Clinical Observation of Intraperitoneal Implant with Fluorouracil Sustained-Release in Operation of Rectal Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 陆雪明 , 王树钦

揭阳市人民医院肿瘤外科（广东揭阳 522000）;

Corresponding author：

陆雪明, Email: 505739308@qq.com; 505739308@qq.com

Keywords：

直肠癌; 手术; 氟尿嘧啶缓释剂; 局部植入

DOI：

10.7507/1007-9424.20140121

Video：

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Abstract Full text Figures/Tables Video References Cited by

目的观察直肠癌术中局部植入氟尿嘧啶缓释剂（5-FU SRI）的可行性及疗效。方法 92例直肠癌患者分成治疗组和对照组，治疗组术中在瘤床和沿淋巴引流途径分多点植入5-FU SRI 600 mg，对照组行常规直肠癌根治术，观察2组患者的手术情况、毒副反应、近期并发症及远期疗效。结果 2组的手术时间、出血量以及腹膜炎、吻合口漏、肠梗阻和切口感染发生率的差异均无统计学意义（P＞0.05）；2组患者的白细胞计数、肌酐及ALT水平治疗后高于治疗前（P＜0.05），但2组间差异无统计学意义（P＞0.05）。治疗组腹腔局部复发率及远处转移率均较对照组低（P＜0.05）。结论直肠癌术中植入5-FU SRI是安全可行的，是预防术后复发转移的有效途径。

Citation： 陆雪明, 王树钦. Clinical Observation of Intraperitoneal Implant with Fluorouracil Sustained-Release in Operation of Rectal Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2014, 21(4): 495-497. doi: 10.7507/1007-9424.20140121 Copy

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1. 梁君林, 万德森, 潘志忠, 等.结直肠癌根治术后复发转移的多因素分析[J].癌症, 2004, 23(5):564-567.
2. 万德森主编.临床肿瘤学[M].第3版.北京:科学出版社, 2010:394-396.
3. 顾晋.美国NCCN直肠癌治疗规范(2006)解读[J].医学继续教育, 2007, 21(9):30-34.
4. 余波.结直肠癌局部复发的外科治疗[J].中华胃肠外科杂志, 2006, 9(3):199-200.
5. Li TS, Kaneda Y, Ueda K, et al. The influence of tumor resection on angiostatin levels and tumor growth:a experimental study in tumor-bearing nice[J]. Eur J Cancer, 2001, 37(3):2283-2288.
6. Glehen O, Kwiatkowski F, Sugarbaker PH, et al. Cytoreductive surgery combinedwith perioperative intraperitoneal chemotherapy for themanagement of peritoneal carcinomatosis from colorectal cancer:amult-institutional study[J]. J Clin Oncol, 2004, 22(16):3284-3292.
7. Glehen O, Mithieux F, Osinsky D, et al. Surgery combined with peritonectomy procedures and intraperitoneal chemohyperthermia in abdominal cancerswith peritoneal carcinomatosis:a phaseⅡstudy[J]. J Clin Oncol, 2003, 21(5):799-806.
8. Glehen O, Gilly FN, Sugarbaker PH. New perspectives in the managementof colorectal cancer:what about peritoneal carcinomatosis[J]. Scand J Surg, 2003, 92(2):178-179.
9. 朱正纲.术中腹腔内温热化疗在胃癌外科综合治疗中的临床意义[J].外科理论与实践, 2000, 5(3):138-142.
10. 任统伟, 王润莲, 张敏, 等.植入用缓释氟尿嘧啶治疗胃肠道肿瘤安全性研究[J].肿瘤学杂志, 2007, 13(4):309-310.
11. 刘华顶, 王世亮, 武四化, 等.缓释氟尿嘧啶植入剂在大肠癌患者的药动学研究[J].中国新药杂志, 2005, 14(10):1199-1200.
12. Maeda M, Moriuchi S, Sano A, et al. New drug delivery system for water-soluble drugs using silicone and its usefulness for local treatment:application of GCV-silicone to GCV/HSV-tk gene therapy for brain tumor[J]. J Control Release, 2002, 84(1-2):15-25.
13. Ning S, Yu N, Brown DM, et al. Radiosensitization by intratu-moral administration ofcisplatin in a sustained-release drug delivery system[J]. Radiother Oncol, 1999, 50(2):215-223.
14. 吴在德, 吴肇汉主编.外科学[M].第7版.北京:人民卫生出版社, 2012:492-496.
15. 莫隽全, 庄思敏, 谭卫民, 等.术中植入缓释氟尿嘧啶预防大肠癌术后肝转移的效果[J].广东医学, 2006, 27(9):1346-1347.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Clinical Observation of Intraperitoneal Implant with Fluorouracil Sustained-Release in Operation of Rectal Cancer

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