Analysis on Diagnosis and Treatment of 14 Cases of Ectopic Thyroid Gland Disease_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 HUANGQiu-shi , WEITao , ZHUXin-xin ,  DUZhen-hong , ZHUJing-qiang

Department of Thyroid and Breast Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China;

Corresponding author：

DUZhen-hong, Email: zjq-wkys@163.com

Keywords：

Ectopic thyroid gland; Diagnosis; Treatment

DOI：

10.7507/1007-9424.20140107

Video：

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Objective To explore the clinical characteristics, diagnosis and treatment of ectopic thyroid gland (ETG) so as to reduce the misdiagnosis and improper treatment. Methods According to the patients who were definitely diagnosed ETG by pathology from 2002 to 2010 in our hospital, their clinical and pathological data were retrospectively analyzed. Results There were 14 patients, 4 cases of male and 10 cases of female. Five patients had clinical symptoms. Eight cases were diagnosed before operation and six cases were diagnosed by pathology after operation. There were 4 cases were malignancy and 10 were benign. Three cases of differentiated ectopic thyroid carcinoma patients and 1 normal position's thyroid had papillary carcinoma patient accepted TSH suppression treatment after operation, 4 benign patients and 1 ectopic thyroid medullary carcinoma patient accepted levothyroxine substitution treatment after operation, and the other 5 benign patients did not accept any treatment after operation. Nine patients who accepted follow-up in 1-10 years had orthobiosis, and the malignancy patients without recurrence and metastasis. Conclusions ETG usually reveal no any special clinical features. For any masses from root of tongue to mediastinum, especially cervical masses, should be carefully check whether there are thyroid in normal position, and to exclude ETG. The color Doppler ultrasound, thyroid radioactive scanning, thyroid function tests, computed tomography, and fine needle aspiration cytology are all important examination measures. Due to the ETG may occur the same lesions as the normal position's thyroid, so once it is be definitly diagnosed, the treatment should be based on patient's age, position, size, and type of ETG, and nature of the lesions to select follow-up observation, operative treatment, levothyroxine replacement or therapeutic inhibition of TSH, and ¹³¹I therapy.

Citation： HUANGQiu-shi, WEITao, ZHUXin-xin, DUZhen-hong, ZHUJing-qiang. Analysis on Diagnosis and Treatment of 14 Cases of Ectopic Thyroid Gland Disease. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2014, 21(4): 442-447. doi: 10.7507/1007-9424.20140107 Copy

1.	Amoodi HA, Makki F, Taylor M, et al. Lateral ectopic thyroid goiter with a normally located thyroid[J]. Thyroid, 2010, 20(2):217-220.
2.	徐峰, 田景琦, 黄黎明.异位甲状腺临床诊治分析[J].中国耳鼻咽喉头颈外科, 2013, 20(4):221-222.
3.	Kozol RA, Geelhoed GW, Flynn SD, et al. Management of ectopic thyroid nodules[J]. Surgery, 1993, 114(6):1103-1106.
4.	王宏, 孙莹, 贾静, 等.国内近30年报道的198例异位甲状腺病例的文献分析[J].临床耳鼻咽喉头颈外科杂志, 2012, 26(18):814-816.
5.	兰新海.舌根异位甲状腺诊治分析[J].临床耳鼻咽喉头颈外科杂志, 2011, 25(22):1044-1045.
6.	李思源, 吴新淮, 李珍红.迷走型舌根异位甲状腺1例[J].中国医学影像技术, 2005, 21(7):1077.
7.	Ulug T, Ulubil SA, Alagol F. Dual ectopic thyroid:report of a case[J]. J Laryngol Otol, 2003, 117(7):574-576.
8.	李向东, 郑艳, 刘世喜.颈部异位甲状腺临床分析[J].中国耳鼻咽喉头颈外科, 2008, 15(7):388-390.
9.	Prasad KC, Bhat V. Surgical management of lingual thyroid:a report of four cases[J]. J Oral Maxillofac Surg, 2000, 58(2):223-227.
10.	李军, 孙坚.舌异位甲状腺1例报告[J].口腔颌面外科杂志, 2000, 10(4):370.
11.	Batsakis JG, EL-Naggar AK, Luna MA. Thyroid gland ectopias[J]. Ann Otol Rhinol Laryngol, 1996, 105(12):996-1000.
12.	黄选兆, 汪吉宝.实用耳鼻喉科学[M].北京:人民卫生出版社, 1998:39.
13.	赵华, 陈刚, 李亮, 等.异位甲状腺诊治分析[J].中国耳鼻咽喉头颈外科, 2008, 15(6):327-329.
14.	Williams JD, Sclafani AP, Slupchinskij O, et al. Evaluation and management of the lingual thyroid gland[J]. Ann Otol Rhinol Laryngol, 1996, 105(4):312-316.
15.	Sood A, Kumar R. The ectopic thyroid gland and the role of nuclear medicine techniques in its diagnosis and management[J]. Hell J Nucl Med, 2008, 11(3):168-171.
16.	Gkeli MG, Apergis S, Klapsinou E, et al. Submandibular ectopic thyroid tissue diagnosed by ultrasound-guided fine needle biopsy[J]. J Oral Sci, 2011, 53(2):249-252.
17.	甄宏韬, 刘秋润, 崔永华, 等.提高异位甲状腺诊断符合率的方法[J].临床耳鼻咽喉科杂志, 2002, 16(5):265-266.
18.	Bukachevsky RP, Casler JD, Oliver J, et al. Squamous cell carc-inoma and lingual thyroid[J]. Ear NoseThroat J, 1991, 70(8):505-507.
19.	张云宏, 王广军, 贾氢, 等.罕见异位甲状腺腺瘤误诊切除引发医疗纠纷的思考[J].法律与医学杂志, 2006, 13(2):88-89.
20.	徐雅男, 王家东.隐匿性甲状腺癌的外科治疗[J].临床耳鼻咽喉科杂志, 2006, 20(24):1150-1152.
21.	Abdul-Jabar HB, Lynn J. The surgical management of thyroid cancer[J]. Nuel Med Commun, 2004, 25(9):869-872.

1. Amoodi HA, Makki F, Taylor M, et al. Lateral ectopic thyroid goiter with a normally located thyroid[J]. Thyroid, 2010, 20(2):217-220.
2. 徐峰, 田景琦, 黄黎明.异位甲状腺临床诊治分析[J].中国耳鼻咽喉头颈外科, 2013, 20(4):221-222.
3. Kozol RA, Geelhoed GW, Flynn SD, et al. Management of ectopic thyroid nodules[J]. Surgery, 1993, 114(6):1103-1106.
4. 王宏, 孙莹, 贾静, 等.国内近30年报道的198例异位甲状腺病例的文献分析[J].临床耳鼻咽喉头颈外科杂志, 2012, 26(18):814-816.
5. 兰新海.舌根异位甲状腺诊治分析[J].临床耳鼻咽喉头颈外科杂志, 2011, 25(22):1044-1045.
6. 李思源, 吴新淮, 李珍红.迷走型舌根异位甲状腺1例[J].中国医学影像技术, 2005, 21(7):1077.
7. Ulug T, Ulubil SA, Alagol F. Dual ectopic thyroid:report of a case[J]. J Laryngol Otol, 2003, 117(7):574-576.
8. 李向东, 郑艳, 刘世喜.颈部异位甲状腺临床分析[J].中国耳鼻咽喉头颈外科, 2008, 15(7):388-390.
9. Prasad KC, Bhat V. Surgical management of lingual thyroid:a report of four cases[J]. J Oral Maxillofac Surg, 2000, 58(2):223-227.
10. 李军, 孙坚.舌异位甲状腺1例报告[J].口腔颌面外科杂志, 2000, 10(4):370.
11. Batsakis JG, EL-Naggar AK, Luna MA. Thyroid gland ectopias[J]. Ann Otol Rhinol Laryngol, 1996, 105(12):996-1000.
12. 黄选兆, 汪吉宝.实用耳鼻喉科学[M].北京:人民卫生出版社, 1998:39.
13. 赵华, 陈刚, 李亮, 等.异位甲状腺诊治分析[J].中国耳鼻咽喉头颈外科, 2008, 15(6):327-329.
14. Williams JD, Sclafani AP, Slupchinskij O, et al. Evaluation and management of the lingual thyroid gland[J]. Ann Otol Rhinol Laryngol, 1996, 105(4):312-316.
15. Sood A, Kumar R. The ectopic thyroid gland and the role of nuclear medicine techniques in its diagnosis and management[J]. Hell J Nucl Med, 2008, 11(3):168-171.
16. Gkeli MG, Apergis S, Klapsinou E, et al. Submandibular ectopic thyroid tissue diagnosed by ultrasound-guided fine needle biopsy[J]. J Oral Sci, 2011, 53(2):249-252.
17. 甄宏韬, 刘秋润, 崔永华, 等.提高异位甲状腺诊断符合率的方法[J].临床耳鼻咽喉科杂志, 2002, 16(5):265-266.
18. Bukachevsky RP, Casler JD, Oliver J, et al. Squamous cell carc-inoma and lingual thyroid[J]. Ear NoseThroat J, 1991, 70(8):505-507.
19. 张云宏, 王广军, 贾氢, 等.罕见异位甲状腺腺瘤误诊切除引发医疗纠纷的思考[J].法律与医学杂志, 2006, 13(2):88-89.
20. 徐雅男, 王家东.隐匿性甲状腺癌的外科治疗[J].临床耳鼻咽喉科杂志, 2006, 20(24):1150-1152.
21. Abdul-Jabar HB, Lynn J. The surgical management of thyroid cancer[J]. Nuel Med Commun, 2004, 25(9):869-872.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Analysis on Diagnosis and Treatment of 14 Cases of Ectopic Thyroid Gland Disease

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