JF, et al. Controlled release strategies for bone, cartilage, and osteochondral engineering—Part Ⅰ: recapitulation of native tissue healing and variables for the design of delivery systems. Tissue Eng Part B Rev, 2013, 19(4): 308-326.
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Chinese Journal of Reparative and Reconstructive Surgery

Research progress of structured repair of tendon-bone interface

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