Analysis of the survival time in 302 elderly patients with esophageal cancer_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

LIU Jingjing ¹ , LIU Yishan ² , ZHU Lei ¹ , LU Jiaju ¹ , SHI Jiang ¹ , XUE Hong ¹ , YUE Hanxun ¹ ,  LIU Jian ³

1. The First Clinical Medical College of Lanzhou University, Lanzhou, 730000, P.R.China;
2. Clinical Medical College of Zhongshan University, Guangzhou, 528400, P.R.China;
3. Deparment of ICU, The First Hospital of Lanzhou University, Lanzhou, 730000, P.R.China;

Corresponding author：

LIU Jian, Email: medecinliu@sina.com

Keywords：

Elderly; esophageal cancer; survival time; factors; treatment

DOI：

10.7507/1007-4848.201804058

Video：

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Objective To explore the possible factors which influence the survival time of elderly patients with esophageal cancer.Methods We retrospectively analyzed the data of patients with esophageal cancer treated in the First Hospital of Lanzhou University, Gansu Province Tumor Hospital from January 2012 to October 2016. Kaplan-Meier method was used to estimate and analyze the single factor, survival curve with log-rank test. The Cox regression model was used for multivariate prognostic analysis．Results According to the inclusion and exclusion criteria, 302 patients were eventually collected, including 231 males and 71 females, with an average age of 66.0±6.0 years. The univariate analysis showed that age, tumor stage, tumor site, Karnosfsky performance satus (KPS) score, and treatment were prognostic factors (P<0.05). Multivariate analysis showed that the patient age and treatment were independent factors for overall survival (OS) and progress-free survival (PFS) (P<0.05). The OS and PFS of the patients with age≤70 years were better than those of the patients more than 70 years. Chemotherapy alone and surgery alone was better for survival situation than radiotherapy alone.Conclusion Age and treatment are independent prognostic factors in survival time of the elderly patients with esophageal cancer.

Citation： LIU Jingjing, LIU Yishan, ZHU Lei, LU Jiaju, SHI Jiang, XUE Hong, YUE Hanxun, LIU Jian. Analysis of the survival time in 302 elderly patients with esophageal cancer. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2019, 26(1): 83-87. doi: 10.7507/1007-4848.201804058 Copy

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15.	王玉祥, 王军, 祝淑钗, 等. 老年食管癌三维适形与调强放射治疗疗效比较. 肿瘤防治研究, 2012, 39(8): 1008-1013.
16.	曹小琴, 孙喜斌. 食管癌发病水平及变化趋势. 中国肿瘤临床, 2016, 43(21): 932-936.
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1. Jemal A, Bray F, Center MM. Global cancer statistics, 2011. CA Cancer J Clin, 2011, 61(2): 69.
2. Ferlay J, Soerjomataram I, Dikshit R, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer, 2015, 136(5): E359.
3. Chen W, Zheng R, Baade P D, et al. Cancer statistics in China, 2015. CA Cancer J Clin, 2016, 66(2): 115.
4. Chen WQ, Peng XB. Prevention and control of common digestive carcinoma. Beijing: Military Medical Science press, 2014. 42-45.
5. Thallinger CM, Kiesewetter B, Raderer M, et al. Pre- and postoperative treatment modalities for esophageal squamous cell carcinoma. Anticancer Res, 2012, 32(11): 4609.
6. Stephen B. The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol, 2010, 17(6): 1471-1474.
7. Yamashita H, Okuma K, Wakui R, et al. Details of recurrence sites after elective nodal irradiation (ENI) using 3D-conformal radiotherapy (3D-CRT) combined with chemotherapy for thoracic esophageal squamous cell carcinoma--a retrospective analysis. Radiother Oncol, 2011, 98(2): 255-260.
8. Carter HE, Martin A, Schofield D, et al. A decision model to estimate the cost-effectiveness of intensity modulated radiation therapy (IMRT) compared to three dimensional conformal radiation therapy (3DCRT) in patients receiving radiotherapy to the prostate bed. Radiother Oncol, 2014, 112(2): 187-193.
9. 张安度, 韩春, 兰堃田, 等. 食管鳞癌3DCRT患者年龄与预后分析. 中华放射肿瘤学杂志, 2014, 23(5): 392-395.
10. Tougeron D, Hamidou H, Scotté M, et al. Esophageal cancer in the elderly: an analysis of the factors associated with treatment decisions and outcomes. BMC Cancer, 2010, 10(1): 1-10.
11. Hagiwara K, Kochi M, Fujii M, et al. Radiochemotherapy for esophageal squamous cell carcinoma in elderly patients. Hepato-gastroenterology, 2014, 61(134): 1617-1622.
12. 王澜, 孔洁, 韩春, 等. 781例不同部位食管癌三维放疗预后分析. 中华放射肿瘤学杂志, 2013, 22(1): 18-21.
13. 陈丽, 汪步海, 戴尔珣, 等. 90例不同部位食管癌同步放化疗后疗效分析. 国际肿瘤学杂志, 2016, 43(3): 177-179.
14. 张安度, 孔洁, 刘丽虹,等. 1349例食管癌三维适形放疗疗效及预后分析. 四川医学, 2015, 6: 774-778.
15. 王玉祥, 王军, 祝淑钗, 等. 老年食管癌三维适形与调强放射治疗疗效比较. 肿瘤防治研究, 2012, 39(8): 1008-1013.
16. 曹小琴, 孙喜斌. 食管癌发病水平及变化趋势. 中国肿瘤临床, 2016, 43(21): 932-936.
17. Liu J, Xue L, Zhen F, et al. Efficacy and safety of chemoradiation therapy compared with chemotherapy for esophageal carcinoma: An updated meta-analysis of randomized controlled trials. Medicine (Baltimore), 2017, 96(47): e8929.
18. Kumagai K, Mariosa D, Tsai J A, et al. Systematic review and meta-analysis on the significance of salvage esophagectomy for persistent or recurrent esophageal squamous cell carcinoma after definitive chemoradiotherapy. Dis Esophagus, 2016, 29(7): 734-739.
19. Ajani JA, D'Amico TA, Almhanna K, et al. Esophageal and esophagogastric junction cancers, version 1 1.2015. J Natl Compr Canc Netw, 2015, 13(2): 194-227.

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Analysis of the survival time in 302 elderly patients with esophageal cancer

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