CHENSu-feng 1,2 , ZHANGYa-wei 1,2 , HUHong 1,2 , ZHANGJie 1,2 , SUNYi-hua 1,2 , WANGLong-fu 2,3 , CHENYing 2,3 , WANGYan-li 2,3 , XIANGJia-qing 1,2 , CHENHai-quan 1,2
  • 1. Department of Thoracic Surgery, Fudan University Shanghai Cancer Center;
  • 2. Department of Oncology, Shanghai Medical College, Fudan University, shanghai 200032, P. R. China;
  • 3. Department of Pathology, Fudan University Shanghai Cancer Center, shanghai 200032, P. R. China;
CHENHai-quan, Email: hqchen1@yahoo.com
Export PDF Favorites Scan Get Citation

Objective To analyse epidermal growth factor receptor (EGFR) gene mutations in pathologically confirmed lung adenocarcinoma (LAC) samples obtained by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). Methods Clinical data of 964 consecutive patients who underwent EBUS-TBNA in Department of Thoracic Surgery, Fudan University Shanghai Cancer Center from April 2009 to September 2013 were retrospectively reviewed. EGFR gene mutations in 77 LAC patients who were comfirmed by cell morphology and immunohistochemistry were analyzed. There were 48 males and 29 females with their median age of 61 (range 33-78) years, and 43 patients were smokers. Results All the 77 LAC patients were confirmed by immunohistochemistry. Among them, 31 patients (40.26%) were found to have EGFR gene mutations. There was no statistical difference in EGFR gene mutations between male and female patients (P=0.088). Mutation rate of EGFR genes of non-smokers was significantly higher than that of smokers (P=0.032). Conclusion Samples obtained by EBUS-TBNA can be used for EGFR gene mutations analysis. The mutation rate of EGFR genes of non-smokers is higher than that of smokers.

Citation: CHENSu-feng, ZHANGYa-wei, HUHong, ZHANGJie, SUNYi-hua, WANGLong-fu, CHENYing, WANGYan-li, XIANGJia-qing, CHENHai-quan. Analysis of Epidermal Growth Factor Receptor (EGFR) Gene Mutations in Pathologically Confirmed Lung Adenocarcinoma by Endobronchial Ultrasound-guided Transbronchial Needle Aspiration. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2015, 22(1): 44-47. doi: 10.7507/1007-4848.20150013 Copy

  • Previous Article

    Pathogenesis of Acute Pancreatitis During Pregnancy and The Standardization of Diagnosis and Treatment
  • Next Article

    The Advances of Application of JAK/STAT Signal Transduction Pathways in Severe Acute Pancreatitis