Progress in Research of Adenocarcinoma of Esophagogastric Junction_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 MAXiao-ming ,  WUJian-qiang , WANGJian.

Department of General Surgery, The People's Hospital of Suqian City, Suqian 223800, Jiangsu Province, China;

Corresponding author：

WUJian-qiang, Email: wjq-10@163.com

Keywords：

Adenocarcinoma of esophagogastric junction; Siewert classification; Lymph node metastasis; Surgical procedure

DOI：

10.7507/1007-9424.20150166

Video：

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Objective To summarize the current advancement of adenocarcinoma of the esophagogastric junction (AEG) and improve the knowledge and cognition about AEG and find a feasible treatment strategy.Method Relevant literatures about current advancement of AEG published domestically and abroad recently were collected and reviewed. Results AEG had obvious differences from other parts of stomach tumors in anatomy, physiology, and pathology. The study of AEG in definition, biology origin, classification, lymph node metastasis and other aspects had basically reached a consensus. But for the surgical approach, the extent of resection, lymph node dissection or the way of the digestive tract reconstruction was controversial for a long time. Conclusions AEG as a kind of independent disease is increasing hazard to human health．By far, the most effective treatment is surgical resection, and how to choose the surgical method needs to be further researched.

Citation： MAXiao-ming, WUJian-qiang, WANGJian.. Progress in Research of Adenocarcinoma of Esophagogastric Junction. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2015, 22(5): 637-641. doi: 10.7507/1007-9424.20150166 Copy

1.	Siewert JR, Feith M, Stein HJ. Biologic and clinical variations of adenocarcinoma at the esophago-gastric junction:Relevance of a topographic-anatomic subclassification. J Surg Oncol, 2005, 90(3):139-146.
2.	Ohno S, Tomisaki S, Oiwa H, et al. Clinicopathologic characteristics and outcome of adenocarcinoma of the human gastric cardia in comparison with carcinoma of other regions of the stomach. J Am Coll Surg, 1995, 180(5):577-582.
3.	Saito H, Fukumoto Y, Osaki T, et al. Distinct recurrence pattern and outcome of adenocarcinoma of the gastric cardia in comparison with carcinoma of other regions of the stomach. World J Surg, 2006, 30(10):1864-1869.
4.	Siewert JR, Stein HJ. Classification of adenocarcinoma of the oesophagogastric junction. Br J Surg, 1998, 85(11):1457-1459.
5.	陈俊强, 张诗峰.食管-胃结合部癌.中华外科杂志, 2005, 43(17):1161-1163.
6.	Japanese Gastric Cancer Association. Japanese classification of gastric carcinoma:3rd English edition. Gastric Cancer, 2011, 14(2):101-112.
7.	Kurokawa Y, Sasako M, Doki Y. Treatment approaches to esophagogastric junction tumors. Dig Surg, 2013, 30(2):169-173.
8.	肖文光, 马可, 彭林, 等.食管胃交界部腺癌淋巴结转移特点及手术方式选择.中华胃肠外科杂志, 2012, 15(9):897-900.
9.	杨宏, 武爱文, 季加孚, 等.食管胃结合部腺癌471例Siewert分型临床研究.中国实用外科杂志, 2012, 32(4):310-315.
10.	Devesa SS, Blot WJ, Fraumeni JF. Changing patterns in the incidence of esophageal and gastric carcinoma in the United States. Cancer, 1998, 83(10):2049-2053.
11.	季加孚, 季鑫.食管胃结合部腺癌的外科治疗.中华消化外科杂志, 2014, 13(2):81-84.
12.	Siewert JR, Stein HJ, Feith M. Adenocarcinoma of the esophagogastric Junction. Scand J Surg, 2006, 95(4):260-269.
13.	Hasegawa S, Yoshikawa T, Cho H, et al. Is adenocarcinoma of the esophagogastric junction different between Japan and western countries? The incidence and clinicopathological features at a Japanese high-volume cancer center. World J Surg, 2009, 33(1):95-103.
14.	Schroder W, Monig SP, Baldus SE, et al. Frequency of nodal metastases to the upper mediastinum in Barrett's cancer. Ann Surg Oncol, 2002, 9(8):807-811.
15.	Schuhmacher C, Novotny A, Ott K, et al. Lymphadenectomy with tumors of the upper gastrointestinal tract. Chirurg, 2007, 78(3):203-206, 208-212, 214-216.
16.	Pedrazzani C, De Manzoni G, Marrelli D, et al. Lymph node involvement in advanced gastroesophageal junction adenocarcinoma. J Thorac Cardiovasc Surg, 2007, 134(2):378-385.
17.	李守淼, 李子禹, 季鑫. SiewertⅡ型胃食管结合部腺癌淋巴结转移的特点.中华肿瘤杂志, 2013, 35(4):288-291.
18.	Rüdiger Siewert J, Feith M, Werner M, et al. Adenocarcinoma of the esophagogastric junction:results of surgical therapy based on anatomical/topographic classification in 1 002 consecutive patients. Ann Surg, 2000, 232(3):353-361.
19.	Gertler R, Stein HJ, Langer R, et al. Long-term outcome of 2 920 patients with cancers of the esophagus and esophagogastric junction evaluation of the New Union Internationale Contre le Cancer/American Joint Cancer Committee Staging System. Ann Surg, 2011, 253(4):689-698.
20.	Von Rahden BH, Stein HJ, Siewert JR. Surgical management of esophagogastric junction tumors. World J Gastroenterol, 2006, 12 (41):6608-6613.
21.	Hulscher JB, van Sandick JW, de Boer AG, et al. Extended transthoracic resection compared with limited transhiatal resection for adenocarcinoma of the esophagus. N Engl J Med, 2002, 347(21):1662-1669.
22.	Sasako M, Sano T, Yamamoto S, et al. Left thoracoabdominal approach versus abdominal-transhiatal approach for gastric cancer of the cardia or subcardia:a randomised controlled trial. Lancet Oncol, 2006, 7(8):644-651.
23.	孙益红.食管胃结合部腺癌的外科治疗原则.中华普外科手术学杂志:电子版, 2010, 4(2):119-122.
24.	李茂竹, 马善符, 马琴, 等.胃底贲门癌手术径路的选择.中华普通外科杂志, 2000, 15(2):80-81.
25.	Amenabar A, Hoppo T, Jobe BA. Surgical management of gastroesophageal junction tumors. Semin Radiat Oncol, 2013, 23(1):16-23.
26.	Mariette C, Piessen G, Briez N, et al. Oesophagogastric junction adenocarcinoma:which therapeutic approach? Lancet Oncol, 2011, 12(3):296-305.
27.	Ito H, Clancy TE, Osteen RT, et al. Adenocarcinoma of the gastric cardia:What is the optimal surgical approach? J Am Coll Surg, 2004, 199(6):880-886.
28.	Hasegawa S, Yoshikawa T. Adenocarcinoma of the esophagogastric junction:incidence, characteristics, and treatment strategies. Gastric Cancer, 2010, 13(2):63-73.
29.	Mine S, Sano T, Hiki N, et al. Proximal margin length with transhiatal gastrectomy for Siewert typeⅡandⅢadenocarcinomas of the oesophagogastric junction. Br J Surg, 2013, 100(8):1050-1054.
30.	薛英威, 于雪峰.提高对食管胃结合部肿瘤的认识.中华胃肠外科杂志, 2013, 16(2):125-127.
31.	Siewert JR, Feith M. Adenocarcinoma of the esophagogastric junction:competition between Barrett and gastric cancer. J Am Coll Surg, 2007, 205(4 Suppl):S49-S53.
32.	Kim JH, Park SS, Kim J, et al. Surgical outcomes for gastric cancer in the upper third of the stomach. World J Surg, 2006, 30(10):1870-1878.
33.	杨宏, 武爱文, 李子禹, 等.胃食管结合部癌514例外科治疗结果及其预后分析.中华外科杂志, 2010, 48(17):1289-1294.
34.	Yamamoto M, Baba H, Egashira A, et al. Adenocarcinoma of the esophagogastric junction in Japan. Hepatogastroenterology, 2008, 55(81):103-107.
35.	Lerut T, Nafteux P, Moons J, et al. Three-field lymphadenectomy for carcinoma of the esophagus and gastroesophageal junction in 174 R0 resections:impact on staging, disease-free survival, and outcome:a plea for adaptation of TNM classification in upper-half esophageal carcinoma. Ann Surg, 2004, 240(6):962-974.
36.	Nunobe S, Ohyama S, Sonoo H, et al. Benefit of mediastinal and para-aortic lymph-node dissection for advanced gastric cancer with esophageal invasion. J Surg Oncol, 2008, 97(5):392-395.
37.	Shin SH, Jung H, Choi SH, et al. Clinical significance of splenic hilar lymph node metastasis in proximal gastric cancer. Ann Surg Oncol, 2009, 16(5):1304-1309.
38.	张成海, 武爱文, 李子禹, 等.进展期胃癌脾门区淋巴结转移及其清扫方式.中华胃肠外科杂志, 2011, 14(8):589-592.
39.	Kim JW, Yoon H, Kong SH, et al. Analysis of esophageal reflux after proximal gastrectomy measured by wireless ambulatory 24-Hr esophageal pH monitoring and TC-99m diisopropyliminodiacetic acid (DISIDA) scan. J Surg Oncol, 2010, 101(7):626-633.
40.	Tokunaga M, Ohyama S, Hiki N, et al. Endoscopic evaluation of reflux esophagitis after proximal gastrectomy:comparison between esophagogastric anastomosis and jejunal interposition. World J Surg, 2008, 32(7):1473-1477.
41.	肖江卫, 刘紫麟, 叶鹏程, 等.保留胃窦的间置空肠双通道术式在食管胃结合部癌根治术中的应用探讨.中华临床医师杂志:电子版, 2014, 8(19):3427-3431.
42.	吴建强, 管小青, 吴际生, 等.近端胃切除残胃空肠双通道吻合在胃上部癌根治术中的应用.中国普外基础与临床杂志, 2010, 17(9):963-966.

1. Siewert JR, Feith M, Stein HJ. Biologic and clinical variations of adenocarcinoma at the esophago-gastric junction:Relevance of a topographic-anatomic subclassification. J Surg Oncol, 2005, 90(3):139-146.
2. Ohno S, Tomisaki S, Oiwa H, et al. Clinicopathologic characteristics and outcome of adenocarcinoma of the human gastric cardia in comparison with carcinoma of other regions of the stomach. J Am Coll Surg, 1995, 180(5):577-582.
3. Saito H, Fukumoto Y, Osaki T, et al. Distinct recurrence pattern and outcome of adenocarcinoma of the gastric cardia in comparison with carcinoma of other regions of the stomach. World J Surg, 2006, 30(10):1864-1869.
4. Siewert JR, Stein HJ. Classification of adenocarcinoma of the oesophagogastric junction. Br J Surg, 1998, 85(11):1457-1459.
5. 陈俊强, 张诗峰.食管-胃结合部癌.中华外科杂志, 2005, 43(17):1161-1163.
6. Japanese Gastric Cancer Association. Japanese classification of gastric carcinoma:3rd English edition. Gastric Cancer, 2011, 14(2):101-112.
7. Kurokawa Y, Sasako M, Doki Y. Treatment approaches to esophagogastric junction tumors. Dig Surg, 2013, 30(2):169-173.
8. 肖文光, 马可, 彭林, 等.食管胃交界部腺癌淋巴结转移特点及手术方式选择.中华胃肠外科杂志, 2012, 15(9):897-900.
9. 杨宏, 武爱文, 季加孚, 等.食管胃结合部腺癌471例Siewert分型临床研究.中国实用外科杂志, 2012, 32(4):310-315.
10. Devesa SS, Blot WJ, Fraumeni JF. Changing patterns in the incidence of esophageal and gastric carcinoma in the United States. Cancer, 1998, 83(10):2049-2053.
11. 季加孚, 季鑫.食管胃结合部腺癌的外科治疗.中华消化外科杂志, 2014, 13(2):81-84.
12. Siewert JR, Stein HJ, Feith M. Adenocarcinoma of the esophagogastric Junction. Scand J Surg, 2006, 95(4):260-269.
13. Hasegawa S, Yoshikawa T, Cho H, et al. Is adenocarcinoma of the esophagogastric junction different between Japan and western countries? The incidence and clinicopathological features at a Japanese high-volume cancer center. World J Surg, 2009, 33(1):95-103.
14. Schroder W, Monig SP, Baldus SE, et al. Frequency of nodal metastases to the upper mediastinum in Barrett's cancer. Ann Surg Oncol, 2002, 9(8):807-811.
15. Schuhmacher C, Novotny A, Ott K, et al. Lymphadenectomy with tumors of the upper gastrointestinal tract. Chirurg, 2007, 78(3):203-206, 208-212, 214-216.
16. Pedrazzani C, De Manzoni G, Marrelli D, et al. Lymph node involvement in advanced gastroesophageal junction adenocarcinoma. J Thorac Cardiovasc Surg, 2007, 134(2):378-385.
17. 李守淼, 李子禹, 季鑫. SiewertⅡ型胃食管结合部腺癌淋巴结转移的特点.中华肿瘤杂志, 2013, 35(4):288-291.
18. Rüdiger Siewert J, Feith M, Werner M, et al. Adenocarcinoma of the esophagogastric junction:results of surgical therapy based on anatomical/topographic classification in 1 002 consecutive patients. Ann Surg, 2000, 232(3):353-361.
19. Gertler R, Stein HJ, Langer R, et al. Long-term outcome of 2 920 patients with cancers of the esophagus and esophagogastric junction evaluation of the New Union Internationale Contre le Cancer/American Joint Cancer Committee Staging System. Ann Surg, 2011, 253(4):689-698.
20. Von Rahden BH, Stein HJ, Siewert JR. Surgical management of esophagogastric junction tumors. World J Gastroenterol, 2006, 12 (41):6608-6613.
21. Hulscher JB, van Sandick JW, de Boer AG, et al. Extended transthoracic resection compared with limited transhiatal resection for adenocarcinoma of the esophagus. N Engl J Med, 2002, 347(21):1662-1669.
22. Sasako M, Sano T, Yamamoto S, et al. Left thoracoabdominal approach versus abdominal-transhiatal approach for gastric cancer of the cardia or subcardia:a randomised controlled trial. Lancet Oncol, 2006, 7(8):644-651.
23. 孙益红.食管胃结合部腺癌的外科治疗原则.中华普外科手术学杂志:电子版, 2010, 4(2):119-122.
24. 李茂竹, 马善符, 马琴, 等.胃底贲门癌手术径路的选择.中华普通外科杂志, 2000, 15(2):80-81.
25. Amenabar A, Hoppo T, Jobe BA. Surgical management of gastroesophageal junction tumors. Semin Radiat Oncol, 2013, 23(1):16-23.
26. Mariette C, Piessen G, Briez N, et al. Oesophagogastric junction adenocarcinoma:which therapeutic approach? Lancet Oncol, 2011, 12(3):296-305.
27. Ito H, Clancy TE, Osteen RT, et al. Adenocarcinoma of the gastric cardia:What is the optimal surgical approach? J Am Coll Surg, 2004, 199(6):880-886.
28. Hasegawa S, Yoshikawa T. Adenocarcinoma of the esophagogastric junction:incidence, characteristics, and treatment strategies. Gastric Cancer, 2010, 13(2):63-73.
29. Mine S, Sano T, Hiki N, et al. Proximal margin length with transhiatal gastrectomy for Siewert typeⅡandⅢadenocarcinomas of the oesophagogastric junction. Br J Surg, 2013, 100(8):1050-1054.
30. 薛英威, 于雪峰.提高对食管胃结合部肿瘤的认识.中华胃肠外科杂志, 2013, 16(2):125-127.
31. Siewert JR, Feith M. Adenocarcinoma of the esophagogastric junction:competition between Barrett and gastric cancer. J Am Coll Surg, 2007, 205(4 Suppl):S49-S53.
32. Kim JH, Park SS, Kim J, et al. Surgical outcomes for gastric cancer in the upper third of the stomach. World J Surg, 2006, 30(10):1870-1878.
33. 杨宏, 武爱文, 李子禹, 等.胃食管结合部癌514例外科治疗结果及其预后分析.中华外科杂志, 2010, 48(17):1289-1294.
34. Yamamoto M, Baba H, Egashira A, et al. Adenocarcinoma of the esophagogastric junction in Japan. Hepatogastroenterology, 2008, 55(81):103-107.
35. Lerut T, Nafteux P, Moons J, et al. Three-field lymphadenectomy for carcinoma of the esophagus and gastroesophageal junction in 174 R0 resections:impact on staging, disease-free survival, and outcome:a plea for adaptation of TNM classification in upper-half esophageal carcinoma. Ann Surg, 2004, 240(6):962-974.
36. Nunobe S, Ohyama S, Sonoo H, et al. Benefit of mediastinal and para-aortic lymph-node dissection for advanced gastric cancer with esophageal invasion. J Surg Oncol, 2008, 97(5):392-395.
37. Shin SH, Jung H, Choi SH, et al. Clinical significance of splenic hilar lymph node metastasis in proximal gastric cancer. Ann Surg Oncol, 2009, 16(5):1304-1309.
38. 张成海, 武爱文, 李子禹, 等.进展期胃癌脾门区淋巴结转移及其清扫方式.中华胃肠外科杂志, 2011, 14(8):589-592.
39. Kim JW, Yoon H, Kong SH, et al. Analysis of esophageal reflux after proximal gastrectomy measured by wireless ambulatory 24-Hr esophageal pH monitoring and TC-99m diisopropyliminodiacetic acid (DISIDA) scan. J Surg Oncol, 2010, 101(7):626-633.
40. Tokunaga M, Ohyama S, Hiki N, et al. Endoscopic evaluation of reflux esophagitis after proximal gastrectomy:comparison between esophagogastric anastomosis and jejunal interposition. World J Surg, 2008, 32(7):1473-1477.
41. 肖江卫, 刘紫麟, 叶鹏程, 等.保留胃窦的间置空肠双通道术式在食管胃结合部癌根治术中的应用探讨.中华临床医师杂志:电子版, 2014, 8(19):3427-3431.
42. 吴建强, 管小青, 吴际生, 等.近端胃切除残胃空肠双通道吻合在胃上部癌根治术中的应用.中国普外基础与临床杂志, 2010, 17(9):963-966.

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Progress in Research of Adenocarcinoma of Esophagogastric Junction

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