Influence Factors of Pancreatic Cancer: Analysis of 71 Cases_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 TIANMing ^1,2 , MENGWen-bo ¹ , ZHAGNLei ¹ , ZHANGHui ¹ , WANGZheng-feng ¹ , ZHUXiao-liang ¹ , ZHUKe-xiang ¹ , LIXun ¹ ,  ZHOUWen-ce ^1,2

1. The Second Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China;
2. The First Clinical Medical School of Lanzhou University, Lanzhou 730000, Gansu Province, China;

Corresponding author：

ZHOUWen-ce, Email: zhouwc129@163.com

Keywords：

Pancreatic cancer; Prognosis; Influence factor

DOI：

10.7507/1007-9424.20150277

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To explore the prognostic factors of pancreatic cancer. Methods Clinical data of 71 patients of pancreatic cancer who treated in The First Hospital of Lanzhou University from January 2010 to December 2014 were retrospectively collected to analyze the prognostic factors of pancreatic cancer. Results Sixty patients of the 71 patients were followed up for 5-36 months, with the median time of 16 months, and the 1, 2, and 3-year cumulative survival rates were 60.6%, 23.9%, and 1.4% respectively. Univariate analysis results showed that, gender (P=0.043), lymph node metastasis (P=0.002), distant metastasis (P=0.000), TNM staging (P=0.000), and peripancreatic invasion (P=0.000) were correlated with the prognosis of pancreatic cancer, that female patients, patients with the presence of lymph node metastasis, distant metastasis, later TNM staging, and peripancreatic invasion had worse prognosis. Cox proportional hazard model results showed that, distant metastasis (P=0.047), TNM staging (P=0.002), and peripancreatic invasion (P=0.016) were prognostic factors of pancreatic cancer, patients with the presence of distant metastasis, later TNM staging, and peripancreatic invasion had poor prognosis. Conclusion Distant metastasis, TNM staging, and peripancreatic invasion were independent prognostic factors of pancreatic cancer.

Citation： TIANMing, MENGWen-bo, ZHAGNLei, ZHANGHui, WANGZheng-feng, ZHUXiao-liang, ZHUKe-xiang, LIXun, ZHOUWen-ce. Influence Factors of Pancreatic Cancer: Analysis of 71 Cases. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2015, 22(9): 1057-1061. doi: 10.7507/1007-9424.20150277 Copy

1.	Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin, 2015, 65(1):5-29.
2.	Bilimoria KY, Bentrem DJ, Ko CY, et al. Validation of the 6th edition AJCC Pancreatic Cancer Staging System:report from the National Cancer Database. Cancer, 2007, 110(4):738-744.
3.	Bosman FT, Carneiro F, Hruban RH, et al. WHO classification of tumours of the digestive system, fourth edition. Lyon:LARC Press, 2010:279-337.
4.	Edge SB, Byrd DR, Compton CC, et al. AJCC cancer staging manual. 7th ed. New York:Springer, 2010:241-249.
5.	Paiella S, De Pastena M, Esposito A, et al. Selective agenesis of pancreatic isthmus parenchyma with preservation of main pancreatic duct continuity, a very rare entity:case report. Int J Surg Case Rep, 2015, 6C:169-171.
6.	Xiao J, Peng F, Yu C, et al. MicroRNA-137 modulates pancreatic cancer cells tumor growth, invasion and sensitivity to chemotherapy. Int J Clin Exp Pathol, 2014, 7(11):7442-7450.
7.	Chu D, Kohlmann W, Adler DG. Identification and screening of individuals at increased risk for pancreatic cancer with emphasis on known environmental and genetic factors and hereditary syndromes. JOP, 2010, 11(3):203-212.
8.	Herreros-Villanueva M, Gironella M, Castells A, et al. Molecular markers in pancreatic cancer diagnosis. Clin Chim Acta, 2013, 418:22-29.
9.	刘子文, 赵玉沛. 2011版《NCCN胰腺癌临床实践指南》中若干问题的探讨. 临床肝胆病杂志, 2011, 27(11):1131-1134.
10.	Hidalgo M. Pancreatic cancer. N Engl J Med, 2010, 362(17):1605-1617.
11.	于琦, 赵平, 王成锋. 胰腺癌预后相关因素分析. 中国临床医生, 2014, 42(3):23-26.
12.	洪国斌, 周经兴, 梁碧玲. 影响中晚期胰腺癌预后因素的Cox回归分析. 循证医学, 2006, 6(3):164-166.
13.	马少军, 孔棣. 胰腺癌预后相关因素的分析研究. 中国中西医结合外科杂志, 2014, 20(1):11-16.
14.	戴月娣, 张德祥, 袁苏徐, 等. 胰腺癌治疗方式评价及预后分析. 中国癌症杂志, 2011, 21(3):211-215.
15.	李文英, 张晓峰, 曹淑红, 等. 胰腺癌手术患者115例的预后分析. 中国老年学杂志, 2011, 31(15):2867-2869.
16.	李学彦, 郭晓钟, 李宏宇, 等. 肿瘤标志物检测在胰腺癌诊断和预后评估中的价值研究. 中国实用内科杂志, 2014, 34(5):499-503.
17.	郭石, 艾福录. 胰腺癌手术治疗预后因素分析. 中华普外科手术学杂志:电子版, 2012, 6(3):301-306.
18.	潘岩, 刘鲁明, 陈震, 等. 中西医结合治疗190例老年胰腺癌的预后分析. 临床肝胆病杂志, 2014, 30(4):330-334.
19.	Kwak BJ, Kim SC, Song KB, et al. Prognostic factors associated with early mortality after surgical resection for pancreatic adenocar-cinoma. Korean J Hepatobiliary Pancreat Surg, 2014, 18(4):138-146.
20.	李诗杰, 胡军红, 谢永铮, 等. 根治性切除胰头癌患者临床病理资料与预后的关系. 中国普外基础与临床杂志, 2014, 21(8):965-970.
21.	周江蛟, 田艳涛, 刘昊, 等. 胰腺癌临床病理特征与淋巴结转移的关系. 中华肿瘤杂志, 2013, 35(2):132-134.
22.	魏晓平, 刁畅, 胡明道, 等. 165例胰头癌的外科治疗与预后分析. 腹部外科, 2011, 24(6):355-356.
23.	Li D, Tang H, Hassan MM, et al. Diabetes and risk of pancreatic cancer:a pooled analysis of three large case-control studies. Cancer Causes Control, 2011, 22(2):189-197.
24.	马娜, 邓德茂. 64层螺旋CT血管造影结合Ang-2表达评价胰腺癌胰周血管侵犯. 中国CT和MRI杂志, 2014, 12(8):52-54.
25.	赵玉沛. 2011年《NCCN胰腺癌临床实践指南》中国版解读. 中华外科杂志, 2011, 49(9):771-773.

1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin, 2015, 65(1):5-29.
2. Bilimoria KY, Bentrem DJ, Ko CY, et al. Validation of the 6th edition AJCC Pancreatic Cancer Staging System:report from the National Cancer Database. Cancer, 2007, 110(4):738-744.
3. Bosman FT, Carneiro F, Hruban RH, et al. WHO classification of tumours of the digestive system, fourth edition. Lyon:LARC Press, 2010:279-337.
4. Edge SB, Byrd DR, Compton CC, et al. AJCC cancer staging manual. 7th ed. New York:Springer, 2010:241-249.
5. Paiella S, De Pastena M, Esposito A, et al. Selective agenesis of pancreatic isthmus parenchyma with preservation of main pancreatic duct continuity, a very rare entity:case report. Int J Surg Case Rep, 2015, 6C:169-171.
6. Xiao J, Peng F, Yu C, et al. MicroRNA-137 modulates pancreatic cancer cells tumor growth, invasion and sensitivity to chemotherapy. Int J Clin Exp Pathol, 2014, 7(11):7442-7450.
7. Chu D, Kohlmann W, Adler DG. Identification and screening of individuals at increased risk for pancreatic cancer with emphasis on known environmental and genetic factors and hereditary syndromes. JOP, 2010, 11(3):203-212.
8. Herreros-Villanueva M, Gironella M, Castells A, et al. Molecular markers in pancreatic cancer diagnosis. Clin Chim Acta, 2013, 418:22-29.
9. 刘子文, 赵玉沛. 2011版《NCCN胰腺癌临床实践指南》中若干问题的探讨. 临床肝胆病杂志, 2011, 27(11):1131-1134.
10. Hidalgo M. Pancreatic cancer. N Engl J Med, 2010, 362(17):1605-1617.
11. 于琦, 赵平, 王成锋. 胰腺癌预后相关因素分析. 中国临床医生, 2014, 42(3):23-26.
12. 洪国斌, 周经兴, 梁碧玲. 影响中晚期胰腺癌预后因素的Cox回归分析. 循证医学, 2006, 6(3):164-166.
13. 马少军, 孔棣. 胰腺癌预后相关因素的分析研究. 中国中西医结合外科杂志, 2014, 20(1):11-16.
14. 戴月娣, 张德祥, 袁苏徐, 等. 胰腺癌治疗方式评价及预后分析. 中国癌症杂志, 2011, 21(3):211-215.
15. 李文英, 张晓峰, 曹淑红, 等. 胰腺癌手术患者115例的预后分析. 中国老年学杂志, 2011, 31(15):2867-2869.
16. 李学彦, 郭晓钟, 李宏宇, 等. 肿瘤标志物检测在胰腺癌诊断和预后评估中的价值研究. 中国实用内科杂志, 2014, 34(5):499-503.
17. 郭石, 艾福录. 胰腺癌手术治疗预后因素分析. 中华普外科手术学杂志:电子版, 2012, 6(3):301-306.
18. 潘岩, 刘鲁明, 陈震, 等. 中西医结合治疗190例老年胰腺癌的预后分析. 临床肝胆病杂志, 2014, 30(4):330-334.
19. Kwak BJ, Kim SC, Song KB, et al. Prognostic factors associated with early mortality after surgical resection for pancreatic adenocar-cinoma. Korean J Hepatobiliary Pancreat Surg, 2014, 18(4):138-146.
20. 李诗杰, 胡军红, 谢永铮, 等. 根治性切除胰头癌患者临床病理资料与预后的关系. 中国普外基础与临床杂志, 2014, 21(8):965-970.
21. 周江蛟, 田艳涛, 刘昊, 等. 胰腺癌临床病理特征与淋巴结转移的关系. 中华肿瘤杂志, 2013, 35(2):132-134.
22. 魏晓平, 刁畅, 胡明道, 等. 165例胰头癌的外科治疗与预后分析. 腹部外科, 2011, 24(6):355-356.
23. Li D, Tang H, Hassan MM, et al. Diabetes and risk of pancreatic cancer:a pooled analysis of three large case-control studies. Cancer Causes Control, 2011, 22(2):189-197.
24. 马娜, 邓德茂. 64层螺旋CT血管造影结合Ang-2表达评价胰腺癌胰周血管侵犯. 中国CT和MRI杂志, 2014, 12(8):52-54.
25. 赵玉沛. 2011年《NCCN胰腺癌临床实践指南》中国版解读. 中华外科杂志, 2011, 49(9):771-773.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Influence Factors of Pancreatic Cancer: Analysis of 71 Cases

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content