Advance in microRNAs and epidermal growth factor receptor mutation on metastasis of non-small cell lung cancer_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

SHEN Cheng , ZHOU Kun ,  CHE Guowei

Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, 610041, P.R.China;

Corresponding author：

CHE Guowei, Email: chebenben2005@163.com

Keywords：

MicroRNA; epidermal growth factor receptor; non-small cell lung cancer; metastasis

DOI：

10.7507/1007-4848.201707030

Video：

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Abstract Full text Figures/Tables Video References Cited by

MicroRNA (miRNA) is a noncoding RNA and protein involved in regulating gene expression in the transcription level. Epidermal growth factor receptor (EGFR) is a protein tyrosine kinase receptor and its mutations have been confirmed in non-small cell lung cancer (NSCLC) by a large number of studies in recent years. EGFR tyrosine kinase inhibitor (EGFR-TKI) is widely used for treatment of NSCLC patients with EGFR mutation. In recent years, miRNA is more and more important in tumor metastasis. The role of EGFR mutations in NSCLC has become a hot spot as well. New researches report that the relationship between miRNA and EGFR mutations plays an important role in NSCLC metastasis. Therefore, we write this review to discuss the mechanisms of miRNA and EGFR mutations in metastasis of NSCLC.

Citation： SHEN Cheng, ZHOU Kun, CHE Guowei. Advance in microRNAs and epidermal growth factor receptor mutation on metastasis of non-small cell lung cancer. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2018, 25(5): 440-444. doi: 10.7507/1007-4848.201707030 Copy

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2.	Li D, Wei Y, Wang D, et al. MicroRNA-26b suppresses the metastasis of non-small cell lung cancer by targeting MIEN1 via NF-kappaB/MMP-9/VEGF pathways. Biochem Biophys Res Commun, 2016, 472(3): 465-470.
3.	Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell, 1993, 75(5): 843-854.
4.	Kozomara A, Griffiths-Jones S. MiRBase: annotating high confidence microRNAs using deep sequencing data. Nucleic Acids Res, 2014, 42(Database issue): D68- D 73.
5.	Ling DJ, Chen ZS, Zhang YD, et al. MicroRNA-145 inhibits lung cancer cell metastasis. Mol Med Rep, 2015, 11(4): 3108-3114.
6.	Yamamoto H, Imai K. Microsatellite instability: an update. Arch Toxicol, 2015, 89(6): 899-921.
7.	Chen SW, Wang TB, Tian YH, et al. Down-regulation of microRNA-126 and microRNA-133b acts as novel predictor biomarkers in progression and metastasis of non small cell lung cancer. Int J Clin Exp Pathol, 2015, 8(11): 14983-14988.
8.	Parker LH, Schmidt M, Jin SW, et al. The endothelial-cell-derived secreted factor Egfl7 regulates vascular tube formation. Nature, 2004, 428(6984): 754-758.
9.	唐夏莉, 焦德敏, 陈君, 等. miRNA-126 对肺癌 A549 细胞的增殖、迁移、侵袭及 EGFR/AKT/mTOR 信号通路的影响. 中国病理生理杂志, 2016, 32(3): 216-220.
10.	Zhang Y, Yang P, Sun T, et al. miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis. Nat Cell Biol, 2013, 15(3): 284-294.
11.	Miko E, Margitai Z, Czimmerer Z, et al. miR-126 inhibits proliferation of small cell lung cancer cells by targeting SLC7A5. FEBS Lett, 2011, 585(8): 1191-1196.
12.	Crawford M, Brawner E, Batte K, et al. MicroRNA-126 inhibits invasion in non-small cell lung carcinoma cell lines. Biochem Biophys Res Commun, 2008, 373(4): 607-612.
13.	Liu B, Peng XC, Zheng XL, et al. MiR-126 restoration down-regulate VEGF and inhibit the growth of lung cancer cell lines in vitro and in vivo. Lung Cancer, 2009, 66(2): 169-175.
14.	Nakanishi H, Taccioli C, Palatini J, et al. Loss of miR-125b-1 contributes to head and neck cancer development by dysregulating TACSTD2 and MAPK pathway. Oncogene, 2014, 33(6): 702-712.
15.	Coskun M, Bjerrum JT, Seidelin JB, et al. miR-20b, miR-98, miR-125b-1, and let-7e as new potential diagnostic biomarkers in ulcerative colitis. World J Gastroenterol, 2013, 19(27): 4289-4299.
16.	Tsai CH, Lin LT, Wang CY, et al. Over-expression of cofilin-1 suppressed growth and invasion of cancer cells is associated with up-regulation of let-7 microRNA. Biochim Biophys Acta, 2015, 1852(5): 851-861.
17.	Zhu WY, Luo B, An JY, et al. Differential expression of miR-125a-5p and let-7e predicts the progression and prognosis of non-small cell lung cancer. Cancer Invest, 2014, 32(8): 394-401.
18.	Wang J, Li J, Shen J, et al. MicroRNA-182 downregulates metastasis suppressor 1 and contributes to metastasis of hepatocellular carcinoma. BMC Cancer, 2012, 12: 227.
19.	Rasheed SA, Teo CR, Beillard EJ, et al. MicroRNA-182 and microRNA-200a control G-protein subunit alpha-13 (GNA13) expression and cell invasion synergistically in prostate cancer cells. J Biol Chem, 2013, 288(11): 7986-7995.
20.	Yan D, Dong XD, Chen X, et al. Role of microRNA-182 in posterior uveal melanoma: regulation of tumor development through MITF, BCL2 and cyclin D2. PLoS One, 2012, 7(7): e40967.
21.	Wang M, Wang Y, Zang W, et al. Downregulation of microRNA-182 inhibits cell growth and invasion by targeting programmed cell death 4 in human lung adenocarcinoma cells. Tumour Biol, 2014, 35(1): 39-46.
22.	Ning FL, Wang F, Li ML, et al. MicroRNA-182 modulates chemosensitivity of human non-small cell lung cancer to cisplatin by targeting PDCD4. Diagn Pathol, 2014, 9: 143.
23.	Wang Y, Zhang ZX, Chen S, et al. Methylation status of SP1 sites within miR-23a-27a-24-2 promoter region influences laryngeal cancer cell proliferation and apoptosis. Biomed Res Int, 2016, 2016:2061248.
24.	Cao M, Seike M, Soeno C, et al. MiR-23a regulates TGF-beta-induced epithelial-mesenchymal transition by targeting E-cadherin in lung cancer cells. Int J Oncol, 2012, 41(3): 869-875.
25.	Meng W, Ye Z, Cui R, et al. MicroRNA-31 predicts the presence of lymph node metastases and survival in patients with lung adenocarcinoma. Clin Cancer Res, 2013, 19(19): 5423-5433.
26.	Konduri K, Gallant JN, Chae YK, et al. EGFR fusions as novel therapeutic targets in lung cancer. Cancer Discov, 2016, 6(6): 601-611.
27.	Cohen S. Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal. J Biol Chem, 1962, 237: 1555-1562.
28.	Lu Y, Fan Y. Combined action of EGFR tyrosine kinase inhibitors and whole-brain radiotherapy on EGFR-mutated non-small-cell lung cancer patients with brain metastasis. Onco Targets Ther, 2016, 9: 1135-1143.
29.	Jia XF, Li J, Zhao HB, et al. Correlation of EGFR gene amplification with invasion and metastasis of non-small cell lung cancer. Genet Mol Res, 2015, 14(3): 11006-11012.
30.	Castanon E, Rolfo C, Vinal D, et al. Impact of epidermal growth factor receptor (EGFR) activating mutations and their targeted treatment in the prognosis of stage IV non-small cell lung cancer (NSCLC) patients harboring liver metastasis. J Transl Med, 2015, 13: 257.
31.	Renaud S, Schaeffer M, Voegeli AC, et al. Impact of EGFR mutations and KRAS amino acid substitution on the response to radiotherapy for brain metastasis of non-small-cell lung cancer. Future Oncol, 2016, 12(1):59-70.
32.	Koo JS, Kim SH. EGFR and HER-2 status of non-small cell lung cancer brain metastasis and corresponding primary tumor. Neoplasma, 2011, 58(1):27-34.
33.	Matsumoto S, Takahashi K, Iwakawa R, et al. Frequent EGFR mutations in brain metastases of lung adenocarcinoma. Int J Cancer, 2006, 119(6):1491-1494.
34.	Aiken R. Molecular neuro-oncology and the challenge of the blood-brain barrier. Semin Oncol, 2014, 41(4):438-445.
35.	Kemper EM, Boogerd W, Thuis I, et al. Modulation of the blood-brain barrier in oncology: therapeutic opportunities for the treatment of brain tumours? Cancer Treat Rev, 2004, 30(5):415-423.
36.	Wang F, Fang P, Hou DY, et al. Comparison of epidermal growth factor receptor mutations between primary tumors and lymph nodes in non-small cell lung cancer: a review and meta-analysis of published data. Asian Pac J Cancer Prev, 2014, 15(11):4493-4497.
37.	陈晓林, 欧阳小平, 黄玉民, 等. MicroRNA-182 在非小细胞肺癌中的表达及临床意义.临床肺科杂志, 2015, 20(6):997-1000.
38.	Seike M, Goto A, Okano T, et al. MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers. Proc Natl Acad Sci U S A, 2009, 106(29):12085-12090.
39.	Hu J, Cheng Y, Li Y, et al. MicroRNA-128 plays a critical role in human non-small cell lung cancer tumourigenesis, angiogenesis and lymphangiogenesis by directly targeting vascular endothelial growth factor-C. Eur J Cancer, 2014, 50(13):2336-2350.
40.	Webster RJ, Giles KM, Price KJ, et al. Regulation of epidermal growth factor receptor signaling in human cancer cells by microRNA-7. J Biol Chem, 2009, 284(9):5731-5741.
41.	Guo YH, Gao FH, Shi J, et al. EGFR-ERK signaling pathway down-regulates miRNA-145 in lung cancer cells. Zhonghua Zhong Liu Za Zhi, 2013, 35(3):187-192.
42.	Li Y, Li Y, Liu J, et al. Expression levels of microRNA-145 and microRNA-10b are associated with metastasis in non-small cell lung cancer. Cancer Biol Ther, 2016, 17(3):272-279.
43.	王永生, 丁晶晶, 苗立云, 等. 人肺腺癌吉非替尼获得性耐药株 H1975 细胞与敏感株 PC9 细胞 miRNA 谱表达差异.中国肿瘤, 2013, 22(9):743-747.
44.	Chen D, Mei L, Zhou Y, et al. A novel differential diagnostic model for multiple primary lung cancer: Differentially-expressed gene analysis of multiple primary lung cancer and intrapulmonary metastasis. Oncol Lett, 2015, 9(3):1081-1088.

1. 马沙蕊, 宋刘梅, 李冬民. miRNA-497 在肿瘤中的研究进展.国外医学(医学地理分册), 2015, 136(1): 75-78.
2. Li D, Wei Y, Wang D, et al. MicroRNA-26b suppresses the metastasis of non-small cell lung cancer by targeting MIEN1 via NF-kappaB/MMP-9/VEGF pathways. Biochem Biophys Res Commun, 2016, 472(3): 465-470.
3. Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell, 1993, 75(5): 843-854.
4. Kozomara A, Griffiths-Jones S. MiRBase: annotating high confidence microRNAs using deep sequencing data. Nucleic Acids Res, 2014, 42(Database issue): D68- D 73.
5. Ling DJ, Chen ZS, Zhang YD, et al. MicroRNA-145 inhibits lung cancer cell metastasis. Mol Med Rep, 2015, 11(4): 3108-3114.
6. Yamamoto H, Imai K. Microsatellite instability: an update. Arch Toxicol, 2015, 89(6): 899-921.
7. Chen SW, Wang TB, Tian YH, et al. Down-regulation of microRNA-126 and microRNA-133b acts as novel predictor biomarkers in progression and metastasis of non small cell lung cancer. Int J Clin Exp Pathol, 2015, 8(11): 14983-14988.
8. Parker LH, Schmidt M, Jin SW, et al. The endothelial-cell-derived secreted factor Egfl7 regulates vascular tube formation. Nature, 2004, 428(6984): 754-758.
9. 唐夏莉, 焦德敏, 陈君, 等. miRNA-126 对肺癌 A549 细胞的增殖、迁移、侵袭及 EGFR/AKT/mTOR 信号通路的影响. 中国病理生理杂志, 2016, 32(3): 216-220.
10. Zhang Y, Yang P, Sun T, et al. miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis. Nat Cell Biol, 2013, 15(3): 284-294.
11. Miko E, Margitai Z, Czimmerer Z, et al. miR-126 inhibits proliferation of small cell lung cancer cells by targeting SLC7A5. FEBS Lett, 2011, 585(8): 1191-1196.
12. Crawford M, Brawner E, Batte K, et al. MicroRNA-126 inhibits invasion in non-small cell lung carcinoma cell lines. Biochem Biophys Res Commun, 2008, 373(4): 607-612.
13. Liu B, Peng XC, Zheng XL, et al. MiR-126 restoration down-regulate VEGF and inhibit the growth of lung cancer cell lines in vitro and in vivo. Lung Cancer, 2009, 66(2): 169-175.
14. Nakanishi H, Taccioli C, Palatini J, et al. Loss of miR-125b-1 contributes to head and neck cancer development by dysregulating TACSTD2 and MAPK pathway. Oncogene, 2014, 33(6): 702-712.
15. Coskun M, Bjerrum JT, Seidelin JB, et al. miR-20b, miR-98, miR-125b-1*, and let-7e* as new potential diagnostic biomarkers in ulcerative colitis. World J Gastroenterol, 2013, 19(27): 4289-4299.
16. Tsai CH, Lin LT, Wang CY, et al. Over-expression of cofilin-1 suppressed growth and invasion of cancer cells is associated with up-regulation of let-7 microRNA. Biochim Biophys Acta, 2015, 1852(5): 851-861.
17. Zhu WY, Luo B, An JY, et al. Differential expression of miR-125a-5p and let-7e predicts the progression and prognosis of non-small cell lung cancer. Cancer Invest, 2014, 32(8): 394-401.
18. Wang J, Li J, Shen J, et al. MicroRNA-182 downregulates metastasis suppressor 1 and contributes to metastasis of hepatocellular carcinoma. BMC Cancer, 2012, 12: 227.
19. Rasheed SA, Teo CR, Beillard EJ, et al. MicroRNA-182 and microRNA-200a control G-protein subunit alpha-13 (GNA13) expression and cell invasion synergistically in prostate cancer cells. J Biol Chem, 2013, 288(11): 7986-7995.
20. Yan D, Dong XD, Chen X, et al. Role of microRNA-182 in posterior uveal melanoma: regulation of tumor development through MITF, BCL2 and cyclin D2. PLoS One, 2012, 7(7): e40967.
21. Wang M, Wang Y, Zang W, et al. Downregulation of microRNA-182 inhibits cell growth and invasion by targeting programmed cell death 4 in human lung adenocarcinoma cells. Tumour Biol, 2014, 35(1): 39-46.
22. Ning FL, Wang F, Li ML, et al. MicroRNA-182 modulates chemosensitivity of human non-small cell lung cancer to cisplatin by targeting PDCD4. Diagn Pathol, 2014, 9: 143.
23. Wang Y, Zhang ZX, Chen S, et al. Methylation status of SP1 sites within miR-23a-27a-24-2 promoter region influences laryngeal cancer cell proliferation and apoptosis. Biomed Res Int, 2016, 2016:2061248.
24. Cao M, Seike M, Soeno C, et al. MiR-23a regulates TGF-beta-induced epithelial-mesenchymal transition by targeting E-cadherin in lung cancer cells. Int J Oncol, 2012, 41(3): 869-875.
25. Meng W, Ye Z, Cui R, et al. MicroRNA-31 predicts the presence of lymph node metastases and survival in patients with lung adenocarcinoma. Clin Cancer Res, 2013, 19(19): 5423-5433.
26. Konduri K, Gallant JN, Chae YK, et al. EGFR fusions as novel therapeutic targets in lung cancer. Cancer Discov, 2016, 6(6): 601-611.
27. Cohen S. Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal. J Biol Chem, 1962, 237: 1555-1562.
28. Lu Y, Fan Y. Combined action of EGFR tyrosine kinase inhibitors and whole-brain radiotherapy on EGFR-mutated non-small-cell lung cancer patients with brain metastasis. Onco Targets Ther, 2016, 9: 1135-1143.
29. Jia XF, Li J, Zhao HB, et al. Correlation of EGFR gene amplification with invasion and metastasis of non-small cell lung cancer. Genet Mol Res, 2015, 14(3): 11006-11012.
30. Castanon E, Rolfo C, Vinal D, et al. Impact of epidermal growth factor receptor (EGFR) activating mutations and their targeted treatment in the prognosis of stage IV non-small cell lung cancer (NSCLC) patients harboring liver metastasis. J Transl Med, 2015, 13: 257.
31. Renaud S, Schaeffer M, Voegeli AC, et al. Impact of EGFR mutations and KRAS amino acid substitution on the response to radiotherapy for brain metastasis of non-small-cell lung cancer. Future Oncol, 2016, 12(1):59-70.
32. Koo JS, Kim SH. EGFR and HER-2 status of non-small cell lung cancer brain metastasis and corresponding primary tumor. Neoplasma, 2011, 58(1):27-34.
33. Matsumoto S, Takahashi K, Iwakawa R, et al. Frequent EGFR mutations in brain metastases of lung adenocarcinoma. Int J Cancer, 2006, 119(6):1491-1494.
34. Aiken R. Molecular neuro-oncology and the challenge of the blood-brain barrier. Semin Oncol, 2014, 41(4):438-445.
35. Kemper EM, Boogerd W, Thuis I, et al. Modulation of the blood-brain barrier in oncology: therapeutic opportunities for the treatment of brain tumours? Cancer Treat Rev, 2004, 30(5):415-423.
36. Wang F, Fang P, Hou DY, et al. Comparison of epidermal growth factor receptor mutations between primary tumors and lymph nodes in non-small cell lung cancer: a review and meta-analysis of published data. Asian Pac J Cancer Prev, 2014, 15(11):4493-4497.
37. 陈晓林, 欧阳小平, 黄玉民, 等. MicroRNA-182 在非小细胞肺癌中的表达及临床意义.临床肺科杂志, 2015, 20(6):997-1000.
38. Seike M, Goto A, Okano T, et al. MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers. Proc Natl Acad Sci U S A, 2009, 106(29):12085-12090.
39. Hu J, Cheng Y, Li Y, et al. MicroRNA-128 plays a critical role in human non-small cell lung cancer tumourigenesis, angiogenesis and lymphangiogenesis by directly targeting vascular endothelial growth factor-C. Eur J Cancer, 2014, 50(13):2336-2350.
40. Webster RJ, Giles KM, Price KJ, et al. Regulation of epidermal growth factor receptor signaling in human cancer cells by microRNA-7. J Biol Chem, 2009, 284(9):5731-5741.
41. Guo YH, Gao FH, Shi J, et al. EGFR-ERK signaling pathway down-regulates miRNA-145 in lung cancer cells. Zhonghua Zhong Liu Za Zhi, 2013, 35(3):187-192.
42. Li Y, Li Y, Liu J, et al. Expression levels of microRNA-145 and microRNA-10b are associated with metastasis in non-small cell lung cancer. Cancer Biol Ther, 2016, 17(3):272-279.
43. 王永生, 丁晶晶, 苗立云, 等. 人肺腺癌吉非替尼获得性耐药株 H1975 细胞与敏感株 PC9 细胞 miRNA 谱表达差异.中国肿瘤, 2013, 22(9):743-747.
44. Chen D, Mei L, Zhou Y, et al. A novel differential diagnostic model for multiple primary lung cancer: Differentially-expressed gene analysis of multiple primary lung cancer and intrapulmonary metastasis. Oncol Lett, 2015, 9(3):1081-1088.

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Advance in microRNAs and epidermal growth factor receptor mutation on metastasis of non-small cell lung cancer

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