Effects of rehabilitation exercise on exercise tolerance and cardiovascular risk factors in patients with non-acute coronary syndrome after interventional therapy: A randomized controlled trial_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

HUANG Dan ¹ , DU Rongsheng ¹ , ZHANG Hongwei ² , QU Muying ¹ ,  YOU Guiying ¹

1. Department of Cardiology, West China Hospital, Sichuan University, Chengdu, 610041, P.R.China;
2. Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, 610041, P.R.China;

Corresponding author：

YOU Guiying, Email: guiying_you@163.com

Keywords：

Non-acute coronary syndrome; rehabilitation exercise; exercise tolerance; cardiovascular risk factors; treatment compliance

DOI：

10.7507/1007-4848.202006026

Video：

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Objective To investigate the effects of rehabilitation exercise on exercise tolerance and cardiovascular risk factors in patients with non-acute coronary syndrome (non-ACS) after interventional therapy.Methods A total of 102 patients with coronary heart disease and non-ACS in our hospital from December 2018 to June 2019 were selected and randomly divided into a control group (n=51, 30 males and 21 females with an average age of 56.1±4.8 years) and a trial group (n=51, 34 males and 17 females with an average age of 55.1±4.9 years). The control group received routine treatment, while the trial group received regular supervised rehabilitation exercise on the basis of routine treatment. Patients were followed up for 6 months to compare the differences in cardiovascular risk factors (blood pressure, blood lipid, fasting blood glucose), 6-minute walking distance (6MWD), adverse lifestyle changes and treatment compliance between the two groups after treatment.Results The difference of 6MWD between the two groups was statistically significant (P<0.05). In the trial group, 6MWD increased after intervention compared with that before intervention, and the difference was statistically significant (P<0.05). Comparison of total cholesterol (TC), high density liptein cholesterol (HDL-C), low density liptein cholesterol (LDL-C) and fasting blood glucose in the trial group before and after intervention showed statistically significant differences (P<0.05). The differences in TC, HDL-C and LDL-C in the control group before and after intervention were statistically significant (P<0.05). It was statistically significant in dietary compliance rate, smoking cessation rate and alcohol cessation rate between the two groups (P<0.05); the differences in the dietary compliance and drug compliance of the trial group before and after intervention were statistically significant (P<0.05).Conclusion Regular supervised rehabilitation exercise can significantly improve the exercise tolerance and cardiovascular risk factors of non-ACS patients after coronary intervention treatment, so as to improve the quality of life and long-term prognosis of non-ACS patients, which is worthy of clinical application.

Citation： HUANG Dan, DU Rongsheng, ZHANG Hongwei, QU Muying, YOU Guiying. Effects of rehabilitation exercise on exercise tolerance and cardiovascular risk factors in patients with non-acute coronary syndrome after interventional therapy: A randomized controlled trial. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2021, 28(8): 915-920. doi: 10.7507/1007-4848.202006026 Copy

1.	中国心血管病报告编写组. 《中国心血管病报告2016》概要. 中国循环杂志, 2017, 32(6): 521-530.
2.	边素艳, 刘宏斌, 刘宏伟, 等. 2005至2014年因循环系统疾病住院的老年患者疾病谱分析. 中华老年心脑血管病杂志, 2016, 18(10): 1049-1052.
3.	Bruthans J, Cífková R, Lánská V, et al. Explaining the decline in coronary heart disease mortality in the Czech Republic between 1985 and 2007. Eur J Prev Cardiol, 2014, 21(7): 829-839.
4.	陈纪言, 陈韵岱, 韩雅玲. 经皮冠状动脉介入治疗术后运动康复专家共识. 中国介入心脏病学杂志, 2016, 24(7): 361-369.
5.	Aragam KG, Dai D, Neely ML, et al. Gaps in referral to cardiac rehabilitation of patients undergoing percutaneous coronary intervention in the United States. J Am Coll Cardiol, 2015, 65(19): 2079-2088.
6.	Boden WE, O'Rourke RA, Teo KK, et al. Optimal medical therapy with or without PCI for stable coronary disease. N Engl J Med, 2007, 356(15): 1503-1516.
7.	Chou CL, Lee SH, Su YT, et al. Impact of phaseⅡcardiac rehabilitation on abnormal heart rate recovery. J Chin Med Assoc, 2014, 77(9): 482-486.
8.	Jurczak I, Kowalski J, Irzmański R. Impact of cardiac rehabilitation on peripheral circulation as assessed by impedance plethysmography: A randomized clinical trial. Eur J Phys Rehabil Med, 2014, 50(6): 609-616.
9.	Menotti A, Puddu PE, Lanti M, et al. Cardiovascular risk factors predict survival in middle-aged men during 50 years. Eur J Intern Med, 2013, 24(1): 67-74.
10.	Cicero AF, D'Addato S, Santi F, et al. Leisure-time physical activity and cardiovascular disease mortality: The Brisighella Heart Study. J Cardiovasc Med (Hagerstown), 2012, 13(9): 559-564.
11.	Boden WE, Franklin BA, Wenger NK. Physical activity and structured exercise for patients with stable ischemic heart disease. JAMA, 2013, 309(2): 143-144.
12.	Bito V, de Waard MC, Biesmans L, et al. Early exercise training after myocardial infarction prevents contractile but not electrical remodelling or hypertrophy. Cardiovasc Res, 2010, 86(1): 72-81.
13.	沈迎, 吴宗贵, 沈卫峰. 冠状动脉侧支循环研究进展. 国际心血管病杂志, 2013, 40(5): 265-268.
14.	Onishi T, Shimada K, Sato H, et al. Effects of phase Ⅲ cardiac rehabilitation on mortality and cardiovascular events in elderly patients with stable coronary artery disease. Circ J, 2010, 74(4): 709-714.
15.	毛立伟, 余萍, 季鹏, 等. 有氧联合抗组运动对冠心病合并2 型糖尿病患者影响的观察. 中国心血管杂志, 2016, 21(6): 442-446.
16.	Magalhães S, Viamonte S, Miguel Ribeiro M, et al. Long-term effects of a cardiac rehabilitation program in the control of cardiovascular risk factors. Rev Port Cardiol, 2013, 32(3): 191-199.
17.	Conraads VM, Pattyn N, De Maeyer C, et al. Aerobic interval training and continuous training equally improve aerobic exercise capacity in patients with coronary artery disease: The SAINTEX-CAD study. Int J Cardiol, 2015, 179: 203-210.
18.	Lavie CJ, Milani RV. Cardiac rehabilitation and exercise training in secondary coronary heart disease prevention. Prog Cardiovasc Dis, 2011, 53(6): 397-403.

1. 中国心血管病报告编写组. 《中国心血管病报告2016》概要. 中国循环杂志, 2017, 32(6): 521-530.
2. 边素艳, 刘宏斌, 刘宏伟, 等. 2005至2014年因循环系统疾病住院的老年患者疾病谱分析. 中华老年心脑血管病杂志, 2016, 18(10): 1049-1052.
3. Bruthans J, Cífková R, Lánská V, et al. Explaining the decline in coronary heart disease mortality in the Czech Republic between 1985 and 2007. Eur J Prev Cardiol, 2014, 21(7): 829-839.
4. 陈纪言, 陈韵岱, 韩雅玲. 经皮冠状动脉介入治疗术后运动康复专家共识. 中国介入心脏病学杂志, 2016, 24(7): 361-369.
5. Aragam KG, Dai D, Neely ML, et al. Gaps in referral to cardiac rehabilitation of patients undergoing percutaneous coronary intervention in the United States. J Am Coll Cardiol, 2015, 65(19): 2079-2088.
6. Boden WE, O'Rourke RA, Teo KK, et al. Optimal medical therapy with or without PCI for stable coronary disease. N Engl J Med, 2007, 356(15): 1503-1516.
7. Chou CL, Lee SH, Su YT, et al. Impact of phaseⅡcardiac rehabilitation on abnormal heart rate recovery. J Chin Med Assoc, 2014, 77(9): 482-486.
8. Jurczak I, Kowalski J, Irzmański R. Impact of cardiac rehabilitation on peripheral circulation as assessed by impedance plethysmography: A randomized clinical trial. Eur J Phys Rehabil Med, 2014, 50(6): 609-616.
9. Menotti A, Puddu PE, Lanti M, et al. Cardiovascular risk factors predict survival in middle-aged men during 50 years. Eur J Intern Med, 2013, 24(1): 67-74.
10. Cicero AF, D'Addato S, Santi F, et al. Leisure-time physical activity and cardiovascular disease mortality: The Brisighella Heart Study. J Cardiovasc Med (Hagerstown), 2012, 13(9): 559-564.
11. Boden WE, Franklin BA, Wenger NK. Physical activity and structured exercise for patients with stable ischemic heart disease. JAMA, 2013, 309(2): 143-144.
12. Bito V, de Waard MC, Biesmans L, et al. Early exercise training after myocardial infarction prevents contractile but not electrical remodelling or hypertrophy. Cardiovasc Res, 2010, 86(1): 72-81.
13. 沈迎, 吴宗贵, 沈卫峰. 冠状动脉侧支循环研究进展. 国际心血管病杂志, 2013, 40(5): 265-268.
14. Onishi T, Shimada K, Sato H, et al. Effects of phase Ⅲ cardiac rehabilitation on mortality and cardiovascular events in elderly patients with stable coronary artery disease. Circ J, 2010, 74(4): 709-714.
15. 毛立伟, 余萍, 季鹏, 等. 有氧联合抗组运动对冠心病合并2 型糖尿病患者影响的观察. 中国心血管杂志, 2016, 21(6): 442-446.
16. Magalhães S, Viamonte S, Miguel Ribeiro M, et al. Long-term effects of a cardiac rehabilitation program in the control of cardiovascular risk factors. Rev Port Cardiol, 2013, 32(3): 191-199.
17. Conraads VM, Pattyn N, De Maeyer C, et al. Aerobic interval training and continuous training equally improve aerobic exercise capacity in patients with coronary artery disease: The SAINTEX-CAD study. Int J Cardiol, 2015, 179: 203-210.
18. Lavie CJ, Milani RV. Cardiac rehabilitation and exercise training in secondary coronary heart disease prevention. Prog Cardiovasc Dis, 2011, 53(6): 397-403.

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Effects of rehabilitation exercise on exercise tolerance and cardiovascular risk factors in patients with non-acute coronary syndrome after interventional therapy: A randomized controlled trial

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