Pancreatic Glucagonoma:A Case Report and Review of Literature_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 刘毫 ¹ ,  吴诚义 ¹ , 朱之坤 ² , 屈洪波 ³

1. ;
2. ;
3. ;

Corresponding author：

吴诚义, Email: liuhaomail@126.com

Keywords：

坏死性溶解性游走性红斑; 糖尿病; 胰高血糖素瘤; 胰腺

DOI：

10.7507/1007-9424.20140209

Video：

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Abstract Full text Figures/Tables Video References Cited by

目的探讨胰高血糖素瘤的临床特征及诊治方法。方法报道重庆医科大学附一院新发胰腺胰高血糖素瘤临床案例1例，并对该病相关文献进行复习。结果胰高血糖素瘤主要来源于胰腺α2细胞，少数来自于胃或十二指肠的氨前体摄取和脱羧细胞，以坏死性溶解性游走性红斑、糖尿病、消瘦、贫血等为主要临床表现，手术疗效理想。结论胰高血糖素瘤是一种临床上罕见的消化道神经内分泌肿瘤，手术切除是其最为有效的治疗手段。

Citation： 刘毫, 吴诚义, 朱之坤, 屈洪波. Pancreatic Glucagonoma:A Case Report and Review of Literature. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2014, 21(7): 880-882. doi: 10.7507/1007-9424.20140209 Copy

1.	Echenique-Elizondo M, Tuneu Valls A, Elorza Orúe JL, et al. Glucagonoma and pseudoglucagonoma syndrome[J]. JOP, 2004, 5(4):179-185.
2.	O'Grady HL, Conlon KC. Pancreatic neuroendocrine tumours[J]. Eur J Surg Oncol, 2008, 34(3):324-332.
3.	Mallinson CN, Bloom SR, Warin AP, et al. A glucagonoma syndrome[J]. Lancet, 1974, 2(7871):1-5.
4.	徐建明, 杨晨.胃肠胰腺神经内分泌肿瘤国际诊断共识的解读[J].临床肿瘤学杂志, 2011, 16(11):1033-1038.
5.	Bosman FT, Carneiro F, Hruban RH, et al. WHO classification of tumours of the digestive system[M]. Lyon:IARC Press, 2010:279-334.
6.	Castro PG, de León AM, Trancón JG, et al. Glucagonoma syndrome:a case report[J]. J Med Case Rep, 2011, 5:402.
7.	Compton NL, Chien AJ. A rare but revealing sign:necrolytic migratory erythema[J]. Am J Med, 2013, 126(5):387-389.
8.	Soga J, Yakuwa Y. Glucagonomas/diabetico-dermatogenic syndrome (DDS):a statistical evaluation of 407 reported cases[J]. J Hepatobiliary Pancreat Surg, 1998, 5(3):312-319.
9.	梁后杰, 杨晨.胃肠胰腺神经内分泌肿瘤治疗共识(NCCN、ENETs、NANETs)解读[J].临床肿瘤学杂志, 2011, 16(11): 1039-1043.
10.	李永翔, 盂翔凌, 曹立宇, 等.胰高血糖素瘤:附2例报告并文献复习[J].中国普通外科杂志, 2008, 17(3):286-288.
11.	Dourakis SP, Alexopoulou A, Georgousi KK, et al. Glucagonoma syndrome:survival 21 years with concurrent liver metastases[J]. Am J Med Sci, 2007, 334(3):225-227.
12.	2013年中国胃肠胰腺神经内分泌肿瘤病理诊断共识专家组.中国神经内分泌肿瘤病理诊断共识(2013版)[J].中华病理学杂志, 2013, 42(10):691-694.
13.	Boudreaux JP, Klimstra DS, Hassan MM, et al. The NANTTS consensus guidelines for the diagnosis and management of neuroendocrine tumors:well-differentiated neuroendocrine tumors of the Jejunum, Ileum, Appendix, and Cecum[J]. Pancreas, 2010, 39(6):753-766.
14.	Arnold R, Chen YJ, Costa F, et al. ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors:followup and documentantion[J]. Neuroendocrinology, 2009, 90(2): 227-233.
15.	National Comprehensive Cancer Network (NCCN). NCCN practice guidelines for neuroedorine tumors[EB/OL]. 2011-07-25. http://www.nccn.org/professionals/physician_gls/pdf/neuroendocrine.pdf.

1. Echenique-Elizondo M, Tuneu Valls A, Elorza Orúe JL, et al. Glucagonoma and pseudoglucagonoma syndrome[J]. JOP, 2004, 5(4):179-185.
2. O'Grady HL, Conlon KC. Pancreatic neuroendocrine tumours[J]. Eur J Surg Oncol, 2008, 34(3):324-332.
3. Mallinson CN, Bloom SR, Warin AP, et al. A glucagonoma syndrome[J]. Lancet, 1974, 2(7871):1-5.
4. 徐建明, 杨晨.胃肠胰腺神经内分泌肿瘤国际诊断共识的解读[J].临床肿瘤学杂志, 2011, 16(11):1033-1038.
5. Bosman FT, Carneiro F, Hruban RH, et al. WHO classification of tumours of the digestive system[M]. Lyon:IARC Press, 2010:279-334.
6. Castro PG, de León AM, Trancón JG, et al. Glucagonoma syndrome:a case report[J]. J Med Case Rep, 2011, 5:402.
7. Compton NL, Chien AJ. A rare but revealing sign:necrolytic migratory erythema[J]. Am J Med, 2013, 126(5):387-389.
8. Soga J, Yakuwa Y. Glucagonomas/diabetico-dermatogenic syndrome (DDS):a statistical evaluation of 407 reported cases[J]. J Hepatobiliary Pancreat Surg, 1998, 5(3):312-319.
9. 梁后杰, 杨晨.胃肠胰腺神经内分泌肿瘤治疗共识(NCCN、ENETs、NANETs)解读[J].临床肿瘤学杂志, 2011, 16(11): 1039-1043.
10. 李永翔, 盂翔凌, 曹立宇, 等.胰高血糖素瘤:附2例报告并文献复习[J].中国普通外科杂志, 2008, 17(3):286-288.
11. Dourakis SP, Alexopoulou A, Georgousi KK, et al. Glucagonoma syndrome:survival 21 years with concurrent liver metastases[J]. Am J Med Sci, 2007, 334(3):225-227.
12. 2013年中国胃肠胰腺神经内分泌肿瘤病理诊断共识专家组.中国神经内分泌肿瘤病理诊断共识(2013版)[J].中华病理学杂志, 2013, 42(10):691-694.
13. Boudreaux JP, Klimstra DS, Hassan MM, et al. The NANTTS consensus guidelines for the diagnosis and management of neuroendocrine tumors:well-differentiated neuroendocrine tumors of the Jejunum, Ileum, Appendix, and Cecum[J]. Pancreas, 2010, 39(6):753-766.
14. Arnold R, Chen YJ, Costa F, et al. ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors:followup and documentantion[J]. Neuroendocrinology, 2009, 90(2): 227-233.
15. National Comprehensive Cancer Network (NCCN). NCCN practice guidelines for neuroedorine tumors[EB/OL]. 2011-07-25. http://www.nccn.org/professionals/physician_gls/pdf/neuroendocrine.pdf.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Pancreatic Glucagonoma:A Case Report and Review of Literature

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