Magnetic Resonance Imaging for The T Staging of Gastric Cancer: A Meta-Analysis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 ZHAOShuang , TANGJing , HUANGZi-xing ,  LIURong-bo

Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China;

Corresponding author：

LIURong-bo, Email: medicalimage@163.com

Keywords：

Magnetic resonance imaging; Gastric cancer; T staging; Meta-analysis

DOI：

10.7507/1007-9424.20140025

Video：

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Object To evaluate the sensitivity, specificity, and accuracy of magnetic resonance imaging (MRI) for the preoperative T staging of gastric cancer. Methods The databases such as the PubMed, Cochrane Database Systematic Reviews, EMbase, CNKI, and Wanfang Data were searched on computer from 1993 to 2012.The reviewers screened the trials according to inclusion and exclusion criteria strictly, extracted the data, and assessed the methodology quality.Meta-analysis were performed using the Metadisc 1.40 software, the pathology diagnosis as gold standard.The acquired pooled sensitivity, specificity, and summary receiver operating characteristic curve (SROC) were used to describe the value of MRI in T staging. Results Eight case-control studies involving 302 patients with gastric cancer were included in the study.The pooled statistical results of Meta-analysis showed that:the pooled sensitivity and specificity of MRI for T1-stage gastric cancer were 85%(55%-98%) and 97%(91%-99%) respectively, and the area under the SROC curve (AUC) was 0.961.The pooled sensitivity and specificity of MRI for T2-stage gastric cancer were 73%(60%-84%) and 93%(89%-96%) respectively, and the AUC was 0.935.The pooled sensitivity and specificity of MRI for T3-stage gastric cancer were 87%(81%-92%) and 82%(74%-88%) respectively, and the AUC was 0.914.The pooled sensitivity and specificity of MRI for T4-stage gastric cancer were 75%(62%-86%) and 97%(94%-99%) respectively, and the AUC was 0.963. Conclusion MRI has the high consistency in preoperative T staging with pathology, and should be recommended as a preferred to increase the accuracy of preoperative staging, and improve the prognosis.

Citation： ZHAOShuang, TANGJing, HUANGZi-xing, LIURong-bo. Magnetic Resonance Imaging for The T Staging of Gastric Cancer: A Meta-Analysis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2014, 21(1): 106-111. doi: 10.7507/1007-9424.20140025 Copy

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8.	Chen CY, Wu DC, Kang WY, et al.Staging of gastric cancer with 16-channel MDCT[J].Abdom Imaging, 2006, 31(5):514-520.
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20.	吴建胜, 陈哲京, 程骏, 等.MRI和内镜在胃癌诊断及pT分期中的对照研究[J].实用医学杂志, 2003, 19(9):969-970.
21.	汤群峰, 沈钧康, 冯一中, 等.胃癌动态增强MRI表现与肿瘤血管形成关系的研究[J].中华放射学杂志, 2004, 38(10):1075-1080.
22.	邱岩, 罗娅红, 于韬, 等.应用低场MRI平扫评价进展期胃癌的胃壁及胃周浸润[J].实用肿瘤学杂志, 2008, 22(1:32-34.
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1. 曾红梅, 陈万青.中国癌症流行病学与防治研究现状[J].化学进展, 2013, 25(9):1415-1420.
2. Ly QP, Sasson AR.Modern surgical considerations for gastric cancer[J].J Natl Compr Cancer Netw, 2008, 6(9):885-894.
3. Kovoor PA, Hwang J.Treatment of resectable gastric cancer:current standards of care[J].Expert Rev Anticancer Ther, 2009, 9(1):135-142.
4. Hartgrink HH, Jansen EP, van Grieken NC, et al.Gastric cancer[J].Lancet, 2009, 374(9688):477-490.
5. Catalano V, Labianca R, Beretta GD, et al.Gastric cancer[J].Crit Rev Oncol Hematol, 2009, 71(2):127-164.
6. 胡建昆, 陈心足.胃癌多学科协作诊疗模式现状[J].中国普外基础与临床杂志, 2012, 19(1):1-3.
7. Tsuzuki T, Okada H, Kawahara Y, et al.Usefulness and problems of endoscopic ultrasonography in prediction of the depth of tumor invasion in early gastric cancer[J].Acta Med Okayama, 2011, 65(2):105-112.
8. Chen CY, Wu DC, Kang WY, et al.Staging of gastric cancer with 16-channel MDCT[J].Abdom Imaging, 2006, 31(5):514-520.
9. Kim AY, Kim HJ, Ha HK.Gastric cancer by multidetector row CT:preoperative staging[J].Abdom Imaging, 2005, 30(4):465-472.
10. Makino T, Fujiwara Y, Takiguchi S, et al.Preoperative T staging of gastric cancer by multi-detector row computed tomography[J].Surgery, 2011, 149(5):672-679.
11. Furukawa K, Miyahara R, Itoh A, et al.Diagnosis of the invasion depth of gastric cancer using MDCT with virtual gastroscopy:comparison with staging with endoscopic ultrasound[J].AJR Am J Roentgenol, 2011, 197(4):867-875.
12. Tunaci M.Carcinoma of stomach and duodenum:radiologic dia-gnosis and staging[J].Eur J Radiol, 2002, 42(3):181-192.
13. Kwee RM, Kwee TC.Imaging in local staging of gastric cancer:a systematic review[J].J Clin Oncol, 2007, 25(15):2107-2116.
14. Higgins JPT, Green S.Cochrane handbook for systematic reviews of interventions version 5.1.0[DB/OL].2009, www.cochrane-handbook.org/.
15. Wang CK, Kuo YT, Liu GC, et al.Dynamic contrast-enhanced subtraction and delayed MRI of gastric tumors:radiologic-pathologic correlation[J].J Comput Assist Tomogr, 2000, 24(6):872-877.
16. Kang BC, Kim JH, Kim KW, et al.Value of the dynamic and delayed MR sequence with Gd-DTPA in the T-staging of stomach cancer:correlation with the histopathology[J].Abdom Imaging, 2000, 25(1):14-24.
17. Sohn KM, Lee JM, Lee SY, et al.Comparing MR imaging and CT in the staging of gastric carcinoma[J].AJR Am J Roentgenol, 2000, 174(6):1551-1557.
18. 汤光宇, 邢萍萍, 郭庆禄.MRI对进展期胃癌术前分期的评价[J].江西医学院学报, 1996, 36(2):29-32.
19. 王宏, 吕剑, 方敏, 等.MRI在胃癌诊断与分期中的应用研究[J].中国医学影像技术, 1999, 15(10):781-783.
20. 吴建胜, 陈哲京, 程骏, 等.MRI和内镜在胃癌诊断及pT分期中的对照研究[J].实用医学杂志, 2003, 19(9):969-970.
21. 汤群峰, 沈钧康, 冯一中, 等.胃癌动态增强MRI表现与肿瘤血管形成关系的研究[J].中华放射学杂志, 2004, 38(10):1075-1080.
22. 邱岩, 罗娅红, 于韬, 等.应用低场MRI平扫评价进展期胃癌的胃壁及胃周浸润[J].实用肿瘤学杂志, 2008, 22(1:32-34.
23. Edge SB, Byrd DR, Compton CC, et al.AJCC Cancer Staging Manual, 7th edition[M].New York:Springer-Verlag, 2010:117-126.

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Magnetic Resonance Imaging for The T Staging of Gastric Cancer: A Meta-Analysis

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