• 1. Department of Thoracic Surgery of Tianjin Chest Hospital, Tianjin, 300051, P.R.China;
  • 2. Hainan Institute of Real World Data, Department of Biostatistics, Southern Medical University, Guangzhou, 510515, P.R.China;
  • 3. Department of Thoracic Surgery of West China Hospital, Sichuan University, Chengdu, 610041, P.R.China;
  • 4. Department of Thoracic Surgery of Tangdu Hospital, Fourth Military Medical University, Xi’an, 710038, P.R.China;
  • 5. Department of Thoracic Surgery of The First Hospital Affiliated to Medical College of Zhejiang University, Hangzhou, 310009, P.R.China;
  • 6. Department of Thoracic Surgery of Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Cancer Institute of Jiangsu Province, Nanjing, 210009, P.R.China;
  • 7. Department of Thoracic Surgery of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430010, P.R.China;
  • 8. Department of Thoracic Surgery of Chinese People’s Liberation Army General Hospital, Beijing, 100038, P.R.China;
  • 9. Department of Thoracic Surgery of China-Japan Friendship Hospital, Beijing, 100029, P.R.China;
  • 10. Department of Thoracic Surgery of The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, P.R.China;
HE Jianxing, Email: drjianxing.he@gmail.com
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Objective To compare the 5-year survival rates between two different follow-up patterns of postoperative stage Ⅰ-ⅢA non-small cell lung cancer (NSCLC) patients.Methods Pathological stage Ⅰ-ⅢA NSCLC 11 958 patients who underwent surgical resection and received follow-up within 6 months after initial diagnosis through telephone follow-up system were included in nine hospitals from July 2014 to July 2020. The patients were divided into two groups including a proactive follow-up group (n=3 825) and a passive follow-up group (n=8133) according to the way of following-up. There were 6 939 males and 5 019 females aged 59.8±9.5 years. The Kaplan-Meier and Cox proportional hazards regression model were used.Results The median follow-up frequency was 8.0 times in the proactive follow-up group and 7.0 times in the passive follow-up group. The median call duration was 3.77 minutes in the proactive follow-up group and 3.58 minutes in the passive follow-up group. The 5-year survival rate was 81.8% and 74.2% (HR=0.60, 95CI 0.53-0.67, P<0.001) in the proactive follow-up group and the passive follow-up group, respectively. Multivariate analysis showed that follow-up pattern, age, gender and operation mode were independent prognostic factors, and the results were consistent in all subgroups stratified by clinical stages.Conclusion The proactive follow-up leads to better overall survival for resected stage Ⅰ-ⅢA NSCLC patients, especially in the stage ⅢA.

Citation: SUN Daqiang, CHEN Pingyan, LIU Lunxu, LI Xiaofei, HU Jian, XU Lin, FU Xiangning, LIU Yang, LIU Deruo, ZHANG Xun, HE Jianxing. The 5-year survival rate of 11 958 postoperative non-small cell lung cancer patients in stage -A by two different follow-up patterns: A multi-center, real-world study. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2021, 28(6): 615-622. doi: 10.7507/1007-4848.202104103 Copy

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