MENG Yanhai 1 , YU Haiyun 2 , WANG Shuiyun 3 , YANG Keming 3 , CHANG Shuo 1 , HUANG Haibo 1 , JU Fan 1 , ZHANG Yanbo 1
  • 1. Center 2 of Adult Surgical Recovery, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, P.R.China;
  • 2. Department of Pathology, Beijing Obstetrics and Gynecology Hospital Affiliated to Capital Medical University, Beijing, 100026, P.R.China;
  • 3. Department of Cardiac Surgery, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, P.R.China;
ZHANG Yanbo, Email: yanbozhang@126.com
Tetralogy of fallot; pulmonary valve replacement; reoperation
10.7507/1007-4848.201902029
Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables References Cited by

Objective To evaluate the clinical outcomes of pulmonary valve replacement (PVR) in patients with tetralogy of Fallot (TOF) after re-PVR surgery.Methods PubMed, EMbase, the Cochrane Controlled Trials Register databases, CNKI, CBM disc and VIP datebases were searched, and study eligibility and data abstraction were determined independently and in duplicate. Literature searches from database establishment to December 2018. The heterogeneity and data were analyzed by the software of Stata 11.0.Results Of 4 831 studies identified, 26 studies met eligibility criteria, and invovled with a total of 3 613 patients. The combined 30-day mortality for PVR was 2.2% (95% CI 1.5%-3.1%) and follow-up mortality was 3.4% (95% CI 2.4%-4.9%), re-PVR rate was 6.8% (95% CI 5.1%-9.2%), and the rate of intervention was 11.4% (95% CI 8.0%-16.4%). Subgroup analysis showed that the patient's age range may be a heterogeneous source of mortality during the follow-up period, and there was no statistical heterogeneity for adult patients (P=0.63, I2=0%), with a lower incidence than those including adolescents patients. The type of valve was likely to be a source of retrospective PVR. There was no statistical heterogeneity in bioprosthetic valves and allograft lobes (P=0.24, I2=25%). And the incidence of re-PVR was lower than that of the mechanical valve patients. Heart function classification (NYHA) of patients with TOF after PVR was statistically improved (P<0.05). Electrocardiogram QRS change was not statistically differently (P>0.05). Postoperative MRI findings showed a decrease in RVEDV, an increase in RVEF, a decrease in RV/LV ratio, and a decrease in pulmonary valve (all P<0.05). Funnel map monitoring, Begg test and Egger's test both indicated that there was no publication bias.Conclusions According to the results of the analysis, PVR after TOF surgery is a more mature surgery, the clinical effect was significant, with lower early and long-term mortality. The long-term mortality rate of adolescent patients undergoing PVR is higher than that of adult patients. Long-term outocme of re-PVR or re-intervention is still the main problem affecting the effect of the operation. Indications for surgery and choice of valve need further investigation.

Citation： MENG Yanhai, YU Haiyun, WANG Shuiyun, YANG Keming, CHANG Shuo, HUANG Haibo, JU Fan, ZHANG Yanbo. Clinical effects of pulmonary valve replacement after tetralogy of Fallot repair: A systematic review and meta-analysis. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2019, 26(12): 1239-1246. doi: 10.7507/1007-4848.201902029 Copy

  • Previous Article

    Surgical treatment for hypertrophic obstructive cardiomyopathy associated with aortic stenosis

  • Next Article

    Association between preoperative red cell distribution width and prognosis in esophageal cancer: A systematic review and meta-analysis