Research Progress of microRNA in Regulating Tumor Microenvironment_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 YANGLiang , LIHang-yu ,  LIUJin-gang

Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China;

Corresponding author：

LIUJin-gang, Email: liujg@sj-hospital.org

Keywords：

microRNA; Tumor microenvironment; Hypoxia-inducible factor; Tumor associated fibroblast; Extracellular matrix

DOI：

10.7507/1007-9424.20150067

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To summarize the regulating mechanism of microRNA in tumor microenvironment. Method The literatures about the studies on the mechanism regulated by microRNA for tumor microenvironment were reviewed according to the results searched from PubMed in recent years. Results microRNA might be participated in regulation of tumor microenvironment factors such as hypoxia-inducible factor, tumor associated fibroblasts, extracellular matrix, which leaded to a change in biological behavior of tumor cells by reforming the microenviroment. Conclusions microRNA has been participated in regulating many factors of tumor microenvironment. The change of neoplastic microenvironment has been recognized to play a critical role in the development of cancer. Therefore revealing microRNA mechanism for tumor microenvironment could not only help exploring the biological behavior of tumor cells, but also come an important insight for new means of diagnosis and treatment of cancer.

Citation： YANGLiang, LIHang-yu, LIUJin-gang. Research Progress of microRNA in Regulating Tumor Microenvironment. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2015, 22(2): 251-255. doi: 10.7507/1007-9424.20150067 Copy

1.	Li X, Wu Z, Fu X, et al. A microRNA component of the neoplastic microenvironment: microregulators with far-reaching impact. Biomed Res Int, 2013, 2013: 762183.
2.	Ma H, Xu H, Qin J. Biomimetic tumor microenvironment on a microfluidic platform. Biomicrofluidics, 2013, 7(1): 11501.
3.	Davidson B, Trope CG, Reich R. The role of the tumor stroma in ovarian cancer. Front Oncol, 2014, 4: 104.
4.	Wentz-Hunter KK, Potashkin JA. The role of mirna as key regulators in the neoplastic microenvironment. Mol Biol Int, 2011: 839872.
5.	Crosby ME, Devlin CM, Glazer PM, et al. Emerging roles of microRNAs in the molecular responses to hypoxia. Curr Pharm Des, 2009, 15(33): 3861-3866.
6.	Harris AL. Hypoxia-key regulatory factor in tumour growth. Nat Rev Cancer, 2002, 2(1): 38-47.
7.	Huang X, Le QT, Giaccia AJ. MiR-210-micromanager of the hypoxia pathway. Trends Mol Med, 2010, 16(5): 230-237.
8.	Brocato J, Chervona Y, Costa M. Molecular responses to hypoxia-inducible factor 1αand beyond. Mol Pharmacol, 2014, 85(5): 651-657.
9.	Yamakuchi M, Lotterman CD, Bao C, et al. P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis. Proc Natl Acad Sci USA, 2010, 107(14): 6334-6339.
10.	Pocock R. Invited review: decoding the microRNA response to hypoxia. Pflugers Arch, 2011, 461(3): 307-315.
11.	Moch H, Lukamowicz-Rajska M. miR-30c-2-3p and miR-30a-3p: new pieces of the jigsaw puzzle in HIF2αregulation. Cancer Discov, 2014, 4(1): 22-24.
12.	Zhang H, Pu J, Qi T, et al. MicroRNA-145 inhibits the growth, invasion, metastasis and angiogenesis of neuroblastoma cells through targeting hypoxia-inducible factor 2 alpha. Oncogene, 2014, 33(3): 387-397.
13.	Yeh YM, Chuang CM, Chao KC, et al. MicroRNA-138 suppresses ovarian cancer cell invasion and metastasis by targeting SOX4 and HIF-1α. Int J Cancer, 2013, 133(4): 867-878.
14.	Shang W, Chen X, Nie L, et al. MiR199b suppresses expression of hypoxia-inducible factor 1α(HIF-1α) in prostate cancer cells. Int J Mol Sci, 2013, 14(4): 8422-8436.
15.	Neal CS, Michael MZ, Rawlings LH, et al. The VHL-dependent regulation of microRNAs in renal cancer. BMC Med, 2010, 8: 64.
16.	Taguchi A, Yanagisawa K, Tanaka M, et al. Identification of hypoxia-inducible factor-1 alpha as a novel target for miR-17-92 microRNA cluster. Cancer Res, 2008, 68(14): 5540-5545.
17.	Cha ST, Chen PS, Johansson G, et al. MicroRNA-519c suppresses hypoxia-inducible factor-1alpha expression and tumor angiogenesis. Cancer Res, 2010, 70(7): 2675-2685.
18.	Zhou B, Chen WL, Wang YY, et al. A role for cancer-associated fibroblasts in inducing the epithelial-to-mesenchymal transition in human tongue squamous cell carcinoma. J Oral Pathol Med, 2014, 43(8): 585-592.
19.	Png KJ, Halberg N, Yoshida M, et al. A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells. Nature, 2012, 481(7380): 190-194.
20.	Nouraee N, Van Roosbroeck K, Vasei M, et al. Expression, tissue distribution and function of miR-21 in esophageal squamous cell carcinoma. PLoS One, 2013, 8(9): e73009.
21.	Li Q, Zhang D, Wang Y, et al. MiR-21/Smad 7 signaling determines TGF-β1-induced CAF formation. Sci Rep, 2013, 3: 2038.
22.	Verghese ET, Drury R, Green CA, et al. MiR-26b is down-regulated in carcinoma-associated fibroblasts from ER-positive breast cancers leading to enhanced cell migration and invasion. J Pathol, 2013, 231(3): 388-399.
23.	Gandellini P, Giannoni E, Casamichele A, et al. miR-205 hinders the malignant interplay between prostate cancer cells and associated fibroblasts. Antioxid Redox Signal, 2014, 20(7): 1045-1059.
24.	Mitra AK, Zillhardt M, Hua Y, et al. MicroRNAs reprogram normal fibroblasts into cancer-associated fibroblasts in ovarian cancer. Cancer Discov, 2012, 2(12): 1100-1108.
25.	Qiu T, Zhou X, Wang J, et al. MiR-145, miR-133a and miR-133b inhibit proliferation, migration, invasion and cell cycle progression via targeting transcription factor Sp1 in gastric cancer. FEBS Lett, 2014, 588(7): 1168-1177.
26.	Li P, Xu Q, Zhang D, et al. Upregulated miR-106a plays an oncogenic role in pancreatic cancer. FEBS Lett, 2014, 588(5): 705-712.
27.	Zhang LL, Wu J, Liu Q, et al. MiR-886-5p inhibition inhibits growth and induces apoptosis of MCF7 cells. Asian Pac J Cancer Prev, 2014, 15(4): 1511-1515.
28.	Yang TQ, Lu XJ, Wu TF, et al. MicroRNA-16 inhibits glioma cell growth and invasion through suppression of BCL2 and the nuclear factor-κB1/MMP9 signaling pathway. Cancer Sci, 2014, 105(3): 265-271.
29.	Ries C. Cytokine functions of TIMP-1. Cell Mol Life Sci, 2014, 71(4): 659-672.
30.	Li J, Zhang Y, Zhang W, et al. Genetic heterogeneity of breast cancer metastasis may be related to miR-21 regulation of TIMP-3 in translation. Int J Surg Oncol, 2013, 2013: 875078.
31.	Zhou X, Ren Y, Liu A, et al. STAT3 inhibitor WP1066 attenuates miRNA-21 to suppress human oral squamous cell carcinoma growth in vitro and in vivo. Oncol Rep, 2014, 31(5): 2173-2180.
32.	Wu TY, Zhang TH, Qu LM, et al. MiR-19a is correlated with prognosis and apoptosis of laryngeal squamous cell carcinoma by regulating TIMP-2 expression. Int J Clin Exp Pathol, 2014, 7(1): 56-63.

1. Li X, Wu Z, Fu X, et al. A microRNA component of the neoplastic microenvironment: microregulators with far-reaching impact. Biomed Res Int, 2013, 2013: 762183.
2. Ma H, Xu H, Qin J. Biomimetic tumor microenvironment on a microfluidic platform. Biomicrofluidics, 2013, 7(1): 11501.
3. Davidson B, Trope CG, Reich R. The role of the tumor stroma in ovarian cancer. Front Oncol, 2014, 4: 104.
4. Wentz-Hunter KK, Potashkin JA. The role of mirna as key regulators in the neoplastic microenvironment. Mol Biol Int, 2011: 839872.
5. Crosby ME, Devlin CM, Glazer PM, et al. Emerging roles of microRNAs in the molecular responses to hypoxia. Curr Pharm Des, 2009, 15(33): 3861-3866.
6. Harris AL. Hypoxia-key regulatory factor in tumour growth. Nat Rev Cancer, 2002, 2(1): 38-47.
7. Huang X, Le QT, Giaccia AJ. MiR-210-micromanager of the hypoxia pathway. Trends Mol Med, 2010, 16(5): 230-237.
8. Brocato J, Chervona Y, Costa M. Molecular responses to hypoxia-inducible factor 1αand beyond. Mol Pharmacol, 2014, 85(5): 651-657.
9. Yamakuchi M, Lotterman CD, Bao C, et al. P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis. Proc Natl Acad Sci USA, 2010, 107(14): 6334-6339.
10. Pocock R. Invited review: decoding the microRNA response to hypoxia. Pflugers Arch, 2011, 461(3): 307-315.
11. Moch H, Lukamowicz-Rajska M. miR-30c-2-3p and miR-30a-3p: new pieces of the jigsaw puzzle in HIF2αregulation. Cancer Discov, 2014, 4(1): 22-24.
12. Zhang H, Pu J, Qi T, et al. MicroRNA-145 inhibits the growth, invasion, metastasis and angiogenesis of neuroblastoma cells through targeting hypoxia-inducible factor 2 alpha. Oncogene, 2014, 33(3): 387-397.
13. Yeh YM, Chuang CM, Chao KC, et al. MicroRNA-138 suppresses ovarian cancer cell invasion and metastasis by targeting SOX4 and HIF-1α. Int J Cancer, 2013, 133(4): 867-878.
14. Shang W, Chen X, Nie L, et al. MiR199b suppresses expression of hypoxia-inducible factor 1α(HIF-1α) in prostate cancer cells. Int J Mol Sci, 2013, 14(4): 8422-8436.
15. Neal CS, Michael MZ, Rawlings LH, et al. The VHL-dependent regulation of microRNAs in renal cancer. BMC Med, 2010, 8: 64.
16. Taguchi A, Yanagisawa K, Tanaka M, et al. Identification of hypoxia-inducible factor-1 alpha as a novel target for miR-17-92 microRNA cluster. Cancer Res, 2008, 68(14): 5540-5545.
17. Cha ST, Chen PS, Johansson G, et al. MicroRNA-519c suppresses hypoxia-inducible factor-1alpha expression and tumor angiogenesis. Cancer Res, 2010, 70(7): 2675-2685.
18. Zhou B, Chen WL, Wang YY, et al. A role for cancer-associated fibroblasts in inducing the epithelial-to-mesenchymal transition in human tongue squamous cell carcinoma. J Oral Pathol Med, 2014, 43(8): 585-592.
19. Png KJ, Halberg N, Yoshida M, et al. A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells. Nature, 2012, 481(7380): 190-194.
20. Nouraee N, Van Roosbroeck K, Vasei M, et al. Expression, tissue distribution and function of miR-21 in esophageal squamous cell carcinoma. PLoS One, 2013, 8(9): e73009.
21. Li Q, Zhang D, Wang Y, et al. MiR-21/Smad 7 signaling determines TGF-β1-induced CAF formation. Sci Rep, 2013, 3: 2038.
22. Verghese ET, Drury R, Green CA, et al. MiR-26b is down-regulated in carcinoma-associated fibroblasts from ER-positive breast cancers leading to enhanced cell migration and invasion. J Pathol, 2013, 231(3): 388-399.
23. Gandellini P, Giannoni E, Casamichele A, et al. miR-205 hinders the malignant interplay between prostate cancer cells and associated fibroblasts. Antioxid Redox Signal, 2014, 20(7): 1045-1059.
24. Mitra AK, Zillhardt M, Hua Y, et al. MicroRNAs reprogram normal fibroblasts into cancer-associated fibroblasts in ovarian cancer. Cancer Discov, 2012, 2(12): 1100-1108.
25. Qiu T, Zhou X, Wang J, et al. MiR-145, miR-133a and miR-133b inhibit proliferation, migration, invasion and cell cycle progression via targeting transcription factor Sp1 in gastric cancer. FEBS Lett, 2014, 588(7): 1168-1177.
26. Li P, Xu Q, Zhang D, et al. Upregulated miR-106a plays an oncogenic role in pancreatic cancer. FEBS Lett, 2014, 588(5): 705-712.
27. Zhang LL, Wu J, Liu Q, et al. MiR-886-5p inhibition inhibits growth and induces apoptosis of MCF7 cells. Asian Pac J Cancer Prev, 2014, 15(4): 1511-1515.
28. Yang TQ, Lu XJ, Wu TF, et al. MicroRNA-16 inhibits glioma cell growth and invasion through suppression of BCL2 and the nuclear factor-κB1/MMP9 signaling pathway. Cancer Sci, 2014, 105(3): 265-271.
29. Ries C. Cytokine functions of TIMP-1. Cell Mol Life Sci, 2014, 71(4): 659-672.
30. Li J, Zhang Y, Zhang W, et al. Genetic heterogeneity of breast cancer metastasis may be related to miR-21 regulation of TIMP-3 in translation. Int J Surg Oncol, 2013, 2013: 875078.
31. Zhou X, Ren Y, Liu A, et al. STAT3 inhibitor WP1066 attenuates miRNA-21 to suppress human oral squamous cell carcinoma growth in vitro and in vivo. Oncol Rep, 2014, 31(5): 2173-2180.
32. Wu TY, Zhang TH, Qu LM, et al. MiR-19a is correlated with prognosis and apoptosis of laryngeal squamous cell carcinoma by regulating TIMP-2 expression. Int J Clin Exp Pathol, 2014, 7(1): 56-63.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Research Progress of microRNA in Regulating Tumor Microenvironment

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