Research Progress of The Regulation of Energy Metabolism in Tumor Cells by MicroRNA_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 TANGShi-lei , LIYan , LIUDan ,  LIHang-yu

Department of General Surgery, Shengjing Hospital of China Medical University, Shen Yang 110004, Liaoning Province, China;

Corresponding author：

LIHang-yu, Email: li_hangyu@126.com

Keywords：

MicroRNA; Neoplasms; Bioenergetic metabolism; Warburg effect

DOI：

10.7507/1007-9424.20140218

Video：

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Objective To summarize the research progress of bioenergetic metabolic mechanisms regulated of tumor cells by microRNA in recent years. Methods Literatures about the recent studies on the bioenergetic metabolic mechanisms regulated of tumor cells by microRNA were reviewed according to the results searched from PUBMED. Results Aerobic glycolysis(Warburg effect) is the most significant characteristics of bioenergetic metabolism in tumor cells. MicroRNAs can regulate many key progressions involved in tumor cells bioenergetic metabolism, such as uptake of glucose, glycolytic pathway, tricarboxylic acid cycle(TAC), and the relationship among lipid metabolism, amino acid metabolism and TAC, resulting in accelerated uptake of glucose and glycolysis. Thus we believe that the transportation and metabolic procession are vital important for tumor cells and related to poor prognosis of patients. Conclusions The studies on relationship between microRNA and bioenergetic metabolism have come an important insight for malignant biological behavior of tumor cells based on abnormal bioenergetic metabolism and also become new and important supplementary means of diagnosis and treatment of cancer. As far as the research progress about tumor cells bioenergetic metabolism regulated by microRNA, one of the things must be revealed is that which metablic factors can directly change tumor biological behavior after tumor cells bioenergetic metabolism changed caused by microRNA.

Citation： TANGShi-lei, LIYan, LIUDan, LIHang-yu. Research Progress of The Regulation of Energy Metabolism in Tumor Cells by MicroRNA. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2014, 21(7): 905-909. doi: 10.7507/1007-9424.20140218 Copy

1.	Iorio MV, Croce CM. microRNA involvement in human cancer[J]. Carcinogenesis, 2012, 33(6):1126-1133.
2.	Yanaihara N, Harris CC. MicroRNA Involvement in Human Cancers[J]. Clin Chem, 2013, 59(12):1811-1812.
3.	Esquela-Kerscher A, Slack FJ. Oncomirs-microRNAs with a role in cancer[J]. Nat Rev Cancer, 2006, 6(4):259-269.
4.	Wojcicka A, de la Chapelle A, Jazdzewski K. MicroRNA-related sequence variations in human cancers[J]. Hum Genet, 2014, 133(4):463-469.
5.	彭伟, 杨韵, 刘韵霄, 等. microRNA在结直肠癌中的研究及应用进展[J].中国普外基础与临床杂志, 2013, 20(6):691-696.
6.	姚汝铖, 郑军, 邢荣春.微小RNA在胰腺癌中的研究进展[J].中国普外基础与临床杂志, 2012, 19(8):911-915.
7.	Hatziapostolou M, Polytarchou C, Iliopoulos D. miRNAs link metabolic reprogramming to oncogenesis[J]. Trends Endocrinol Metab, 2013, 24(7):361-373.
8.	Chen B, Li H, Zeng X, et al. Roles of microRNA on cancer cell metabolism[J]. J Transl Med, 2012, 10:228.
9.	Gao P, Sun L, He X, et al. MicroRNAs and the Warburg effect: new players in an old arena[J]. Cur Gene Ther, 2012, 12(4): 285-291.
10.	Szablewski L. Expression of glucose transporters in cancers[J]. Biochim Biophys Acta, 2013, 1835(2):164-169.
11.	Jóźwiak P, Lipińska A. The role of glucose transporter 1(GLUT1) in the diagnosis and therapy of tumors[J]. Postepy Hig Med Dosw (Online), 2012, 66:165-174.
12.	Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect:the metabolic requirements of cell proliferation[J]. Science, 2009, 324(5930):1029-1033.
13.	Zhao FQ, Keating AF. Functional properties and genomics of glucose transporters[J]. Curr Genomics, 2007, 8(2):113-128.
14.	Fei X, Qi M, Wu B, et al. MicroRNA-195-5p suppresses glucose uptake and proliferation of human bladder cancer T24 cells by regulating GLUT3 expression[J]. FEBS Lett, 2012, 586(4): 392-397.
15.	Gregersen LH, Jacobsen A, Frankel LB, et al. MicroRNA-143 down-regulates Hexokinase 2 in colon cancer cells[J]. BMC Cancer, 2012, 12:232.
16.	Sun Y, Zhao X, Zhou Y, et al. miR-124, miR-137 and miR-340 regulate colorectal cancer growth via inhibition of the Warburg effect[J]. Oncol Rep, 2012, 28(4):1346-1352.
17.	Kefas B, Comeau L, Erdle N, et al. Pyruvate kinase M2 is a target of the tumor-suppressive microRNA-326 and regulates the survival of glioma cells[J]. Neuro Oncol, 2010, 12(11):1102-1112.
18.	Kinoshita T, Nohata N, Yoshino H, et al. Tumor suppressive microRNA-375 regulates lactate dehydrogenase B in maxillary sinus squamous cell carcinoma[J]. Int J Oncol, 2012, 40(1): 185-193.
19.	Warburg O. On respiratory impairment in cancer cells[J]. Science, 1956, 124(3215):269-270.
20.	Weinhouse S. On respiratory impairment in cancer cells[J]. Science, 1956, 124(3215):267-269.
21.	Mayevsky A. Mitochondrial function and energy metabolism in cancer cells:past overview and future perspectives[J]. Mitochondrion, 2009, 9(3):165-179.
22.	Burk D, Schade AL. On respiratory impairment in cancer cells[J]. Science, 1956, 124(3215):270-272.
23.	Frezza C, Gottlieb E. Mitochondria in cancer:not just innocent bystanders[J]. Semin Cancer Biol, 2009, 19(1):4-11.
24.	Rossignol R, Gilkerson R, Aggeler R, et al. Energy substrate modulates mitochondrial structure and oxidative capacity in cancer cells[J]. Cancer Res, 2004, 64(3):985-993.
25.	Eichner LJ, Perry MC, Dufour CR, et al. miR-378(*) mediates metabolic shift in breast cancer cells via the PGC-1β/ERRγtranscriptional pathway[J]. Cell Metab, 2010, 12(4):352-361.
26.	Chan SY, Zhang YY, Hemann C, et al. MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the ironsulfur cluster assembly proteins ISCU1/2[J]. Cell Metab, 2009, 10(4):273-284.
27.	Favaro E, Ramachandran A, McCormick R, et al. MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU[J]. PLoS One, 2010, 5(4):e10345.
28.	Zha S, Ferdinandusse S, Hicks JL, et al. Peroxisomal branched chain fatty acid beta-oxidation pathway is upregulated in prostate cancer[J]. Prostate, 2005, 63(4):316-323.
29.	Lin Q, Gao Z, Alarcon RM, et al. A role of miR-27 in the regulation of adipogenesis[J]. FEBS J, 2009, 276(8):2348-2358.
30.	Najafi-Shoushtari SH, Kristo F, Li Y, et al. MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis[J]. Science, 2010, 328(5985):1566-1569.
31.	Gerin I, Clerbaux LA, Haumont O, et al. Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation[J]. J Biol Chem, 2010, 285(44):33652-33661.
32.	Iliopoulos D, Drosatos K, Hiyama Y, et al. MicroRNA-370 controls the expression of microRNA-122 and Cpt1alpha and affects lipid metabolism[J]. J Lipid Res, 2010, 51(6):1513-1523.
33.	Liu Y, Zuckier LS, Ghesani NV. Dominant uptake of fatty acid over glucose by prostate cells:a potential new diagnostic and therapeutic approach[J]. Anticancer Res, 2010, 30(2):369-374.
34.	Gao P, Tchernyshyov I, Chang TC, et al. c-Myc suppression of miR-23 enhances mitochondrial glutaminase expression and glutamine metabolism[J]. Nature, 2009, 458(7239):762-765.
35.	Dang CV. Glutaminolysis:supplying carbon or nitrogen or both for cancer cells?[J]. Cell Cycle, 2010, 9(19):3884-3886.
36.	Gatenby RA, Girlies RJ. Why do cancers have high aerobic glycolysis?[J]. Nat Rev Cancer, 2004, 4(11):891-899.

1. Iorio MV, Croce CM. microRNA involvement in human cancer[J]. Carcinogenesis, 2012, 33(6):1126-1133.
2. Yanaihara N, Harris CC. MicroRNA Involvement in Human Cancers[J]. Clin Chem, 2013, 59(12):1811-1812.
3. Esquela-Kerscher A, Slack FJ. Oncomirs-microRNAs with a role in cancer[J]. Nat Rev Cancer, 2006, 6(4):259-269.
4. Wojcicka A, de la Chapelle A, Jazdzewski K. MicroRNA-related sequence variations in human cancers[J]. Hum Genet, 2014, 133(4):463-469.
5. 彭伟, 杨韵, 刘韵霄, 等. microRNA在结直肠癌中的研究及应用进展[J].中国普外基础与临床杂志, 2013, 20(6):691-696.
6. 姚汝铖, 郑军, 邢荣春.微小RNA在胰腺癌中的研究进展[J].中国普外基础与临床杂志, 2012, 19(8):911-915.
7. Hatziapostolou M, Polytarchou C, Iliopoulos D. miRNAs link metabolic reprogramming to oncogenesis[J]. Trends Endocrinol Metab, 2013, 24(7):361-373.
8. Chen B, Li H, Zeng X, et al. Roles of microRNA on cancer cell metabolism[J]. J Transl Med, 2012, 10:228.
9. Gao P, Sun L, He X, et al. MicroRNAs and the Warburg effect: new players in an old arena[J]. Cur Gene Ther, 2012, 12(4): 285-291.
10. Szablewski L. Expression of glucose transporters in cancers[J]. Biochim Biophys Acta, 2013, 1835(2):164-169.
11. Jóźwiak P, Lipińska A. The role of glucose transporter 1(GLUT1) in the diagnosis and therapy of tumors[J]. Postepy Hig Med Dosw (Online), 2012, 66:165-174.
12. Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect:the metabolic requirements of cell proliferation[J]. Science, 2009, 324(5930):1029-1033.
13. Zhao FQ, Keating AF. Functional properties and genomics of glucose transporters[J]. Curr Genomics, 2007, 8(2):113-128.
14. Fei X, Qi M, Wu B, et al. MicroRNA-195-5p suppresses glucose uptake and proliferation of human bladder cancer T24 cells by regulating GLUT3 expression[J]. FEBS Lett, 2012, 586(4): 392-397.
15. Gregersen LH, Jacobsen A, Frankel LB, et al. MicroRNA-143 down-regulates Hexokinase 2 in colon cancer cells[J]. BMC Cancer, 2012, 12:232.
16. Sun Y, Zhao X, Zhou Y, et al. miR-124, miR-137 and miR-340 regulate colorectal cancer growth via inhibition of the Warburg effect[J]. Oncol Rep, 2012, 28(4):1346-1352.
17. Kefas B, Comeau L, Erdle N, et al. Pyruvate kinase M2 is a target of the tumor-suppressive microRNA-326 and regulates the survival of glioma cells[J]. Neuro Oncol, 2010, 12(11):1102-1112.
18. Kinoshita T, Nohata N, Yoshino H, et al. Tumor suppressive microRNA-375 regulates lactate dehydrogenase B in maxillary sinus squamous cell carcinoma[J]. Int J Oncol, 2012, 40(1): 185-193.
19. Warburg O. On respiratory impairment in cancer cells[J]. Science, 1956, 124(3215):269-270.
20. Weinhouse S. On respiratory impairment in cancer cells[J]. Science, 1956, 124(3215):267-269.
21. Mayevsky A. Mitochondrial function and energy metabolism in cancer cells:past overview and future perspectives[J]. Mitochondrion, 2009, 9(3):165-179.
22. Burk D, Schade AL. On respiratory impairment in cancer cells[J]. Science, 1956, 124(3215):270-272.
23. Frezza C, Gottlieb E. Mitochondria in cancer:not just innocent bystanders[J]. Semin Cancer Biol, 2009, 19(1):4-11.
24. Rossignol R, Gilkerson R, Aggeler R, et al. Energy substrate modulates mitochondrial structure and oxidative capacity in cancer cells[J]. Cancer Res, 2004, 64(3):985-993.
25. Eichner LJ, Perry MC, Dufour CR, et al. miR-378(*) mediates metabolic shift in breast cancer cells via the PGC-1β/ERRγtranscriptional pathway[J]. Cell Metab, 2010, 12(4):352-361.
26. Chan SY, Zhang YY, Hemann C, et al. MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the ironsulfur cluster assembly proteins ISCU1/2[J]. Cell Metab, 2009, 10(4):273-284.
27. Favaro E, Ramachandran A, McCormick R, et al. MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU[J]. PLoS One, 2010, 5(4):e10345.
28. Zha S, Ferdinandusse S, Hicks JL, et al. Peroxisomal branched chain fatty acid beta-oxidation pathway is upregulated in prostate cancer[J]. Prostate, 2005, 63(4):316-323.
29. Lin Q, Gao Z, Alarcon RM, et al. A role of miR-27 in the regulation of adipogenesis[J]. FEBS J, 2009, 276(8):2348-2358.
30. Najafi-Shoushtari SH, Kristo F, Li Y, et al. MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis[J]. Science, 2010, 328(5985):1566-1569.
31. Gerin I, Clerbaux LA, Haumont O, et al. Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation[J]. J Biol Chem, 2010, 285(44):33652-33661.
32. Iliopoulos D, Drosatos K, Hiyama Y, et al. MicroRNA-370 controls the expression of microRNA-122 and Cpt1alpha and affects lipid metabolism[J]. J Lipid Res, 2010, 51(6):1513-1523.
33. Liu Y, Zuckier LS, Ghesani NV. Dominant uptake of fatty acid over glucose by prostate cells:a potential new diagnostic and therapeutic approach[J]. Anticancer Res, 2010, 30(2):369-374.
34. Gao P, Tchernyshyov I, Chang TC, et al. c-Myc suppression of miR-23 enhances mitochondrial glutaminase expression and glutamine metabolism[J]. Nature, 2009, 458(7239):762-765.
35. Dang CV. Glutaminolysis:supplying carbon or nitrogen or both for cancer cells?[J]. Cell Cycle, 2010, 9(19):3884-3886.
36. Gatenby RA, Girlies RJ. Why do cancers have high aerobic glycolysis?[J]. Nat Rev Cancer, 2004, 4(11):891-899.

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Research Progress of The Regulation of Energy Metabolism in Tumor Cells by MicroRNA

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