Progress in Diagnosis and Treatment of Double Primary Lung Cancer_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

WANGHui , WANGXiao-jun , CHENShu ,  GUOXi-ping

Department of Thoracic Surgery, The Second Hospital of Jilin University, Changchun 130021, P. R. China;

Corresponding author：

GUOXi-ping, Email: 3399787213@qq.com

Keywords：

Double primary lung cancer; Video-assisted thoracoscopic surgery; Radiotherapy alone

DOI：

10.7507/1007-4848.20160173

Video：

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With the continuous development of living standards, medical imageology, pathology and the technique of cell biology, the morbidity of double primary lung cancer (DPLC) grows rapidly in recent years. The thoracic surgeons have constantly improved its standard of diagnosis and treatment. At the present, union diagnosis of multiple indexes, defining clinical stage based on a single leision, and the early surgery have been accepted by most of the thoracic surgeons. The video-assisted thoracoscopic surgery (VATS), for its advantage of small trauma, has been accepted by thoracic surgeons and been widely used now. It's a promising treatment for DPLC and other chest diseases. In addition, it has been proved that there was no statistical diffence in prognosis between the simple radiotherapy and surgical treatment. The traditional concept of thoracic surgery is facing severe challenges. Therefore, we review the clinical diagnosis and treatment progress of DPLC as follows.

Citation： WANGHui, WANGXiao-jun, CHENShu, GUOXi-ping. Progress in Diagnosis and Treatment of Double Primary Lung Cancer. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2016, 23(7): 724-727. doi: 10.7507/1007-4848.20160173 Copy

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6.	Biuroth T, Fukuda M, Soda H, et al. Clinical pattern and patholo-gicstage but not histologic features predict outcome for bronchioloal-veolarcarcinoma. Ann ThoracSurg, 2002, 74(8):1640-1647.
7.	Rea F, Zuin A, Callegaro D, et al. Surgical results for multiple primary lung cancers. Eur J Cardiothorac Surg, 2001, 20(3):489-495.
8.	Luraghi P, Schelter F, Kruger A, et al. The MET oncogene as a therapeutical target in cancer invasive growth. Front Pharmacol, 2012, 3(2):164.
9.	Schmid F, Wang Q, Huska MR, et al. A target genef MACC1, conter-butes to colorectal cancer metastasis. Proc Am Ass Res, 2012, 54 (10):416.
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11.	Vineis P, Alavanja M, Buffler P, et al. Tobacco and cancer:recent epidemiological evidence. J Natl Cancer Inst, 2004, 96(2):99-106.
12.	张国钦, 王宁, 王涛,等. 北京市城区居民烟草消费和大气污染对肺癌死亡率的影响. 环境与健康杂志, 2009, 26(8):666-669.
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18.	Martini N, Melamed MR. Multiple primary lung cancer. J Thorac Cardiovas Surg, 2005, 70(5):606-612.
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20.	董贺, 孙青. 分子病理学技术在肿瘤诊治中的应用. 分子诊断与治疗杂志, 2015, 7(2):73-77, 82.
21.	Kontic M, Stevic R, Stojsic J, et al. Synchronous primary lung cancers:a muhidisciplinary approach in diagnosis. Tumori, 2011, 97(4):e16-19.
22.	Stella GM, Cemmi F, Inghilleri S, et al. Synchronous lung cancers:when saine histological types feature different molecular profiles and response phenotypes. J Cancer, 2011, 2(2):474-477.
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24.	Hayes JL, Tzeuka A, Thygesen H, et al. Diagnosis of copy number variation by Illumina next generation sequencing is comparable in performance to oligonucleotide array comparative genomic hybridisation. Genomics, 2013, 102(3):174-181.
25.	张洋, 苏玉虹, 巴彩凤, 等. 流式细胞微球芯片捕获技术在医学领域中的应用价值. 中国临床康复, 2006, 37:129-131.
26.	Ichinose X, Hara N, Ohta M, et al. DNA ploidypat-terns of tumors diagnosed as metachronous or recurrent lung cancers. Ann Thorac Surg, 1991, 52(4):496-473.
27.	姚健. MACC1和c-Met在同期多发肺癌中的表达及临床意义. 长春:吉林大学, 2014.13-105.
28.	Trousse D, Barlesi F, Loundou A, et al. Synchronous multiple primary lung cancer:an increasing clinicaloc-currence repuiring multidisciplinary management. J Thorac Cardiovasc Surg, 2007, 133(5):1193-1200.
29.	廖虎. 刘伦旭教授成功开展国际首例双侧单孔胸腔镜手术同期治疗多原发肺癌. 中国胸心血管外科临床杂志, 2014, 21(2):177.
30.	Niessen RC, Berends MJ, Wu Y, et al. Identification of mismatch repair gene mutations in young patients with colorectal cancer and in patients with multiple tumours associated with hereditary nonpolyposis colorectal cancer. Gut, 2006, 55(12):1781-1788.
31.	Landreneau RJ. Sugarbaker DJ, Mack MJ, et al. Wedge resection versuslobect my for stage 1 (T₁N₀M₀) Non small cell lung cancer. J Thorac Cardiovasc surg, 1997, 113(5):691-700.
32.	Kobayashi S, Okada S, Hasumi T, et al. Long-term survival of a poor risk octogenarian following wedge resetion under AVTS for small cell lung cancer:report of a case. Surg Today, 2000, 30(3):286-290.
33.	Johnson BE. Second lung in patients after treatment for an mutal lung cancer. J Natl Cancer Inst, 1998, 90(2):1335-1345.
34.	Gold DR, Bloomberg GR, Gruikshank WW, et al. Parental charac-teristics,somatic fetal growth and season of birth influence innate and adaptive cord.blood cyctokine responses. J Allergy Clin Immunol, 2009, 124(5):1078-1087.
35.	Yoshizawa A, Sumiyoshi N, Sonobe M, et a1. Validation of the lst. C/ATS/ERS lung adenoearcinoma classification for prognosis and association with EGFR and KRASgene mutations:analysis of 440 Japanese patients. J Thorac Oncol, 2013, 8:52-61.
36.	Tsuta K, Kawago M, Inoue E, et al. The utility of the proposed IASLC/ATS/ERS lung adenocarcinoma subtypes for disease prognosis and correlation of driver gene alterations. Lung cancer, 2013, 81(1):371-376.
37.	Woo T, Okudela K, Mitsui H, et al. Prognostic value of the IASLC/ATS/ERS classification of lung adenocarcinoma in stage 1 disease of Japanese cases. Pathol Int, 2012, 62(3):785-791.
38.	Naohiro T, Tsutomu K. A case of synchronous double primary lung cancer presenting with pleomorphic carcinoma and adenocarcinoma. Am J Case Rep, 2014, 15(7):576-579.
39.	Depierre A, Westeel V. Overview of the role of neoadjuvant therapy for early stage non-small cell lung cancer. Sein Oncol, 2001, 28 (4Suppl 14):29-36.
40.	Matthiesen C, Thompson JS, De La Fuente HT, et a1. Use of stereo-tactic body radiation therapy for medically inoperable multiple pfimary lung cancer. J Med Imaging Radiat Oncol, 2012, 56(5):56l-566.
41.	初向阳,薛志强,刘毅, 等. 单操作孔电视胸腔镜肺叶切除术治疗早期肺癌的临床研究. 中国胸心血管外科临床杂志, 2012, 19(2):113-115.

1. Siegel R, Ma J, Zou Z, et al. Cancer statistics, 2014. CA Cancer J Clin, 2014, 64(1):9-29.
2. 罗汶鑫, 周萍, 李为民.多原发性肺癌的诊治进展.中国肺癌杂志, 2015, 18(10):640-643.
3. 张雷, 李文涛, 丁嘉安, 等. 多原发性肺癌的外科治疗. 中华胸心血管外科杂志, 2004, 20(1):63.
4. 付强, 李钦, 刘涌. 同时性多原发性肺癌的外科治疗. 四川医学, 2007, 28(2):188-189.
5. Beyreuther H. Multiplicitat von canciinomen bei einem Fall von sog. "Schenecberger" Lungenkrebs mit tuberkulose. Virchows Arch, 1924, 250(5):230-243.
6. Biuroth T, Fukuda M, Soda H, et al. Clinical pattern and patholo-gicstage but not histologic features predict outcome for bronchioloal-veolarcarcinoma. Ann ThoracSurg, 2002, 74(8):1640-1647.
7. Rea F, Zuin A, Callegaro D, et al. Surgical results for multiple primary lung cancers. Eur J Cardiothorac Surg, 2001, 20(3):489-495.
8. Luraghi P, Schelter F, Kruger A, et al. The MET oncogene as a therapeutical target in cancer invasive growth. Front Pharmacol, 2012, 3(2):164.
9. Schmid F, Wang Q, Huska MR, et al. A target genef MACC1, conter-butes to colorectal cancer metastasis. Proc Am Ass Res, 2012, 54 (10):416.
10. Shiro F, Katsuhiro M. Multiple primary malignancies in patients with non-small cell lung cancer. Intern Med, 2015, 54(3):325-331.
11. Vineis P, Alavanja M, Buffler P, et al. Tobacco and cancer:recent epidemiological evidence. J Natl Cancer Inst, 2004, 96(2):99-106.
12. 张国钦, 王宁, 王涛,等. 北京市城区居民烟草消费和大气污染对肺癌死亡率的影响. 环境与健康杂志, 2009, 26(8):666-669.
13. Adams AM, Berg CD. Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med, 2011, 365(9):395-409.
14. Bach PB, Mirkin JN, Oliver TK, et al. Benefits and harms of CT screening for lung cancer:a systematic review. JAMA, 2012, 307 (22):2418-2429.
15. Hellwig D, Baum RP, Kirsch C. FDG, PET, PET/CT and conven-tional nuclear medicine procedures in the evaluation of lung cancer:a systematic review. Nuklearmedizin, 2009, 48(2):59-69.
16. 冯飞跃, 张德超, 刘向阳, 等. 31例同期双原发肺癌的手术方式和患者生存情况分析. 癌症杂志, 2005, 24(2):215-218.
17. Antakli T, Schaefer RF, Rutherford JE, et al. Second primary lung cancer. Ann Thorac Surg, 1995, 59(4):863-866.
18. Martini N, Melamed MR. Multiple primary lung cancer. J Thorac Cardiovas Surg, 2005, 70(5):606-612.
19. Kozower BD, Larner JM, Detterbeck FC, et al. Special treatment issues in non-small cell lung cancer:Diagnosis and management of lung cancer:American College of Chest Physicians evidence-based clinical practice guidelines. Chest, 2013, 143(5 Suppl):e369-e399.
20. 董贺, 孙青. 分子病理学技术在肿瘤诊治中的应用. 分子诊断与治疗杂志, 2015, 7(2):73-77, 82.
21. Kontic M, Stevic R, Stojsic J, et al. Synchronous primary lung cancers:a muhidisciplinary approach in diagnosis. Tumori, 2011, 97(4):e16-19.
22. Stella GM, Cemmi F, Inghilleri S, et al. Synchronous lung cancers:when saine histological types feature different molecular profiles and response phenotypes. J Cancer, 2011, 2(2):474-477.
23. Graziano P, Cardillo G, Mancuse A, et al. Long-term disease free survival of a patient with synchronous bilateral lung adenecareinoma displaying different EGFR and C-MYC molecular characteristics. Chest, 2011, 140(5):1354-1356.
24. Hayes JL, Tzeuka A, Thygesen H, et al. Diagnosis of copy number variation by Illumina next generation sequencing is comparable in performance to oligonucleotide array comparative genomic hybridisation. Genomics, 2013, 102(3):174-181.
25. 张洋, 苏玉虹, 巴彩凤, 等. 流式细胞微球芯片捕获技术在医学领域中的应用价值. 中国临床康复, 2006, 37:129-131.
26. Ichinose X, Hara N, Ohta M, et al. DNA ploidypat-terns of tumors diagnosed as metachronous or recurrent lung cancers. Ann Thorac Surg, 1991, 52(4):496-473.
27. 姚健. MACC1和c-Met在同期多发肺癌中的表达及临床意义. 长春:吉林大学, 2014.13-105.
28. Trousse D, Barlesi F, Loundou A, et al. Synchronous multiple primary lung cancer:an increasing clinicaloc-currence repuiring multidisciplinary management. J Thorac Cardiovasc Surg, 2007, 133(5):1193-1200.
29. 廖虎. 刘伦旭教授成功开展国际首例双侧单孔胸腔镜手术同期治疗多原发肺癌. 中国胸心血管外科临床杂志, 2014, 21(2):177.
30. Niessen RC, Berends MJ, Wu Y, et al. Identification of mismatch repair gene mutations in young patients with colorectal cancer and in patients with multiple tumours associated with hereditary nonpolyposis colorectal cancer. Gut, 2006, 55(12):1781-1788.
31. Landreneau RJ. Sugarbaker DJ, Mack MJ, et al. Wedge resection versuslobect my for stage 1 (T₁N₀M₀) Non small cell lung cancer. J Thorac Cardiovasc surg, 1997, 113(5):691-700.
32. Kobayashi S, Okada S, Hasumi T, et al. Long-term survival of a poor risk octogenarian following wedge resetion under AVTS for small cell lung cancer:report of a case. Surg Today, 2000, 30(3):286-290.
33. Johnson BE. Second lung in patients after treatment for an mutal lung cancer. J Natl Cancer Inst, 1998, 90(2):1335-1345.
34. Gold DR, Bloomberg GR, Gruikshank WW, et al. Parental charac-teristics,somatic fetal growth and season of birth influence innate and adaptive cord.blood cyctokine responses. J Allergy Clin Immunol, 2009, 124(5):1078-1087.
35. Yoshizawa A, Sumiyoshi N, Sonobe M, et a1. Validation of the lst. C/ATS/ERS lung adenoearcinoma classification for prognosis and association with EGFR and KRASgene mutations:analysis of 440 Japanese patients. J Thorac Oncol, 2013, 8:52-61.
36. Tsuta K, Kawago M, Inoue E, et al. The utility of the proposed IASLC/ATS/ERS lung adenocarcinoma subtypes for disease prognosis and correlation of driver gene alterations. Lung cancer, 2013, 81(1):371-376.
37. Woo T, Okudela K, Mitsui H, et al. Prognostic value of the IASLC/ATS/ERS classification of lung adenocarcinoma in stage 1 disease of Japanese cases. Pathol Int, 2012, 62(3):785-791.
38. Naohiro T, Tsutomu K. A case of synchronous double primary lung cancer presenting with pleomorphic carcinoma and adenocarcinoma. Am J Case Rep, 2014, 15(7):576-579.
39. Depierre A, Westeel V. Overview of the role of neoadjuvant therapy for early stage non-small cell lung cancer. Sein Oncol, 2001, 28 (4Suppl 14):29-36.
40. Matthiesen C, Thompson JS, De La Fuente HT, et a1. Use of stereo-tactic body radiation therapy for medically inoperable multiple pfimary lung cancer. J Med Imaging Radiat Oncol, 2012, 56(5):56l-566.
41. 初向阳,薛志强,刘毅, 等. 单操作孔电视胸腔镜肺叶切除术治疗早期肺癌的临床研究. 中国胸心血管外科临床杂志, 2012, 19(2):113-115.

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