Learning Curve of Allogeneic Mouse Model of Peritoneal Heart Transplantation_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

CHENXin-zu ^1,2 , WANGShi-jun ² , ZHOUCheng ³ ,  HUJian-kun ¹

1. Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, P. R. China;
2. Department of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany;
3. Translational Radiation Oncology, National Center for Tumor Diseases, German Cancer Research Center, Heidelberg, Germany;

Corresponding author：

HUJian-kun, Email: hujkwch@126.com

Keywords：

Heart transplantation; Mouse; Animal surgery; Experimental model; Learning curve

DOI：

10.7507/1007-4848.20150219

Video：

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Allogeneic mouse model of peritoneal heart transplant is a microscopic surgery on small animal with complex techniques. For a beginner, a learning curve of this surgical technique has to be experienced. The learning curve contains three stages:(1) to be familiar with the local anatomy of either donor or recipient mouse; (2) to be capable of collecting donor heart and well preparing the major peritoneal vessels of recipient; (3) to be skillful in the anastomosis of major vessels. The bottleneck of the learning curve is the valid skill of vascular anastomosis. The stepwise essentials are to "understand, be familiar, be accurate, and be quick" in the learning curve.

Citation： CHENXin-zu, WANGShi-jun, ZHOUCheng, HUJian-kun. Learning Curve of Allogeneic Mouse Model of Peritoneal Heart Transplantation. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2015, 22(9): 879-882. doi: 10.7507/1007-4848.20150219 Copy

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2.	Judd KP, Trentin JJ. Cardiac transplantation in mice. Ⅱ. Effect of continuous immunosuppressive therapy on the survival of H-2-incompatible allografts. Transplantation, 1971, 11(3):303-308.
3.	Plenter RJ, Zamora MR, Grazia TJ. Four decades of vascularized heterotopic cardiac transplantation in the mouse. J Invest Surg, 2013, 26(4):223-228.
4.	Setoguchi K, Hattori Y, Iida S, et al. Endogenous memory CD8 T cells are activated within cardiac allografts without mediating rejection. Am J Transplant, 2013, 13(9):2293-2307.
5.	Jane-Wit D, Manes TD, Yi T, et al. Alloantibody and complement promote T cell-mediated cardiac allograft vasculopathy through noncanonical nuclear factor-kappaB signaling in endothelial cells. Circulation, 2013, 128(23):2504-2516.
6.	Wang S, Schmaderer C, Kiss E, et al. Recipient Toll-like receptors contribute to chronic graft dysfunction by both MyD88-and TRIFdependent signaling. Dis Model Mech, 2010, 3(1-2):92-103.
7.	史成伟, 萧明第. 小鼠异位心脏移植术. 中国循环杂志, 1991, 6(1):74.
8.	李锦文, 邵启祥, 陈刚, 等. 小鼠异位心脏移植的经验与体会.江苏大学学报(医学版), 2001, 11(3):335-337.
9.	倪一鸣, 冯强, 梁宏立. 小鼠异位心脏移植模型的建立. 中华器官移植杂志, 2002, 23(6):339-340.
10.	杨自力, 严盛, 于吉人, 等. 建立小鼠心脏移植模型手术方法的改良. 浙江医学, 2002, 24(6):342-344.
11.	柳祎, 孙宗全. 小鼠颈部异位心脏移植技术的改进. 华中科技大学学报(医学版), 2003, 32(5):522-525.
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13.	吴龙, 孙宗全, 柳祎, 等. 小鼠颈部异位心脏移植技术的改进.中华器官移植杂志, 2004, 25(6):375.
14.	王铭辉, 付鉴, 宋尔卫, 等. 改进的小鼠颈部心脏移植模型的制作. 现代临床医学生物工程学杂志, 2000, 6(4):259-260.
15.	冯剑锷, 孙宗全. 应用Cuff技术建立小鼠异位心脏移植模型.中华实验外科杂志, 2005, 22(12):1576-1577.
16.	高开柱, 孙宗全, 杜心灵, 等. 套管法与缝合法在建立小鼠颈部心脏移植模型的比较. 心肺血管病杂志, 2006, 25(3):178-180.
17.	程峰, 顾晓冬, 项建斌, 等. 改良Cuff技术建立小鼠颈部异位心脏移植模型. 复旦学报(医学版), 2008, 35(6):919-921.
18.	牟艳, 杨洪吉. 小鼠腹腔异位心脏移植模型的建立及注意事项.四川医学, 2012, 33(1):24-25.
19.	苏松. 介绍一种新型的小鼠腹部心脏移植方法. 生物医学工程学杂志, 2013, 30(5):1108-1111.
20.	郁雷, 高丽. 小鼠腹部心脏移植模型建立及并发症预防. 中国胸心血管外科临床杂志, 2014, 21(2):249-252.

1. Judd KP, Trentin JJ. Cardiac transplantation in mice. I. Factors influencing the take and survival of heterotopic grafts. Transplantation, 1971, 11(3):298-302.
2. Judd KP, Trentin JJ. Cardiac transplantation in mice. Ⅱ. Effect of continuous immunosuppressive therapy on the survival of H-2-incompatible allografts. Transplantation, 1971, 11(3):303-308.
3. Plenter RJ, Zamora MR, Grazia TJ. Four decades of vascularized heterotopic cardiac transplantation in the mouse. J Invest Surg, 2013, 26(4):223-228.
4. Setoguchi K, Hattori Y, Iida S, et al. Endogenous memory CD8 T cells are activated within cardiac allografts without mediating rejection. Am J Transplant, 2013, 13(9):2293-2307.
5. Jane-Wit D, Manes TD, Yi T, et al. Alloantibody and complement promote T cell-mediated cardiac allograft vasculopathy through noncanonical nuclear factor-kappaB signaling in endothelial cells. Circulation, 2013, 128(23):2504-2516.
6. Wang S, Schmaderer C, Kiss E, et al. Recipient Toll-like receptors contribute to chronic graft dysfunction by both MyD88-and TRIFdependent signaling. Dis Model Mech, 2010, 3(1-2):92-103.
7. 史成伟, 萧明第. 小鼠异位心脏移植术. 中国循环杂志, 1991, 6(1):74.
8. 李锦文, 邵启祥, 陈刚, 等. 小鼠异位心脏移植的经验与体会.江苏大学学报(医学版), 2001, 11(3):335-337.
9. 倪一鸣, 冯强, 梁宏立. 小鼠异位心脏移植模型的建立. 中华器官移植杂志, 2002, 23(6):339-340.
10. 杨自力, 严盛, 于吉人, 等. 建立小鼠心脏移植模型手术方法的改良. 浙江医学, 2002, 24(6):342-344.
11. 柳祎, 孙宗全. 小鼠颈部异位心脏移植技术的改进. 华中科技大学学报(医学版), 2003, 32(5):522-525.
12. 高思海, 李平, 黄亚非, 等. 小鼠颈部异位心脏移植术的改进及体会(英文). 中国现代医学杂志, 2004, 14(6):9-11.
13. 吴龙, 孙宗全, 柳祎, 等. 小鼠颈部异位心脏移植技术的改进.中华器官移植杂志, 2004, 25(6):375.
14. 王铭辉, 付鉴, 宋尔卫, 等. 改进的小鼠颈部心脏移植模型的制作. 现代临床医学生物工程学杂志, 2000, 6(4):259-260.
15. 冯剑锷, 孙宗全. 应用Cuff技术建立小鼠异位心脏移植模型.中华实验外科杂志, 2005, 22(12):1576-1577.
16. 高开柱, 孙宗全, 杜心灵, 等. 套管法与缝合法在建立小鼠颈部心脏移植模型的比较. 心肺血管病杂志, 2006, 25(3):178-180.
17. 程峰, 顾晓冬, 项建斌, 等. 改良Cuff技术建立小鼠颈部异位心脏移植模型. 复旦学报(医学版), 2008, 35(6):919-921.
18. 牟艳, 杨洪吉. 小鼠腹腔异位心脏移植模型的建立及注意事项.四川医学, 2012, 33(1):24-25.
19. 苏松. 介绍一种新型的小鼠腹部心脏移植方法. 生物医学工程学杂志, 2013, 30(5):1108-1111.
20. 郁雷, 高丽. 小鼠腹部心脏移植模型建立及并发症预防. 中国胸心血管外科临床杂志, 2014, 21(2):249-252.

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