腹水胆固醇浓度鉴别门静脉高压性与非门静脉高压性腹水的临床研究_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 张迪 ,  黎一鸣 , 陆宏伟 , 吉鸿

西安交通大学医学院第二附属医院普通外科（陕西西安 710004）;

Corresponding author：

黎一鸣, Email: liyiming2003@sina.com

Keywords：

腹水; 胆固醇; 门静脉高压

DOI：

10.7507/1007-9424.20150126

Video：

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Abstract Full text Figures/Tables Video References Cited by

目的探讨腹水胆固醇浓度在鉴别门静脉高压性与非门静脉高压性腹水中的临床意义。方法应用胆固醇氧化酶比色法对159例确诊病例的腹水及血液样本进行胆固醇浓度的测定，并对检测结果进行分析，其中包括门静脉高压性腹水81例，非门静脉高压性腹水78例。结果门静脉高压性腹水组腹水中胆固醇浓度为（0.61±0.55）mmol/L，非门静脉高压性腹水组腹水中的胆固醇浓度为（2.32±1.05）mmol/L，前者明显低于后者（P＜0.01）。根据受试者工作特征曲线（ROC曲线），腹水胆固醇浓度诊断门静脉高压性腹水的敏感度为96%，特异度为98%。结论对于一些临床表现不典型、原因不明确的腹水患者，腹水中胆固醇浓度对于门静脉高压性腹水与非门静脉高压性腹水的鉴别具有一定的价值。

Citation： 张迪, 黎一鸣, 陆宏伟, 吉鸿. 腹水胆固醇浓度鉴别门静脉高压性与非门静脉高压性腹水的临床研究. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2015, 22(4): 482-483. doi: 10.7507/1007-9424.20150126 Copy

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2.	Rana SV, Babu SG, Kocchar R.Usefulness of ascetic fluid cholesterol as a marker for malignant ascites.Med Sci Monit, 2005, 11(3):136-142.
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7.	Castaldo G, Oriani G, Cimino L, et al.Total discrimination of peritoneal malignant ascites from cirrhosis and hepato-carcinoma-associated ascites by assays of ascitic cholesterol and lactate dehydrogenase.Clin Chem, 1994, 40(3):478-483.
8.	Kahn FY.Ascites in the state of Qatar:aetiology and diagnostic value of ascitic fluid analysis.Singapore Med J, 2007, 48(5):434-439.
9.	王继见.门脉高压症发病机理的研究近况.中国普外基础与临床杂志, 2000, 7(4):275-276.
10.	何远春, 李俊, 陈振东.胸腹水胆固醇测定对良恶性病变鉴别诊断的价值.安徽医科大学学报, 2009, 44(5):655-656.
11.	Gerbes AL, Jungst D.Role of cholesterol determination in ascitic fluid analysis.Hepatology, 2009, 50(4):1320.
12.	陈国平, 桂满元.胸腹水生化指标联合应用的临床诊断价值探讨.中外医学研究, 2011, 9(9):35-36.
13.	刘辉, 左芳, 胡芳.胆固醇比值对胸腹水鉴别诊断的意义.检验医学与临床, 2007, 4(6):499.
14.	张淑艳, 王海英, 熊慧顺.胸腹水与血清胆固醇联合测定对胸腹水性质的鉴别诊断意义.临床军医杂志, 2011, 39(5):907-908.
15.	蔡根度, 吕雁群, 洪迎华, 等.胆固醇分析对良恶性腹水的诊断价值.上海医药检验杂志, 1996, 11(2):127.
16.	盛裕芬.胸腹水/血清胆固醇比值鉴别胸腹水性质.临床检验杂志, 1994, 12(3):138.

1. Gulyás M, Kaposi AD, Elek G, et al.Value of carcinoenmbryonic antigen (CEA) and cholesterol assays of ascetic fluid in cases of inconclusive cytology.J Clin Pathol, 2001, 54(11):831-835.
2. Rana SV, Babu SG, Kocchar R.Usefulness of ascetic fluid cholesterol as a marker for malignant ascites.Med Sci Monit, 2005, 11(3):136-142.
3. 罗春丽.临床检验基础.第3版.北京:人民卫生出版社, 2004:203-204.
4. Almakdisi T, Massoud S, Makdisi G.Lymphomas and chylous ascites:review of the literature.Oncologist, 2005, 10(8):632-635.
5. Balint PV, Kane D, Sturrock RD.Case number 26:massive cholesterol crystal deposition:unusual location in rheumatoid arthritis.Arm Rheum Dis, 2003, 62(6):512.
6. Bothenherg ME.Eosinophilic gastrointeatinal disorders (EGID).J Allergy Clin Immunol, 2004, 113(1):11-28.
7. Castaldo G, Oriani G, Cimino L, et al.Total discrimination of peritoneal malignant ascites from cirrhosis and hepato-carcinoma-associated ascites by assays of ascitic cholesterol and lactate dehydrogenase.Clin Chem, 1994, 40(3):478-483.
8. Kahn FY.Ascites in the state of Qatar:aetiology and diagnostic value of ascitic fluid analysis.Singapore Med J, 2007, 48(5):434-439.
9. 王继见.门脉高压症发病机理的研究近况.中国普外基础与临床杂志, 2000, 7(4):275-276.
10. 何远春, 李俊, 陈振东.胸腹水胆固醇测定对良恶性病变鉴别诊断的价值.安徽医科大学学报, 2009, 44(5):655-656.
11. Gerbes AL, Jungst D.Role of cholesterol determination in ascitic fluid analysis.Hepatology, 2009, 50(4):1320.
12. 陈国平, 桂满元.胸腹水生化指标联合应用的临床诊断价值探讨.中外医学研究, 2011, 9(9):35-36.
13. 刘辉, 左芳, 胡芳.胆固醇比值对胸腹水鉴别诊断的意义.检验医学与临床, 2007, 4(6):499.
14. 张淑艳, 王海英, 熊慧顺.胸腹水与血清胆固醇联合测定对胸腹水性质的鉴别诊断意义.临床军医杂志, 2011, 39(5):907-908.
15. 蔡根度, 吕雁群, 洪迎华, 等.胆固醇分析对良恶性腹水的诊断价值.上海医药检验杂志, 1996, 11(2):127.
16. 盛裕芬.胸腹水/血清胆固醇比值鉴别胸腹水性质.临床检验杂志, 1994, 12(3):138.

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腹水胆固醇浓度鉴别门静脉高压性与非门静脉高压性腹水的临床研究

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