Correlaiton Between Dynamic Contrast Enhanced Magnetic Resonance Imaging and WHO Histological Grade in Patients with Invasive Ductal Breast Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 HUANGJuan ,  YUJian-qun

Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China;

Corresponding author：

YUJian-qun, Email: cjr.yujianqun@vip.163.com

Keywords：

Invasive ductal breast cancer; Magnetic resonance imaging; Diagnosis; Histological grade

DOI：

10.7507/1007-9424.20140154

Video：

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Objective To investigate the relationship of dynamic contrast enhanced(DCE) MRI scan of the mass type of invasive ductal breast cancer to histological grade. Method The imagings of DCEMRI of 92 patients confirmed with operation or biopsy pathology and its correlation with WHO histological grade were analyzed. Results There were 29(31.52%) patients with the tumor long diameter≤2 cm, 53(57.61%) 2-5 cm, 10(10.87%)≥5 cm. There were 3(3.26%) patients with round of the morphological lesions, 7(7.61%) oval, 33(35.87%) lobulated shape, 49(53.26%) irregular shape. There were 11 (11.96%) patients with smooth margin of the periphery of the lesions, 47 (51.09%) irregular shape, 34(36.96%) spiculate margin. There were 15(16.30%) patients with homogeneous enhancement, 40(43.48%) heterogeneous enhancement, 37(40.22%) ring-like enhancement. WHO pathological grade:grade 1 was in 5 cases(5.43%), grade 2 in 30 cases(32.61%), grade 3 in 57 cases(61.96%). The statistical results showed that MRI dynamic enhancement characteristics of lesions in size, shape, and enhanced features were correlated with WHO pathological grade (P < 0.05), there was no correlation between the edge features of the tumor and WHO histological grade(P > 0.05). Conclusion There is a certain correlation between the breast cancer enhanced MRI features and WHO histological grade, which can be evaluated biological behavior and prognosis according to MRI signs of lesions.

Citation： HUANGJuan, YUJian-qun. Correlaiton Between Dynamic Contrast Enhanced Magnetic Resonance Imaging and WHO Histological Grade in Patients with Invasive Ductal Breast Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2014, 21(5): 636-640. doi: 10.7507/1007-9424.20140154 Copy

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20.	刘佩芳, 鲍润贤, 牛昀, 等.乳腺良恶性病变动态增强MRI表现特征与血管生成相关性的初步研究[J].中华放射学杂志, 2002, 36(11):967-972.
21.	Matsubayashi R, Matsuo Y, Edakuni G, et al.Breast masses with peripheral rim enhancement on dynamic contrast-enhanced MR images:Correlation of MR findings with histologic features and expression of growth factors[J].Radiology, 2000, 217(3):841-848.
22.	Buadu LD, Murakami J, Murayama S, et al.Patterns of peripheral enhancement in breast masses:Correlation of findings on contrast medium enhanced MRI with histologic features and tumor angiogenesis[J].J Comput Assist Tomogr, 1997, 21(3):421-430.
23.	Macura KJ, Ouwerkerk R, Jacobs MA, et al.Patterns of enhancement on breast MR images:interpretation and imaging pitfalls[J].Radiographics, 2006, 26(6):1719-1734.
24.	Kuhl CK, Schild HH, Morakkabati N.Dynamic bilateral contrastenhanced MR imaging of the breast:trade-off between spatial and temporal resolution[J].Radiology, 2005, 236(3):789-800.
25.	El Khouli RH, Macura KJ, Jacobs MA, et al.Dynamic contrastenhanced MRI of the breast:quantitative method for kinetic curve type assessment[J].AJR Am J Roentgenol, 2009, 193(4):W295-W300.
26.	Mussurakis S, Gibbs P, Horsman A.Peripheral enhancement and spatial contrast uptake heterogeneity of primary breast tumours:quantitative assessment with dynamic MRI[J].J Comput Assist Tomogr, 1998, 22(1):35-46.

1. Kuhl CK.MRI of breast tumors[J].Eur Radiol, 2000, 10(1):46-58.
2. Fitzgibbons PL, Page DL, Weaver D, et al.Prognostic factors in breast cancer.College of American Pathologists Consensus Statement 1999[J].Arch Pathol Lab Med, 2000, 124(7):966-978.
3. Brennan M, Spillane A, Houssami N.The role of breast MRI in clinical practice[J].Aust Fam Physician, 2009, 38(7):513-519.
4. Saslow D, Boetes C, Burke W, et al.American cancer society guidelines for breast screening with MRI as an adjunct to mammography[J].CA Cancer J Clin, 2007, 57(2):75-89.
5. Szabó BK, Aspelin P, Kristoffersen Wiberg M, et al.Invasive breast cancer:correlation of dynamic MR features with prognostic factors[J].Eur Radiol, 2003, 13(11):2425-2435.
6. Lee SH, Cho N, Kim SJ, et al.Correlation between high resolution dynamic MR features and prognostic factors in breast cancer[J].Korean J Radiol, 2008, 9(1):10-18.
7. Szabó BK, Aspelin P, Kristoffersen Wiberg M, et al.Invasive breast cancer:correlation of dynamic MR features with prognostic factors[J].Eur Radiol, 2003, 13(11):2425-2435.
8. 王黎明.乳腺浸润性导管癌3T磁共振动态增强特征与预后的相关性研究[J].中国医学影像学杂志, 2011, 19(8):596-600.
9. Elston CW, Ellis IO.Pathological prognostic factors in breast cancer.Ⅰ.The value of histological grade in breast cancer:experience from a large study with long-term follow-up[J].Histopathology, 1991, 19(5):403-410.
10. Lamb PM, Perry NM, Vinnicombe SJ, et al.Correlation between ultrasound characteristics, mammographic findings and histological grade in patients with invasive ductal carcinoma of the breast[J].Clin Radiol, 2000, 55(1):40-44.
11. Tozaki M, Igarashi T, Fukuda K.Positive and negative predictive values of BI-RADS-MRI descriptors for focal breast masses[J].Magn Reson Med Sci, 2006, 5(1):7-15.
12. LaTrenta LR, Menell JH, Morris EA, et al.Breast lesions detected with Mr imaging:utility and histopathologic importance of identification with US[J].Radiology, 2003, 227(3):856-861.
13. Van Goethem M, Schelfout K, Dijckmans L, et al.MR mammography in the pre-operative staging of breast cancer in patients with dense breast tissue:comparison with mammography and ultrasound[J].Eur Radiol, 2004, 14(5):809-816.
14. Esserman L, Hylton N, George T, et al.Contrast-Enhanced magnetic resonance imaging to assess tumor histopathology and angiogenesis in breast carcinoma[J].Breast J, 1999, 5(1):13-21.
15. Liu PF, Bao RX, Niu Y, et al.Breast lesions:Correlation of dynamic contrast enhancement patterns on MR images with tumor angiogenesis[J].Chin J Clin Oncol, 2004, 1(2):78-85.
16. Buadu LD, Murakami J, Murayama S, et al.Breast lesions:correlation of contrast medium enhancement patterns on MR images with histopathologic findings and tumor angiogenesis[J].Radiology, 1996, 200(3):639-649.
17. Matsubayashi RN, Fujii T, Yasumori K, et al.Apparent Diffusion Coefficient in Invasive Ductal Breast Carcinoma:Correlation with Detailed Histologic Features and the Enhancement Ratio on Dynamic Contrast-Enhanced MR Images[J].J Oncol, 2010, 2010.pii:821048.doi:10.1155/2010/821048..
18. Su MY, Baik HM, Yu HJ, et al.Comparison of choline and pharmacokinetic parameters in breast cancer measured by MR spectroscopic imaging and dynamic contrast enhanced MRI[J].Technol Cancer Res Treat, 2006, 5(4):401-410.
19. Paradiso A, Mangia A, Barletta A, et al.Mammography and morphobiologic characteristics of human breast cancer[J].Tumori, 1993, 79(6):422-426.
20. 刘佩芳, 鲍润贤, 牛昀, 等.乳腺良恶性病变动态增强MRI表现特征与血管生成相关性的初步研究[J].中华放射学杂志, 2002, 36(11):967-972.
21. Matsubayashi R, Matsuo Y, Edakuni G, et al.Breast masses with peripheral rim enhancement on dynamic contrast-enhanced MR images:Correlation of MR findings with histologic features and expression of growth factors[J].Radiology, 2000, 217(3):841-848.
22. Buadu LD, Murakami J, Murayama S, et al.Patterns of peripheral enhancement in breast masses:Correlation of findings on contrast medium enhanced MRI with histologic features and tumor angiogenesis[J].J Comput Assist Tomogr, 1997, 21(3):421-430.
23. Macura KJ, Ouwerkerk R, Jacobs MA, et al.Patterns of enhancement on breast MR images:interpretation and imaging pitfalls[J].Radiographics, 2006, 26(6):1719-1734.
24. Kuhl CK, Schild HH, Morakkabati N.Dynamic bilateral contrastenhanced MR imaging of the breast:trade-off between spatial and temporal resolution[J].Radiology, 2005, 236(3):789-800.
25. El Khouli RH, Macura KJ, Jacobs MA, et al.Dynamic contrastenhanced MRI of the breast:quantitative method for kinetic curve type assessment[J].AJR Am J Roentgenol, 2009, 193(4):W295-W300.
26. Mussurakis S, Gibbs P, Horsman A.Peripheral enhancement and spatial contrast uptake heterogeneity of primary breast tumours:quantitative assessment with dynamic MRI[J].J Comput Assist Tomogr, 1998, 22(1):35-46.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Correlaiton Between Dynamic Contrast Enhanced Magnetic Resonance Imaging and WHO Histological Grade in Patients with Invasive Ductal Breast Cancer

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