Outcome of thoracoscopic lobectomy for stageⅠ/Ⅱnon-small cell lung cancer_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

DOU Yawei ¹ ,  LV Shanshan ² , TIAN Wei ¹ , WANG Hongtao ¹ , ZHU Jianfei ¹ , DAI Yun ¹ , LUO Xianghui ¹

1. Department of Thoracic Surgery, Shaanxi People's Hospital, Xi'an, 710068, P.R.China;
2. Department of Cardiovascular Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710068, P.R.China;

Corresponding author：

LV Shanshan, Email: lvshan2007@163.com

Keywords：

Video-assisted thoracoscopic surgery; lobectomy; non-small cell lung cancer

DOI：

10.7507/1007-4848.201607031

Video：

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Objective To evaluate the efficacy and safety of total thoracoscopic lobectomy for patients with stage Ⅰ/Ⅱ non-small cell lung cancer (NSCLC). Methods The clinical data of 138 NSCLC patients from January 2013 to June 2015 in Shaanxi People's Hospital were retrospectively analyzed. There were 88 males and 50 females with an average age of 57.4±8.8 years, ranging from 44 to 76 years. According to the operation methods, they were divided into a video-assisted thoracoscopic surgery (VATS) group (thoracoscopic lobectomy in 63 cases) and a thoracotomy group (conventional open chest surgery in 75 cases). The intra- and postoperative clinical data, surgical complications and pulmonary function were compared. Results There was no significant difference in the operation time, intraoperative lymph node dissection groups, intraoperative lymph node dissection number between two groups (P>0.05). The blood loss, postoperative drainage volume, duration of postoperative analgesia, Numeric Rating Scale for pain and hospital stay in the VATS group were significantly lower than those of the thoracotomy group (P<0.05). The pre- and postoperative FVC%pred and FEV1%pred in both groups were compared and there was no significant difference (P>0.05). However the postoperative FVC%pred and FEV1%pred in both groups significantly reduced compared with preoperative ones (P<0.05). Complication rate of thoracoscopic group was significantly less than that of the thoracotomy group (20.63%vs. 32.00%,χ²=3.974,P=0.046). Conclusion Thoracoscopic lobectomy for NSCLCⅠ/Ⅱpatients is reliable, and achieves rapid postoperative recovery as well as less complications.

Citation： DOU Yawei, LV Shanshan, TIAN Wei, WANG Hongtao, ZHU Jianfei, DAI Yun, LUO Xianghui. Outcome of thoracoscopic lobectomy for stageⅠ/Ⅱnon-small cell lung cancer. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2017, 24(3): 192-195. doi: 10.7507/1007-4848.201607031 Copy

1.	龙志华. 全胸腔镜肺叶切除系统淋巴结清扫对Ⅰ至ⅡA期非小细胞肺癌 (NSCLC) 的临床疗效研究. 中国实用医药, 2014, 9(12): 72-73.
2.	牟志民, 张海, 毛广显, 等. 胸腔镜肺叶切除术与开胸肺叶切除术治疗临床Ⅰa 期非小细胞肺癌对比研究. 新乡医学院学报, 2015, 32(2): 149-151.
3.	Kato M, Onishi H, Furugaki K, et al. New approach to complete video-assisted thoracoscopic lobectomy in T2 and T3 non-small cell lung cancer. Anticancer Res, 2015, 35(6): 3585-3589.
4.	田文鑫, 佟宏峰, 孙耀光, 等. 非小细胞肺癌胸腔镜与常规开胸术后血清 VEGF、MMP-9 变化的研究. 中国肺癌杂志, 2014, 17(1): 24-29.
5.	何圆, 尤长宣. 非小细胞肺癌免疫治疗进展. 中国肺癌杂志, 2014, 46(3): 277-281.
6.	张卫强, 左建新, 谭健, 等. 电视胸腔镜手术对老年非小细胞肺癌患者术后心肺并发症的影响分析. 中国全科医学, 2014, 17(2): 220-222.
7.	廉政君, 黄建国. 晚期非小细胞肺癌预后相关因素分析. 现代肿瘤医学, 2014, 22(1): 95-97.
8.	梁宇强, 黄健, 王茂生, 等. 电视胸腔镜在Ⅰ-Ⅱ期 NSCLC 切除中的中远期疗效及安全性分析. 临床肺科杂志, 2014, 19(10): 1874-1877.
9.	周亚夫, 颜建华, 冯键, 等. 全胸腔镜肺叶切除术与传统开放式肺叶切除术在Ⅰ、Ⅱ期肺癌治疗中的对比研究. 中国临床医生, 2016, 44(4): 62-64.
10.	魏崴, 李勇生, 钟标, 等. 全胸腔镜肺叶切除术治疗直径大于 5 cm 的非小细胞肺癌. 贵阳医学院学报, 2015, 40(4): 397-400.
11.	Kim SJ, Lee YJ, Park JS, et al. Changes in pulmonary function in lung cancer patients after video-assisted thoracic surgery. Ann Thorac Surg, 2015, 99(1): 210-217.
12.	朱勇, 梁明强, 吴维栋, 等. 单孔全胸腔镜肺叶切除术治疗非小细胞肺癌的初步探索. 福建医科大学学报, 2014, 48(6): 382-384.
13.	王祥安, 冯国斌, 朱军, 等. 电视胸腔镜肺叶切除术临床疗效分析. 养生保健指南: 医药研究, 2016, 12(3): 18-19.
14.	毛小亮, 童继春, 朱征, 等. 全胸腔镜解剖性肺段切除治疗Ⅰa 期非小细胞肺癌 (附 6 例报告). 实用临床医药杂志, 2015, 19(24): 76-77.
15.	石正军, 林学军, 李铁彬, 等. 胸腔镜在治疗早期非小细胞肺癌的临床效果分析. 临床肺科杂志, 2014, 19(3): 456-458.
16.	孙琦, 孙振宇, 顾敏威, 等. 全胸腔镜肺叶切除联合淋巴结清扫术治疗老年非小细胞肺癌的疗效. 中国老年学杂志, 2015, 35(10): 2736-2737.
17.	Yang ZM, Sun YH, Rui WM, et al. Meta-analysis of lobectomy, segmentectomy, and wedge resection for stage I non-small cell lung cancer. J Surg Oncol, 2015, 111(3): 334-340.
18.	Rančić M, Ristić L, Rančić S, et al. Pulmonary function parameters as prognostic factors in advanced non-small cell lung cancer. Med Glas (Zenica), 2014, 11(1): 58-65.
19.	Murakawa T, Ichinose J, Hino H, et al. Long-term outcomes of open and video-assisted thoracoscopic lung lobectomy for the treatment of early stage non-small cell lung cancer are similar: A propensity-matched study. World J Surg, 2015, 39(5): 1084-1091.
20.	Vannucci F, Gonzalez-Rivas D. Is VATS lobectomy standard of care for operable non-small cell lung cancer? Lung Cancer, 2016, 100: 114-119.

1. 龙志华. 全胸腔镜肺叶切除系统淋巴结清扫对Ⅰ至ⅡA期非小细胞肺癌 (NSCLC) 的临床疗效研究. 中国实用医药, 2014, 9(12): 72-73.
2. 牟志民, 张海, 毛广显, 等. 胸腔镜肺叶切除术与开胸肺叶切除术治疗临床Ⅰa 期非小细胞肺癌对比研究. 新乡医学院学报, 2015, 32(2): 149-151.
3. Kato M, Onishi H, Furugaki K, et al. New approach to complete video-assisted thoracoscopic lobectomy in T2 and T3 non-small cell lung cancer. Anticancer Res, 2015, 35(6): 3585-3589.
4. 田文鑫, 佟宏峰, 孙耀光, 等. 非小细胞肺癌胸腔镜与常规开胸术后血清 VEGF、MMP-9 变化的研究. 中国肺癌杂志, 2014, 17(1): 24-29.
5. 何圆, 尤长宣. 非小细胞肺癌免疫治疗进展. 中国肺癌杂志, 2014, 46(3): 277-281.
6. 张卫强, 左建新, 谭健, 等. 电视胸腔镜手术对老年非小细胞肺癌患者术后心肺并发症的影响分析. 中国全科医学, 2014, 17(2): 220-222.
7. 廉政君, 黄建国. 晚期非小细胞肺癌预后相关因素分析. 现代肿瘤医学, 2014, 22(1): 95-97.
8. 梁宇强, 黄健, 王茂生, 等. 电视胸腔镜在Ⅰ-Ⅱ期 NSCLC 切除中的中远期疗效及安全性分析. 临床肺科杂志, 2014, 19(10): 1874-1877.
9. 周亚夫, 颜建华, 冯键, 等. 全胸腔镜肺叶切除术与传统开放式肺叶切除术在Ⅰ、Ⅱ期肺癌治疗中的对比研究. 中国临床医生, 2016, 44(4): 62-64.
10. 魏崴, 李勇生, 钟标, 等. 全胸腔镜肺叶切除术治疗直径大于 5 cm 的非小细胞肺癌. 贵阳医学院学报, 2015, 40(4): 397-400.
11. Kim SJ, Lee YJ, Park JS, et al. Changes in pulmonary function in lung cancer patients after video-assisted thoracic surgery. Ann Thorac Surg, 2015, 99(1): 210-217.
12. 朱勇, 梁明强, 吴维栋, 等. 单孔全胸腔镜肺叶切除术治疗非小细胞肺癌的初步探索. 福建医科大学学报, 2014, 48(6): 382-384.
13. 王祥安, 冯国斌, 朱军, 等. 电视胸腔镜肺叶切除术临床疗效分析. 养生保健指南: 医药研究, 2016, 12(3): 18-19.
14. 毛小亮, 童继春, 朱征, 等. 全胸腔镜解剖性肺段切除治疗Ⅰa 期非小细胞肺癌 (附 6 例报告). 实用临床医药杂志, 2015, 19(24): 76-77.
15. 石正军, 林学军, 李铁彬, 等. 胸腔镜在治疗早期非小细胞肺癌的临床效果分析. 临床肺科杂志, 2014, 19(3): 456-458.
16. 孙琦, 孙振宇, 顾敏威, 等. 全胸腔镜肺叶切除联合淋巴结清扫术治疗老年非小细胞肺癌的疗效. 中国老年学杂志, 2015, 35(10): 2736-2737.
17. Yang ZM, Sun YH, Rui WM, et al. Meta-analysis of lobectomy, segmentectomy, and wedge resection for stage I non-small cell lung cancer. J Surg Oncol, 2015, 111(3): 334-340.
18. Rančić M, Ristić L, Rančić S, et al. Pulmonary function parameters as prognostic factors in advanced non-small cell lung cancer. Med Glas (Zenica), 2014, 11(1): 58-65.
19. Murakawa T, Ichinose J, Hino H, et al. Long-term outcomes of open and video-assisted thoracoscopic lung lobectomy for the treatment of early stage non-small cell lung cancer are similar: A propensity-matched study. World J Surg, 2015, 39(5): 1084-1091.
20. Vannucci F, Gonzalez-Rivas D. Is VATS lobectomy standard of care for operable non-small cell lung cancer? Lung Cancer, 2016, 100: 114-119.

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Outcome of thoracoscopic lobectomy for stageⅠ/Ⅱnon-small cell lung cancer

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