Analysis of risk factors for lymph node metastasis in T2 stage non-small cell lung cancer_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

ZHANG Xianfei , JIN Runsen , ZHENG Yuyan , ZHANG Yajie , HAN Dingpei , CHEN Kai ,  LI Hecheng

Department of Thoracic Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, P.R.China;

Corresponding author：

LI Hecheng, Email: lihecheng2000@hotmail.com

Keywords：

Non-small cell lung cancer; T2 stage; risk factors; surgery

DOI：

10.7507/1007-4848.202001039

Video：

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Objective To explore the risk factors for lymph node metastasis in patients with T2 stage non-small cell lung cancer.Methods The clinical data of 271 patients with non-small cell lung cancer who underwent surgical treatment in our hospital from 2014 to 2017 were collected, including 179 males and 92 females, with an average age of 62.73±0.58 years. The patients were divided into N0, N1, and N2 groups according to the lymph node metastasis status. The clinical data of the patients in different groups were compared.Results The body mass index (BMI, P=0.043), preoperative lymph node enlargement (P<0.001), and tumor diameter (P<0.001) were significantly different among groups. The BMI (OR=1.131, 95%CI 1.001-1.277, P=0.048) and preoperative lymph node enlargement (OR=3.498, 95%CI 1.666-7.342, P=0.001) were independent risk factors for N2 lymph node metastasis, and tumor diameter was an independent risk factor for both N1 (OR=1.538, 95%CI 1.067-2.218, P=0.021) and N2 (OR=1.814, 95%CI 1.196-2.752, P=0.005) lymph node metastasis.Conclusion Patients with high BMI or enlarged lymph nodes before surgery have a high risk for N2 lymph node metastasis, and those with large tumor diameter have a high risk for both N1 and N2 lymph node metastasis.

Citation： ZHANG Xianfei, JIN Runsen, ZHENG Yuyan, ZHANG Yajie, HAN Dingpei, CHEN Kai, LI Hecheng. Analysis of risk factors for lymph node metastasis in T2 stage non-small cell lung cancer. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2020, 27(10): 1194-1200. doi: 10.7507/1007-4848.202001039 Copy

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1. Detterbeck FC, Boffa DJ, Kim AW, <italic>et al</italic>. The eighth edition lung cancer stage classification. Chest, 2017, 151(1): 193-203.
2. Chansky K, Detterbeck FC, Nicholson AG, <italic>et al</italic>. The IASLC Lung Cancer Staging Project: External validation of the revision of the TNM Stage Groupings in the eighth edition of the TNM classification of lung cancer. J Thorac Oncol, 2017, 12(7): 1109-1121.
3. Sui X, Jiang W, Chen H, <italic>et al</italic>. Validation of the stage groupings in the eighth edition of the TNM classification for lung cancer. J Thorac Oncol, 2017, 12(11): 1679-1686.
4. 李珊珊, 许凝, 高岩, 等. T2 期非小细胞肺癌 N1 特点及影响因素分析. 中国胸心血管外科临床杂志, 2018, 25(3): 293-298.
5. 蔡磊, 梁津逍, 陈倩, 等. 非小细胞肺癌患者 N2 组淋巴结转移相关因素分析和淋巴结清除范围选择. 中国医师杂志, 2019, 21(2): 232-234, 238.
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7. 苏鸣岗, 李芳兰, 田蓉, 等. 非小细胞肺癌 N2 淋巴结转移的危险因素分析. 中华核医学与分子影像杂志, 2014, 34(2): 86-90.
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9. 张晓林, 余建群, 李春晴, 等. CT 检查非小细胞肺癌患者纵隔淋巴结转移效果研究. 河北医药, 2018, 40(21): 3253-3256.
10. 张治发. 术前增强 CT 检查与淋巴结转移相关性在非小细胞肺癌患者诊断中的研究. 影像研究与医学应用, 2019, 3(17): 129-130.

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Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Analysis of risk factors for lymph node metastasis in T2 stage non-small cell lung cancer

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