Research progress on the pathogenesis of chronic obstructive pulmonary disease complicated with lung cancer_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

LI Anying ¹ , LI Zhiwei ¹ , SUN Dianhan ¹ , CHEN Yong ² , WU Jun ² ,  SHU Yusheng ²

1. Dalian Medical University, Dalian, 116044, Liaoning, P. R. China;
2. Department of Thoracic Surgery, Subei People’s Hospital, Yangzhou, 225009, Jiangsu, P. R. China;

Corresponding author：

SHU Yusheng, Email: 18051061999@yzu.edu.cn

Keywords：

Chronic obstructive pulmonary disease; lung cancer; pathogenesis; genetic inheritance

DOI：

10.7507/1007-4848.202307030

Video：

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[Abstract ]Chronic obstructive pulmonary disease (COPD) occurs mostly in middle-aged and elderly people, and patients often have poor quality of life and can also induce a variety of other lung diseases. At the same time, the lung cancer with the highest morbidity and mortality in the world, has claimed the lives of countless patients. Since the incidence of lung cancer is much higher in patients with COPD than in the general population, there are many links between the two diseases that need to be studied and explored. Although many studies have explored the association between the two, there are few studies on the molecular level of them. This review will focuse on the latest research progress of the pathogenesis of COPD complicated with lung cancer from four aspects: the role of chronic inflammation, programmed cell death, gene and molecular role and lung microbiome imbalance, so as to provide a new reference for the prevention, diagnosis and treatment of COPD complicated with lung cancer.

1.	Forder A, Zhuang R, Souza VGP, et al. Mechanisms contributing to the comorbidity of COPD and lung cancer. Int J Mol Sci, 2023, 24(3): 2859.
2.	McRobbie H, Kwan B. Tobacco use disorder and the lungs. Addiction, 2021, 116(9): 2559-2571.
3.	Houghton AM. Mechanistic links between COPD and lung cancer. Nat Rev Cancer, 2013, 13(4): 233-245.
4.	Young RP, Hopkins RJ, Christmas T, et al. COPD prevalence is increased in lung cancer, independent of age, sex and smoking history. Eur Respir J, 2009, 34(2): 380-386.
5.	Agustí A, Celli BR, Criner GJ, et al. Global initiative for chronic obstructive lung disease 2023 report: GOLD executive summary. Arch Bronconeumol, 2023, 59(4): 232-248.
6.	GBD 2019 Chronic Respiratory Diseases Collaborators. Global burden of chronic respiratory diseases and risk factors, 1990-2019: An update from the Global Burden of Disease Study 2019. EClinicalMedicine, 2023, 59: 101936.
7.	Duffy SP, Criner GJ. Chronic obstructive pulmonary disease: Evaluation and management. Med Clin North Am, 2019, 103(3): 453-461.
8.	Yang IA, Jenkins CR, Salvi SS. Chronic obstructive pulmonary disease in never-smokers: Risk factors, pathogenesis, and implications for prevention and treatment. Lancet Respir Med, 2022, 10(5): 497-511.
9.	Stoller JK, Aboussouan LS. Alpha1-antitrypsin deficiency. Lancet, 2005, 365(9478): 2225-2236.
10.	Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2021, 71(3): 209-249.
11.	Nicholson AG, Tsao MS, Beasley MB, et al. The 2021 WHO classification of lung tumors: Impact of advances since 2015. J Thorac Oncol, 2022, 17(3): 362-387.
12.	Chen P, Liu Y, Wen Y, et al. Non-small cell lung cancer in China. Cancer Commun (Lond), 2022, 42(10): 937-970.
13.	Zhang S, Pang K, Feng X, et al. Transcriptomic data exploration of consensus genes and molecular mechanisms between chronic obstructive pulmonary disease and lung adenocarcinoma. Sci Rep, 2022, 12(1): 13214.
14.	Lancaster HL, Heuvelmans MA, Oudkerk M. Low-dose computed tomography lung cancer screening: Clinical evidence and implementation research. J Intern Med, 2022, 292(1): 68-80.
15.	Yang SR, Schultheis AM, Yu H, et al. Precision medicine in non-small cell lung cancer: Current applications and future directions. Semin Cancer Biol, 2022, 84: 184-198.
16.	de Torres JP, Marín JM, Casanova C, et al. Lung cancer in patients with chronic obstructive pulmonary disease-- Incidence and predicting factors. Am J Respir Crit Care Med, 2011, 184(8): 913-919.
17.	赵艳青, 侯明霞, 张彩苹. 慢性阻塞性肺疾病对肺癌免疫治疗临床疗效影响的分析. 临床肺科杂志, 2023, 28(9): 1304-1309.
18.	Forder A, Zhuang R, Souza VGP, et al. Mechanisms contributing to the comorbidity of COPD and lung cancer. Int J Mol Sci, 2023, 24(3): 2859.
19.	张瑶, 刘学军. 慢性阻塞性肺疾病合并肺癌发病机制的研究进展. 中华老年多器官疾病杂志, 2022, 21(1): 76-80.
20.	王娅洁, 吴爽爽, 储江, 等. 肺部微生物组通过炎症反应介导慢性阻塞性肺疾病转化为肺癌的研究进展. 遗传, 2021, 43(1): 30-39.
21.	魏智民, 孙玉发, 李刚, 等. 癌症相关性炎症与肿瘤微环境相关研究进展. 中国肿瘤临床, 2018, 45(21): 1117-1121.
22.	Fan T, Li S, Xiao C, et al. CCL20 promotes lung adenocarcinoma progression by driving epithelial-mesenchymal transition. Int J Biol Sci, 2022, 18(11): 4275-4288.
23.	Chang YS, Tu SJ, Chen YC, et al. Mutation profile of non-small cell lung cancer revealed by next generation sequencing. Respir Res, 2021, 22(1): 3.
24.	Shukla SD, Walters EH, Simpson JL, et al. Hypoxia-inducible factor and bacterial infections in chronic obstructive pulmonary disease. Respirology, 2020, 25(1): 53-63.
25.	Baek EB, Kim YJ, Rho JH, et al. Anti-inflammatory effect of Gyeji-tang in a chronic obstructive pulmonary disease mouse model induced by cigarette smoke and lipopolysaccharide. Pharm Biol, 2022, 60(1): 2040-2048.
26.	Aquilina NJ, Havel CM, Harrison RM, et al. Determination of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone (NNK) arising from tobacco smoke in airborne particulate matter. Environ Int, 2022 Jan: 158: 106992.
27.	Liu CH, Chen Z, Chen K, et al. Lipopolysaccharide-mediated chronic inflammation promotes tobacco carcinogen-induced lung cancer and determines the efficacy of immunotherapy. Cancer Res, 2021, 81(1): 144-157.
28.	沈诚, 车国卫. 炎症因子与肺癌研究进展. 中华肿瘤防治杂志, 2014, 21(2): 157-160.
29.	Budisan L, Zanoaga O, Braicu C, et al. Links between infections, lung cancer, and the immune system. Int J Mol Sci, 2021, 22(17): 9394.
30.	Akbay EA, Koyama S, Liu Y, et al. Interleukin-17A promotes lung tumor progression through neutrophil attraction to tumor sites and mediating resistance to PD-1 blockade. J Thorac Oncol, 2017, 12(8): 1268-1279.
31.	Tamura T, Miyazaki K, Satoh H. Features of COPD as predictors of lung cancer. Chest, 2018, 154(3): 720-721.
32.	García-Rio F, Romero D, Lores V, et al. Dynamic hyperinflation, arterial blood oxygen, and airway oxidative stress in stable patients with COPD. Chest, 2011, 140(4): 961-969.
33.	Zamarrón E, Prats E, Tejero E, et al. Static lung hyperinflation is an independent risk factor for lung cancer in patients with chronic obstructive pulmonary disease. Lung Cancer, 2019, 128: 40-46.
34.	Yu S, Jia J, Zheng J, et al. Recent progress of ferroptosis in lung diseases. Front Cell Dev Biol, 2021, 9: 789517.
35.	Oliveri V. Selective targeting of cancer cells by copper ionophores: An overview. Front Mol Biosci, 2022 Mar 4: 9: 841814.
36.	Dixon SJ, Lemberg KM, Lamprecht MR, et al. Ferroptosis: An iron-dependent form of nonapoptotic cell death. Cell, 2012, 149(5): 1060-1072.
37.	Xia H, Wu Y, Zhao J, et al. N6-Methyladenosine-modified circSAV1 triggers ferroptosis in COPD through recruiting YTHDF1 to facilitate the translation of IREB2. Cell Death Differ, 2023, 30(5): 1293-1304.
38.	Qiao D, Hu C, Li Q, et al. Circ-RBMS1 knockdown alleviates cse-induced apoptosis, inflammation and oxidative stress via up-regulating FBXO11 through miR-197-3p in 16HBE cells. Int J Chron Obstruct Pulmon Dis, 2021, 16: 2105-2118.
39.	Zhang W, Sun Y, Bai L, et al. RBMS1 regulates lung cancer ferroptosis through translational control of SLC7A11. J Clin Invest, 2021, 131(22): e152067.
40.	Li R, Li X, Hagood J, et al. Myofibroblast contraction is essential for generating and regenerating the gas-exchange surface. J Clin Invest, 2020, 130(6): 2859-2871.
41.	Wang Y, Duan H, Zhang J, et al. YAP1 protects against PM2. 5-induced lung toxicity by suppressing pyroptosis and ferroptosis. Ecotoxicol Environ Saf, 2023, 253: 114708.
42.	Tsvetkov P, Coy S, Petrova B, et al. Copper induces cell death by targeting lipoylated TCA cycle proteins. Science, 2022, 375(6586): 1254-1261.
43.	Fei Q, Weng X, Liu K, et al. The Relationship between metal exposure and chronic obstructive pulmonary disease in the general US population: NHANES 2015-2016. Int J Environ Res Public Health, 2022, 19(4): 2085.
44.	Healy C, Munoz-Wolf N, Strydom J, et al. Nutritional immunity: The impact of metals on lung immune cells and the airway microbiome during chronic respiratory disease. Respir Res, 2021, 22(1): 133.
45.	Chen Y, Tang L, Huang W, et al. Identification and validation of a novel cuproptosis-related signature as a prognostic model for lung adenocarcinoma. Front Endocrinol (Lausanne), 2022 Oct 24: 13: 963220.
46.	Li X, Dai Z, Liu J, et al. Characterization of the functional effects of ferredoxin 1 as a cuproptosis biomarker in cancer. Front Genet, 2022, 13: 969856.
47.	Cai Y, Liu R, Lu X, et al. Correlation in gene expression between the aggravation of chronic obstructive pulmonary disease and the occurrence of complications. Bioengineered, 2020, 11(1): 1245-1257.
48.	Zhong F, Lin Y, Zhao L, et al. Reshaping the tumour immune microenvironment in solid tumours via tumour cell and immune cell DNA methylation: From mechanisms to therapeutics. Br J Cancer, 2023, 129(1): 24-37.
49.	Córdoba-Lanús E, Domínguez de-Barros A, Oliva A, et al. Circulating miR-206 and miR-1246 as markers in the early diagnosis of lung cancer in patients with chronic obstructive pulmonary disease. Int J Mol Sci, 2023, 24(15): 12437.
50.	Fujimoto J, Nunomura-Nakamura S, Liu Y, et al. Development of Kras mutant lung adenocarcinoma in mice with knockout of the airway lineage-specific gene Gprc5a. Int J Cancer, 2017, 141(8): 1589-1599.
51.	Treekitkarnmongkol W, Hassane M, Sinjab A, et al. Augmented lipocalin-2 is associated with chronic obstructive pulmonary disease and counteracts lung adenocarcinoma development. Am J Respir Crit Care Med, 2021, 203(1): 90-101.
52.	Wang Q, Li S, Tang X, et al. Lipocalin 2 protects against escherichia coli infection by modulating neutrophil and macrophage function. Front Immunol, 2019, 10: 2594.
53.	Zhou RH, Zhang JT, Chen C, et al. Identification of CDC5L as bridge gene between chronic obstructive pulmonary disease and lung adenocarcinoma. Epigenomics, 2020, 12(17): 1515-1529.
54.	Conlon TM, John-Schuster G, Heide D, et al. Inhibition of LTβR signalling activates WNT-induced regeneration in lung. Nature, 2020, 588(7836): 151-156.
55.	Koerner L, Schmiel M, Yang TP, et al. NEMO- and RelA-dependent NF-κB signaling promotes small cell lung cancer. Cell Death Differ, 2023, 30(4): 938-951.
56.	Su X, Liu N, Wu W, et al. Comprehensive analysis of prognostic value and immune infiltration of kindlin family members in non-small cell lung cancer. BMC Med Genomics, 2021, 14(1): 119.
57.	Su X, Chen J, Lin X, et al. FERMT3 mediates cigarette smoke-induced epithelial-mesenchymal transition through Wnt/β-catenin signaling. Respir Res, 2021, 22(1): 286.
58.	Verdura S, Encinar JA, Teixidor E, et al. Silibinin overcomes EMT-driven lung cancer resistance to new-generation ALK inhibitors. Cancers (Basel), 2022, 14(24): 6101.
59.	Ahmad S, Manzoor S, Siddiqui S, et al. Epigenetic underpinnings of inflammation: Connecting the dots between pulmonary diseases, lung cancer and COVID-19. Semin Cancer Biol, 2022, 83: 384-398.
60.	Kumar S, Gonzalez EA, Rameshwar P, et al. Non-coding RNAs as mediators of epigenetic changes in malignancies. Cancers (Basel), 2020, 12(12): 3657.
61.	Shahverdi M, Hajiasgharzadeh K, Sorkhabi AD, et al. The regulatory role of autophagy-related miRNAs in lung cancer drug resistance. Biomed Pharmacother, 2022, 148: 112735.
62.	Zeng Z, He S, Lu J, et al. MicroRNA-21 aggravates chronic obstructive pulmonary disease by promoting autophagy. Exp Lung Res, 2018, 44(2): 89-97.
63.	Li S, Zeng X, Ma R, et al. MicroRNA-21 promotes the proliferation, migration and invasion of non-small cell lung cancer A549 cells by regulating autophagy activity via AMPK/ULK1 signaling pathway. Exp Ther Med, 2018, 16(3): 2038-2045.
64.	Rezaei S, Mahjoubin-Tehran M, Aghaee-Bakhtiari SH, et al. Autophagy-related MicroRNAs in chronic lung diseases and lung cancer. Crit Rev Oncol Hematol, 2020, 153: 103063.
65.	Li Y, Yin Z, Fan J, et al. The roles of exosomal miRNAs and lncRNAs in lung diseases. Signal Transduct Target Ther, 2019 Nov 13: 4: 47.
66.	Sun L, Xu A, Li M, et al. Effect of Methylation status of lncRNA-MALAT1 and MicroRNA-146a on pulmonary function and expression level of COX2 in patients with chronic obstructive pulmonary disease. Front Cell Dev Biol, 2021 Sep 8: 9: 667624.
67.	Li S, Mei Z, Hu HB, et al. The lncRNA MALAT1 contributes to non-small cell lung cancer development via modulating miR-124/STAT3 axis. J Cell Physiol, 2018, 233(9): 6679-6688.
68.	Li N, Liu Y, Cai J. LncRNA MIR155HG regulates M1/M2 macrophage polarization in chronic obstructive pulmonary disease. Biomed Pharmacother, 2019 Sep: 117: 109015.
69.	Guo Y, Li G, Xu M, et al. A lncRNA signature of tumor-infiltrating macrophages is associated with prognosis and tumor immunity in lung adenocarcinoma. Comput Biol Med, 2022 Sep: 148: 105655.
70.	van der Werf J, Chin CV, Fleming NI. SnoRNA in cancer progression, metastasis and immunotherapy response. Biology (Basel), 2021, 10(8): 809.
71.	Wang K, Wang S, Zhang Y, et al. SNORD88C guided 2'-O-methylation of 28S rRNA regulates SCD1 translation to inhibit autophagy and promote growth and metastasis in non-small cell lung cancer. Cell Death Differ, 2023, 30(2): 341-355.
72.	Liu X, Ali MK, Zhao L, et al. The emerging diagnostic and therapeutic roles of small nucleolar RNAs in lung diseases. Biomed Pharmacother, 2023, 161: 114519.
73.	Bratkovič T, Božič J, Rogelj B. Functional diversity of small nucleolar RNAs. Nucleic Acids Res, 2020, 48(4): 1627-1651.
74.	Ahmad S, Zhang XL, Ahmad A. Epigenetic regulation of pulmonary inflammation. Semin Cell Dev Biol, 2024, 154(Pt C): 346-354.
75.	Hussain S, Tulsyan S, Dar SA, et al. Role of epigenetics in carcinogenesis: Recent advancements in anticancer therapy. Semin Cancer Biol, 2022, 83: 441-451.
76.	Li P, Liu S, Du L, et al. Liquid biopsies based on DNA methylation as biomarkers for the detection and prognosis of lung cancer. Clin Epigenetics, 2022, 14(1): 118.
77.	He LX, Tang ZH, Huang QS, et al. DNA methylation: A potential biomarker of chronic obstructive pulmonary disease. Front Cell Dev Biol, 2020 Jul 7: 8: 585.
78.	Aggarwal T, Wadhwa R, Thapliyal N, et al. Oxidative, inflammatory, genetic, and epigenetic biomarkers associated with chronic obstructive pulmonary disorder. J Cell Physiol, 2019, 234(3): 2067-2082.
79.	Fang Y, Qu Y, Ji L, et al. Novel blood-based FUT7 DNA methylation is associated with lung cancer: especially for lung squamous cell carcinoma. Clin Epigenetics, 2022, 14(1): 167.
80.	Zhang G, Wang Z, Song P, et al. DNA and histone modifications as potent diagnostic and therapeutic targets to advance non-small cell lung cancer management from the perspective of 3P medicine. EPMA J, 2022, 13(4): 649-669.
81.	Günes Günsel G, Conlon TM, Jeridi A, et al. The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD. Nat Commun, 2022, 13(1): 1303.
82.	Cheng D, He Z, Zheng L, et al. PRMT7 contributes to the metastasis phenotype in human non-small-cell lung cancer cells possibly through the interaction with HSPA5 and EEF2. Onco Targets Ther, 2018 Aug 14: 11: 4869-4876.
83.	Su Y, Han W, Kovacs-Kasa A, et al. HDAC6 Activates ERK in airway and pulmonary vascular remodeling of chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol, 2021, 65(6): 603-614.
84.	Wattanathamsan O, Chantaravisoot N, Wongkongkathep P, et al. Inhibition of histone deacetylase 6 destabilizes ERK phosphorylation and suppresses cancer proliferation via modulation of the tubulin acetylation-GRP78 interaction. J Biomed Sci, 2023, 30(1): 4.
85.	Zhao L, Luo JL, Ali MK, et al. The human respiratory microbiome: Current understandings and future directions. Am J Respir Cell Mol Biol, 2023, 68(3): 245-255.
86.	木亚莎尔·吐逊江, 王雨琳, 曹洪丽. 慢性阻塞性肺疾病合并肺癌共同发病机制. 中国组织化学与细胞化学杂志, 2022, 31(4): 412-416.
87.	Liang W, Yang Y, Gong S, et al. Airway dysbiosis accelerates lung function decline in chronic obstructive pulmonary disease. Cell Host Microbe, 2023, 31(6): 1054-1070.
88.	Madapoosi SS, Cruickshank-Quinn C, Opron K, et al. Lung microbiota and metabolites collectively associate with clinical outcomes in milder stage chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 2022, 206(4): 427-439.
89.	Cameron SJS, Lewis KE, Huws SA, et al. A pilot study using metagenomic sequencing of the sputum microbiome suggests potential bacterial biomarkers for lung cancer. PLoS One, 2017, 12(5): e0177062.
90.	Kong LY, Chen XY, Lu X, et al. Association of lung-intestinal microecology and lung cancer therapy. Chin Med, 2023, 18(1): 37.
91.	Wang W, Liang X, Kong H, et al. Correlation analysis of lung mucosa-colonizing bacteria with clinical features reveals metastasis-associated bacterial community structure in non-small cell lung cancer patients. Respir Res, 2023, 24(1): 129.

1. Forder A, Zhuang R, Souza VGP, et al. Mechanisms contributing to the comorbidity of COPD and lung cancer. Int J Mol Sci, 2023, 24(3): 2859.
2. McRobbie H, Kwan B. Tobacco use disorder and the lungs. Addiction, 2021, 116(9): 2559-2571.
3. Houghton AM. Mechanistic links between COPD and lung cancer. Nat Rev Cancer, 2013, 13(4): 233-245.
4. Young RP, Hopkins RJ, Christmas T, et al. COPD prevalence is increased in lung cancer, independent of age, sex and smoking history. Eur Respir J, 2009, 34(2): 380-386.
5. Agustí A, Celli BR, Criner GJ, et al. Global initiative for chronic obstructive lung disease 2023 report: GOLD executive summary. Arch Bronconeumol, 2023, 59(4): 232-248.
6. GBD 2019 Chronic Respiratory Diseases Collaborators. Global burden of chronic respiratory diseases and risk factors, 1990-2019: An update from the Global Burden of Disease Study 2019. EClinicalMedicine, 2023, 59: 101936.
7. Duffy SP, Criner GJ. Chronic obstructive pulmonary disease: Evaluation and management. Med Clin North Am, 2019, 103(3): 453-461.
8. Yang IA, Jenkins CR, Salvi SS. Chronic obstructive pulmonary disease in never-smokers: Risk factors, pathogenesis, and implications for prevention and treatment. Lancet Respir Med, 2022, 10(5): 497-511.
9. Stoller JK, Aboussouan LS. Alpha1-antitrypsin deficiency. Lancet, 2005, 365(9478): 2225-2236.
10. Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2021, 71(3): 209-249.
11. Nicholson AG, Tsao MS, Beasley MB, et al. The 2021 WHO classification of lung tumors: Impact of advances since 2015. J Thorac Oncol, 2022, 17(3): 362-387.
12. Chen P, Liu Y, Wen Y, et al. Non-small cell lung cancer in China. Cancer Commun (Lond), 2022, 42(10): 937-970.
13. Zhang S, Pang K, Feng X, et al. Transcriptomic data exploration of consensus genes and molecular mechanisms between chronic obstructive pulmonary disease and lung adenocarcinoma. Sci Rep, 2022, 12(1): 13214.
14. Lancaster HL, Heuvelmans MA, Oudkerk M. Low-dose computed tomography lung cancer screening: Clinical evidence and implementation research. J Intern Med, 2022, 292(1): 68-80.
15. Yang SR, Schultheis AM, Yu H, et al. Precision medicine in non-small cell lung cancer: Current applications and future directions. Semin Cancer Biol, 2022, 84: 184-198.
16. de Torres JP, Marín JM, Casanova C, et al. Lung cancer in patients with chronic obstructive pulmonary disease-- Incidence and predicting factors. Am J Respir Crit Care Med, 2011, 184(8): 913-919.
17. 赵艳青, 侯明霞, 张彩苹. 慢性阻塞性肺疾病对肺癌免疫治疗临床疗效影响的分析. 临床肺科杂志, 2023, 28(9): 1304-1309.
18. Forder A, Zhuang R, Souza VGP, et al. Mechanisms contributing to the comorbidity of COPD and lung cancer. Int J Mol Sci, 2023, 24(3): 2859.
19. 张瑶, 刘学军. 慢性阻塞性肺疾病合并肺癌发病机制的研究进展. 中华老年多器官疾病杂志, 2022, 21(1): 76-80.
20. 王娅洁, 吴爽爽, 储江, 等. 肺部微生物组通过炎症反应介导慢性阻塞性肺疾病转化为肺癌的研究进展. 遗传, 2021, 43(1): 30-39.
21. 魏智民, 孙玉发, 李刚, 等. 癌症相关性炎症与肿瘤微环境相关研究进展. 中国肿瘤临床, 2018, 45(21): 1117-1121.
22. Fan T, Li S, Xiao C, et al. CCL20 promotes lung adenocarcinoma progression by driving epithelial-mesenchymal transition. Int J Biol Sci, 2022, 18(11): 4275-4288.
23. Chang YS, Tu SJ, Chen YC, et al. Mutation profile of non-small cell lung cancer revealed by next generation sequencing. Respir Res, 2021, 22(1): 3.
24. Shukla SD, Walters EH, Simpson JL, et al. Hypoxia-inducible factor and bacterial infections in chronic obstructive pulmonary disease. Respirology, 2020, 25(1): 53-63.
25. Baek EB, Kim YJ, Rho JH, et al. Anti-inflammatory effect of Gyeji-tang in a chronic obstructive pulmonary disease mouse model induced by cigarette smoke and lipopolysaccharide. Pharm Biol, 2022, 60(1): 2040-2048.
26. Aquilina NJ, Havel CM, Harrison RM, et al. Determination of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone (NNK) arising from tobacco smoke in airborne particulate matter. Environ Int, 2022 Jan: 158: 106992.
27. Liu CH, Chen Z, Chen K, et al. Lipopolysaccharide-mediated chronic inflammation promotes tobacco carcinogen-induced lung cancer and determines the efficacy of immunotherapy. Cancer Res, 2021, 81(1): 144-157.
28. 沈诚, 车国卫. 炎症因子与肺癌研究进展. 中华肿瘤防治杂志, 2014, 21(2): 157-160.
29. Budisan L, Zanoaga O, Braicu C, et al. Links between infections, lung cancer, and the immune system. Int J Mol Sci, 2021, 22(17): 9394.
30. Akbay EA, Koyama S, Liu Y, et al. Interleukin-17A promotes lung tumor progression through neutrophil attraction to tumor sites and mediating resistance to PD-1 blockade. J Thorac Oncol, 2017, 12(8): 1268-1279.
31. Tamura T, Miyazaki K, Satoh H. Features of COPD as predictors of lung cancer. Chest, 2018, 154(3): 720-721.
32. García-Rio F, Romero D, Lores V, et al. Dynamic hyperinflation, arterial blood oxygen, and airway oxidative stress in stable patients with COPD. Chest, 2011, 140(4): 961-969.
33. Zamarrón E, Prats E, Tejero E, et al. Static lung hyperinflation is an independent risk factor for lung cancer in patients with chronic obstructive pulmonary disease. Lung Cancer, 2019, 128: 40-46.
34. Yu S, Jia J, Zheng J, et al. Recent progress of ferroptosis in lung diseases. Front Cell Dev Biol, 2021, 9: 789517.
35. Oliveri V. Selective targeting of cancer cells by copper ionophores: An overview. Front Mol Biosci, 2022 Mar 4: 9: 841814.
36. Dixon SJ, Lemberg KM, Lamprecht MR, et al. Ferroptosis: An iron-dependent form of nonapoptotic cell death. Cell, 2012, 149(5): 1060-1072.
37. Xia H, Wu Y, Zhao J, et al. N6-Methyladenosine-modified circSAV1 triggers ferroptosis in COPD through recruiting YTHDF1 to facilitate the translation of IREB2. Cell Death Differ, 2023, 30(5): 1293-1304.
38. Qiao D, Hu C, Li Q, et al. Circ-RBMS1 knockdown alleviates cse-induced apoptosis, inflammation and oxidative stress via up-regulating FBXO11 through miR-197-3p in 16HBE cells. Int J Chron Obstruct Pulmon Dis, 2021, 16: 2105-2118.
39. Zhang W, Sun Y, Bai L, et al. RBMS1 regulates lung cancer ferroptosis through translational control of SLC7A11. J Clin Invest, 2021, 131(22): e152067.
40. Li R, Li X, Hagood J, et al. Myofibroblast contraction is essential for generating and regenerating the gas-exchange surface. J Clin Invest, 2020, 130(6): 2859-2871.
41. Wang Y, Duan H, Zhang J, et al. YAP1 protects against PM2. 5-induced lung toxicity by suppressing pyroptosis and ferroptosis. Ecotoxicol Environ Saf, 2023, 253: 114708.
42. Tsvetkov P, Coy S, Petrova B, et al. Copper induces cell death by targeting lipoylated TCA cycle proteins. Science, 2022, 375(6586): 1254-1261.
43. Fei Q, Weng X, Liu K, et al. The Relationship between metal exposure and chronic obstructive pulmonary disease in the general US population: NHANES 2015-2016. Int J Environ Res Public Health, 2022, 19(4): 2085.
44. Healy C, Munoz-Wolf N, Strydom J, et al. Nutritional immunity: The impact of metals on lung immune cells and the airway microbiome during chronic respiratory disease. Respir Res, 2021, 22(1): 133.
45. Chen Y, Tang L, Huang W, et al. Identification and validation of a novel cuproptosis-related signature as a prognostic model for lung adenocarcinoma. Front Endocrinol (Lausanne), 2022 Oct 24: 13: 963220.
46. Li X, Dai Z, Liu J, et al. Characterization of the functional effects of ferredoxin 1 as a cuproptosis biomarker in cancer. Front Genet, 2022, 13: 969856.
47. Cai Y, Liu R, Lu X, et al. Correlation in gene expression between the aggravation of chronic obstructive pulmonary disease and the occurrence of complications. Bioengineered, 2020, 11(1): 1245-1257.
48. Zhong F, Lin Y, Zhao L, et al. Reshaping the tumour immune microenvironment in solid tumours via tumour cell and immune cell DNA methylation: From mechanisms to therapeutics. Br J Cancer, 2023, 129(1): 24-37.
49. Córdoba-Lanús E, Domínguez de-Barros A, Oliva A, et al. Circulating miR-206 and miR-1246 as markers in the early diagnosis of lung cancer in patients with chronic obstructive pulmonary disease. Int J Mol Sci, 2023, 24(15): 12437.
50. Fujimoto J, Nunomura-Nakamura S, Liu Y, et al. Development of Kras mutant lung adenocarcinoma in mice with knockout of the airway lineage-specific gene Gprc5a. Int J Cancer, 2017, 141(8): 1589-1599.
51. Treekitkarnmongkol W, Hassane M, Sinjab A, et al. Augmented lipocalin-2 is associated with chronic obstructive pulmonary disease and counteracts lung adenocarcinoma development. Am J Respir Crit Care Med, 2021, 203(1): 90-101.
52. Wang Q, Li S, Tang X, et al. Lipocalin 2 protects against escherichia coli infection by modulating neutrophil and macrophage function. Front Immunol, 2019, 10: 2594.
53. Zhou RH, Zhang JT, Chen C, et al. Identification of CDC5L as bridge gene between chronic obstructive pulmonary disease and lung adenocarcinoma. Epigenomics, 2020, 12(17): 1515-1529.
54. Conlon TM, John-Schuster G, Heide D, et al. Inhibition of LTβR signalling activates WNT-induced regeneration in lung. Nature, 2020, 588(7836): 151-156.
55. Koerner L, Schmiel M, Yang TP, et al. NEMO- and RelA-dependent NF-κB signaling promotes small cell lung cancer. Cell Death Differ, 2023, 30(4): 938-951.
56. Su X, Liu N, Wu W, et al. Comprehensive analysis of prognostic value and immune infiltration of kindlin family members in non-small cell lung cancer. BMC Med Genomics, 2021, 14(1): 119.
57. Su X, Chen J, Lin X, et al. FERMT3 mediates cigarette smoke-induced epithelial-mesenchymal transition through Wnt/β-catenin signaling. Respir Res, 2021, 22(1): 286.
58. Verdura S, Encinar JA, Teixidor E, et al. Silibinin overcomes EMT-driven lung cancer resistance to new-generation ALK inhibitors. Cancers (Basel), 2022, 14(24): 6101.
59. Ahmad S, Manzoor S, Siddiqui S, et al. Epigenetic underpinnings of inflammation: Connecting the dots between pulmonary diseases, lung cancer and COVID-19. Semin Cancer Biol, 2022, 83: 384-398.
60. Kumar S, Gonzalez EA, Rameshwar P, et al. Non-coding RNAs as mediators of epigenetic changes in malignancies. Cancers (Basel), 2020, 12(12): 3657.
61. Shahverdi M, Hajiasgharzadeh K, Sorkhabi AD, et al. The regulatory role of autophagy-related miRNAs in lung cancer drug resistance. Biomed Pharmacother, 2022, 148: 112735.
62. Zeng Z, He S, Lu J, et al. MicroRNA-21 aggravates chronic obstructive pulmonary disease by promoting autophagy. Exp Lung Res, 2018, 44(2): 89-97.
63. Li S, Zeng X, Ma R, et al. MicroRNA-21 promotes the proliferation, migration and invasion of non-small cell lung cancer A549 cells by regulating autophagy activity via AMPK/ULK1 signaling pathway. Exp Ther Med, 2018, 16(3): 2038-2045.
64. Rezaei S, Mahjoubin-Tehran M, Aghaee-Bakhtiari SH, et al. Autophagy-related MicroRNAs in chronic lung diseases and lung cancer. Crit Rev Oncol Hematol, 2020, 153: 103063.
65. Li Y, Yin Z, Fan J, et al. The roles of exosomal miRNAs and lncRNAs in lung diseases. Signal Transduct Target Ther, 2019 Nov 13: 4: 47.
66. Sun L, Xu A, Li M, et al. Effect of Methylation status of lncRNA-MALAT1 and MicroRNA-146a on pulmonary function and expression level of COX2 in patients with chronic obstructive pulmonary disease. Front Cell Dev Biol, 2021 Sep 8: 9: 667624.
67. Li S, Mei Z, Hu HB, et al. The lncRNA MALAT1 contributes to non-small cell lung cancer development via modulating miR-124/STAT3 axis. J Cell Physiol, 2018, 233(9): 6679-6688.
68. Li N, Liu Y, Cai J. LncRNA MIR155HG regulates M1/M2 macrophage polarization in chronic obstructive pulmonary disease. Biomed Pharmacother, 2019 Sep: 117: 109015.
69. Guo Y, Li G, Xu M, et al. A lncRNA signature of tumor-infiltrating macrophages is associated with prognosis and tumor immunity in lung adenocarcinoma. Comput Biol Med, 2022 Sep: 148: 105655.
70. van der Werf J, Chin CV, Fleming NI. SnoRNA in cancer progression, metastasis and immunotherapy response. Biology (Basel), 2021, 10(8): 809.
71. Wang K, Wang S, Zhang Y, et al. SNORD88C guided 2'-O-methylation of 28S rRNA regulates SCD1 translation to inhibit autophagy and promote growth and metastasis in non-small cell lung cancer. Cell Death Differ, 2023, 30(2): 341-355.
72. Liu X, Ali MK, Zhao L, et al. The emerging diagnostic and therapeutic roles of small nucleolar RNAs in lung diseases. Biomed Pharmacother, 2023, 161: 114519.
73. Bratkovič T, Božič J, Rogelj B. Functional diversity of small nucleolar RNAs. Nucleic Acids Res, 2020, 48(4): 1627-1651.
74. Ahmad S, Zhang XL, Ahmad A. Epigenetic regulation of pulmonary inflammation. Semin Cell Dev Biol, 2024, 154(Pt C): 346-354.
75. Hussain S, Tulsyan S, Dar SA, et al. Role of epigenetics in carcinogenesis: Recent advancements in anticancer therapy. Semin Cancer Biol, 2022, 83: 441-451.
76. Li P, Liu S, Du L, et al. Liquid biopsies based on DNA methylation as biomarkers for the detection and prognosis of lung cancer. Clin Epigenetics, 2022, 14(1): 118.
77. He LX, Tang ZH, Huang QS, et al. DNA methylation: A potential biomarker of chronic obstructive pulmonary disease. Front Cell Dev Biol, 2020 Jul 7: 8: 585.
78. Aggarwal T, Wadhwa R, Thapliyal N, et al. Oxidative, inflammatory, genetic, and epigenetic biomarkers associated with chronic obstructive pulmonary disorder. J Cell Physiol, 2019, 234(3): 2067-2082.
79. Fang Y, Qu Y, Ji L, et al. Novel blood-based FUT7 DNA methylation is associated with lung cancer: especially for lung squamous cell carcinoma. Clin Epigenetics, 2022, 14(1): 167.
80. Zhang G, Wang Z, Song P, et al. DNA and histone modifications as potent diagnostic and therapeutic targets to advance non-small cell lung cancer management from the perspective of 3P medicine. EPMA J, 2022, 13(4): 649-669.
81. Günes Günsel G, Conlon TM, Jeridi A, et al. The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD. Nat Commun, 2022, 13(1): 1303.
82. Cheng D, He Z, Zheng L, et al. PRMT7 contributes to the metastasis phenotype in human non-small-cell lung cancer cells possibly through the interaction with HSPA5 and EEF2. Onco Targets Ther, 2018 Aug 14: 11: 4869-4876.
83. Su Y, Han W, Kovacs-Kasa A, et al. HDAC6 Activates ERK in airway and pulmonary vascular remodeling of chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol, 2021, 65(6): 603-614.
84. Wattanathamsan O, Chantaravisoot N, Wongkongkathep P, et al. Inhibition of histone deacetylase 6 destabilizes ERK phosphorylation and suppresses cancer proliferation via modulation of the tubulin acetylation-GRP78 interaction. J Biomed Sci, 2023, 30(1): 4.
85. Zhao L, Luo JL, Ali MK, et al. The human respiratory microbiome: Current understandings and future directions. Am J Respir Cell Mol Biol, 2023, 68(3): 245-255.
86. 木亚莎尔·吐逊江, 王雨琳, 曹洪丽. 慢性阻塞性肺疾病合并肺癌共同发病机制. 中国组织化学与细胞化学杂志, 2022, 31(4): 412-416.
87. Liang W, Yang Y, Gong S, et al. Airway dysbiosis accelerates lung function decline in chronic obstructive pulmonary disease. Cell Host Microbe, 2023, 31(6): 1054-1070.
88. Madapoosi SS, Cruickshank-Quinn C, Opron K, et al. Lung microbiota and metabolites collectively associate with clinical outcomes in milder stage chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 2022, 206(4): 427-439.
89. Cameron SJS, Lewis KE, Huws SA, et al. A pilot study using metagenomic sequencing of the sputum microbiome suggests potential bacterial biomarkers for lung cancer. PLoS One, 2017, 12(5): e0177062.
90. Kong LY, Chen XY, Lu X, et al. Association of lung-intestinal microecology and lung cancer therapy. Chin Med, 2023, 18(1): 37.
91. Wang W, Liang X, Kong H, et al. Correlation analysis of lung mucosa-colonizing bacteria with clinical features reveals metastasis-associated bacterial community structure in non-small cell lung cancer patients. Respir Res, 2023, 24(1): 129.

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