Expression and Clinical Significance of Oct-4 in Gastric Cancer:A Meta-Analysis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 QIAOWen-hui , YAONan ,  WANGJun

Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China;

Corresponding author：

WANGJun, Email: juan_phd@163.com

Keywords：

Octamer-binding transcription factor 4; Gastric cancer; Cancer stem cell; Meta-analysis

DOI：

10.7507/1007-9424.20140015

Video：

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Objective To investigate the expression and clinical significance of octamer-binding transcription factor 4(Oct-4) in gastric cancer (GC) tissues with meta-analysis. Methods PubMed, EMBASE, Web of Science, CBM, VIP, CNKI, and WanFang Database were searched from their establishment to Oct.2012 for related studies, to investigate the relationship between expression of Oct-4 and the clinicopathological characteristics of GC.After evaluating methodo-logical quality of studies that met the inclusion criteria, RevMan 5.1 software was used to data analysis. Results Eight studies which enrolled 623 cases of GC were identified.The results of the meta-analysis showed that, as for the positive expression rate of Oct-4, there were significant differences between GC tissues and normal stomach tissues (OR=37.50, 95% CI: 4.76-295.51, P < 0.01), as well as the cell differentiation (OR=0.27, 95% CI: 0.16-0.45, P < 0.01), for that the positive expression rate of Oct-4 in low differentiation of gastric cancer tissues was higher than those of moderate-high differentation group.But there were no significant differences between GC tissues with lymph node metastasis and non-lymph node metastasis (OR=2.09, 95% CI: 0.63-6.94, P=0.23), as well as Ⅰ-Ⅱ stage and Ⅲ-Ⅳ stage (OR=0.62, 95% CI: 0.25-1.54, P=0.30) of GC tissues. Conclusions Oct-4 may participate in the whole course of carcinogenesis of GC, but the relationship between expression of Oct-4 and lymph node metastasis as well as the TNM stage of GC is unclear, which needs more high quality studies to explore the question clearly.

Citation： QIAOWen-hui, YAONan, WANGJun. Expression and Clinical Significance of Oct-4 in Gastric Cancer:A Meta-Analysis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2014, 21(1): 76-81. doi: 10.7507/1007-9424.20140015 Copy

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4.	秦薇, 张晓伟, 章莉, 等.Oct-4在胃癌组织中的表达及临床意义[J].上海交通大学学报:医学版, 2009, 29(6):733-736.
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7.	Tai MH, Chang CC, Kiupel M, et al.Oct4 expression in adult human stem cells:evidence in support of the stem cell theory of carcinogenesis[J].Carcinogenesis, 2005, 26(2):495-502.
8.	Atlasi Y, Mowla SJ, Ziaee SA, et al.OCT-4, an embryonic stem cell marker, is highly expressed in bladder cancer[J].Int J Cancer, 2007, 120(7):1598-1602.
9.	Ezeh UI, Turek PJ, Reijo RA, et al.Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma[J].Cancer, 2005, 104(10):2255-2265.
10.	Iki K, Pour PM.Expression of Oct4, a stem cell marker, in the hamster pancreatic cancer model[J].Pancreatology, 2006, 6(4):406-413.
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14.	邱江锋, 张志奇, 尤俊, 等.胃癌组织中Oct4表达及其临床病理意义的探讨[J].中华肿瘤防治杂志, 2011, 18(5):342-344.
15.	翁厚光, 曹维克, 张铁成, 等.Oct4蛋白在胃癌及癌旁组织中的表达及其意义[J].江苏医药, 2011, 37(1):71-73.
16.	姚宏亮, 杨竹林, 李永国.胃良恶性病变组织中PSCA和Oct-4的表达及意义[J].中南大学学报:医学版, 2008, 33(7):623-627.
17.	张金龙, 王海娟, 路中, 等.Oct4在多种人腺癌组织中表达水平的研究[J].中国医药导报, 2011, 8(8):17-20.
18.	Lichtenstein MJ, Mulrow CD, Elwood PC.Guidelines for reading case-control studies[J].J Chronic Dis, 1987, 40(9):893-903.
19.	Yeom YI, Ha HS, Balling R, et al.Structure, expression and chromosomal location of the Oct-4 gene[J].Mech Dev, 1991, 35(3):171-179.
20.	Pan GJ, Pei DQ.Identification of two distinct transactivation dom-ains in the pluripotency sustaining factor nanog[J].Cell Res, 2003, 13(6):499-502.
21.	周一叶, 曾凡一.维持胚胎干细胞多能性和自我更新的转录因子Oct-4/Nanog以及相关的调控网络[J].遗传, 2008, 30(5):529-536.
22.	Ezashi T, Ghosh D, Roberts RM.Repression of Ets-2-induced transactivation of the tau interferon promoter by Oct-4[J].Mol Cell Biol, 2001, 21(23):7883-7891.
23.	Guo Y, Costa R, Ramsey H, et al.The embryonic stem cell tran-scription factors Oct-4 and FoxD3 interact to regulate endodermal-specific promoter expression[J].Proc Natl Acad Sci U S A, 2002, 99(6):3663-3667.
24.	Grinnell KL, Yang B, Eckert RL, et al.De-differentiation of mouse interfollicular keratinocytes by the embryonic transcription factor Oct-4[J].J Invest Dermatol, 2007, 127(2):372-380.
25.	Buitrago W, Roop DR.Oct-4:the almighty POUripotent regulator?[J].J Invest Dermatol, 2007, 127(2):260-262.

1. Brenner H, Rothenbacher D, Arndt V.Epidemiology of stomach cancer[J].Methods Mol Biol, 2009, 472(1):467-477.
2. Han ME, Lee YS, Baek SY, et al.Hedgehog signaling regulates the survival of gastric cancer cells by regulating the expression of Bcl-2[J].Int J Mol Sci, 2009, 10(7):3033-3043.
3. Parker SL, Tong T, Bolden S, et al.Cancer statistics, 1997[J].CA Cancer J Clin, 1997, 47(1):5-27.
4. 秦薇, 张晓伟, 章莉, 等.Oct-4在胃癌组织中的表达及临床意义[J].上海交通大学学报:医学版, 2009, 29(6):733-736.
5. Soltysova A, Altanerova V, Altaner C.Cancer stem cells[J].Neoplasma, 2005, 52(6):435-440.
6. Reya T, Morrison SJ, Clarke MF, et al.Stem cells, cancer, and cancer stem cells[J].Nature, 2001, 414(6859):105-111.
7. Tai MH, Chang CC, Kiupel M, et al.Oct4 expression in adult human stem cells:evidence in support of the stem cell theory of carcinogenesis[J].Carcinogenesis, 2005, 26(2):495-502.
8. Atlasi Y, Mowla SJ, Ziaee SA, et al.OCT-4, an embryonic stem cell marker, is highly expressed in bladder cancer[J].Int J Cancer, 2007, 120(7):1598-1602.
9. Ezeh UI, Turek PJ, Reijo RA, et al.Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma[J].Cancer, 2005, 104(10):2255-2265.
10. Iki K, Pour PM.Expression of Oct4, a stem cell marker, in the hamster pancreatic cancer model[J].Pancreatology, 2006, 6(4):406-413.
11. Chen Z, Xu WR, Qian H, et al.Oct4, a novel marker for human gastric cancer[J].J Surg Oncol, 2009, 99(7):414-419.
12. Matsuoka J, Yashiro M, Sakurai K, et al.Role of the stemness factors sox2, oct3/4, and nanog in gastric carcinoma[J].J Surg Res, 2012, 174(1):130-135.
13. 曹梦苒, 谢剑明, 刘斐烨.转录因子Oct-4在胃癌中的表达及意义[J].山东医药, 2012, 52(32):78-80.
14. 邱江锋, 张志奇, 尤俊, 等.胃癌组织中Oct4表达及其临床病理意义的探讨[J].中华肿瘤防治杂志, 2011, 18(5):342-344.
15. 翁厚光, 曹维克, 张铁成, 等.Oct4蛋白在胃癌及癌旁组织中的表达及其意义[J].江苏医药, 2011, 37(1):71-73.
16. 姚宏亮, 杨竹林, 李永国.胃良恶性病变组织中PSCA和Oct-4的表达及意义[J].中南大学学报:医学版, 2008, 33(7):623-627.
17. 张金龙, 王海娟, 路中, 等.Oct4在多种人腺癌组织中表达水平的研究[J].中国医药导报, 2011, 8(8):17-20.
18. Lichtenstein MJ, Mulrow CD, Elwood PC.Guidelines for reading case-control studies[J].J Chronic Dis, 1987, 40(9):893-903.
19. Yeom YI, Ha HS, Balling R, et al.Structure, expression and chromosomal location of the Oct-4 gene[J].Mech Dev, 1991, 35(3):171-179.
20. Pan GJ, Pei DQ.Identification of two distinct transactivation dom-ains in the pluripotency sustaining factor nanog[J].Cell Res, 2003, 13(6):499-502.
21. 周一叶, 曾凡一.维持胚胎干细胞多能性和自我更新的转录因子Oct-4/Nanog以及相关的调控网络[J].遗传, 2008, 30(5):529-536.
22. Ezashi T, Ghosh D, Roberts RM.Repression of Ets-2-induced transactivation of the tau interferon promoter by Oct-4[J].Mol Cell Biol, 2001, 21(23):7883-7891.
23. Guo Y, Costa R, Ramsey H, et al.The embryonic stem cell tran-scription factors Oct-4 and FoxD3 interact to regulate endodermal-specific promoter expression[J].Proc Natl Acad Sci U S A, 2002, 99(6):3663-3667.
24. Grinnell KL, Yang B, Eckert RL, et al.De-differentiation of mouse interfollicular keratinocytes by the embryonic transcription factor Oct-4[J].J Invest Dermatol, 2007, 127(2):372-380.
25. Buitrago W, Roop DR.Oct-4:the almighty POUripotent regulator?[J].J Invest Dermatol, 2007, 127(2):260-262.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Expression and Clinical Significance of Oct-4 in Gastric Cancer:A Meta-Analysis

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