Correlation of X-Ray Repair Cross-Complementing Gene 1 (Arg399Gln, Arg280His, and Arg194Trp) Polymorphisms and Susceptibility to Gastric Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 YANGJian , NARi-su , GUOChun-liang

Department of Hepatobiliary Surgery, Affiliated Hospital of Armed Police Logistics Institute, Tianjin 300162, China;

Corresponding author：

YANGJian, Email: yangjianzg@126.com

Keywords：

Gastric cancer; X-ray repair cross-complementing gene 1; Arg399Gln; Arg280His; Arg194Trp; Polymorphisms; Susceptibility

DOI：

10.7507/1007-9424.20150056

Video：

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Objective To investigate the correlation of X-ray repair cross-complementing gene 1 (XRCC1-Arg399Gln, Arg280His, and Arg194Trp) polymorphisms and susceptibility to gastric cancer. Methods One hundred and twenty patients with gastric cancer were included in study group, 120 healthy volunteers were included in control group. The DNA was extracted from peripheral blood. Arg399Gln, Arg280His, and Arg194Trp gene polymorphisms were detected and analyzed using polymerase chain reaction-restriction fragment length polymorphism technique, and the susceptibility between different genotypes and gastric cancer was compared in two groups. Results The age, gender, smoking, drinking, diet, and other common characteristics of exposure factors had no significant differences in two groups (P > 0.05). The mutation locus genotype frequencies of Arg399Gln and Arg280His had no significant differences between two groups (P > 0.05). However, the mutation locus genotype frequencies of Arg/Trp, Trp/Trp, and Arg/Trp+Trp/Trp were higher and the mutation locus genotype frequency of Arg/Arg was lower in the study group as compared with the control group (P < 0.05). Conclusion The preliminary results from this study shows that XRCC1 Arg399Gln and Arg280His polymorphisms are not correlated with susceptibility to gastric cancer; However, Arg194Trp polymorphism is correlated with susceptibility to gastric cancer.

Citation： YANGJian, NARi-su, GUOChun-liang. Correlation of X-Ray Repair Cross-Complementing Gene 1 (Arg399Gln, Arg280His, and Arg194Trp) Polymorphisms and Susceptibility to Gastric Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2015, 22(2): 208-211. doi: 10.7507/1007-9424.20150056 Copy

1.	Engin AB, Karahalil B, Karakaya AE, et al. Association between XRCC1 ARG399GLN and P53 ARG72PRO polymorphisms and the risk of gastric and colorectal cancer in Turkish population. Arh Hig Rada Toksikol, 2011, 62(3): 207-214.
2.	Yuan T, Deng S, Chen M, et al. Association of DNA repair gene XRCC1 and XPD polymorphisms with genetic susceptibility to gastric cancer in a Chinese population. Cancer Epidemiol, 2011, 35(2): 170-174.
3.	王永兵, 何苗, 程宏文. BRCA1、XRCC1基因多态性与乳腺癌易感性研究进展.中国医药导报, 2012, 9(33): 30-31.
4.	Xue H, Ni P, Lin B, et al. X-ray repair cross-complementing group 1 (XRCC1) genetic polymorphisms and gastric cancer risk: A HuGE review and meta-analysis. Am J Epidemiol, 2011, 173(4): 363-375.
5.	Liu BM, Liu TM, You BS, et al. Lack of an association between the XRCC1 Arg399Gln polymorphism and gastric cancer based on a meta-analysis. Genet Mol Res, 2012, 11(4): 3852-3860.
6.	Wen YY, Pan XF, Loh M, et al. ADPRT Val762Ala and XRCC1 Arg194Trp polymorphisms and risk of gastric cancer in Sichuan of China. Asian Pac J Cancer Prev, 2012, 13(5): 2139-2144.
7.	赵久达, 李豪, 曹成珠, 等. 1 962例胃癌流行病学分析.现代预防医学, 2008, 35(3): 439-440.
8.	文拓.胃癌外科治疗的现状与进展.中国卫生产业, 2013, 10(4): 191.
9.	Zhang YM, Wang ML, Gu DY, et al. Association of XRCC1 gene polymorphisms with the survival and clinicopathological characteristics of gastric cancer. DNA Cell Biol, 2013, 32(3): 111-118.
10.	司君利, 亓玉琴, 纪丽莎, 等. hTERT基因多态性与胃癌易感性的研究.胃肠病学, 2014, 19(5): 270-274.
11.	Li G, Jin TB, Wei XB, et al. Selected polymorphisms of GSTP1 and TERT were associated with glioma risk in Han Chinese. Cancer Epidemiol, 2012, 36(6): 525-527.
12.	Krejs GJ. Gastric cancer: epidemiology and risk factors. Dig Dis, 2010, 28(4/5): 600-603.
13.	徐诚, 严丽锋, 王心如, 等. DNA损伤修复蛋白XRCC1的研究进展.东南大学学报:医学版, 2014, 33(3): 376-380.
14.	Hanssen-Bauer A, Solvang-Garten K, Sundheim O, et al. XRCC1 coordinates disparate responses and multiprotein repair complexes depending on the nature and context of the DNA damage. Environ Mol Mutagen, 2011, 52(8): 623-635.
15.	黄姗, 易斌, 杨星海, 等.结直肠癌患者的DNA修复基因XRCC1单核苷酸多态研究.中华实验外科杂志, 2010, 27(8): 1057-1059.
16.	Huang Y, Li L, Yu L. XRCC1 Arg399Gln, Arg194Trp and Arg280His polymorphisms in breast cancer risk: a meta-analysis. Mutagenesis, 2009, 24(4): 331-339.
17.	宋春英, 谭文, 林东昕.中国人DNA修复基因XRCC1单核苷酸多态及其与食管癌风险的关系.癌症, 2001, 20(1): 28-31.
18.	Huang J, Zhang J, Zhao Y, et al. The Arg194Trp polymorphism in the XRCC1 gene and cancer risk in Chinese mainland population: a meta-analysis. Mol Biol Rep, 2011, 38(7): 4565-4573.
19.	Gsur A, Bernhart K, Baierl A, et al. No association of XRCC1 polymorphisms Arg194Trp and Arg399Gln with colorectal cancer risk. Cancer Epidemiol, 2011, 35(5): e38-e41.
20.	Li HH, Ha TC, Tai BC. XRCC1 gene polymorphisms and breast cancer risk in different populations: A meta-analysis. Breast, 2009, 18(3): 183-191.
21.	Jiang J, Liang X, Zhou X, et al. DNA repair gene X-ray repair cross complementing group 1 Arg194Trp polymorphism on the risk of lung cancer: a meta-analysis on 22 studies. J Thorac Oncol, 2010, 5(11): 1741-1747.
22.	Zhao DY, Cheng L, Yu J, et al. XRCC1 genetic polymorphism Arg339Gln, Arg194Trp, Arg280His and gastric cancer risk: An evidence based decision. Cancer Biomark, 2014, 14(6): 449-456.

1. Engin AB, Karahalil B, Karakaya AE, et al. Association between XRCC1 ARG399GLN and P53 ARG72PRO polymorphisms and the risk of gastric and colorectal cancer in Turkish population. Arh Hig Rada Toksikol, 2011, 62(3): 207-214.
2. Yuan T, Deng S, Chen M, et al. Association of DNA repair gene XRCC1 and XPD polymorphisms with genetic susceptibility to gastric cancer in a Chinese population. Cancer Epidemiol, 2011, 35(2): 170-174.
3. 王永兵, 何苗, 程宏文. BRCA1、XRCC1基因多态性与乳腺癌易感性研究进展.中国医药导报, 2012, 9(33): 30-31.
4. Xue H, Ni P, Lin B, et al. X-ray repair cross-complementing group 1 (XRCC1) genetic polymorphisms and gastric cancer risk: A HuGE review and meta-analysis. Am J Epidemiol, 2011, 173(4): 363-375.
5. Liu BM, Liu TM, You BS, et al. Lack of an association between the XRCC1 Arg399Gln polymorphism and gastric cancer based on a meta-analysis. Genet Mol Res, 2012, 11(4): 3852-3860.
6. Wen YY, Pan XF, Loh M, et al. ADPRT Val762Ala and XRCC1 Arg194Trp polymorphisms and risk of gastric cancer in Sichuan of China. Asian Pac J Cancer Prev, 2012, 13(5): 2139-2144.
7. 赵久达, 李豪, 曹成珠, 等. 1 962例胃癌流行病学分析.现代预防医学, 2008, 35(3): 439-440.
8. 文拓.胃癌外科治疗的现状与进展.中国卫生产业, 2013, 10(4): 191.
9. Zhang YM, Wang ML, Gu DY, et al. Association of XRCC1 gene polymorphisms with the survival and clinicopathological characteristics of gastric cancer. DNA Cell Biol, 2013, 32(3): 111-118.
10. 司君利, 亓玉琴, 纪丽莎, 等. hTERT基因多态性与胃癌易感性的研究.胃肠病学, 2014, 19(5): 270-274.
11. Li G, Jin TB, Wei XB, et al. Selected polymorphisms of GSTP1 and TERT were associated with glioma risk in Han Chinese. Cancer Epidemiol, 2012, 36(6): 525-527.
12. Krejs GJ. Gastric cancer: epidemiology and risk factors. Dig Dis, 2010, 28(4/5): 600-603.
13. 徐诚, 严丽锋, 王心如, 等. DNA损伤修复蛋白XRCC1的研究进展.东南大学学报:医学版, 2014, 33(3): 376-380.
14. Hanssen-Bauer A, Solvang-Garten K, Sundheim O, et al. XRCC1 coordinates disparate responses and multiprotein repair complexes depending on the nature and context of the DNA damage. Environ Mol Mutagen, 2011, 52(8): 623-635.
15. 黄姗, 易斌, 杨星海, 等.结直肠癌患者的DNA修复基因XRCC1单核苷酸多态研究.中华实验外科杂志, 2010, 27(8): 1057-1059.
16. Huang Y, Li L, Yu L. XRCC1 Arg399Gln, Arg194Trp and Arg280His polymorphisms in breast cancer risk: a meta-analysis. Mutagenesis, 2009, 24(4): 331-339.
17. 宋春英, 谭文, 林东昕.中国人DNA修复基因XRCC1单核苷酸多态及其与食管癌风险的关系.癌症, 2001, 20(1): 28-31.
18. Huang J, Zhang J, Zhao Y, et al. The Arg194Trp polymorphism in the XRCC1 gene and cancer risk in Chinese mainland population: a meta-analysis. Mol Biol Rep, 2011, 38(7): 4565-4573.
19. Gsur A, Bernhart K, Baierl A, et al. No association of XRCC1 polymorphisms Arg194Trp and Arg399Gln with colorectal cancer risk. Cancer Epidemiol, 2011, 35(5): e38-e41.
20. Li HH, Ha TC, Tai BC. XRCC1 gene polymorphisms and breast cancer risk in different populations: A meta-analysis. Breast, 2009, 18(3): 183-191.
21. Jiang J, Liang X, Zhou X, et al. DNA repair gene X-ray repair cross complementing group 1 Arg194Trp polymorphism on the risk of lung cancer: a meta-analysis on 22 studies. J Thorac Oncol, 2010, 5(11): 1741-1747.
22. Zhao DY, Cheng L, Yu J, et al. XRCC1 genetic polymorphism Arg339Gln, Arg194Trp, Arg280His and gastric cancer risk: An evidence based decision. Cancer Biomark, 2014, 14(6): 449-456.

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CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Correlation of X-Ray Repair Cross-Complementing Gene 1 (Arg399Gln, Arg280His, and Arg194Trp) Polymorphisms and Susceptibility to Gastric Cancer

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