Objective To investigate the early clinical results of MitraClip system in domestic patients. Methods We retrospectively analyzed the clinical data of 36 patients who underwent transcatheter edge-to-edge repair procedure using MitraClip system in Beijing Fuwai Hospital, Shenzhen Fuwai Hospital and Fuwai Yunnan Cardiovascular Hospital between January and June 2021. There were 24 males and 12 females, with a median age of 70 (47-86) years. Ten (27.8%) patients had 3+ mitral regurgitation (MR) and 26 (72.2%) patients had 4+ MR preoperatively. Results All procedures were successfully performed. The reduction in MR was 2+ at least immediately after surgery, and 91.7% of patients had MR≤2+ at 3 days postoperatively. There was no statistical difference in left ventricular ejection fraction change postoperatively. Forward velocity and peak gradient of mitral valve were increased after the procedure. Mean gradient of mitral valve were increased at 3 days postoperatively than immediately after surgery (P<0.001). Two patients had acute pericardial effusion intraoperatively, and received pericardial puncture and drainage immediately. Conclusion MitraClip system has been applied well in domestic patients and can significantly improve MR. This sutdy has a good consistency with foreign studies, and the early results are satisfactory.
Citation：
GAO Manchen, DUAN Fujian, ZHANG Gejun, XIE Yongquan, WANG Shouzheng, HU Xiaopeng, HU Haibo, WAN Junyi, LUO Zhiling, PAN Jiahua, ZHANG Jing, SONG Huijun, XIONG Hui, PAN Xiangbin. Primary practice of transcatheter edge-to-edge repair for mitral regurgitation: Early results of MitraClip in multiple centers. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2022, 29(5): 547-552. doi: 10.7507/1007-4848.202111088
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Copyright © the editorial department of Chinese Journal of Clinical Thoracic and Cardiovascular Surgery of West China Medical Publisher. All rights reserved
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Nkomo VT, Gardin JM, Skelton TN, et al. Burden of valvular heart diseases: A population-based study. Lancet, 2006, 368(9540): 1005-1011.
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潘文志, 金沁纯, 周达新. 房性功能性二尖瓣反流的定义及经导管缘对缘修复术对其治疗的可行性. 华西医学, 2021, 36(9): 1172-1176.
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| 3. |
Condado JA, Acquatella H, Rodriguez L, et al. Percutaneous edge-to-edge mitral valve repair: 2-year follow-up in the first human case. Catheter Cardiovasc Interv, 2006, 67(2): 323-325.
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| 4. |
Feldman T, Kar S, Elmariah S, et al. Randomized comparison of percutaneous repair and surgery for mitral regurgitation: 5-year results of EVEREST Ⅱ. J Am Coll Cardiol, 2015, 66(25): 2844-2854.
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| 5. |
Stone GW, Lindenfeld J, Abraham WT, et al. Transcatheter mitral-valve repair in patients with heart failure. N Engl J Med, 2018, 379(24): 2307-2318.
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| 6. |
Mack MJ, Lindenfeld J, Abraham WT, et al. 3-year outcomes of transcatheter mitral valve repair in patients with heart failure. J Am Coll Cardiol, 2021, 77(8): 1029-1040.
|
| 7. |
Yeo KK, Yap J, Yamen E, et al. Percutaneous mitral valve repair with the MitraClip: Early results from the MitraClip Asia-Pacific Registry (MARS). EuroIntervention, 2014, 10(5): 620-625.
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| 8. |
Tay E, Muda N, Yap J, et al. The MitraClip Asia-Pacific Registry: Differences in outcomes between functional and degenerative mitral regurgitation. Catheter Cardiovasc Interv, 2016, 87(7): E275-E281.
|
| 9. |
Bavry AA, Arnaoutakis GJ. Perspective to 2020 American College of Cardiology/American Heart Association (ACC/AHA) guideline for the management of patients with valvular heart disease. Circulation, 2021, 143(5): 407-409.
|
| 10. |
Baumgartner H, Falk V, Bax JJ, et al. 2017 ESC/EACTS guidelines for the management of valvular heart disease. Eur Heart J, 2017, 38(36): 2739-2791.
|
| 11. |
Glower DD, Kar S, Trento A, et al. Percutaneous mitral valve repair for mitral regurgitation in high-risk patients: Results of the EVEREST Ⅱ study. J Am Coll Cardiol, 2014, 64(2): 172-181.
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- 1. Nkomo VT, Gardin JM, Skelton TN, et al. Burden of valvular heart diseases: A population-based study. Lancet, 2006, 368(9540): 1005-1011.
- 2. 潘文志, 金沁纯, 周达新. 房性功能性二尖瓣反流的定义及经导管缘对缘修复术对其治疗的可行性. 华西医学, 2021, 36(9): 1172-1176.
- 3. Condado JA, Acquatella H, Rodriguez L, et al. Percutaneous edge-to-edge mitral valve repair: 2-year follow-up in the first human case. Catheter Cardiovasc Interv, 2006, 67(2): 323-325.
- 4. Feldman T, Kar S, Elmariah S, et al. Randomized comparison of percutaneous repair and surgery for mitral regurgitation: 5-year results of EVEREST Ⅱ. J Am Coll Cardiol, 2015, 66(25): 2844-2854.
- 5. Stone GW, Lindenfeld J, Abraham WT, et al. Transcatheter mitral-valve repair in patients with heart failure. N Engl J Med, 2018, 379(24): 2307-2318.
- 6. Mack MJ, Lindenfeld J, Abraham WT, et al. 3-year outcomes of transcatheter mitral valve repair in patients with heart failure. J Am Coll Cardiol, 2021, 77(8): 1029-1040.
- 7. Yeo KK, Yap J, Yamen E, et al. Percutaneous mitral valve repair with the MitraClip: Early results from the MitraClip Asia-Pacific Registry (MARS). EuroIntervention, 2014, 10(5): 620-625.
- 8. Tay E, Muda N, Yap J, et al. The MitraClip Asia-Pacific Registry: Differences in outcomes between functional and degenerative mitral regurgitation. Catheter Cardiovasc Interv, 2016, 87(7): E275-E281.
- 9. Bavry AA, Arnaoutakis GJ. Perspective to 2020 American College of Cardiology/American Heart Association (ACC/AHA) guideline for the management of patients with valvular heart disease. Circulation, 2021, 143(5): 407-409.
- 10. Baumgartner H, Falk V, Bax JJ, et al. 2017 ESC/EACTS guidelines for the management of valvular heart disease. Eur Heart J, 2017, 38(36): 2739-2791.
- 11. Glower DD, Kar S, Trento A, et al. Percutaneous mitral valve repair for mitral regurgitation in high-risk patients: Results of the EVEREST Ⅱ study. J Am Coll Cardiol, 2014, 64(2): 172-181.
