Research Progress of Correlation between Adipocytokines and Myocardial Remodeling_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

 FEIJun-jie , LAIYing-long

Department of Cardiothoracic Surgery, Affiliated Hospital, North Sichuan Medical College, Nanchong 637000 Sichuan, P. R. China;

Corresponding author：

FEIJun-jie, Email: robick@163.com

Keywords：

Myocardial Remodeling; Adipocytokines; Leptin; Adiponectin; Visfatin

DOI：

10.7507/1007-4848.20160177

Video：

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Abstract Full text Figures/Tables Video References Cited by

Myocardial remodeling is a common pathological physiology change for a variety of heart diseases under stimulation such as stress or ischemia. The engine body will release a lot of cytokines to promote the change of myocardial structure and ultimately lead to heart failure. Myocardial remodeling includes myocardial cells remodeling and the extracellular matrix remodeling. In recent years, we find that the function of adipose tissue is not only about energy storage, buffering to protect, supporting and filling, but also has a powerful function of secretion. Adipose tissue can secrete various adipocytokines, such as leptin, adiponectin, visfatin, omentin, angiotensin Ⅱ, and so on. Current studies have shown that adipocytokines and myocardial remodeling are intimated. And this article will summarize the function of adipocytokines on myocardial remodeling.

Citation： FEIJun-jie, LAIYing-long. Research Progress of Correlation between Adipocytokines and Myocardial Remodeling. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2016, 23(7): 742-745. doi: 10.7507/1007-4848.20160177 Copy

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4.	侯宁,罗建.PPAR-α在瘦素诱导心肌细胞肥大中的作用. 广东医学, 2011, 9:1092-1095.
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10.	Fukuhara A, Matsuda M, Nishizawa M, et al. Visfatin:a protein secreted by visceral fat that mimics the effects of insulin. Science, 2005, 307:426-430.
11.	Kawano H, Do YS, Kawano Y, et al. Angiotensin Ⅱ has multiple profibrotic effects in human cardiac fibroblasts. Circulation, 2000, 101(2078):1130-1137.
12.	Matsubara H. Pathophysiological role of angiotensin-Ⅱ type 2 receptor in cardiovascular and renal diseases. Circ Res, l 998, 83(10):1182-1191.
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14.	Hori M, Nishida K. Oxidative stress and left ventricular remodelling after myocardial infarction. Cardiovasc Res, 2009, 81(1):457-464.
15.	Denzel MS, Scimia MC, Zumstein PM, et al. T-cadherin is critical for adiponectin-mediated cardioprotection in mice. J Clin Invest, 2010, 120(12):4342-4352.
16.	Marso SP, Mehta SK, Frutkin A, et al. Low adiponectin levels are associated with atherogenic dyslipidemia and lipid-rich plaque in nondiabetic coronary arteries. Diabetes Care, 2008, 31(5):989-994.
17.	Mitsuhashi H, Yatsuya H, Tamakoshi K, et al. Adiponectin level and left ventricular hypertrophy in Japanese men. Hypertension, 2007, 49(6):1448-1454.
18.	Liao Y, Takashima S, Maeda N, et al. Exacerbation of heart failure in adiponectin-deficient mice due to impaired regulation of AMPK and glucose metabolism. Cardiovasc Res, 2005, 67:705-713.
19.	Shibata R, Ouchi N, Ito M, et al. Adiponectin-mediated modulation of hypertrophic signals in the heart. Nat Med, 2004, 10(12):1384-1389.
20.	Yamauchi T, Kamon J, Ito Y, et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature, 2003, 423(6941):762-769.
21.	Das S, Otani H, Manlik N, et al. Redox regulation of angiotensin II preconditioning of the myocardium requires MAP kinase signaling. J Mol Cell Cardiol, 2006, 41(2):248-255.
22.	Essick EE, Ouchi N, Wilson R M, et al. Adiponectin mediates cardio-protection in oxidative stress-induced cardiac myocyte remodeling. Am J Physiol Heart Circ Physiol, 2011, 301(3):984-993.
23.	Ohashi K, Kihara S, Ouchi N,et al. Adiponectin replenishment ameliorates obe-sity-related hypertension. Hypertension, 2006, 47 (6):1108-1116.
24.	Gao F, Gao E, YUE TL, et al. Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion:the roles of PI3-kinase, Akt, and endothelial nitric oxide synthase phosphoryla-tion. Circulation, 2002, 105(12):1497-1502.
25.	Patel L, Buckels AC, Kinghhorn IJ, et al. Resistin is expressed in human macrophages and directly regulated by PPARg activators. Biochem Biophys Res Commun, 2003, 300(2):472.
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28.	McManus DD, Lyass A, Ingelsson E, et al. Relations of circulating resistin and adiponectin and cardiac structure and function:the framingham offspring study. Obesity (Silver Spring), 2012, 20(9):1882-1886.
29.	Gao J, Chang C, Chen Z, et al. Resistin, an adipocytokine, offers protection against acute myocardial infarction. Mol Cell Cardiol, 2007, 43(5):601-609.
30.	Smith CC, Lim SY, Wynne AM, et al. Failure of the adipocytokine, resistin, to protect the heart from schemia reperfusion injury. Cardiovasc Pharmacol Ther, 2011, 16(1):63-71.
31.	Yang RZ, Lee MJ, Hu H, et al. Identification of omentin as a novel depot-specific adipokine in human adipose tissue:possible role in modulating insulin action. Am J Physiol Endocrinol Metab, 2006, 290(6):E1253-E1261.
32.	Fain JN, Sacks HS, Buehrer B, et al. Identification of omentin mRNA in human epicardial adipose tissue:comparison to omentin in subcutaneous, internal mammary artery periadventitial and visceral abdominal depots. Int J Obes(Lond), 2008, 32(5):810-815.
33.	Schaffler A, Neumeier M, Herfarth H, et al. Genomic structure of human omentin, a new adipocytokine expressed in omental adipose tissue. Biochem Biophys Acta, 2005, 1732(1-3):96-102.
34.	Suzuki Y, Shin K, Lonnerdal B. Molecular cloning and functional expression of a human intestinal lactoferrin receptor. Biochemistry, 2001, 40(51):15771-15779.
35.	Yamawaki H, Kuramoto J, Kameshima S, et al. Omentin, a novel adipocytokine inhibits TNF-induced vascular inflammation in human endothelial cells. Bichem Biophys Res Commun, 2011, 408(2):339-343.
36.	Tan BK, Adya R, Farhatullah S, et al. Metformin treatment may increase omentin-1 levels in women with polycystic ovary syndrome. Diabetes, 2010, 59(12):3023-3031.
37.	石翠翠, 张昕. 脂肪因子与心血管疾病的研究进展. 中国循环杂志, 2014, (10):858-860.
38.	Gao X, Mi S, Zhang F, et al. Association of chemerin mRNA expre-ssion in human epicardial adipose tissue with coronary atherosc-lerosis. Cardiovasc Diabetol, 2011, 10:87.
39.	Rhee EJ. Chemerin:A Novel Link between Inflammation and Atherosclerosis? Diabetes Metab J, 2011, 35(3):216-218.
40.	Ernst MC, Haidl ID, Zuniga LA, et al. Disruption of the chemokine-like receptor-1(CMKLR1) gene is associated with reduced adiposity and glucose intolerance. Endocrinology, 2012, 153(2):672-682.

1. Zhang Y, Proenca R, Maffei M. Positional cloning of the mouse obese gene and its human homologue. Nature, 1994, 372:425-432.
2. Ghilardi N, Skoda RC. The leptin receptor activates Janus kinase and signals for proliferation in a factor-dependent cell line. Mol Endocrinol, 1997, 11(4):393-399.
3. Xu FP, Chen MS, Wang YZ, et al. Leptin induces hypertrophy via endothelin-1-reactive oxygen species pathway in cultured neonatal rat cardiomyocytes. Circulation, 2004, 110:1269-1275.
4. 侯宁,罗建.PPAR-α在瘦素诱导心肌细胞肥大中的作用. 广东医学, 2011, 9:1092-1095.
5. Matsui H, Mot ooka M, Koike H, et al. Ischemia/reperfusion in rat heart induces leptin and leptin receptor gene expression. Life Sci, 2007, 80(7):672-680.
6. Madani S, De Girolamo S, Munoz DM, et al. Direct effects of leptin on size and extracellular matrix components of human pediatric ventricular myocytes. Cardiovasc Res, 2006, 69:716-725.
7. Barouch LA, Berkowitz DE, Harrison RW, et al. Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice. Circulation, 2003, 108(6):754-759.
8. Smith CC, Mocanu MM, Davidson SM, et al. Leptin, the obesity-associated hormone, exhibits direct cardioprotective effects. Br J Pharmacol, 2006, 149(1):5-13.
9. Hausenloy DJ, Tsang A, Yellon DM. The reperfusion injury salvage kinase pathway:a common target for both ischemic preconditioning and postconditioning. Trends Cardiovasc Med, 2005, 15(2):69-75.
10. Fukuhara A, Matsuda M, Nishizawa M, et al. Visfatin:a protein secreted by visceral fat that mimics the effects of insulin. Science, 2005, 307:426-430.
11. Kawano H, Do YS, Kawano Y, et al. Angiotensin Ⅱ has multiple profibrotic effects in human cardiac fibroblasts. Circulation, 2000, 101(2078):1130-1137.
12. Matsubara H. Pathophysiological role of angiotensin-Ⅱ type 2 receptor in cardiovascular and renal diseases. Circ Res, l 998, 83(10):1182-1191.
13. 常亮. 内脂素在心肌细胞肥厚和炎症反应中的作用及其机制. 石家庄:河北医科大学, 2012.12-98.
14. Hori M, Nishida K. Oxidative stress and left ventricular remodelling after myocardial infarction. Cardiovasc Res, 2009, 81(1):457-464.
15. Denzel MS, Scimia MC, Zumstein PM, et al. T-cadherin is critical for adiponectin-mediated cardioprotection in mice. J Clin Invest, 2010, 120(12):4342-4352.
16. Marso SP, Mehta SK, Frutkin A, et al. Low adiponectin levels are associated with atherogenic dyslipidemia and lipid-rich plaque in nondiabetic coronary arteries. Diabetes Care, 2008, 31(5):989-994.
17. Mitsuhashi H, Yatsuya H, Tamakoshi K, et al. Adiponectin level and left ventricular hypertrophy in Japanese men. Hypertension, 2007, 49(6):1448-1454.
18. Liao Y, Takashima S, Maeda N, et al. Exacerbation of heart failure in adiponectin-deficient mice due to impaired regulation of AMPK and glucose metabolism. Cardiovasc Res, 2005, 67:705-713.
19. Shibata R, Ouchi N, Ito M, et al. Adiponectin-mediated modulation of hypertrophic signals in the heart. Nat Med, 2004, 10(12):1384-1389.
20. Yamauchi T, Kamon J, Ito Y, et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature, 2003, 423(6941):762-769.
21. Das S, Otani H, Manlik N, et al. Redox regulation of angiotensin II preconditioning of the myocardium requires MAP kinase signaling. J Mol Cell Cardiol, 2006, 41(2):248-255.
22. Essick EE, Ouchi N, Wilson R M, et al. Adiponectin mediates cardio-protection in oxidative stress-induced cardiac myocyte remodeling. Am J Physiol Heart Circ Physiol, 2011, 301(3):984-993.
23. Ohashi K, Kihara S, Ouchi N,et al. Adiponectin replenishment ameliorates obe-sity-related hypertension. Hypertension, 2006, 47 (6):1108-1116.
24. Gao F, Gao E, YUE TL, et al. Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion:the roles of PI3-kinase, Akt, and endothelial nitric oxide synthase phosphoryla-tion. Circulation, 2002, 105(12):1497-1502.
25. Patel L, Buckels AC, Kinghhorn IJ, et al. Resistin is expressed in human macrophages and directly regulated by PPARg activators. Biochem Biophys Res Commun, 2003, 300(2):472.
26. 王新成, 李国庆. 抵抗素的研究进展. 现代生物医学进展, 2010, 26(1):3598-3600.
27. Chemaly ER, Hadri L, Zhang S, et al. Long-term in vivo resistin overexpression induces myocardial dysfunction and remodeling in rats. J Mol Cell Cardiol, 2011, 51(2):144-155.
28. McManus DD, Lyass A, Ingelsson E, et al. Relations of circulating resistin and adiponectin and cardiac structure and function:the framingham offspring study. Obesity (Silver Spring), 2012, 20(9):1882-1886.
29. Gao J, Chang C, Chen Z, et al. Resistin, an adipocytokine, offers protection against acute myocardial infarction. Mol Cell Cardiol, 2007, 43(5):601-609.
30. Smith CC, Lim SY, Wynne AM, et al. Failure of the adipocytokine, resistin, to protect the heart from schemia reperfusion injury. Cardiovasc Pharmacol Ther, 2011, 16(1):63-71.
31. Yang RZ, Lee MJ, Hu H, et al. Identification of omentin as a novel depot-specific adipokine in human adipose tissue:possible role in modulating insulin action. Am J Physiol Endocrinol Metab, 2006, 290(6):E1253-E1261.
32. Fain JN, Sacks HS, Buehrer B, et al. Identification of omentin mRNA in human epicardial adipose tissue:comparison to omentin in subcutaneous, internal mammary artery periadventitial and visceral abdominal depots. Int J Obes(Lond), 2008, 32(5):810-815.
33. Schaffler A, Neumeier M, Herfarth H, et al. Genomic structure of human omentin, a new adipocytokine expressed in omental adipose tissue. Biochem Biophys Acta, 2005, 1732(1-3):96-102.
34. Suzuki Y, Shin K, Lonnerdal B. Molecular cloning and functional expression of a human intestinal lactoferrin receptor. Biochemistry, 2001, 40(51):15771-15779.
35. Yamawaki H, Kuramoto J, Kameshima S, et al. Omentin, a novel adipocytokine inhibits TNF-induced vascular inflammation in human endothelial cells. Bichem Biophys Res Commun, 2011, 408(2):339-343.
36. Tan BK, Adya R, Farhatullah S, et al. Metformin treatment may increase omentin-1 levels in women with polycystic ovary syndrome. Diabetes, 2010, 59(12):3023-3031.
37. 石翠翠, 张昕. 脂肪因子与心血管疾病的研究进展. 中国循环杂志, 2014, (10):858-860.
38. Gao X, Mi S, Zhang F, et al. Association of chemerin mRNA expre-ssion in human epicardial adipose tissue with coronary atherosc-lerosis. Cardiovasc Diabetol, 2011, 10:87.
39. Rhee EJ. Chemerin:A Novel Link between Inflammation and Atherosclerosis? Diabetes Metab J, 2011, 35(3):216-218.
40. Ernst MC, Haidl ID, Zuniga LA, et al. Disruption of the chemokine-like receptor-1(CMKLR1) gene is associated with reduced adiposity and glucose intolerance. Endocrinology, 2012, 153(2):672-682.

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Research Progress of Correlation between Adipocytokines and Myocardial Remodeling

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