The 5-year survival rate of 11 958 postoperative non-small cell lung cancer patients in stage <b>Ⅰ</b>-<b>Ⅲ</b>A by two different follow-up patterns: A multi-center, real-world study_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

SUN Daqiang ¹ , CHEN Pingyan ² , LIU Lunxu ³ , LI Xiaofei ⁴ , HU Jian ⁵ , XU Lin ⁶ , FU Xiangning ⁷ , LIU Yang ⁸ , LIU Deruo ⁹ , ZHANG Xun ¹ ,  HE Jianxing ¹⁰

1. Department of Thoracic Surgery of Tianjin Chest Hospital, Tianjin, 300051, P.R.China;
2. Hainan Institute of Real World Data, Department of Biostatistics, Southern Medical University, Guangzhou, 510515, P.R.China;
3. Department of Thoracic Surgery of West China Hospital, Sichuan University, Chengdu, 610041, P.R.China;
4. Department of Thoracic Surgery of Tangdu Hospital, Fourth Military Medical University, Xi’an, 710038, P.R.China;
5. Department of Thoracic Surgery of The First Hospital Affiliated to Medical College of Zhejiang University, Hangzhou, 310009, P.R.China;
6. Department of Thoracic Surgery of Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Cancer Institute of Jiangsu Province, Nanjing, 210009, P.R.China;
7. Department of Thoracic Surgery of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430010, P.R.China;
8. Department of Thoracic Surgery of Chinese People’s Liberation Army General Hospital, Beijing, 100038, P.R.China;
9. Department of Thoracic Surgery of China-Japan Friendship Hospital, Beijing, 100029, P.R.China;
10. Department of Thoracic Surgery of The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, P.R.China;

Corresponding author：

HE Jianxing, Email: drjianxing.he@gmail.com

Keywords：

Non-small cell lung cancer; surgical resection; follow-up pattern; 5-year survival rate; real-world study

DOI：

10.7507/1007-4848.202104103

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Objective To compare the 5-year survival rates between two different follow-up patterns of postoperative stage Ⅰ-ⅢA non-small cell lung cancer (NSCLC) patients.Methods Pathological stage Ⅰ-ⅢA NSCLC 11 958 patients who underwent surgical resection and received follow-up within 6 months after initial diagnosis through telephone follow-up system were included in nine hospitals from July 2014 to July 2020. The patients were divided into two groups including a proactive follow-up group (n=3 825) and a passive follow-up group (n=8133) according to the way of following-up. There were 6 939 males and 5 019 females aged 59.8±9.5 years. The Kaplan-Meier and Cox proportional hazards regression model were used.Results The median follow-up frequency was 8.0 times in the proactive follow-up group and 7.0 times in the passive follow-up group. The median call duration was 3.77 minutes in the proactive follow-up group and 3.58 minutes in the passive follow-up group. The 5-year survival rate was 81.8% and 74.2% (HR=0.60, 95CI 0.53-0.67, P<0.001) in the proactive follow-up group and the passive follow-up group, respectively. Multivariate analysis showed that follow-up pattern, age, gender and operation mode were independent prognostic factors, and the results were consistent in all subgroups stratified by clinical stages.Conclusion The proactive follow-up leads to better overall survival for resected stage Ⅰ-ⅢA NSCLC patients, especially in the stage ⅢA.

Citation： SUN Daqiang, CHEN Pingyan, LIU Lunxu, LI Xiaofei, HU Jian, XU Lin, FU Xiangning, LIU Yang, LIU Deruo, ZHANG Xun, HE Jianxing. The 5-year survival rate of 11 958 postoperative non-small cell lung cancer patients in stage Ⅰ-ⅢA by two different follow-up patterns: A multi-center, real-world study. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2021, 28(6): 615-622. doi: 10.7507/1007-4848.202104103 Copy

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1. 郑荣寿, 孙可欣, 张思维, 等. 2015年中国恶性肿瘤流行情况分析. 中华肿瘤杂志, 2019, 41(1): 19-28.
2. 周来燕, 卢铀. 早期非小细胞肺癌术后复发的预测因子. 临床肿瘤学杂志, 2020, 25(7): 650-655.
3. 刘伦旭, 高树庚, 何建行, 等. 非小细胞肺癌术后随访中国胸外科专家共识. 中国胸心血管外科临床杂志, 2021, 28(1): 4-10.
4. Yun YH, Kim YA, Sim JA, et al. Prognostic value of quality of life score in disease-free survivors of surgically-treated lung cancer. BMC Cancer, 2016, 20(16): 505.
5. Denis F, Basch E, Septans AL, Bennouna J, et al. Two-year survival comparing web-based symptom monitoring vs routine surveillance following treatment for lung cancer. JAMA, 2019, 321(3): 306-307.
6. Ruland CM, Holte HH, Røislien J, et al. Effects of a computer-supported interactive tailored patient assessment tool on patient care, symptom distress, and patients' need for symptom management support: A randomized clinical trial. JAMIA, 2010, 17(4): 403-410.
7. Gustavell T, Sundberg K, Segersvärd R, et al. Decreased symptom burden following surgery due to support from an interactive app for symptom management for patients with pancreatic and periampullary cancer. Acta Oncol, 2019, 58(9): 1307-1314.
8. 廖虎, 梅建东, 刘成武, 等. 中国三级医院胸外科学科临床发展现状的调查研究. 中华外科杂志, 2018, 56(12): 888-891.
9. 李萍, 苏泽琦, 李园, 等. 影响中医临床随访研究数据质量的常见问题及对策. 现代中医临床, 2019, 26(6): 44-49.
10. 王天园, 孙星, 胡晶, 等. 中医药临床试验中电话随访的方法学应对与思考. 中国全科医学, 2021, 24(2): 248-252.
11. U. S. Department of Health and Human Services FDA Center for Drug Evaluation and Research, U. S. Department of Health and Human Services FDA Center for Biologics Evaluation and Research; U. S. Department of Health and Human Services FDA Center for Devices and Radiological Health. Guidance for industry: Patient-reported outcome measures: Use in medical product development to support labeling claims: Draft guidance. Health Qual Life Outcomes, 2006, 4: 79.
12. Gustavell T, Sundberg K, Langius-Eklöf A. Using an interactive app for symptom reporting and management following pancreatic cancer surgery to facilitate person-centered care: Descriptive study. JMIR Mhealth Uhealth, 2020, 8(6): e17855.
13. Onuma AE, Palmer Kelly E, Chakedis J, et al. Patient preferences on the use of technology in cancer surveillance after curative surgery: A cross-sectional analysis. Surg, 2019, 165(4): 782-788.
14. Degenhardt T, Harbeck N, Fasching PA, et al. Documentation patterns and impact on observed side effects of the CANKADO ehealth application: An exploratory analysis of the PreCycle trial. J Clin Oncol, 2020, 38(15): 2083-2083.
15. Basch E, Deal AM, Dueck AC, et al. Overall survival results of a trial assessing patient-reported outcomes for symptom monitoring during routine cancer treatment. JAMA, 2017, 318(2): 197-198.
16. Sawicki C, Friend KE, Patel R, et al. Two-way clinical messaging in a CML specialty pharmacy service model. J Manag Care Spec Pharm, 2019, 25(11): 1290-1296.
17. 戴维, 石丘玲, 李强, 等. 基于患者报告结局的症状管理在肺癌外科的应用现状. 中国胸心血管外科临床杂志, 2020, 27(10): 1228-1234.
18. 刘加林, 梁传余, 王力红, 等. 《华西医学》临床资料随访的现状与对策. 华西医学, 2005, 20(1): 7-8.
19. 常艳鹏, 魏戌, 谢雁鸣. 临床随访研究中存在的问题及对策. 中医杂志, 2012, 53(22): 1913-1916.

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The 5-year survival rate of 11 958 postoperative non-small cell lung cancer patients in stage Ⅰ-ⅢA by two different follow-up patterns: A multi-center, real-world study

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