Preliminary Utility of Magnetic Resonance-T1ρ-Weighted Imaging in The Diagnosis of Human Primary Hepatic Carcinoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 ZHENGXing-ju ¹ , ZHENGJie ² , SUNJia-yu ¹ , WUBing ¹ , GAOFa-bao ¹ ,  SONGBin ¹

1. Department of Radiology, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China;
2. Mallinckrodt Radiological Institute in Washington University, Washington DC 63110, America;

Corresponding author：

SONGBin, Email: cjr.songbin@vip.163.com

Keywords：

Magnetic resonance-T1ρ-weighted imaging; Primary Hepatic carcinoma; Application value

DOI：

10.7507/1007-9424.20150194

Video：

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Objective To explore the utility of magnetic resonance-T1ρ-weighted imaging (T1ρWI) in the diagnosis of human primary hepatic carcinoma. Methods Nine patients were prospectively collected from West China Hospital of Sichuan University during January 2014 and June 2014, who had liver lesion that identified by the ultrasound or CT examination, and then were verified as primary hepatic carcinoma with pathological biopsy. A routine T2WI, pre-and post-contrast T1WI, pre-and post-contrast T1ρWI were performed on a 3.0 T clinical imager. The tumor-to-normal-tissue contrast was compared between pre-contrast T1ρWI/post-contrast T1ρWI and other sequences respectively, to investigate the value of T1ρWI in the diagnosis of human primary hepatic carcinoma. Results The tumor-to-normal-tissue contrast of pre-and post-contrast T1WI were lower than that of pre-contrast T1ρWI (t=3.532, P=0.008; t=3.666, P=0.006), while there was no statistical difference between T2WI and pre-contrast T1ρWI (t=-1.448, P=0.186). And compared with post-contrast T1ρWI, post-contrast T1WI had lower tumor-to-normal-tissue contrast (t=3.468, P=0.008). Conclusions T1ρWI can provide a better image of human primary hepatic carcinoma, thus T1ρWI is expected to become a new and useful method in MR scanning. It also shows potential value who can be used as an artery imaging that without using contrast agents.

Citation： ZHENGXing-ju, ZHENGJie, SUNJia-yu, WUBing, GAOFa-bao, SONGBin. Preliminary Utility of Magnetic Resonance-T1ρ-Weighted Imaging in The Diagnosis of Human Primary Hepatic Carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2015, 22(6): 743-745. doi: 10.7507/1007-9424.20150194 Copy

1.	武柏林, 刘怀军. MR-T1ρ成像的基本原理及临床应用.国际生物医学工程杂志, 2010, 33(4):249-253.
2.	Makela HI, Grohn OH, Kettunen MI, et al. Proton exchange as a relaxation mechanism for T1 in the rotating frame in native and immobilized protein solutions. Biochem Biophys Res Commun, 2001, 289(4):813-818.
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6.	Johannessen W, Auerbach JD, Wheaton AJ, et al. Assessment of human disc degeneration and proteoglycan content using T1ρweighted magnetic resonance imaging. Spine (Phila Pa 1976), 2006, 31(11):1253-1257.
7.	Poptani H, Duvvuri U, Miller CG, et al. T1rho imagine of murine brain tumors at 4 T. Acad Radiol, 2001, 8(1):42-47.
8.	Aronen HJ, Ramadan UA, Peltonen TK, et al. 3D spin-lock imaging of human gliomas. Magn Reson Imaging, 1999, 17(7):1001-1010.
9.	Duvvuri U, Poptani H, Feldman M, et al. Quantitative T1rho magnetic resonance imaging of RIF-1 tumors in vivo:detection of early response to cyclophosphamide therapy. Cancer Res, 2001, 61(21):7747-7753.
10.	Sierra A, Michaeli S, Niskanen JP, et al. Water spin dynamics during apoptotic cell death in glioma gene therapy probed by T1rho and T2rho. Magn Reson Med, 2008, 59(6):1311-1319.
11.	Zhang H, Xie Y, Ji T. Water diffusion-exchange effect on the paramagnetic relaxation enhancement in off-resonance rotating frame. J Magn Reson, 2007, 186(2):259-272.

1. 武柏林, 刘怀军. MR-T1ρ成像的基本原理及临床应用.国际生物医学工程杂志, 2010, 33(4):249-253.
2. Makela HI, Grohn OH, Kettunen MI, et al. Proton exchange as a relaxation mechanism for T1 in the rotating frame in native and immobilized protein solutions. Biochem Biophys Res Commun, 2001, 289(4):813-818.
3. Li X, Benjamin Ma C, Link TM, et al. In vivo T1ρand T2 mapping of articular cartilage in osteoarthritis of the knee using 3 T MRI. Osteoarthritis Cartilage, 2007, 15(7):789-797.
4. 周智洋, 单鸿, Steffen R, 等. 7.0 TMR关节软骨自旋锁定三维自旋-晶格弛豫时间成像与量化分析的实验研究.中华放射学杂志, 2008, 42(10):1101-1105.
5. Blumenkrantz G, Li X, Han ET, et al. A feasibility study of in vivo T1rho imaging of the intervertebral disc. Magn Reson Imaging, 2006, 24(8):1001-1007.
6. Johannessen W, Auerbach JD, Wheaton AJ, et al. Assessment of human disc degeneration and proteoglycan content using T1ρweighted magnetic resonance imaging. Spine (Phila Pa 1976), 2006, 31(11):1253-1257.
7. Poptani H, Duvvuri U, Miller CG, et al. T1rho imagine of murine brain tumors at 4 T. Acad Radiol, 2001, 8(1):42-47.
8. Aronen HJ, Ramadan UA, Peltonen TK, et al. 3D spin-lock imaging of human gliomas. Magn Reson Imaging, 1999, 17(7):1001-1010.
9. Duvvuri U, Poptani H, Feldman M, et al. Quantitative T1rho magnetic resonance imaging of RIF-1 tumors in vivo:detection of early response to cyclophosphamide therapy. Cancer Res, 2001, 61(21):7747-7753.
10. Sierra A, Michaeli S, Niskanen JP, et al. Water spin dynamics during apoptotic cell death in glioma gene therapy probed by T1rho and T2rho. Magn Reson Med, 2008, 59(6):1311-1319.
11. Zhang H, Xie Y, Ji T. Water diffusion-exchange effect on the paramagnetic relaxation enhancement in off-resonance rotating frame. J Magn Reson, 2007, 186(2):259-272.

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Preliminary Utility of Magnetic Resonance-T1ρ-Weighted Imaging in The Diagnosis of Human Primary Hepatic Carcinoma

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