Research Progress of The Regulation Mechanism of YAP in Tumor Cells by Different Signal Pathway_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 ZHANGXiao-dong , YANGZhao-guo , TANGShi-lei ,  LIHang-yu

Department of General Surgery, Fourth Affiliated Hospital of China Medical University, Shen Yang 110032, Liaoning Province, China;

Corresponding author：

LIHang-yu, Email: li_hangyu@126.com

Keywords：

Yes association protein; Tumor; Signaling pathway

DOI：

10.7507/1007-9424.20150331

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To summarize the research progress of yes association protein (YAP) mechanisms regulatedby different signaling pathways in tumor cells in recent years. Methods Literatures about the recent studies on the YAP mechanisms regulated by different signaling pathways in tumor cells were reviewed according to the results searched from PubMed database. Results In addition to the traditional HIPPO pathway for the regulation of YAP, YAP is also regulated by the Rho-GTPases, JNK, and Wnt/β-Catenin signal pathways. Conclusion YAP is regulated by many factors in tumor cells, so better understand the mechanisms of YAP regulated by different signaling pathways will provide anovel putative target fortumor diagnosis and therapy in the future.

Citation： ZHANGXiao-dong, YANGZhao-guo, TANGShi-lei, LIHang-yu. Research Progress of The Regulation Mechanism of YAP in Tumor Cells by Different Signal Pathway. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2015, 22(10): 1270-1273. doi: 10.7507/1007-9424.20150331 Copy

1.	Piccolo S, Cordenonsi M, Dupont S. Molecular pathways:YAP and TAZ take center stage in organ growth and tumorigenesis. Clin Cancer Res, 2013, 19(18):4925-4930.
2.	Steinhardt AA, Gayyed MF, Klein AP, et al. Expression of Yesassociated protein in common solid tumors. Hum Pathol, 2008, 39(11):1582-1589.
3.	Sudol M. Yes-associated protein (YAP65) is a proline-rich phosphoprotein that binds to the SH3 domain of the Yes proto-oncogene product. Oncogene, 1994, 9(8):2145-2152.
4.	Huang J, Wu S, Barrera J, et al, The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP. Cell, 2005, 122(3):421-434.
5.	Chen L, Chan SW, Zhang X, et al. Structural basis of YAP recog nition by TEAD4 in the hippo pathway. Genes Dev, 2010, 24(3):290-300.
6.	Iglesias-Bexiga M, Castillo F, Cobos ES, et al. WW domains of the yes-kinase-associated-protein (YAP) transcriptional regulator behave as independent units with different binding preferences for PPxY motif-containing ligands. PloS one, 2015, 10(1):e0113828.
7.	Overholtzer M, Zhang J, Smolen GA, et al. Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon. Proc Natl Acad Sci U S A, 2006, 103(33):12405-12410.
8.	Dong J, Feldmann G, Huang J, et al. Elucidation of a universal sizecontrol mechanism in Drosophila and mammals. Cell, 2007, 130(6):1120-1133.
9.	Xu MZ, Yao TJ, Lee NP, et al. Yes-associated protein is an independent prognostic marker in hepatocellular carcinoma. Cancer, 2009, 115(19):4576-4585.
10.	Liu JY, Li YH, Lin HX, et al. Overexpression of YAP 1 contributes to progressive features and poor prognosis of human urothelial carcinoma of the bladder. BMC Cancer, 2013, 13:349.
11.	Yuan M, Tomlinson V, Lara R, et al. Yes-associated protein (YAP) functions as a tumor suppressor in breast. Cell Death Differ, 2008, 15(11):1752-1759.
12.	Jaramillo-Rodriguez Y, Cerda-Flores RM, Ruiz-Ramos R, et al. YAP expression in normal and neoplastic breast tissue:an immunohistochemical study. Arch Med Res, 2014, 45(3):223-228.
13.	Zhao B, Wei X, Li W, et al. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes & development, 2007, 21(21):2747-2761.
14.	Su T, Bondar T, Zhou X, et al. Two-signal requirement for growthpromoting function of Yap in hepatocytes. eLife, 2015, 4:e02948.
15.	Codelia VA, Sun G, Irvine KD. Regulation of YAP by mechanical strain through Jnk and Hippo signaling. Curr Biol, 2014, 24(17):2012-2017.
16.	Feng X, Degese MS, Iglesias-Bartolome R, et al. Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry. Cancer Cell, 2014, 25(6):831-845.
17.	Moroishi T, Park HW, Qin B, et al. A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis. Genes Dev, 2015, 29(12):1271-1284.
18.	St John MA, Tao W, Fei X, et al. Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction. Nat Genet, 1999, 21(2):182-186.
19.	Zhao B, Li L, Lei Q, et al. The Hippo-YAP pathway in organ size control and tumorigenesis:an updated version. Genes Dev, 2010, 24(9):862-874.
20.	Zhao B, Li L, Tumaneng K, et al. A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP). Genes Dev, 2010, 24(1):72-85.
21.	Zhou D, Conrad C, Xia F, et al. Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene. Cancer cell, 2009, 16(5):425-438.
22.	Avruch J, Zhou D, Fitamant J, et al. Protein kinases of the Hippo pathway:regulation and substrates. Semin Cell Dev Biol, 2012, 23(7):770-784.
23.	Mokady D, Meiri D. Rho-GTPases-A novel link between cytoskeleton organization and cisplatin resistance. Drug Resist Updat, 2015, 19:22-32.
24.	Ma X, Chen Y, Xu W, et al. Impaired Hippo signaling promotes Rho1-JNK-dependent growth. Proc Natl Acad Sci U S A, 2015, 112(4):1065-1070.
25.	Yu FX, Zhao B, Panupinthu N, et al. Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Cell, 2012, 150(4):780-791.
26.	Wang Z, Wu Y, Wang H, et al. Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility. Proc Natl Acad Sci U S A, 2014, 111(1):E89-E98.
27.	Sorrentino G, Ruggeri N, Specchia V, et al. Metabolic control of YAP and TAZ by the mevalonate pathway. Nat Cell Biol, 2014, 16(4):357-366.
28.	Lien WH, Fuchs E. Wnt some lose some:transcriptional governance of stem cells by Wnt/beta-catenin signaling. Genes Dev, 2014, 28(14):1517-1532.
29.	Gilgenkrantz H. The world according to YAP:a continuous crosstalk between Wnt and Hippo pathways. Med Sci (Paris), 2013, 29(10):868-874.
30.	Konsavage WM Jr, Kyler SL, Rennoll SA, et al. Wnt/β-Catenin Signaling Regulates Yes-associated Protein (YAP) Gene Expression in Colorectal Carcinoma Cells. J Biol Chem, 2012, 287(15):11730-11739.
31.	Wang J, Park JS, Wei Y, et al. TRIB2 acts downstream of Wnt/TCF in liver cancer cells to regulate YAP and C/EBPalpha function. Mol Cell, 2013, 51(2):211-225.
32.	Heallen T, Zhang M, Wang J, et al. Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size. Science, 2011, 332(6028):458-461.
33.	Azzolin L, Panciera T, Soligo S, et al. YAP/TAZ incorporation in the beta-catenin destruction complex orchestrates the Wnt response. Cell, 2014, 158(1):157-170.
34.	Kaneko K, Ito M, Naoe Y, et al. Integrin alphav in the mechanical response of osteoblast lineage cells. Biochem Biophys Res Commun, 2014, 447(2):352-357.
35.	Codelia VA, Sun G, Irvine KD. Regulation of YAP by mechanical strain through Jnk and Hippo signaling. Curr Biol, 2014, 24(17):2012-2017.
36.	Tomlinson V, Gudmundsdottir K, Luong P, et al. JNK phosphorylates Yes-associated protein (YAP) to regulate apoptosis. Cell Death Dis, 2010, 1:e29.

1. Piccolo S, Cordenonsi M, Dupont S. Molecular pathways:YAP and TAZ take center stage in organ growth and tumorigenesis. Clin Cancer Res, 2013, 19(18):4925-4930.
2. Steinhardt AA, Gayyed MF, Klein AP, et al. Expression of Yesassociated protein in common solid tumors. Hum Pathol, 2008, 39(11):1582-1589.
3. Sudol M. Yes-associated protein (YAP65) is a proline-rich phosphoprotein that binds to the SH3 domain of the Yes proto-oncogene product. Oncogene, 1994, 9(8):2145-2152.
4. Huang J, Wu S, Barrera J, et al, The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP. Cell, 2005, 122(3):421-434.
5. Chen L, Chan SW, Zhang X, et al. Structural basis of YAP recog nition by TEAD4 in the hippo pathway. Genes Dev, 2010, 24(3):290-300.
6. Iglesias-Bexiga M, Castillo F, Cobos ES, et al. WW domains of the yes-kinase-associated-protein (YAP) transcriptional regulator behave as independent units with different binding preferences for PPxY motif-containing ligands. PloS one, 2015, 10(1):e0113828.
7. Overholtzer M, Zhang J, Smolen GA, et al. Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon. Proc Natl Acad Sci U S A, 2006, 103(33):12405-12410.
8. Dong J, Feldmann G, Huang J, et al. Elucidation of a universal sizecontrol mechanism in Drosophila and mammals. Cell, 2007, 130(6):1120-1133.
9. Xu MZ, Yao TJ, Lee NP, et al. Yes-associated protein is an independent prognostic marker in hepatocellular carcinoma. Cancer, 2009, 115(19):4576-4585.
10. Liu JY, Li YH, Lin HX, et al. Overexpression of YAP 1 contributes to progressive features and poor prognosis of human urothelial carcinoma of the bladder. BMC Cancer, 2013, 13:349.
11. Yuan M, Tomlinson V, Lara R, et al. Yes-associated protein (YAP) functions as a tumor suppressor in breast. Cell Death Differ, 2008, 15(11):1752-1759.
12. Jaramillo-Rodriguez Y, Cerda-Flores RM, Ruiz-Ramos R, et al. YAP expression in normal and neoplastic breast tissue:an immunohistochemical study. Arch Med Res, 2014, 45(3):223-228.
13. Zhao B, Wei X, Li W, et al. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes & development, 2007, 21(21):2747-2761.
14. Su T, Bondar T, Zhou X, et al. Two-signal requirement for growthpromoting function of Yap in hepatocytes. eLife, 2015, 4:e02948.
15. Codelia VA, Sun G, Irvine KD. Regulation of YAP by mechanical strain through Jnk and Hippo signaling. Curr Biol, 2014, 24(17):2012-2017.
16. Feng X, Degese MS, Iglesias-Bartolome R, et al. Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry. Cancer Cell, 2014, 25(6):831-845.
17. Moroishi T, Park HW, Qin B, et al. A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis. Genes Dev, 2015, 29(12):1271-1284.
18. St John MA, Tao W, Fei X, et al. Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction. Nat Genet, 1999, 21(2):182-186.
19. Zhao B, Li L, Lei Q, et al. The Hippo-YAP pathway in organ size control and tumorigenesis:an updated version. Genes Dev, 2010, 24(9):862-874.
20. Zhao B, Li L, Tumaneng K, et al. A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP). Genes Dev, 2010, 24(1):72-85.
21. Zhou D, Conrad C, Xia F, et al. Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene. Cancer cell, 2009, 16(5):425-438.
22. Avruch J, Zhou D, Fitamant J, et al. Protein kinases of the Hippo pathway:regulation and substrates. Semin Cell Dev Biol, 2012, 23(7):770-784.
23. Mokady D, Meiri D. Rho-GTPases-A novel link between cytoskeleton organization and cisplatin resistance. Drug Resist Updat, 2015, 19:22-32.
24. Ma X, Chen Y, Xu W, et al. Impaired Hippo signaling promotes Rho1-JNK-dependent growth. Proc Natl Acad Sci U S A, 2015, 112(4):1065-1070.
25. Yu FX, Zhao B, Panupinthu N, et al. Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Cell, 2012, 150(4):780-791.
26. Wang Z, Wu Y, Wang H, et al. Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility. Proc Natl Acad Sci U S A, 2014, 111(1):E89-E98.
27. Sorrentino G, Ruggeri N, Specchia V, et al. Metabolic control of YAP and TAZ by the mevalonate pathway. Nat Cell Biol, 2014, 16(4):357-366.
28. Lien WH, Fuchs E. Wnt some lose some:transcriptional governance of stem cells by Wnt/beta-catenin signaling. Genes Dev, 2014, 28(14):1517-1532.
29. Gilgenkrantz H. The world according to YAP:a continuous crosstalk between Wnt and Hippo pathways. Med Sci (Paris), 2013, 29(10):868-874.
30. Konsavage WM Jr, Kyler SL, Rennoll SA, et al. Wnt/β-Catenin Signaling Regulates Yes-associated Protein (YAP) Gene Expression in Colorectal Carcinoma Cells. J Biol Chem, 2012, 287(15):11730-11739.
31. Wang J, Park JS, Wei Y, et al. TRIB2 acts downstream of Wnt/TCF in liver cancer cells to regulate YAP and C/EBPalpha function. Mol Cell, 2013, 51(2):211-225.
32. Heallen T, Zhang M, Wang J, et al. Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size. Science, 2011, 332(6028):458-461.
33. Azzolin L, Panciera T, Soligo S, et al. YAP/TAZ incorporation in the beta-catenin destruction complex orchestrates the Wnt response. Cell, 2014, 158(1):157-170.
34. Kaneko K, Ito M, Naoe Y, et al. Integrin alphav in the mechanical response of osteoblast lineage cells. Biochem Biophys Res Commun, 2014, 447(2):352-357.
35. Codelia VA, Sun G, Irvine KD. Regulation of YAP by mechanical strain through Jnk and Hippo signaling. Curr Biol, 2014, 24(17):2012-2017.
36. Tomlinson V, Gudmundsdottir K, Luong P, et al. JNK phosphorylates Yes-associated protein (YAP) to regulate apoptosis. Cell Death Dis, 2010, 1:e29.

Previous Article
Image Comparative Analysis of Tumorous Acute Pancreatitis and Non-Tumorous Acute Pancreatitis
Next Article
Acute-on-Chronic Liver Failure

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Research Progress of The Regulation Mechanism of YAP in Tumor Cells by Different Signal Pathway

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content