亚甲基四氢叶酸还原酶基因C677T和A1298C位点多态性与胃癌易感性的相关性分析_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 沈宏 , 张宁

武警后勤学院附属医院普通外科（天津 300162）;

Corresponding author：

沈宏, Email: shenhonng@126.com

Keywords：

亚甲基四氢叶酸还原酶基因; 胃癌; C677T位点; A1298C位点; 基因多态性; 易感性

DOI：

10.7507/1007-9424.20150094

Video：

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目的探讨亚甲基四氢叶酸还原酶（MTHFR）基因C677T和A1298C位点多态性与胃癌易感性的相关性。方法回顾性收集2008年1月至2014年1月期间在笔者所在医院住院的、行MTHFR基因C677T和A1298C位点检测的160例胃癌患者作为胃癌组，收集同期160名自愿接受上述基因检测的健康体检人员作为对照组，比较2组2种位点基因型的分布情况。结果胃癌组患者MTHFR基因C677T位点的基因型为：CC 72例，CT 64例，TT 24例；对照组为：CC 78例，CT 69例，TT 13例。胃癌组患者MTHFR基因A1298C位点的基因型为：AA 58例，AC 84例，CC 18例；对照组为：AA 62例，AC 77例，CC 21例。2组C677T位点及A1298C位点的基因型分布比较差异均无统计学意义（P>0.05）。结论 MTHFR基因C677T位点和A1298C位点多态性与胃癌的易感性无明显相关性。

Citation： 沈宏, 张宁. 亚甲基四氢叶酸还原酶基因C677T和A1298C位点多态性与胃癌易感性的相关性分析. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2015, 22(3): 351-353. doi: 10.7507/1007-9424.20150094 Copy

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2.	Yuan T, Deng S, Chen M, et al. Association of DNA repair gene XRCC1 and XPD polymorphisms with genetic susceptibility to gastric cancer in a Chinese population. Cancer Epidemiol, 2011, 35(2):170-174.
3.	Woo HD, Lee J, Choi IJ, et al. Dietary flavonoids and gastric cancer risk in a Korean population. Nutrients, 2014, 6(11):4961-4973.
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5.	Huang GL, Wang SK, Su M, et al. Serum folate, MTHFR C677T polymorphism and esophageal squamous cell carcinoma risk. Biomed Environ Sci, 2013, 26(12):1008-1012.
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8.	文拓. 胃癌外科治疗的现状与进展. 中国卫生产业, 2013, 2(4):191.
9.	Zhang Y, Wang M, Gu D, et al. Association of XRCC1 gene polymor-phisms with the survival and clinicopathological characteristics of gastric cancer. DNA Cell Biol, 2013, 32(3):111-118.
10.	Wu YL, Hu CY, Lu SS, et al. Association between methylenetetrahy-drofolate reductase (MTHFR) C677T/A1298C polymorphisms and essential hypertension:a systematic review and meta-analysis. Metabolism, 2014, 63(12):1503-1511.
11.	马利敏, 赵小强, 刘洪超, 等. 亚甲基四氢叶酸还原酶基因多态性与中国儿童急性淋巴细胞白血病关系的Meta分析. 医学研究杂志, 2014, 43(4):87-90.
12.	Zhou BS, Bu GY, Li M, et al. Tagging SNPs in the MTHFR gene and risk of ischemic stroke in a Chinese population. Int J Mol Sci, 2014, 15(5):8931-8940.
13.	宋姗姗, 杨博逸, 孙贵范. 中国人群中亚甲基四氢叶酸还原酶C677T和A1298C基因多态性与乳腺癌相关性的Meta分析. 中国慢性病预防与控制, 2013, 21(5):560-564.
14.	张军喜, 郭爱叶, 李宗辉, 等. TNF-α-308基因多态性与胃癌的关系研究. 中国现代药物应用, 2014, 8(10):1-2.
15.	刘畅, 张玲, 姜政, 等. TNF-β基因+252A/G多态性与胃癌易感性Meta分析. 重庆医科大学学报, 2014, 39(3):284-289.
16.	司君利, 亓玉琴, 纪丽莎, 等. hTERT基因多态性与胃癌易感性的研究. 胃肠病学, 2014, 19(5):270-274.
17.	小红逄, 李效良, 张国琴. IGF2R基因多态性与胃癌易感性的相关性. 泰山医学院学报, 2013, 34(11):805-807.
18.	王晓龙, 张成武, 刘宁, 等. P53基因Arg72Pro单核苷酸多态性与青海地区人群胃癌易感性的相关性分析. 中国免疫学杂志, 2014, 30(2):178-181.
19.	李丹萍, 侯慧, 徐昌青, 等. xpc 基因多态性与胃癌发生风险的关系. 山东医药, 2014, 54(13):24-26.
20.	Lu Q, Jiang K, Li Q, et al. Polymorphisms in the MTHFR gene are associated with breast cancer risk and prognosis in a Chinese population. Tumour Biol, 2015,[Epub ahead of print].
21.	Liu NB, Li J, Qi JF, et al. Methylenetetrahydrofolate reductase 677TT genotype may be associated with an increased lung cancer risk in North China:an updated meta-analysis. Med Sci Monit, 2014, 20:2817-2823.
22.	Rai V. Folate pathway gene MTHFR C677T polymorphism and risk of lung cancer in Asian populations. Asian Pac J Cancer Prev, 2014, 15(21):9259-9264.

1. Engin AB, Karahalil B, Karakaya AE, et al. Association between XRCC1 ARG399GLN and P53 ARG72PRO polymorphisms and the risk of gastric and colorectal cancer in Turkish population. Arh Hig Rada Toksikol, 2011, 62(3):207-214.
2. Yuan T, Deng S, Chen M, et al. Association of DNA repair gene XRCC1 and XPD polymorphisms with genetic susceptibility to gastric cancer in a Chinese population. Cancer Epidemiol, 2011, 35(2):170-174.
3. Woo HD, Lee J, Choi IJ, et al. Dietary flavonoids and gastric cancer risk in a Korean population. Nutrients, 2014, 6(11):4961-4973.
4. Yoon H, Kim N. Diagnosis and management of high risk group for gastric cancer. Gut Liver, 2015, 9(1):5-17.
5. Huang GL, Wang SK, Su M, et al. Serum folate, MTHFR C677T polymorphism and esophageal squamous cell carcinoma risk. Biomed Environ Sci, 2013, 26(12):1008-1012.
6. 宋洁云, 刘芳宏, 马军, 等. 酚/氯仿法和盐析法提取人类外周血基因组DNA方法的比较. 中国实验诊断学, 2013, 17(5):802-805.
7. Wen YY, Pan XF, Loh M, et al. ADPRT Val762Ala and XRCC1 Arg194Trp polymorphisms and risk of gastric cancer in Sichuan of China. Asian Pac J Cancer Prev, 2012, 13(5):2139-2144.
8. 文拓. 胃癌外科治疗的现状与进展. 中国卫生产业, 2013, 2(4):191.
9. Zhang Y, Wang M, Gu D, et al. Association of XRCC1 gene polymor-phisms with the survival and clinicopathological characteristics of gastric cancer. DNA Cell Biol, 2013, 32(3):111-118.
10. Wu YL, Hu CY, Lu SS, et al. Association between methylenetetrahy-drofolate reductase (MTHFR) C677T/A1298C polymorphisms and essential hypertension:a systematic review and meta-analysis. Metabolism, 2014, 63(12):1503-1511.
11. 马利敏, 赵小强, 刘洪超, 等. 亚甲基四氢叶酸还原酶基因多态性与中国儿童急性淋巴细胞白血病关系的Meta分析. 医学研究杂志, 2014, 43(4):87-90.
12. Zhou BS, Bu GY, Li M, et al. Tagging SNPs in the MTHFR gene and risk of ischemic stroke in a Chinese population. Int J Mol Sci, 2014, 15(5):8931-8940.
13. 宋姗姗, 杨博逸, 孙贵范. 中国人群中亚甲基四氢叶酸还原酶C677T和A1298C基因多态性与乳腺癌相关性的Meta分析. 中国慢性病预防与控制, 2013, 21(5):560-564.
14. 张军喜, 郭爱叶, 李宗辉, 等. TNF-α-308基因多态性与胃癌的关系研究. 中国现代药物应用, 2014, 8(10):1-2.
15. 刘畅, 张玲, 姜政, 等. TNF-β基因+252A/G多态性与胃癌易感性Meta分析. 重庆医科大学学报, 2014, 39(3):284-289.
16. 司君利, 亓玉琴, 纪丽莎, 等. hTERT基因多态性与胃癌易感性的研究. 胃肠病学, 2014, 19(5):270-274.
17. 小红逄, 李效良, 张国琴. IGF2R基因多态性与胃癌易感性的相关性. 泰山医学院学报, 2013, 34(11):805-807.
18. 王晓龙, 张成武, 刘宁, 等. P53基因Arg72Pro单核苷酸多态性与青海地区人群胃癌易感性的相关性分析. 中国免疫学杂志, 2014, 30(2):178-181.
19. 李丹萍, 侯慧, 徐昌青, 等. xpc 基因多态性与胃癌发生风险的关系. 山东医药, 2014, 54(13):24-26.
20. Lu Q, Jiang K, Li Q, et al. Polymorphisms in the MTHFR gene are associated with breast cancer risk and prognosis in a Chinese population. Tumour Biol, 2015,[Epub ahead of print].
21. Liu NB, Li J, Qi JF, et al. Methylenetetrahydrofolate reductase 677TT genotype may be associated with an increased lung cancer risk in North China:an updated meta-analysis. Med Sci Monit, 2014, 20:2817-2823.
22. Rai V. Folate pathway gene MTHFR C677T polymorphism and risk of lung cancer in Asian populations. Asian Pac J Cancer Prev, 2014, 15(21):9259-9264.

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