Systematic Evaluation on Relationship Between Viral Hepatitis and Extrahepatic Cholangiocarcinoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 CHENTing-hao ,  HECheng-jun

Department of General Surgery, The First People's Hospital of Ziyang City, Ziyang 641300, Sichuan Province, China;

Corresponding author：

HECheng-jun, Email: hechengjunhelei@163.com

Keywords：

Extrahepatic cholangiocarcinoma; Hepatitis B virus; Hepatitis C virus; Meta analysis

DOI：

10.7507/1007-9424.20140171

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To explore the association between viral hepatitis and extrahepatic cholangiocarcinoma (ECC). Methods Database of Medline, Embase, PubMed, CNKI, and Wanfang were searched for the articles which were related to the relationship between viral hepatitis and ECC. After the quality evaluation and the data extraction of the literatures, statistical software of RevMan 5.0 was used to perform Meta analysis. Results According to the inclusion criteria and exclusion criteria, 9 articles were enrolled, 8 articles of them were related to hepatitis B virus(HBV) and 6 articles of them were related to hepatitis C virus(HCV). Meta analysis results showed that the HBV infection may be the risk factor for ECC(OR=1.69, 95% CI:1.32-2.17, P<0.000 1). In the United States, HCV infection may be the risk factor for ECC(OR=5.53, 95% CI:2.21-13.82, P=0.000 3), but the relationship was not found in China(OR=0.82, 95% CI:0.44-1.52, P=0.520 0). Conclusions The present studies suggest that HBV infection may be a high risk factor for ECC. HCV in the United States can increase the incidence of ECC, but the situation can not be found in China.

Citation： CHENTing-hao, HECheng-jun. Systematic Evaluation on Relationship Between Viral Hepatitis and Extrahepatic Cholangiocarcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2014, 21(6): 721-726. doi: 10.7507/1007-9424.20140171 Copy

1.	Gatto M, Bragazzi MC, Semeraro R, et al.Cholangiocarcinoma:update and future perspectives[J].Dig Liver Dis, 2010, 42(4):253-260.
2.	Deoliveira ML, Cunningham SC, Cameron JL, et al.Cholangiocarcinoma:thirty-one-year experience with 564 patients at a single institution[J].Ann Surg, 2007, 245(5):755-762.
3.	Shaib Y, El-Serag HB.The epidemiology of cholangiocarcinoma[J].Semin Liver Dis, 2004, 24(2):115-125.
4.	Jin F, Devesa SS, Chow WH, et al.Cancer incidence trends in urban shanghai, 1972-1994:an update[J].Int J Cancer, 1999, 83(4):435-440.
5.	Peng NF, Li LQ, Qin X, et al.Evaluation of risk factors and clinicopathologic features for intrahepatic cholangiocarcinoma in Southern China:a possible role of hepatitis B virus[J].Ann Surg Oncol, 2011, 18(5):1258-1266.
6.	Palmer WC, Patel T.Are common factors involved in the pathogenesis of primary liver cancers? A meta-analysis of risk factors for intrahepatic cholangiocarcinoma[J].J Hepatol, 2012, 57(1):69-76.
7.	Shaib YH, El-Serag HB, Nooka AK, et al.Risk factors for intrahepatic and extrahepatic cholangiocarcinoma:a hospitalbased case-control study[J].Am J Gastroenterol, 2007, 102(5):1016-1021.
8.	Hsing AW, Zhang M, Rashid A, et al.Hepatitis B and C virus infection and the risk of biliary tract cancer:a population-based study in China[J].Int J Cancer, 2008, 122(8):1849-1853.
9.	Tao LY, He XD, Qu Q, et al.Risk factors for intrahepatic and extrahepatic cholangiocarcinoma:a case-control study in China[J].Liver Int, 2010, 30(2):215-221.
10.	Cai WK, Sima H, Chen BD, et al.Risk factors for hilar cholangiocarcinoma:a case-control study in China[J].World J Gastroenterol, 2011, 17(2):249-253.
11.	Qu Z, Cui N, Qin M, et al.Epidemiological survey of biomarkers of hepatitis virus in patients with extrahepatic cholangiocarcinomas[J].Asia Pac J Clin Oncol, 2012, 8(1):83-87.
12.	Wu Q, He XD, Yu L, et al.The metabolic syndrome and risk factors for biliary tract cancer:a case-control study in China[J].Asian Pac J Cancer Prev, 2012, 13(5):1963-1969.
13.	Welzel TM, Graubard BI, El-Serag HB, et al.Risk factors for intra and extrahepatic cholangiocarcinoma in the United States:a population based case-control study[J].Clin Gastroenterol Hepatol, 2007, 5(10):1221-1228.
14.	Zhou Y, Zhou Q, Lin Q, et al.Evaluation of risk factors for extrahepatic cholangiocarcinoma:ABO blood group, hepatitis B virus and their synergism[J].Int J Cancer, 2013, 133(8):1867-1875.
15.	Wu Y, Wang T, Ye S, et al.Detection of hepatitis B virus DNA in paraffin-embedded intrahepatic and extrahepatic cholangiocarcinoma tissue in the northern Chinese population[J].Hum Pathol, 2012, 43(1):56-61.
16.	Shaib YH, El-Serag HB, Davila JA, et al.Risk factors of intrahepatic cholangiocarcinoma in the United States:a case-control study[J].Gastroenterology, 2005, 128(3):620-626.
17.	Donato F, Gelatti U, Tagger A, et al.Intrahepatic cholangiocarcinoma and hepatitis C and B virus infection, alcohol intake, and hepatolithiasis:a case-control study in Italy[J].Cancer Causes Control, 2001, 12(10):959-964.
18.	Yamamoto S, Kubo S, Hai S, et al.Hepatitis C virus infection as a likely etiology of intrahepatic cholangiocarcinoma[J].Cancer Sci, 2004, 95(7):592-595.
19.	Fwu CW, Chien YC, You SL, et al.Hepatitis B virus infection and risk of intrahepatic cholangiocarcinoma and non-Hodgkin lymphoma:a cohort study of parous women in Taiwan[J].Hepatology, 2011, 53(4):1217-1225.
20.	Shaib YH, Davila JA, McGlynn K, et al.Rising incidence of intrahepatic cholangiocarcinoma in the United States:a true increase?[J].J Hepatol, 2004, 40(3):472-477.
21.	刘小方,邹声泉,裘法祖.肝炎病毒感染与肝门部胆管癌发病关系的探讨[J].中华外科杂志, 2002, 40(6):420-422.
22.	屈振亮,邹声泉,魏国红,等.肝外胆管癌组织中HBx mRNA的原位检测和临床病理意义[J].中华外科杂志, 2004, 42(2):88-91.
23.	Yoffe B, Noonan CA.Hepatitis B virus.New and evolving issues[J].Dig Dis Sci, 1992, 37(1):1-9.
24.	Yu MW, Yeh SH, Chen PJ, et al.Hepatitis B virus genotype and DNA level and hepatocellular carcinoma:a prospective study in men[J].J Natl Cancer Inst, 2005, 97(4):265-272.
25.	Abdel Wahab M, Mostafa M, Salah T, et al.Epidemiology of hilar cholangiocarcinoma in Egypt:single center study[J].Hepatogastroenterology, 2007, 54(78):1626-1631.
26.	El-Serag HB, Engels EA, Landgren O, et al.Risk of hepatobiliary and pancreatic cancers after hepatitis C virus infection:a population-based study of U.S.veterans[J].Hepatology, 2009, 49(1):116-123.

1. Gatto M, Bragazzi MC, Semeraro R, et al.Cholangiocarcinoma:update and future perspectives[J].Dig Liver Dis, 2010, 42(4):253-260.
2. Deoliveira ML, Cunningham SC, Cameron JL, et al.Cholangiocarcinoma:thirty-one-year experience with 564 patients at a single institution[J].Ann Surg, 2007, 245(5):755-762.
3. Shaib Y, El-Serag HB.The epidemiology of cholangiocarcinoma[J].Semin Liver Dis, 2004, 24(2):115-125.
4. Jin F, Devesa SS, Chow WH, et al.Cancer incidence trends in urban shanghai, 1972-1994:an update[J].Int J Cancer, 1999, 83(4):435-440.
5. Peng NF, Li LQ, Qin X, et al.Evaluation of risk factors and clinicopathologic features for intrahepatic cholangiocarcinoma in Southern China:a possible role of hepatitis B virus[J].Ann Surg Oncol, 2011, 18(5):1258-1266.
6. Palmer WC, Patel T.Are common factors involved in the pathogenesis of primary liver cancers? A meta-analysis of risk factors for intrahepatic cholangiocarcinoma[J].J Hepatol, 2012, 57(1):69-76.
7. Shaib YH, El-Serag HB, Nooka AK, et al.Risk factors for intrahepatic and extrahepatic cholangiocarcinoma:a hospitalbased case-control study[J].Am J Gastroenterol, 2007, 102(5):1016-1021.
8. Hsing AW, Zhang M, Rashid A, et al.Hepatitis B and C virus infection and the risk of biliary tract cancer:a population-based study in China[J].Int J Cancer, 2008, 122(8):1849-1853.
9. Tao LY, He XD, Qu Q, et al.Risk factors for intrahepatic and extrahepatic cholangiocarcinoma:a case-control study in China[J].Liver Int, 2010, 30(2):215-221.
10. Cai WK, Sima H, Chen BD, et al.Risk factors for hilar cholangiocarcinoma:a case-control study in China[J].World J Gastroenterol, 2011, 17(2):249-253.
11. Qu Z, Cui N, Qin M, et al.Epidemiological survey of biomarkers of hepatitis virus in patients with extrahepatic cholangiocarcinomas[J].Asia Pac J Clin Oncol, 2012, 8(1):83-87.
12. Wu Q, He XD, Yu L, et al.The metabolic syndrome and risk factors for biliary tract cancer:a case-control study in China[J].Asian Pac J Cancer Prev, 2012, 13(5):1963-1969.
13. Welzel TM, Graubard BI, El-Serag HB, et al.Risk factors for intra and extrahepatic cholangiocarcinoma in the United States:a population based case-control study[J].Clin Gastroenterol Hepatol, 2007, 5(10):1221-1228.
14. Zhou Y, Zhou Q, Lin Q, et al.Evaluation of risk factors for extrahepatic cholangiocarcinoma:ABO blood group, hepatitis B virus and their synergism[J].Int J Cancer, 2013, 133(8):1867-1875.
15. Wu Y, Wang T, Ye S, et al.Detection of hepatitis B virus DNA in paraffin-embedded intrahepatic and extrahepatic cholangiocarcinoma tissue in the northern Chinese population[J].Hum Pathol, 2012, 43(1):56-61.
16. Shaib YH, El-Serag HB, Davila JA, et al.Risk factors of intrahepatic cholangiocarcinoma in the United States:a case-control study[J].Gastroenterology, 2005, 128(3):620-626.
17. Donato F, Gelatti U, Tagger A, et al.Intrahepatic cholangiocarcinoma and hepatitis C and B virus infection, alcohol intake, and hepatolithiasis:a case-control study in Italy[J].Cancer Causes Control, 2001, 12(10):959-964.
18. Yamamoto S, Kubo S, Hai S, et al.Hepatitis C virus infection as a likely etiology of intrahepatic cholangiocarcinoma[J].Cancer Sci, 2004, 95(7):592-595.
19. Fwu CW, Chien YC, You SL, et al.Hepatitis B virus infection and risk of intrahepatic cholangiocarcinoma and non-Hodgkin lymphoma:a cohort study of parous women in Taiwan[J].Hepatology, 2011, 53(4):1217-1225.
20. Shaib YH, Davila JA, McGlynn K, et al.Rising incidence of intrahepatic cholangiocarcinoma in the United States:a true increase?[J].J Hepatol, 2004, 40(3):472-477.
21. 刘小方,邹声泉,裘法祖.肝炎病毒感染与肝门部胆管癌发病关系的探讨[J].中华外科杂志, 2002, 40(6):420-422.
22. 屈振亮,邹声泉,魏国红,等.肝外胆管癌组织中HBx mRNA的原位检测和临床病理意义[J].中华外科杂志, 2004, 42(2):88-91.
23. Yoffe B, Noonan CA.Hepatitis B virus.New and evolving issues[J].Dig Dis Sci, 1992, 37(1):1-9.
24. Yu MW, Yeh SH, Chen PJ, et al.Hepatitis B virus genotype and DNA level and hepatocellular carcinoma:a prospective study in men[J].J Natl Cancer Inst, 2005, 97(4):265-272.
25. Abdel Wahab M, Mostafa M, Salah T, et al.Epidemiology of hilar cholangiocarcinoma in Egypt:single center study[J].Hepatogastroenterology, 2007, 54(78):1626-1631.
26. El-Serag HB, Engels EA, Landgren O, et al.Risk of hepatobiliary and pancreatic cancers after hepatitis C virus infection:a population-based study of U.S.veterans[J].Hepatology, 2009, 49(1):116-123.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Systematic Evaluation on Relationship Between Viral Hepatitis and Extrahepatic Cholangiocarcinoma

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