Application of different molecular imaging techniques in predicting the progress of abdominal aortic aneurysm_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

ZHU Guanglang , ZHANG Lei , SUN Huiying ,  ZHOU Jian ,  JING Zaiping

Department of Vascular Surgery, Changhai Hospital, Naval Military Medical University, Shanghai, 200433, P.R.China;

Corresponding author：

ZHOU Jian, Email: zhoujian1-2@163.com; JING Zaiping, Email: jingzpxueguan@smmu.edu.cn

Keywords：

Molecular Imaging; abdominal aortic aneurysm; progress

DOI：

10.7507/1007-4848.201711020

Video：

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Abdominal aortic aneurysm (AAA) is a common lethal aortic disease in clinical practice. At present, the imaging diagnostic methods used for AAA mainly include Doppler ultrasound, computed tomography and magnetic resonance imaging (MRI), but these methods can only observe the morphological changes of the aorta. These techniques used for the risk assessment of aneurysms, such as aneurysm rupture have some certain limitations. With the continuous development of molecular imaging technology and the further understanding of the pathogenesis of AAA, positron emission tomography (PET), molecular MRI and single photon emission computed tomography (SPECT) techniques can be used to observe the pathological changes of the AAA and assess the risk of rupture from cell and molecular level. In this paper, the latest application of PET, molecular MRI, SPECT in the risk assessment was discussed.

Citation： ZHU Guanglang, ZHANG Lei, SUN Huiying, ZHOU Jian, JING Zaiping. Application of different molecular imaging techniques in predicting the progress of abdominal aortic aneurysm. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2018, 25(6): 522-525. doi: 10.7507/1007-4848.201711020 Copy

1.	Sampson UK, Norman PE, Fowkes FG, et al. Global and regional burden of aortic dissection and aneurysms: mortality trends in 21 world regions, 1990 to 2010. Glob Heart, 2014, 9(1): 171-180.
2.	Huber TS, Wang JG, Derrow AE, et al. Experience in the United States with intact abdominal aortic aneurysm repair. J Vasc Surg, 2001, 33(2): 304-310.
3.	Nevitt MP, Ballard DJ, Hallett JW Jr. Prognosis of abdominal aortic aneurysms. A population-based study. N Engl J Med, 1989, 321(15): 1009-1014.
4.	Lederle FA, Johnson GR, Wilson SE, et al. Rupture rate of large abdominal aortic aneurysms in patients refusing or unfit for elective repair. JAMA, 2002, 287(22): 2968-2972.
5.	Li ZY, Sadat U, U-King-Im J, et al. Association between aneurysm shoulder stress and abdominal aortic aneurysm expansion: a longitudinal follow-up study. Circulation, 2010, 122(18): 1815-1822.
6.	Lee H, Paeng JC, Kim KH, et al. Correlation of FDG PET/CT findings with long-term growth and clinical course of abdominal aortic aneurysm. Nucl Med Mol Imaging, 2018, 52(1): 46-52.
7.	Siasos G, Mourouzis K, Oikonomou E, et al. The role of endothelial dysfunction in aortic aneurysms. Curr Pharm Des, 2015, 21(28): 4016-4034.
8.	Dale MA, Xiong W, Carson JS, et al. Elastin-derived peptides promote abdominal aortic aneurysm formation by modulating M1/M2 macrophage polarization. J Immunol, 2016, 196(11): 4536-4543.
9.	English SJ, Piert MR, Diaz JA, et al. Increased 18F-FDG uptake is predictive of rupture in a novel rat abdominal aortic aneurysm rupture model. Ann Surg, 2015, 261(2): 395-404.
10.	Jalalzadeh H, Indrakusuma R, Planken RN, et al. Inflammation as a predictor of abdominal aortic aneurysm growth and rupture: a systematic review of imaging biomarkers. Eur J Vasc Endovasc Surg, 2016, 52(3): 333-342.
11.	Sarda-Mantel L. et al. Comparison of 18F-fluoro-deoxyglucose, 18F-fluoro-methyl-choline, and 18F-DPA714 for positronemission tomography imaging of leukocyte accumulation in the aortic wall of experimental abdominal aneurysms. J Vasc Surg, 2012, 56: 765-773.
12.	MA3RS Study Investigators. Aortic wall inflammation predicts abdominal aortic aneurysm expansion, rupture, and need for surgical repair. Circulation, 2017, 136(9): 787-797.
13.	Courtois A, Nusgens BV, Hustinx R, et al. 18F-FDG uptake assessed by PET/CT in abdominal aortic aneurysms is associated with cellular and molecular alterations prefacing wall deterioration and rupture. J Nucl Med, 2013, 54(10): 1740-1747.
14.	Sakalihasan N, Van Damme H, Gomez P, et al. Positron emission tomography (PET) evaluation of abdominal aortic aneurysm (AAA). Eur J Vasc Endovasc Surg, 2002, 23(5): 431-436.
15.	Sakalihasan N, Hustinx R, Gomez P, et al. Can positron emission tomography (PET) predict the risk of rupture of abdominal aortic aneurysm (AAA)? Intern J Med Robot Comput Assist Surg, 2008, 6(4): 468-72.
16.	Truijers M, Kurvers HA, Bredie SJ, et al. In vivo imaging of abdominal aortic aneurysms: increased FDG uptake suggests inflammation in the aneurysm wall. J Endovasc Ther, 2008, 15(4): 462-467.
17.	Reeps C, Essler M, Pelisek J, et al. Increased 18F fluorodeoxyglucose uptake in abdominal aortic aneurysms in positron emission/computed tomography is associated with inflammation, aortic wall instability, and acute symptoms. J Vasc Surg, 2008, 48(2): 417-23.
18.	Tegler G, Ericson K, Srensen J, et al. Inflammation in the walls of asymptomatic abdominal aortic aneurysms is not associated with increased metabolic activity detectable by 18-fluorodeoxglucose positron-emission tomography. J Vasc Surg, 2012, 56(3): 802-807.
19.	Zhang Z, Liang K, Zou G, et al. Inhibition of miR-155 attenuates abdominal aortic aneurysm in mice by regulating macrophage-mediated inflammation. Biosci Rep, 2018. [Epub ahead of print].
20.	Zhang Z, Xu J, Liu Y, et al. Mouse macrophage specific knockout of SIRT1 influences macrophage polarization and promotes angiotensin II-induced abdominal aortic aneurysm formation. J Genet Genomics, 2018, 45(1): 25-32.
21.	Turner GH, Olzinski AR, Bernard RE, et al. Assessment of macrophage infiltration in a murine model of abdominal aortic aneurysm. J Magn Reson Imaging, 2009, 30(2): 455-460.
22.	Richards JM, Semple SI, MacGillivray TJ, et al. Abdominal aortic aneurysm growth predicted by uptake of ultrasmall superparamagnetic particles of iron oxide: a pilot study. Circ Cardiovasc Imaging, 2011, 4(3): 274-281.
23.	Sadat U, Taviani V, Patterson AJ, et al. Ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging of abdominal aortic aneurysms--a feasibility study. Eur J Vasc Endovasc Surg, 2011, 41(2): 167-174.
24.	McBride OM, Berry C, Burns P, et al. MRI using ultrasmall superparamagnetic particles of iron oxide in patients under surveillance for abdominal aortic aneurysms to predict rupture or surgical repair: MRI for abdominal aortic aneurysms to predict rupture or surgery-the MA(3)RS study. Open Heart, 2015, 2(1): e000190.
25.	Kokje VB, Hamming JF, Lindeman JH. Editor's choice-pharmaceutical management of small abdominal aortic aneurysms: a systematic review of the clinical evidence. Eur J Vasc Endovasc Surg, 2015, 50(6): 702-713.
26.	Madsen MT. Recent advances in SPECT imaging. J Nucl Med, 2007, 48(4): 661-673.
27.	Lambert CT, Jaber W. No fire in the belly: SPECT diagnosis of ruptured abdominal aortic aneurysm. J Nucl Cardiol, 2018, 25(1):351-355.
28.	Ramaswamy AK, Hamilton M, Joshi RV, et al. Molecular imaging of experimental abdominal aortic aneurysms. Sci World J, 2013, 973150.
29.	Razavian M, Zhang J, Nie L, et al. Molecular imaging of matrix metalloproteinase activation to predict murine aneurysm expansion in vivo. J Nucl Med, 2010, 51(7): 1107-1115.
30.	Golestani R, Razavian M, Nie L, et al. Imaging vessel wall biology to predict outcome in abdominal aortic aneurysm. Circ Cardiovasc Imaging, 2014, 8(1): pii: e002471.

1. Sampson UK, Norman PE, Fowkes FG, et al. Global and regional burden of aortic dissection and aneurysms: mortality trends in 21 world regions, 1990 to 2010. Glob Heart, 2014, 9(1): 171-180.
2. Huber TS, Wang JG, Derrow AE, et al. Experience in the United States with intact abdominal aortic aneurysm repair. J Vasc Surg, 2001, 33(2): 304-310.
3. Nevitt MP, Ballard DJ, Hallett JW Jr. Prognosis of abdominal aortic aneurysms. A population-based study. N Engl J Med, 1989, 321(15): 1009-1014.
4. Lederle FA, Johnson GR, Wilson SE, et al. Rupture rate of large abdominal aortic aneurysms in patients refusing or unfit for elective repair. JAMA, 2002, 287(22): 2968-2972.
5. Li ZY, Sadat U, U-King-Im J, et al. Association between aneurysm shoulder stress and abdominal aortic aneurysm expansion: a longitudinal follow-up study. Circulation, 2010, 122(18): 1815-1822.
6. Lee H, Paeng JC, Kim KH, et al. Correlation of FDG PET/CT findings with long-term growth and clinical course of abdominal aortic aneurysm. Nucl Med Mol Imaging, 2018, 52(1): 46-52.
7. Siasos G, Mourouzis K, Oikonomou E, et al. The role of endothelial dysfunction in aortic aneurysms. Curr Pharm Des, 2015, 21(28): 4016-4034.
8. Dale MA, Xiong W, Carson JS, et al. Elastin-derived peptides promote abdominal aortic aneurysm formation by modulating M1/M2 macrophage polarization. J Immunol, 2016, 196(11): 4536-4543.
9. English SJ, Piert MR, Diaz JA, et al. Increased 18F-FDG uptake is predictive of rupture in a novel rat abdominal aortic aneurysm rupture model. Ann Surg, 2015, 261(2): 395-404.
10. Jalalzadeh H, Indrakusuma R, Planken RN, et al. Inflammation as a predictor of abdominal aortic aneurysm growth and rupture: a systematic review of imaging biomarkers. Eur J Vasc Endovasc Surg, 2016, 52(3): 333-342.
11. Sarda-Mantel L. et al. Comparison of 18F-fluoro-deoxyglucose, 18F-fluoro-methyl-choline, and 18F-DPA714 for positronemission tomography imaging of leukocyte accumulation in the aortic wall of experimental abdominal aneurysms. J Vasc Surg, 2012, 56: 765-773.
12. MA3RS Study Investigators. Aortic wall inflammation predicts abdominal aortic aneurysm expansion, rupture, and need for surgical repair. Circulation, 2017, 136(9): 787-797.
13. Courtois A, Nusgens BV, Hustinx R, et al. 18F-FDG uptake assessed by PET/CT in abdominal aortic aneurysms is associated with cellular and molecular alterations prefacing wall deterioration and rupture. J Nucl Med, 2013, 54(10): 1740-1747.
14. Sakalihasan N, Van Damme H, Gomez P, et al. Positron emission tomography (PET) evaluation of abdominal aortic aneurysm (AAA). Eur J Vasc Endovasc Surg, 2002, 23(5): 431-436.
15. Sakalihasan N, Hustinx R, Gomez P, et al. Can positron emission tomography (PET) predict the risk of rupture of abdominal aortic aneurysm (AAA)? Intern J Med Robot Comput Assist Surg, 2008, 6(4): 468-72.
16. Truijers M, Kurvers HA, Bredie SJ, et al. In vivo imaging of abdominal aortic aneurysms: increased FDG uptake suggests inflammation in the aneurysm wall. J Endovasc Ther, 2008, 15(4): 462-467.
17. Reeps C, Essler M, Pelisek J, et al. Increased 18F fluorodeoxyglucose uptake in abdominal aortic aneurysms in positron emission/computed tomography is associated with inflammation, aortic wall instability, and acute symptoms. J Vasc Surg, 2008, 48(2): 417-23.
18. Tegler G, Ericson K, Srensen J, et al. Inflammation in the walls of asymptomatic abdominal aortic aneurysms is not associated with increased metabolic activity detectable by 18-fluorodeoxglucose positron-emission tomography. J Vasc Surg, 2012, 56(3): 802-807.
19. Zhang Z, Liang K, Zou G, et al. Inhibition of miR-155 attenuates abdominal aortic aneurysm in mice by regulating macrophage-mediated inflammation. Biosci Rep, 2018. [Epub ahead of print].
20. Zhang Z, Xu J, Liu Y, et al. Mouse macrophage specific knockout of SIRT1 influences macrophage polarization and promotes angiotensin II-induced abdominal aortic aneurysm formation. J Genet Genomics, 2018, 45(1): 25-32.
21. Turner GH, Olzinski AR, Bernard RE, et al. Assessment of macrophage infiltration in a murine model of abdominal aortic aneurysm. J Magn Reson Imaging, 2009, 30(2): 455-460.
22. Richards JM, Semple SI, MacGillivray TJ, et al. Abdominal aortic aneurysm growth predicted by uptake of ultrasmall superparamagnetic particles of iron oxide: a pilot study. Circ Cardiovasc Imaging, 2011, 4(3): 274-281.
23. Sadat U, Taviani V, Patterson AJ, et al. Ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging of abdominal aortic aneurysms--a feasibility study. Eur J Vasc Endovasc Surg, 2011, 41(2): 167-174.
24. McBride OM, Berry C, Burns P, et al. MRI using ultrasmall superparamagnetic particles of iron oxide in patients under surveillance for abdominal aortic aneurysms to predict rupture or surgical repair: MRI for abdominal aortic aneurysms to predict rupture or surgery-the MA(3)RS study. Open Heart, 2015, 2(1): e000190.
25. Kokje VB, Hamming JF, Lindeman JH. Editor's choice-pharmaceutical management of small abdominal aortic aneurysms: a systematic review of the clinical evidence. Eur J Vasc Endovasc Surg, 2015, 50(6): 702-713.
26. Madsen MT. Recent advances in SPECT imaging. J Nucl Med, 2007, 48(4): 661-673.
27. Lambert CT, Jaber W. No fire in the belly: SPECT diagnosis of ruptured abdominal aortic aneurysm. J Nucl Cardiol, 2018, 25(1):351-355.
28. Ramaswamy AK, Hamilton M, Joshi RV, et al. Molecular imaging of experimental abdominal aortic aneurysms. Sci World J, 2013, 973150.
29. Razavian M, Zhang J, Nie L, et al. Molecular imaging of matrix metalloproteinase activation to predict murine aneurysm expansion in vivo. J Nucl Med, 2010, 51(7): 1107-1115.
30. Golestani R, Razavian M, Nie L, et al. Imaging vessel wall biology to predict outcome in abdominal aortic aneurysm. Circ Cardiovasc Imaging, 2014, 8(1): pii: e002471.

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