Application progress of perioperative intravenous lidocaine injection in thoracic surgery_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

SHI Wei ¹ , REN Yifeng ² ,  YU Hai ¹

1. Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, 610041, P.R.China;
2. Department of Anesthesiology, First Affiliated Hospital of Henan University, Kaifeng, 475001, Henan, P.R.China;

Corresponding author：

YU Hai, Email: yuhaishan117@yahoo.com

Keywords：

Perioperation; intravenous injection; lidocaine; thoracic surgery

DOI：

10.7507/1007-4848.201908056

Video：

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Lidocaine is an amide local anaesthetic. In recent years, clinical evidence shows that perioperative intravenous lidocaine injection plays an active role in anti-inflammation, analgesia, anti-tumor and organ protection. Postoperative pain is severe in patients after thoracic surgery, and the incidence of pulmonary complications and cognitive impairment is high. These adverse reactions and complications are closely related to the inflammatory reaction after thoracic surgery. Intravenous infusion of lidocaine may have some effects on alleviating these adverse reactions and complications. Thus, this article reviews the current status of intravenous lidocaine injection in thoracic surgery and explores the related mechanisms to optimize the management of anaesthesia during the perioperative period of thoracic surgery.

Citation： SHI Wei, REN Yifeng, YU Hai. Application progress of perioperative intravenous lidocaine injection in thoracic surgery. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2020, 27(5): 579-583. doi: 10.7507/1007-4848.201908056 Copy

1.	Geil D, Thomas C, Zimmer A, et al. Chronified pain following operative procedures. Dtsch Arztebl Int, 2019, 116(15): 261-266.
2.	Peng Z, Li H, Zhang C, et al. A retrospective study of chronic post-surgical pain following thoracic surgery: prevalence, risk factors, incidence of neuropathic component, and impact on qualify of life. PLoS One, 2014, 9(2): e90014.
3.	Cui W, Li Y, Li S, et al. Systemic administration of lidocaine reduces morphine requirements and postoperative pain of patients undergoing thoracic surgery after propofol-remifentanil-based anaesthesia. Eur J Anaesthesiol, 2010, 27(1): 41-46.
4.	朱云柯, 林琳, 廖虎, 等. 中国胸外科围手术期疼痛管理专家共识(2018 版). 中国胸心血管外科临床杂志, 2018, 25(11): 921-928.
5.	刘子嘉, 张良燕, 郑旭光, 等. 术中利多卡因持续静脉泵入对胸腔镜肺叶切除术患者阿片类用量及术后恢复的影响. 中国医学科学院学报, 2018, 40(2): 163-169.
6.	王萍, 丁登峰, 张俊志, 等. 静脉注射利多卡因对胸腔镜肺大疱切除术患者镇痛的影响. 中国实验诊断学, 2015, 19(7): 1134-1137.
7.	Weibel S, Jelting Y, Pace NL, et al. Continuous intravenous perioperative lidocaine infusion for postoperative pain and recovery in adults. Cochrane Database Syst Rev, 2018, 6: CD009642.
8.	Piccioni F, Segat M, Falini S, et al. Enhanced recovery pathways in thoracic surgery from Italian VATS Group: perioperative analgesia protocols. J Thorac Dis, 2018, 10(Suppl 4): S555-S563.
9.	Slovack M, Taylor B, Bryce R, et al. Does intravenous lidocaine infusion during video-assisted thoracoscopic surgery reduce postoperative analgesia? A randomized controlled study. Can J Anaesth, 2015, 62(6): 676-677.
10.	曲鸣宇. 利多卡因与右美托咪啶在胸腔镜患者术后恢复的比较研究. 大连医科大学, 2017.
11.	Khan JS, Yousuf M, Victor JC, et al. An estimation for an appropriate end time for an intraoperative intravenous lidocaine infusion in bowel surgery: a comparative meta-analysis. J Clin Anesth, 2016, 28: 95-104.
12.	Kosharskyy B, Almonte W, Shaparin N, et al. Intravenous infusions in chronic pain management. Pain Physician, 2013, 16(3): 231-249.
13.	Moulin DE, Morley-Forster PK, Pirani Z, et al. Intravenous lidocaine in the management of chronic peripheral neuropathic pain: a randomized-controlled trial. Can J Anaesth, 2019, 66(7): 820-827.
14.	Bailey M, Corcoran T, Schug S, et al. Perioperative lidocaine infusions for the prevention of chronic postsurgical pain: a systematic review and meta-analysis of efficacy and safety. Pain, 2018, 159(9): 1696-1704.
15.	Kuo CP, Jao SW, Chen KM, et al. Comparison of the effects of thoracic epidural analgesia and i.v. infusion with lidocaine on cytokine response, postoperative pain and bowel function in patients undergoing colonic surgery. Br J Anaesth, 2006, 97(5): 640-646.
16.	van der Wal SE, van den Heuvel SA, Radema SA, et al. The in vitro mechanisms and in vivo efficacy of intravenous lidocaine on the neuroinflammatory response in acute and chronic pain. Eur J Pain, 2016, 20(5): 655-674.
17.	Yang W, Geng Y, Liu Y, et al. Comparison of effects of thoracic epidural and intravenous administration of lidocaine on target-controlled infusion of propofol and tracheal intubation response during induction of anesthesia. J Cardiothorac Vasc Anesth, 2013, 27(6): 1295-1300.
18.	郭红利. 不同剂量利多卡因对老年胸腔镜肺切除术患者术后谵妄的影响. 西南医科大学, 2018.
19.	胡秀才, 齐英凯, 韩倩, 等. 利多卡因静脉注射对双腔气管导管插管麻醉期间气道压力的影响. 中国实用医药, 2016, 11(21): 29-30.
20.	Shuying L, Ping L, Juan N, et al. Different interventions in preventing opioid-induced cough: a meta-analysis. J Clin Anesth, 2016, 34: 440-447.
21.	Ljungqvist O, Scott M, Fearon KC. Enhanced recovery after surgery: a review. JAMA Surg, 2017, 152(3): 292-298.
22.	Suarez MA, Seddighi R, Egger CM, et al. Effect of fentanyl and lidocaine on the end-tidal sevoflurane concentration preventing motor movement in dogs. Am J Vet Res, 2017, 78(1): 12-16.
23.	王萍, 李亚丽, 罗耀文, 等. 静注利多卡因对老年胸腔镜肺叶切除患者术后谵妄的影响. 实用医学杂志, 2015, 31(16): 2740-2742.
24.	Kulason K, Nouchi R, Hoshikawa Y, et al. Indication of cognitive change and associated risk factor after thoracic surgery in the elderly: a pilot study. Front Aging Neurosci, 2017, 9: 396.
25.	Gholipour Baradari A, Habibi MR, Habibi V, et al. Administration of lidocaine to prevent cognitive deficit in patients undergoing coronary artery bypass grafting and valve plasty: a systematic review and meta-analysis. Expert Rev Clin Pharmacol, 2017, 10(2): 179-185.
26.	游仁芳, 许福生, 王少平. 利多卡因对老年肺癌根治术患者围术期脑氧代谢及术后早期认知功能影响. 临床军医杂志, 2016, 44(1): 64-67, 71.
27.	Habibi MR, Habibi V, Habibi A, et al. Lidocaine dose-response effect on postoperative cognitive deficit: meta-analysis and meta-regression. Expert Rev Clin Pharmacol, 2018, 11(4): 361-371.
28.	黄重峰, 焦丰, 陈华敏, 等. 围手术期利多卡因干预对老年胸科手术患者炎症因子及术后认知功能的影响. 现代医院, 2017, 17(3): 418-420, 424.
29.	叶治, 郭曲练. 利多卡因的脑保护机制. 国际病理科学与临床杂志, 2007, 27(5): 448-452.
30.	吴德华, 马静雅, 徐益萍, 等. 不同麻醉方法下胸科手术老年病人术中房颤发生的比较: 大样本临床研究. 中华麻醉学杂志, 2017, 37(1): 34-38.
31.	Onorati F, Dobson GP, San Biagio L, et al. Superior myocardial protection using "polarizing" adenosine, lidocaine, and Mg²⁺ cardioplegia in humans. J Am Coll Cardiol, 2016, 67(14): 1751-1753.
32.	Kaczmarek DJ, Herzog C, Larmann J, et al. Lidocaine protects from myocardial damage due to ischemia and reperfusion in mice by its antiapoptotic effects. Anesthesiology, 2009, 110(5): 1041-1049.
33.	王天佑. 胸外科围手术期肺保护中国专家共识(2019 版). 中国胸心血管外科临床杂志, 2019, 26(9): 835-842.
34.	Misthos P, Katsaragakis S, Theodorou D, et al. The degree of oxidative stress is associated with major adverse effects after lung resection: a prospective study. Eur J Cardiothorac Surg, 2006, 29(4): 591-595.
35.	Rancan L, Simón C, Marchal-Duval E, et al. Lidocaine administration controls microRNAs alterations observed after lung ischemia-reperfusion injury. Anesth Analg, 2016, 123(6): 1437-1447.
36.	陈菲, 马良, 王忠慧. 利多卡因对单肺通气围术期患者氧化应激反应的干预作用. 昆明医科大学学报, 2015, 36(12): 77-79.
37.	袁林芳, 赵文静, 刘月, 等. 围术期静脉输注利多卡因对食管癌患者的肺保护作用研究. 中国全科医学, 2019. [Epub ahead of print].
38.	Chen LJ, Ding YB, Ma PL, et al. The protective effect of lidocaine on lipopolysaccharide-induced acute lung injury in rats through NF-κB and p38 MAPK signaling pathway and excessive inflammatory responses. Eur Rev Med Pharmacol Sci, 2018, 22(7): 2099-2108.
39.	Ohi M, Toiyama Y, Omura Y, et al. Risk factors and measures of pulmonary complications after thoracoscopic esophagectomy for esophageal cancer. Surg Today, 2019, 49(2): 176-186.
40.	Hogan BV, Peter MB, Shenoy HG, et al. Surgery induced immunosuppression. Surgeon, 2011, 9(1): 38-43.
41.	Freeman J, Crowley PD, Foley AG, et al. Effect of perioperative lidocaine, propofol and steroids on pulmonary metastasis in a murine model of breast cancer surgery. Cancers (Basel), 2019, 11(5): pii: E613.
42.	Xing W, Chen DT, Pan JH, et al. Lidocaine induces apoptosis and suppresses tumor growth in human hepatocellular carcinoma cells in vitro and in a xenograft model in vivo. Anesthesiology, 2017, 126(5): 868-881.
43.	Lucchinetti E, Awad AE, Rahman M, et al. Antiproliferative effects of local anesthetics on mesenchymal stem cells: potential implications for tumor spreading and wound healing. Anesthesiology, 2012, 116(4): 841-856.
44.	Gao J, Hu H, Wang X. Clinically relevant concentrations of lidocaine inhibit tumor angiogenesis through suppressing VEGF/VEGFR2 signaling. Cancer Chemother Pharmacol, 2019, 83(6): 1007-1015.
45.	Beaussier M, Parc Y, Guechot J, et al. Ropivacaine preperitoneal wound infusion for pain relief and prevention of incisional hyperalgesia after laparoscopic colorectal surgery: a randomized, triple-arm, double-blind controlled evaluation vs. intravenous lidocaine infusion, the CATCH study. Colorectal Dis, 2018, 20(6): 509-519.

1. Geil D, Thomas C, Zimmer A, et al. Chronified pain following operative procedures. Dtsch Arztebl Int, 2019, 116(15): 261-266.
2. Peng Z, Li H, Zhang C, et al. A retrospective study of chronic post-surgical pain following thoracic surgery: prevalence, risk factors, incidence of neuropathic component, and impact on qualify of life. PLoS One, 2014, 9(2): e90014.
3. Cui W, Li Y, Li S, et al. Systemic administration of lidocaine reduces morphine requirements and postoperative pain of patients undergoing thoracic surgery after propofol-remifentanil-based anaesthesia. Eur J Anaesthesiol, 2010, 27(1): 41-46.
4. 朱云柯, 林琳, 廖虎, 等. 中国胸外科围手术期疼痛管理专家共识(2018 版). 中国胸心血管外科临床杂志, 2018, 25(11): 921-928.
5. 刘子嘉, 张良燕, 郑旭光, 等. 术中利多卡因持续静脉泵入对胸腔镜肺叶切除术患者阿片类用量及术后恢复的影响. 中国医学科学院学报, 2018, 40(2): 163-169.
6. 王萍, 丁登峰, 张俊志, 等. 静脉注射利多卡因对胸腔镜肺大疱切除术患者镇痛的影响. 中国实验诊断学, 2015, 19(7): 1134-1137.
7. Weibel S, Jelting Y, Pace NL, et al. Continuous intravenous perioperative lidocaine infusion for postoperative pain and recovery in adults. Cochrane Database Syst Rev, 2018, 6: CD009642.
8. Piccioni F, Segat M, Falini S, et al. Enhanced recovery pathways in thoracic surgery from Italian VATS Group: perioperative analgesia protocols. J Thorac Dis, 2018, 10(Suppl 4): S555-S563.
9. Slovack M, Taylor B, Bryce R, et al. Does intravenous lidocaine infusion during video-assisted thoracoscopic surgery reduce postoperative analgesia? A randomized controlled study. Can J Anaesth, 2015, 62(6): 676-677.
10. 曲鸣宇. 利多卡因与右美托咪啶在胸腔镜患者术后恢复的比较研究. 大连医科大学, 2017.
11. Khan JS, Yousuf M, Victor JC, et al. An estimation for an appropriate end time for an intraoperative intravenous lidocaine infusion in bowel surgery: a comparative meta-analysis. J Clin Anesth, 2016, 28: 95-104.
12. Kosharskyy B, Almonte W, Shaparin N, et al. Intravenous infusions in chronic pain management. Pain Physician, 2013, 16(3): 231-249.
13. Moulin DE, Morley-Forster PK, Pirani Z, et al. Intravenous lidocaine in the management of chronic peripheral neuropathic pain: a randomized-controlled trial. Can J Anaesth, 2019, 66(7): 820-827.
14. Bailey M, Corcoran T, Schug S, et al. Perioperative lidocaine infusions for the prevention of chronic postsurgical pain: a systematic review and meta-analysis of efficacy and safety. Pain, 2018, 159(9): 1696-1704.
15. Kuo CP, Jao SW, Chen KM, et al. Comparison of the effects of thoracic epidural analgesia and i.v. infusion with lidocaine on cytokine response, postoperative pain and bowel function in patients undergoing colonic surgery. Br J Anaesth, 2006, 97(5): 640-646.
16. van der Wal SE, van den Heuvel SA, Radema SA, et al. The in vitro mechanisms and in vivo efficacy of intravenous lidocaine on the neuroinflammatory response in acute and chronic pain. Eur J Pain, 2016, 20(5): 655-674.
17. Yang W, Geng Y, Liu Y, et al. Comparison of effects of thoracic epidural and intravenous administration of lidocaine on target-controlled infusion of propofol and tracheal intubation response during induction of anesthesia. J Cardiothorac Vasc Anesth, 2013, 27(6): 1295-1300.
18. 郭红利. 不同剂量利多卡因对老年胸腔镜肺切除术患者术后谵妄的影响. 西南医科大学, 2018.
19. 胡秀才, 齐英凯, 韩倩, 等. 利多卡因静脉注射对双腔气管导管插管麻醉期间气道压力的影响. 中国实用医药, 2016, 11(21): 29-30.
20. Shuying L, Ping L, Juan N, et al. Different interventions in preventing opioid-induced cough: a meta-analysis. J Clin Anesth, 2016, 34: 440-447.
21. Ljungqvist O, Scott M, Fearon KC. Enhanced recovery after surgery: a review. JAMA Surg, 2017, 152(3): 292-298.
22. Suarez MA, Seddighi R, Egger CM, et al. Effect of fentanyl and lidocaine on the end-tidal sevoflurane concentration preventing motor movement in dogs. Am J Vet Res, 2017, 78(1): 12-16.
23. 王萍, 李亚丽, 罗耀文, 等. 静注利多卡因对老年胸腔镜肺叶切除患者术后谵妄的影响. 实用医学杂志, 2015, 31(16): 2740-2742.
24. Kulason K, Nouchi R, Hoshikawa Y, et al. Indication of cognitive change and associated risk factor after thoracic surgery in the elderly: a pilot study. Front Aging Neurosci, 2017, 9: 396.
25. Gholipour Baradari A, Habibi MR, Habibi V, et al. Administration of lidocaine to prevent cognitive deficit in patients undergoing coronary artery bypass grafting and valve plasty: a systematic review and meta-analysis. Expert Rev Clin Pharmacol, 2017, 10(2): 179-185.
26. 游仁芳, 许福生, 王少平. 利多卡因对老年肺癌根治术患者围术期脑氧代谢及术后早期认知功能影响. 临床军医杂志, 2016, 44(1): 64-67, 71.
27. Habibi MR, Habibi V, Habibi A, et al. Lidocaine dose-response effect on postoperative cognitive deficit: meta-analysis and meta-regression. Expert Rev Clin Pharmacol, 2018, 11(4): 361-371.
28. 黄重峰, 焦丰, 陈华敏, 等. 围手术期利多卡因干预对老年胸科手术患者炎症因子及术后认知功能的影响. 现代医院, 2017, 17(3): 418-420, 424.
29. 叶治, 郭曲练. 利多卡因的脑保护机制. 国际病理科学与临床杂志, 2007, 27(5): 448-452.
30. 吴德华, 马静雅, 徐益萍, 等. 不同麻醉方法下胸科手术老年病人术中房颤发生的比较: 大样本临床研究. 中华麻醉学杂志, 2017, 37(1): 34-38.
31. Onorati F, Dobson GP, San Biagio L, et al. Superior myocardial protection using "polarizing" adenosine, lidocaine, and Mg²⁺ cardioplegia in humans. J Am Coll Cardiol, 2016, 67(14): 1751-1753.
32. Kaczmarek DJ, Herzog C, Larmann J, et al. Lidocaine protects from myocardial damage due to ischemia and reperfusion in mice by its antiapoptotic effects. Anesthesiology, 2009, 110(5): 1041-1049.
33. 王天佑. 胸外科围手术期肺保护中国专家共识(2019 版). 中国胸心血管外科临床杂志, 2019, 26(9): 835-842.
34. Misthos P, Katsaragakis S, Theodorou D, et al. The degree of oxidative stress is associated with major adverse effects after lung resection: a prospective study. Eur J Cardiothorac Surg, 2006, 29(4): 591-595.
35. Rancan L, Simón C, Marchal-Duval E, et al. Lidocaine administration controls microRNAs alterations observed after lung ischemia-reperfusion injury. Anesth Analg, 2016, 123(6): 1437-1447.
36. 陈菲, 马良, 王忠慧. 利多卡因对单肺通气围术期患者氧化应激反应的干预作用. 昆明医科大学学报, 2015, 36(12): 77-79.
37. 袁林芳, 赵文静, 刘月, 等. 围术期静脉输注利多卡因对食管癌患者的肺保护作用研究. 中国全科医学, 2019. [Epub ahead of print].
38. Chen LJ, Ding YB, Ma PL, et al. The protective effect of lidocaine on lipopolysaccharide-induced acute lung injury in rats through NF-κB and p38 MAPK signaling pathway and excessive inflammatory responses. Eur Rev Med Pharmacol Sci, 2018, 22(7): 2099-2108.
39. Ohi M, Toiyama Y, Omura Y, et al. Risk factors and measures of pulmonary complications after thoracoscopic esophagectomy for esophageal cancer. Surg Today, 2019, 49(2): 176-186.
40. Hogan BV, Peter MB, Shenoy HG, et al. Surgery induced immunosuppression. Surgeon, 2011, 9(1): 38-43.
41. Freeman J, Crowley PD, Foley AG, et al. Effect of perioperative lidocaine, propofol and steroids on pulmonary metastasis in a murine model of breast cancer surgery. Cancers (Basel), 2019, 11(5): pii: E613.
42. Xing W, Chen DT, Pan JH, et al. Lidocaine induces apoptosis and suppresses tumor growth in human hepatocellular carcinoma cells in vitro and in a xenograft model in vivo. Anesthesiology, 2017, 126(5): 868-881.
43. Lucchinetti E, Awad AE, Rahman M, et al. Antiproliferative effects of local anesthetics on mesenchymal stem cells: potential implications for tumor spreading and wound healing. Anesthesiology, 2012, 116(4): 841-856.
44. Gao J, Hu H, Wang X. Clinically relevant concentrations of lidocaine inhibit tumor angiogenesis through suppressing VEGF/VEGFR2 signaling. Cancer Chemother Pharmacol, 2019, 83(6): 1007-1015.
45. Beaussier M, Parc Y, Guechot J, et al. Ropivacaine preperitoneal wound infusion for pain relief and prevention of incisional hyperalgesia after laparoscopic colorectal surgery: a randomized, triple-arm, double-blind controlled evaluation vs. intravenous lidocaine infusion, the CATCH study. Colorectal Dis, 2018, 20(6): 509-519.

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Application progress of perioperative intravenous lidocaine injection in thoracic surgery

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