Relationship between Multiple Organ Metastasis and Prognosis for Non-small Cell Lung Cancer_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

ZHANGZhen-rong , FENGHong-xiang , GUOYong-qing , SHIBin , SONGZhi-yi , TIANYan-chu , LIANGChao-yang ,  LIUDe-ruo

Department of Thoracic Surgery, China-Japan Friendship Hospital, Beijing 100029, P. R. China;

Corresponding author：

LIUDe-ruo, Email: deruoliu@vip.sina.com

Keywords：

Non-small cell lung cancer; Prognosis; Metastasis

DOI：

10.7507/1007-4848.20160264

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Objective To evaluate the prognostic significance of postoperative metastasis in non-small cell lung cancer (NSCLC). Methods We retrospectively analyzed the clinical data of 94 patients who underwent curative lobectomy and pathologically diagnosed with NSCLC in our hospital between January 2005 and December 2011. There were 53 males and 41 females with a mean age of 62 (57-76) years. Results Among 94 patients, metastasis occurred during late stage (more than 2 years postoperatively) in 49 (52.12%) patients. Single organ metastasis and multiple organ metastasis were found in 85 (90.43%) patients. The most popular metastatic site was lung (38/94,40.42%), and then bone (27/94,28.72%), and brain (24/94,25.53%). The overall survival (OS) rate of all included patients was 41.5%. The median survival time was 43 months and 29 months for the single metastasis and multiple metastasis groups respectively. There was a statistical difference in OS rate between the single metastasis and multiple metastasis groups (45.9% vs. 0.0%, P<0.001). The median survival time was 50 months and 32 months for early metastatic patients and late metastatic patients respectively. Statistical difference was found in OS rate between the single metastasis and multiple metastasis groups (53.3% vs. 30.6%, Cox P=0.130, Breslow P=0.014). Cox regression showed TNM stage (P=0.003) and single organ metastasis (P<0.001) were significant prognostic factors for NSCLC. Conclusion Lung, bone, and brain were the most popular metastatic organs for postoperative NSCLC. The presence of multiple organ metastases can be identified as an independent poor prognostic factor in NSCLC.

Citation： ZHANGZhen-rong, FENGHong-xiang, GUOYong-qing, SHIBin, SONGZhi-yi, TIANYan-chu, LIANGChao-yang, LIUDe-ruo. Relationship between Multiple Organ Metastasis and Prognosis for Non-small Cell Lung Cancer. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2016, 23(12): 1123-1127. doi: 10.7507/1007-4848.20160264 Copy

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1. Chen LL, Blumm N, Christakis NA, et al. Cancer metastasis networks and the prediction of progression patterns. Br J Cancer, 2009, 101 (5): 749-758.
2. Langley RR, Fidler IJ. The seed and soil hypothesis revisited-the role of tumor-stroma interactions in metastasis to different organs. Int J Cancer, 2011, 128(11): 2527-2535.
3. Sugiura H, Yamada K, Sugiura T, et al. Predictors of survival in patients with bone metastasis of lung cancer. Clin Orthop Relat Res, 2008, 466(3): 729-736.
4. Tamura T, Kurishima K, Nakazawa K, et al. Specific organ metas-tases and survival in metastatic non-small-cell lung cancer. Mol Clin Oncol, 2015, 3(1): 217-221.
5. Hess KR, Varadhachary GR, Taylor SH, et al. Metastatic patterns in adenocarcinoma. Cancer, 2006, 106(7): 1624-1633.
6. Quint LE, Tummala S, Brisson LJ, et al. Distribution of distant metastases from newly diagnosed non-small cell lung cancer. Ann Thorac Surg, 1996, 62(1): 246-250.
7. Oikawa A, Takahashi H, Ishikawa H, et al. Application of conditional probability analysis to distant metastases from lung cancer. Oncol Lett, 2012, 3(3): 629-634.
8. Lou F, Sima CS, Rusch VW, et al. Differences in patterns of recurr-ence in early-stage versus locally advanced non-small cell lung cancer. Ann Thorac Surg, 2014, 98(5): 1755-1761.
9. Williams BA, Sugimura H, Endo C, et al. Predicting post-recurrence survival among completely resected nonsmall-cell lung cancer patients. Ann Thorac Surg, 2006, 81(3): 1021-1027.
10. Sugimura H, Nichols FC, Yang P, et al. Survival after recurrent non-small-cell lung cancer after complete pulmonary resection. Ann Thorac Surg, 2007, 83(2): 409-418.
11. Sasaki H, Suzuki A, Tatematsu T, et al. Prognosis of recurrent non-small cell lung cancer following complete resection. Oncol Lett, 2014, 7(4): 1300-1304.
12. Lan YT, Chang SC, Yang SH, et al. Comparison of clinicopatho-logical characteristics and prognosis between early and late recur-rence after curative surgery for colorectal cancer. Am J Surg, 2014, 207(6): 922-930.

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